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Additionally, Entrectinib decreased proinflammatory cytokines and inhibited JNK\/p38\/AKT and NF-\u03baB\/STAT3 signaling in the hippocampus of LPS-treated mice. Notably, Entrectinib ameliorated LPS-induced memory impairments in vivo. Collectively, these findings indicate that Entrectinib attenuates neuroinflammation and improves memory performance, supporting its potential therapeutic relevance for neuroinflammation-associated cognitive disorders.<\/jats:p>","DOI":"10.1007\/s12272-026-01608-x","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T09:31:56Z","timestamp":1775381516000},"page":"393-415","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Entrectinib attenuates LPS-induced neuroinflammation by inhibiting JNK, p38, and AKT pathways and ameliorates cognitive impairment"],"prefix":"10.1007","volume":"49","author":[{"given":"Hanwoong","family":"Woo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehyun","family":"Chae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"1608_CR1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.18.00095","volume":"2","author":"SR Ambati","year":"2018","unstructured":"Ambati SR, Slotkin EK, Chow-Maneval E, Basu EM (2018) Entrectinib in two pediatric patients with inflammatory myofibroblastic tumors harboring ROS1 or ALK gene fusions. 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