{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:00:43Z","timestamp":1792429243690,"version":"4.5.0"},"reference-count":58,"publisher":"Tsinghua University Press","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nano Res."],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s12274-022-5354-4","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T06:37:35Z","timestamp":1677739055000},"page":"7459-7469","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer\u2019s disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay"],"prefix":"10.26599","volume":"16","author":[{"given":"Liding","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11138","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"5354_CR1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/547153a","volume":"547","author":"E McDade","year":"2017","unstructured":"McDade, E.; Bateman, R. J. Stop Alzheimer\u2019s before it starts. Nature 2017, 547, 153\u2013155.","journal-title":"Nature"},{"key":"5354_CR2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","volume":"25","author":"C A Lane","year":"2018","unstructured":"Lane, C. A.; Hardy, J.; Schott, J. M. Alzheimer\u2019s disease. Eur. J. Neurol. 2018, 25, 59\u201370.","journal-title":"Eur. J. Neurol."},{"key":"5354_CR3","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens, P.; De Strooper, B.; Kivipelto, M.; Holstege, H.; Ch\u00e9telat, G.; Teunissen, C. E.; Cummings, J.; van der Flier, W. M. Alzheimer\u2019s disease. Lancet 2021, 397, 1577\u20131590.","journal-title":"Lancet"},{"key":"5354_CR4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","volume":"18","author":"GBD 2016 Dementia Collaborators","year":"2019","unstructured":"GBD 2016 Dementia Collaborators. Global, regional, and national burden of Alzheimer\u2019s disease and other dementias. 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019, 18, 88\u2013106.","journal-title":"Lancet Neurol."},{"key":"5354_CR5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrn2967","volume":"12","author":"L M Ittner","year":"2011","unstructured":"Ittner, L. M.; G\u00f6tz, J. Amyloid-\u03b2 and tau\u2014A toxic pas de deux in Alzheimer\u2019s disease. Nat. Rev. Neurosci. 2011, 12, 65\u201372.","journal-title":"Nat. Rev. Neurosci."},{"key":"5354_CR6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"J A Hardy","year":"1992","unstructured":"Hardy, J. A.; Higgins, G. A. Alzheimer\u2019s disease: The amyloid cascade hypothesis. Science 1992, 256, 184\u2013185.","journal-title":"Science"},{"key":"5354_CR7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nrneurol.2013.223","volume":"9","author":"E Giacobini","year":"2013","unstructured":"Giacobini, E.; Gold, G. Alzheimer disease therapy-moving from amyloid-\u03b2 to tau. Nat. Rev. Neurol. 2013, 9, 677\u2013686.","journal-title":"Nat. Rev. Neurol."},{"key":"5354_CR8","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","volume":"377","author":"C Ballard","year":"2011","unstructured":"Ballard, C.; Gauthier, S.; Corbett, A.; Brayne, C.; Aarsland, D.; Jones, E. Alzheimer\u2019s disease. Lancet 2011, 377, 1019\u20131031.","journal-title":"Lancet"},{"key":"5354_CR9","doi-asserted-by":"crossref","first-page":"13325","DOI":"10.1021\/acsnano.9b06571","volume":"13","author":"L C Brazaca","year":"2019","unstructured":"Brazaca, L. C.; Moreto, J. R.; Mart\u00edn, A.; Tehrani, F.; Wang, J.; Zucolotto, V. Colorimetric paper-based immunosensor for simultaneous determination of fetuin B and clusterin toward early Alzheimer\u2019s diagnosis. ACS Nano 2019, 13, 13325\u201313332.","journal-title":"ACS Nano"},{"key":"5354_CR10","doi-asserted-by":"crossref","first-page":"2230001","DOI":"10.1142\/S1793545822300014","volume":"15","author":"L D Zhang","year":"2022","unstructured":"Zhang, L. D.; Liang, X. H.; Zhang, Z. H.; Luo, H. M. Cerebrospinal fluid and blood biomarkers in the diagnostic assays of Alzheimer\u2019s disease. J. Innov. Opt. Health Sci. 2022, 15, 2230001.","journal-title":"J. Innov. Opt. Health Sci."},{"key":"5354_CR11","doi-asserted-by":"crossref","first-page":"113881","DOI":"10.1016\/j.bios.2021.113881","volume":"199","author":"S Hu","year":"2022","unstructured":"Hu, S.; Yang, C. W.; Li, Y. Q.; Luo, Q. M.; Luo, H. M. Nanozyme sensor array based on manganese dioxide for the distinction between multiple amyloid \u03b2 peptides and their dynamic aggregation process. Biosens. Bioelectron. 2022, 199, 113881.","journal-title":"Biosens. Bioelectron."},{"key":"5354_CR12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/nan.12084","volume":"40","author":"S Mondrag\u00f3n-Rodr\u00edguez","year":"2014","unstructured":"Mondrag\u00f3n-Rodr\u00edguez, S.; Perry, G.; Luna-Mu\u00f1oz, J.; Acevedo-Aquino, M. C.; Williams, S. Phosphorylation of tau protein at sites Ser396-404 is one of the earliest events in Alzheimer\u2019s disease and Down syndrome. Neuropathol. Appl. Neurobiol. 2014, 40, 121\u2013135.","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"5354_CR13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00401-020-02251-6","volume":"141","author":"L A Gomes","year":"2021","unstructured":"Gomes, L. A.; Uytterhoeven, V.; Lopez-Sanmartin, D.; Tom\u00e9, S. O.; Tousseyn, T.; Vandenberghe, R.; Vandenbulcke, M.; von Arnim, C. A. F.; Verstreken, P.; Thal, D. R. Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation. Acta Neuropathol. 2021, 141, 173\u2013192.","journal-title":"Acta Neuropathol."},{"key":"5354_CR14","doi-asserted-by":"crossref","first-page":"112748","DOI":"10.1016\/j.bios.2020.112748","volume":"171","author":"H Ma","year":"2021","unstructured":"Ma, H.; Liu, S. L.; Liu, Y. W.; Zhu, J. Y.; Han, X. X.; Ozaki, Y.; Zhao, B. In-situ fingerprinting phosphorylated proteins via surface-enhanced Raman spectroscopy: Single-site discrimination of Tau biomarkers in Alzheimer\u2019s disease. Biosens. Bioelectron. 2021, 171, 112748.","journal-title":"Biosens. Bioelectron."},{"key":"5354_CR15","first-page":"664","volume":"75","author":"Y C Shi","year":"2020","unstructured":"Shi, Y. C.; Gu, L. H.; Wang, Q.; Gao, L. J.; Zhu, J. L.; Lu, X.; Zhou, F. F.; Zhu, D.; Zhang, H. S.; Xie, C. M. et al. Platelet amyloid-\u03b2 protein precursor (A\u03b2PP) ratio and phosphorylated tau as promising indicators for early Alzheimer\u2019s disease. J. Gerontol. Ser. A 2020, 75, 664\u2013670.","journal-title":"J. Gerontol. Ser. A"},{"key":"5354_CR16","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jalz.2014.06.008","volume":"11","author":"M S Fiandaca","year":"2015","unstructured":"Fiandaca, M. S.; Kapogiannis, D.; Mapstone, M.; Boxer, A.; Eitan, E.; Schwartz, J. B.; Abner, E. L.; Petersen, R. C.; Federoff, H. J.; Miller, B. L. et al. Identification of preclinical Alzheimer\u2019s disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimers Dement. 2015, 11, 600\u2013607.e1.","journal-title":"Alzheimers Dement."},{"key":"5354_CR17","doi-asserted-by":"crossref","first-page":"114935","DOI":"10.1016\/j.bios.2022.114935","volume":"222","author":"L Zhang","year":"2023","unstructured":"Zhang, L.; Cao, K.; Su, Y; Hu, S.; Liang, X.; Luo, Q.; Luo, H. Colorimetric and surface-enhanced Raman scattering dual-mode magnetic immunosensor for ultrasensitive detection of blood phosphorylated tau in Alzheimer\u2019s disease. Biosens Bioelectron. 2023, 222, 114935.","journal-title":"Biosens Bioelectron."},{"key":"5354_CR18","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00401-021-02275-6","volume":"141","author":"N J Ashton","year":"2021","unstructured":"Ashton, N. J.; Pascoal, T. A.; Karikari, T. K.; Benedet, A. L.; Lantero-Rodriguez, J.; Brinkmalm, G.; Snellman, A.; Sch\u00f6ll, M.; Troakes, C.; Hye, A. et al. Plasma p-tau231: A new biomarker for incipient Alzheimer\u2019s disease pathology. Acta Neuropathol. 2021, 141, 709\u2013724.","journal-title":"Acta Neuropathol."},{"key":"5354_CR19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41591-020-0755-1","volume":"26","author":"S Janelidze","year":"2020","unstructured":"Janelidze, S.; Mattsson, N.; Palmqvist, S.; Smith, R.; Beach, T. G.; Serrano, G. E.; Chai, X. Y.; Proctor, N. K.; Eichenlaub, U.; Zetterberg, H. et al. Plasma P-tau181 in Alzheimer\u2019s disease: Relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer\u2019s dementia. Nat. Med. 2020, 26, 379\u2013386.","journal-title":"Nat. Med."},{"key":"5354_CR20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2217\/bmm.09.84","volume":"4","author":"M Thambisetty","year":"2010","unstructured":"Thambisetty, M.; Lovestone, S. Blood-based biomarkers of Alzheimer\u2019s disease: Challenging but feasible. Biomark. Med. 2010, 4, 65\u201379.","journal-title":"Biomark. Med."},{"key":"5354_CR21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41582-018-0079-7","volume":"14","author":"H Hampel","year":"2018","unstructured":"Hampel, H.; O\u2019Bryant, S. E.; Molinuevo, J. L.; Zetterberg, H.; Masters, C. L.; Lista, S.; Kiddle, S. J.; Batrla, R.; Blennow, K. Blood-based biomarkers for Alzheimer disease: Mapping the road to the clinic. Nat. Rev. Neurol. 2018, 14, 639\u2013652.","journal-title":"Nat. Rev. Neurol."},{"key":"5354_CR22","doi-asserted-by":"crossref","first-page":"28625","DOI":"10.1073\/pnas.2009238117","volume":"117","author":"A R Foley","year":"2020","unstructured":"Foley, A. R.; Roseman, G. P.; Chan, K.; Smart, A.; Finn, T. S.; Yang, K.; Lokey, R. S.; Millhauser, G. L.; Raskatov, J. A. Evidence for aggregation-independent, PrPC-mediated A\u03b2 cellular internalization. Proc. Natl. Acad. Sci. USA 2020, 117, 28625\u201328631.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"5354_CR23","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.brainres.2015.06.047","volume":"1622","author":"A F Cintron","year":"2015","unstructured":"Cintron, A. F.; Dalal, N. V.; Dooyema, J.; Betarbet, R.; Walker, L. C. Transport of cargo from periphery to brain by circulating monocytes. Brain Res. 2015, 1622, 328\u2013338.","journal-title":"Brain Res."},{"key":"5354_CR24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00401-014-1373-0","volume":"129","author":"S Boluda","year":"2015","unstructured":"Boluda, S.; Iba, M.; Zhang, B.; Raible, K. M.; Lee, V. M. Y.; Trojanowski, J. Q. Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer\u2019s disease or corticobasal degeneration brains. Acta Neuropathol. 2015, 129, 221\u2013237.","journal-title":"Acta Neuropathol."},{"key":"5354_CR25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuropharm.2013.08.037","volume":"76","author":"F Clavaguera","year":"2014","unstructured":"Clavaguera, F.; Grueninger, F.; Tolnay, M. Intercellular transfer of tau aggregates and spreading of tau pathology: Implications for therapeutic strategies. Neuropharmacology 2014, 76, 9\u201315.","journal-title":"Neuropharmacology"},{"key":"5354_CR26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nm.3457","volume":"20","author":"J L Guo","year":"2014","unstructured":"Guo, J. L.; Lee, V. M. Y. Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases. Nat. Med. 2014, 20, 130\u2013138.","journal-title":"Nat. Med."},{"key":"5354_CR27","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/bpa.12252","volume":"25","author":"L Ye","year":"2015","unstructured":"Ye, L.; Hamaguchi, T.; Fritschi, S. K.; Eisele, Y. S.; Oberm\u00fcller, U.; Jucker, M.; Walker, L. C. Progression of seed-induced A\u03b2 deposition within the limbic connectome. Brain Pathol. 2015, 25, 743\u2013752.","journal-title":"Brain Pathol."},{"key":"5354_CR28","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1007\/s11064-020-03111-1","volume":"45","author":"S Lakshmi","year":"2020","unstructured":"Lakshmi, S.; Essa, M. M.; Hartman, R. E.; Guillemin, G. J.; Sivan, S.; Elumalai, P. Exosomes in Alzheimer\u2019s disease: Potential role as pathological mediators, biomarkers and therapeutic targets. Neurochem. Res. 2020, 45, 2553\u20132559.","journal-title":"Neurochem. Res."},{"key":"5354_CR29","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jalz.2019.05.002","volume":"15","author":"L F Jia","year":"2019","unstructured":"Jia, L. F.; Qiu, Q. Q.; Zhang, H.; Chu, L.; Du, Y. F.; Zhang, J. W.; Zhou, C. K.; Liang, F. R.; Shi, S. L.; Wang, S. et al. Concordance between the assessment of A\u03b242, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid. Alzheimers Dement. 2019, 15, 1071\u20131080.","journal-title":"Alzheimers Dement."},{"key":"5354_CR30","doi-asserted-by":"crossref","first-page":"e20200861","DOI":"10.1084\/jem.20200861","volume":"217","author":"N R Barth\u00e9lemy","year":"2020","unstructured":"Barth\u00e9lemy, N. R.; Horie, K.; Sato, C.; Bateman, R. J. Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer\u2019s disease. J. Exp. Med. 2020, 217, e20200861.","journal-title":"J. Exp. Med."},{"key":"5354_CR31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41591-020-0762-2","volume":"26","author":"E H Thijssen","year":"2020","unstructured":"Thijssen, E. H.; La Joie, R.; Wolf, A.; Strom, A.; Wang, P.; Iaccarino, L.; Bourakova, V.; Cobigo, Y.; Heuer, H.; Spina, S. et al. Diagnostic value of plasma phosphorylated tau181 in Alzheimer\u2019s disease and frontotemporal lobar degeneration. Nat. Med. 2020, 26, 387\u2013397.","journal-title":"Nat. Med."},{"key":"5354_CR32","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molmed.2009.01.003","volume":"15","author":"D P Hanger","year":"2009","unstructured":"Hanger, D. P.; Anderton, B. H.; Noble, W. Tau phosphorylation: The therapeutic challenge for neurodegenerative disease. Trends Mol. Med. 2009, 15, 112\u2013119.","journal-title":"Trends Mol. Med."},{"key":"5354_CR33","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/alz.12457","volume":"18","author":"L Liu","year":"2022","unstructured":"Liu, L.; Kwak, H.; Lawton, T. L.; Jin, S. X.; Meunier, A. L.; Dang, Y. F.; Ostaszewski, B.; Pietras, A. C.; Stern, A. M.; Selkoe, D. J. An ultra-sensitive immunoassay detects and quantifies soluble A\u03b2 oligomers in human plasma. Alzheimers Dement. 2022, 18, 1186\u20131202.","journal-title":"Alzheimers Dement."},{"key":"5354_CR34","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/jama.2020.12134","volume":"324","author":"S Palmqvist","year":"2020","unstructured":"Palmqvist, S.; Janelidze, S.; Quiroz, Y. T.; Zetterberg, H.; Lopera, F.; Stomrud, E.; Su, Y.; Chen, Y. H.; Serrano, G. E.; Leuzy, A. et al. Discriminative accuracy of plasma phospho-tau217 for Alzheimer disease vs other neurodegenerative disorders. JAMA 2020, 324, 772\u2013781.","journal-title":"JAMA"},{"key":"5354_CR35","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1021\/acsnano.0c10035","volume":"15","author":"Y L Liu","year":"2021","unstructured":"Liu, Y. L.; Zhan, L.; Qin, Z. P.; Sackrison, J.; Bischof, J. C. Ultrasensitive and highly specific lateral flow assays for point-of-care diagnosis. ACS Nano 2021, 15, 3593\u20133611.","journal-title":"ACS Nano"},{"key":"5354_CR36","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1021\/acs.analchem.8b04848","volume":"91","author":"W Ren","year":"2019","unstructured":"Ren, W.; Mohammed, S. I.; Wereley, S.; Irudayaraj, J. Magnetic focus lateral flow sensor for detection of cervical cancer biomarkers. Anal. Chem. 2019, 91, 2876\u20132884.","journal-title":"Anal. Chem."},{"key":"5354_CR37","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12951-020-00688-1","volume":"18","author":"C Ruppert","year":"2020","unstructured":"Ruppert, C.; Kaiser, L.; Jacob, L. J.; Laufer, S.; Kohl, M.; Deigner, H. P. Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assay. J. Nanobiotechnol. 2020, 18, 130.","journal-title":"J. Nanobiotechnol."},{"key":"5354_CR38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12951-021-00817-4","volume":"19","author":"H M Kim","year":"2021","unstructured":"Kim, H. M.; Kim, J.; An, J.; Bock, S.; Pham, X. H.; Huynh, K. H.; Choi, Y.; Hahm, E.; Song, H.; Kim, J. W. et al. Au-Ag assembled on silica nanoprobes for visual semiquantitative detection of prostate-specific antigen. J. Nanobiotechnol. 2021, 19, 73.","journal-title":"J. Nanobiotechnol."},{"key":"5354_CR39","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1021\/acsami.9b22449","volume":"12","author":"Q Y Liu","year":"2020","unstructured":"Liu, Q. Y.; Cheng, S. M.; Chen, R.; Ke, J. M.; Liu, Y. W.; Li, Y. F.; Feng, W.; Li, F. Y. Near-infrared lanthanide-doped nanoparticles for a low interference lateral flow immunoassay test. ACS Appl. Mater. Interfaces 2020, 12, 4358\u20134365.","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"5354_CR40","doi-asserted-by":"crossref","first-page":"16864","DOI":"10.1021\/acsnano.0c05700","volume":"14","author":"T X Ji","year":"2020","unstructured":"Ji, T. X.; Xu, X. Q.; Wang, X. D.; Cao, N.; Han, X. R.; Wang, M. H.; Chen, B.; Lin, Z.; Jia, H. Y.; Deng, M. et al. Background-free chromatographic detection of sepsis biomarker in clinical human serum through near-infrared to near-infrared upconversion immunolabeling. ACS Nano 2020, 14, 16864\u201316874.","journal-title":"ACS Nano"},{"key":"5354_CR41","first-page":"1900925","volume":"6","author":"K C Xu","year":"2019","unstructured":"Xu, K. C.; Zhou, R.; Takei, K.; Hong, M. H. Toward flexible surface-enhanced Raman scattering (SERS) sensors for point-of-care diagnostics. Adv. Sci. (Weinh.) 2019, 6, 1900925.","journal-title":"Adv. Sci. (Weinh.)"},{"key":"5354_CR42","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1039\/C7CS00137A","volume":"46","author":"F Madzharova","year":"2017","unstructured":"Madzharova, F.; Heiner, Z.; Kneipp, J. Surface enhanced hyper Raman scattering (SEHRS) and its applications. Chem. Soc. Rev. 2017, 46, 3980\u20133999.","journal-title":"Chem. Soc. Rev."},{"key":"5354_CR43","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s12274-021-3549-y","volume":"15","author":"C Xia","year":"2022","unstructured":"Xia, C.; Zhang, D.; Li, H.; Li, S.; Liu, H.; Ding, L.; Liu, X.; Lyu, M.; Li, R.; Yang, J. et al. Single-walled carbon nanotube based SERS substrate with single molecule sensitivity. Nano Research. 2022, 15, 694\u2013700.","journal-title":"Nano Research."},{"key":"5354_CR44","doi-asserted-by":"crossref","first-page":"596005","DOI":"10.3389\/fmicb.2020.596005","volume":"11","author":"L L Shi","year":"2020","unstructured":"Shi, L. L.; Xu, L.; Xiao, R. H.; Zhou, Z.; Wang, C. W.; Wang, S. Q.; Gu, B. Rapid, quantitative. high-sensitive detection of Escherichia coli O157: H7 by gold-shell silica-core nanospheres-based surface-enhanced Raman scattering lateral flow immunoassay. Front. Microbiol. 2020, 11, 596005.","journal-title":"Front. Microbiol."},{"key":"5354_CR45","doi-asserted-by":"crossref","first-page":"15530","DOI":"10.1039\/C9NR04864B","volume":"11","author":"X L Fu","year":"2019","unstructured":"Fu, X. L.; Wen, J. H.; Li, J. W.; Lin, H.; Liu, Y. M.; Zhuang, X. M.; Tian, C. Y.; Chen, L. X. Highly sensitive detection of prostate cancer specific PCA3 mimic DNA using SERS-based competitive lateral flow assay. Nanoscale 2019, 11, 15530\u201315536.","journal-title":"Nanoscale"},{"key":"5354_CR46","doi-asserted-by":"crossref","first-page":"114434","DOI":"10.1016\/j.bios.2022.114434","volume":"212","author":"M Tian","year":"2022","unstructured":"Tian, M.; Wang, J.; Li, C.; Wang, Z.; Liu, G.; Lv, E.; Zhao, X.; Li, Z.; Cao, D.; Liu, H. et al. Qualitative and quantitative detection of microcystin-LR based on SERS-FET dual-mode biosensor. Biosens Bioelectron. 2022, 212, 114434.","journal-title":"Biosens Bioelectron."},{"key":"5354_CR47","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1021\/acs.analchem.0c05336","volume":"93","author":"K Kim","year":"2021","unstructured":"Kim, K.; Han, D. K.; Choi, N.; Kim, S. H.; Joung, Y.; Kim, K.; Ho, N. T.; Joo, S. W.; Choo, J. Surface-enhanced Raman scattering-based dual-flow lateral flow assay sensor for the ultrasensitive detection of the thyroid-stimulating hormone. Anal. Chem. 2021, 93, 6673\u20136681.","journal-title":"Anal. Chem."},{"key":"5354_CR48","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1007\/s12274-022-4114-z","volume":"15","author":"N Cheng","year":"2022","unstructured":"Cheng, N.; Lou, B.; Wang, H. An intelligent serological SERS test toward early-stage hepatocellular carcinoma diagnosis through ultrasensitive nanobiosensing. Nano Research. 2022, 15, 5331\u20135339.","journal-title":"Nano Research."},{"key":"5354_CR49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s12951-021-01021-0","volume":"19","author":"J J Liang","year":"2021","unstructured":"Liang, J. J.; Teng, P. J.; Xiao, W.; He, G. B.; Song, Q. F.; Zhang, Y.; Peng, B.; Li, G.; Hu, L. S.; Cao, D. L. et al. Application of the amplification-free SERS-based CRISPR\/Cas12a platform in the identification of SARS-CoV-2 from clinical samples. J. Nanobiotechnol. 2021, 19, 273.","journal-title":"J. Nanobiotechnol."},{"key":"5354_CR50","doi-asserted-by":"crossref","first-page":"17042","DOI":"10.1021\/ja907069u","volume":"131","author":"S D Perrault","year":"2009","unstructured":"Perrault, S. D.; Chan, W. C. W. Synthesis and surface modification of highly monodispersed. spherical gold nanoparticles of 50\u2013200 nm. J. Am. Chem. Soc. 2009, 131, 17042\u201317043.","journal-title":"J. Am. Chem. Soc."},{"key":"5354_CR51","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12951-021-01111-z","volume":"19","author":"L D Zhang","year":"2021","unstructured":"Zhang, L. D.; Du, X. W.; Su, Y.; Niu, S. Q.; Li, Y. Q.; Liang, X. H.; Luo, H. M. Quantitative assessment of AD markers using naked eyes: Point-of-care testing with paper-based lateral flow immunoassay. J. Nanobiotechnol. 2021, 19, 366.","journal-title":"J. Nanobiotechnol."},{"key":"5354_CR52","doi-asserted-by":"crossref","first-page":"723317","DOI":"10.3389\/fnmol.2021.723317","volume":"14","author":"L D Zhang","year":"2021","unstructured":"Zhang, L. D.; Yang, C. W.; Li, Y. Q.; Niu, S. Q.; Liang, X. H.; Zhang, Z. H.; Luo, Q. M.; Luo, H. M. Dynamic changes in the levels of amyloid-\u03b242 species in the brain and periphery of APP\/PS1 mice and their significance for Alzheimer\u2019s disease. Front. Mol. Neurosci. 2021, 14, 723317.","journal-title":"Front. Mol. Neurosci."},{"key":"5354_CR53","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/bios13010110","volume":"13","author":"W Qu","year":"2023","unstructured":"Qu, W.; Zhang, L.; Liang, X.; Yu, Z.; Huang, H.; Zhao, J.; Guo, Y.; Zhou, X.; Xu, S.; Luo, H. et al. Elevated plasma oligomeric amyloid \u03b2-42 is associated with cognitive impairments in cerebral small vessel disease. Biosensors (Basel). 2023, 13, 110.","journal-title":"Biosensors (Basel)."},{"key":"5354_CR54","first-page":"36","volume":"11","author":"M D Abramoff","year":"2004","unstructured":"Abramoff, M. D.; Magelhaes, P. J.; Ram, S. J. Image processing with ImageJ. Biophotonics Int. 2004, 11, 36\u201342.","journal-title":"Biophotonics Int."},{"key":"5354_CR55","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.3390\/ijms20184645","volume":"20","author":"L D Zhang","year":"2019","unstructured":"Zhang, L. D.; Du, X. W.; Chen, Z. X.; Chen, C. J.; Gong, N. X.; Song, Y. H.; Song, Y. Z.; Han, Q. Q.; Xia, X. S.; Luo, H. M. et al. Instrument-free and visual detection of salmonella based on magnetic nanoparticles and an antibody probe immunosensor. Int. J. Mol. Sci. 2019, 20, 4645.","journal-title":"Int. J. Mol. Sci."},{"key":"5354_CR56","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0002-9440(10)62554-0","volume":"160","author":"Y Y Hu","year":"2002","unstructured":"Hu, Y. Y.; He, S. S.; Wang, X. C.; Duan, Q. H.; Grundke-Iqbal, I.; Iqbal, K.; Wang, J. Z. Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer\u2019s disease patients: An ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. Am. J. Pathol. 2002, 160, 1269\u20131278.","journal-title":"Am. J. Pathol."},{"key":"5354_CR57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/biomedicines10010093","volume":"10","author":"L M T Phan","year":"2022","unstructured":"Phan, L. M. T.; Cho, S. Fluorescent aptasensor and colorimetric aptablot for p-tau231 detection: Toward early diagnosis of Alzheimer\u2019s disease. Biomedicines 2022, 10, 93.","journal-title":"Biomedicines"},{"key":"5354_CR58","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jneumeth.2009.02.015","volume":"180","author":"C Luk","year":"2009","unstructured":"Luk, C.; Giovannoni, G.; Williams, D. R.; Lees, A. J.; de Silva, R. Development of a sensitive ELISA for quantification of three- and four-repeat tau isoforms in tauopathies. J. Neurosci. Methods 2009, 180, 34\u201342.","journal-title":"J. Neurosci. Methods"}],"container-title":["Nano Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12274-022-5354-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12274-022-5354-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12274-022-5354-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T18:11:14Z","timestamp":1734027074000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12274-022-5354-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,28]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["5354"],"URL":"https:\/\/doi.org\/10.1007\/s12274-022-5354-4","relation":{},"ISSN":["1998-0124","1998-0000"],"issn-type":[{"value":"1998-0124","type":"print"},{"value":"1998-0000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,28]]},"assertion":[{"value":"4 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}