{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:22:58Z","timestamp":1790623378437,"version":"4.1.0"},"reference-count":34,"publisher":"The Microbiological Society of Korea","issue":"7","license":[{"start":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T00:00:00Z","timestamp":1492819200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Microbiol."],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s12275-017-6474-8","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T02:08:23Z","timestamp":1492826903000},"page":"531-537","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Exploring the oral microflora of preschool children"],"prefix":"10.71150","volume":"55","author":[{"given":"Wen","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuenan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4586","published-online":{"date-parts":[[2017,4,22]]},"reference":[{"key":"6474_CR1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ismej.2012.174","volume":"7","author":"L. Abusleme","year":"2013","unstructured":"Abusleme, L., Dupuy, A.K., Dutzan, N., Silva, N., Burleson, J.A., Strausbaugh, L.D., Gamonal, J., and Diaz, P.I. 2013. The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation. ISME J. 7, 1016\u20131025.","journal-title":"ISME J."},{"key":"6474_CR2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/dna.2009.0874","volume":"28","author":"M. Avila","year":"2009","unstructured":"Avila, M., Ojcius, D.M., and Yilmaz, O. 2009. The oral microbiota: living with a permanent guest. DNA Cell Biol. 28, 405\u2013411.","journal-title":"DNA Cell Biol."},{"key":"6474_CR3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ismej.2011.85","volume":"6","author":"P. Belda-Ferre","year":"2012","unstructured":"Belda-Ferre, P., Alcaraz, L.D., Cabrera-Rubio, R., Romero, H., Simon-Soro, A., Pignatelli, M., and Mira, A. 2012. The oral metagenome in health and disease. ISME J. 6, 46\u201356.","journal-title":"ISME J."},{"key":"6474_CR4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","volume":"7","author":"J.G. Caporaso","year":"2010","unstructured":"Caporaso, J.G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F.D., Costello, E.K., Fierer, N., Pena, A.G., Goodrich, J.K., Gordon, J.I., et al. 2010. QIIME allows analysis of high-throughput community sequencing data. Nat. Methods 7, 335\u2013336.","journal-title":"Nat. Methods"},{"key":"6474_CR5","volume-title":"Database 7, baq013","author":"T. Chen","year":"2010","unstructured":"Chen, T., Yu, W.H., Izard, J., Baranova, O.V., Lakshmanan, A., and Dewhirst, F.E. 2010. The Human oral microbiome database: a web accessible resource for investigating oral microbe taxonomic and genomic information. Database 7, baq013."},{"key":"6474_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1755-8794-4-22","volume":"4","author":"W. Crielaard","year":"2011","unstructured":"Crielaard, W., Zaura, E., Schuller, A.A., Huse, S.M., Montijn, R.C., and Keijser, B.J.F. 2011. Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health. BMC Med. Genomics 4, 1\u201313.","journal-title":"BMC Med. Genomics"},{"key":"6474_CR7","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","volume":"192","author":"F.E. Dewhirst","year":"2010","unstructured":"Dewhirst, F.E., Chen, T., Izard, J., Paster, B.J., Tanner, A.C., Yu, W.H., Lakshmanan, A., and Wade, W.G. 2010. The human oral microbiome. J. Bacteriol. 192, 5002\u20135017.","journal-title":"J. Bacteriol."},{"key":"6474_CR8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1601-0825.2005.01094.x","volume":"11Suppl.1","author":"A.C. Donaldson","year":"2005","unstructured":"Donaldson, A.C., McKenzie, D., Riggio, M.P., Hodge, P.J., Rolph, H., Flanagan, A., and Bagg, J. 2005. Microbiological culture analysis of the tongue anaerobic microflora in subjects with and without halitosis. Oral Dis. 11 Suppl. 1, 61\u201363.","journal-title":"Oral Dis."},{"key":"6474_CR9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/138920208783884900","volume":"9","author":"T.K. Fabian","year":"2008","unstructured":"Fabian, T.K., Fejerdy, P., and Csermely, P. 2008. Salivary genomics, transcriptomics and proteomics: the emerging concept of the oral ecosystem and their use in the early diagnosis of cancer and other diseases. Curr. Genomics 9, 11\u201321.","journal-title":"Curr. Genomics"},{"key":"6474_CR10","doi-asserted-by":"crossref","first-page":"1001377","DOI":"10.1371\/journal.pbio.1001377","volume":"10","author":"D. Gevers","year":"2012","unstructured":"Gevers, D., Knight, R., Petrosino, J.F., Huang, K., McGuire, A.L., Birren, B.W., Nelson, K.E., White, O., Methe, B.A., and Huttenhower, C. 2012. The human microbiome project: a community resource for the healthy human microbiome. PLoS Biol. 10, e1001377.","journal-title":"PLoS Biol."},{"key":"6474_CR11","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1101\/gr.096651.109","volume":"19","author":"N.H.W. Group","year":"2009","unstructured":"Group, N.H.W., Peterson, J., Garges, S., Giovanni, M., McInnes, P., Wang, L., Schloss, J.A., Bonazzi, V., McEwen, J.E., Wetterstrand, K.A., et al. 2009. The NIH human microbiome project. Genome Res. 19, 2317\u20132323.","journal-title":"Genome Res."},{"key":"6474_CR12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4248\/ijos.09029","volume":"1","author":"X.S. He","year":"2009","unstructured":"He, X.S. and Shi, W.Y. 2009. Oral microbiology: past, present and future. IJOS 1, 47\u201358.","journal-title":"IJOS"},{"key":"6474_CR13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature11209","volume":"486","author":"C. Human Microbiome Project","year":"2012","unstructured":"Human Microbiome Project, C. 2012a. A framework for human microbiome research. Nature 486, 215\u2013221.","journal-title":"Nature"},{"key":"6474_CR14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","volume":"486","author":"C. Human Microbiome Project","year":"2012","unstructured":"Human Microbiome Project, C. 2012b. Structure, function and diversity of the healthy human microbiome. Nature 486, 207\u2013214.","journal-title":"Nature"},{"key":"6474_CR15","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1177\/154405910808701104","volume":"87","author":"B.J.F. Keijser","year":"2008","unstructured":"Keijser, B.J.F., Zaura, E., Huse, S.M., Van Der Vossen, J.M.B.M., Schuren, F.H.J., Montijn, R.C., Ten Cate, J.M., and Crielaard, W. 2008. Pyrosequencing analysis of the oral microflora of healthy adults. J. Dent. Res. 87, 1016\u20131020.","journal-title":"J. Dent. Res."},{"key":"6474_CR16","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1128\/MMBR.66.3.486-505.2002","volume":"66","author":"P.E. Kolenbrander","year":"2002","unstructured":"Kolenbrander, P.E., Andersen, R.N., Blehert, D.S., Egland, P.G., Foster, J.S., and Palmer, R.J., 2002. Communication among oral bacteria. Microbiol. Mol. Biol. Rev. 66, 486\u2013505.","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"6474_CR17","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","volume":"31","author":"M.G. Langille","year":"2013","unstructured":"Langille, M.G., Zaneveld, J., Caporaso, J.G., McDonald, D., Knights, D., Reyes, J.A., Clemente, J.C., Burkepile, D.E., Vega Thurber, R.L., Knight, R., et al. 2013. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat. Biotechnol. 31, 814\u2013821.","journal-title":"Nat. Biotechnol."},{"key":"6474_CR18","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00248-010-9712-8","volume":"60","author":"Z.X. Ling","year":"2010","unstructured":"Ling, Z.X., Kong, J.M., Jia, P., Wei, C.C., Wang, Y.Z., Pan, Z.W., Huang, W.J., Li, L.J., Chen, H., and Xiang, C. 2010. Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencing. Microb. Ecol. 60, 677\u2013690.","journal-title":"Microb. Ecol."},{"key":"6474_CR19","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000077756","volume":"38","author":"P.D. Marsh","year":"2004","unstructured":"Marsh, P.D. 2004. Dental plaque as a microbial biofilm. Caries Res. 38, 204\u2013211.","journal-title":"Caries Res."},{"key":"6474_CR20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","volume":"464","author":"J.J. Qin","year":"2010","unstructured":"Qin, J.J., Li, R.Q., Raes, J., Arumugam, M., Burgdorf, K.S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., Yamada, T., et al. 2010. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59\u201365.","journal-title":"Nature"},{"key":"6474_CR21","first-page":"337","volume":"164","author":"R. Sender","year":"2016","unstructured":"Sender, R., Fuchs, S., and Milo, R. 2016. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 164, 337\u2013340.","journal-title":"Revisiting the ratio of bacterial to host cells in humans. Cell"},{"key":"6474_CR22","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1128\/JB.06586-11","volume":"194","author":"F.L. Shaw","year":"2012","unstructured":"Shaw, F.L., Mulholland, F., Le Gall, G., Porcelli, I., Hart, D.J., Pearson, B.M., and Van Vliet, A.H. 2012. Selenium-dependent biogenesis of formate dehydrogenase in Campylobacter jejuni is controlled by the fdhTU accessory genes. J. Bacteriol. 194, 3814\u20133823.","journal-title":"J. Bacteriol."},{"key":"6474_CR23","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1177\/0022034513488119","volume":"92","author":"A. Simon-Soro","year":"2013","unstructured":"Simon-Soro, A., Tomas, I., Cabrera-Rubio, R., Catalan, M.D., Nyvad, B., and Mira, A. 2013. Microbial geography of the oral cavity. J. Dent. Res. 92, 616\u2013621.","journal-title":"J. Dent. Res."},{"key":"6474_CR24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1177\/10454411990100040501","volume":"10","author":"N. Takahashi","year":"1999","unstructured":"Takahashi, N. and Yamada, T. 1999. Glucose and lactate metabolism by Actinomyces naeslundii. Crit. Rev. Oral Biol. Med. 10, 487\u2013503.","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"6474_CR25","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1177\/154405910208101202","volume":"81","author":"J. Tenovuo","year":"2002","unstructured":"Tenovuo, J. 2002. Antimicrobial agents in saliva\u2013protection for the whole body. J. Dent. Res. 81, 807\u2013809.","journal-title":"J. Dent. Res."},{"key":"6474_CR26","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","volume":"449","author":"P.J. Turnbaugh","year":"2007","unstructured":"Turnbaugh, P.J., Ley, R.E., Hamady, M., Fraser-Liggett, C.M., Knight, R., and Gordon, J.I. 2007. The human microbiome project. Nature 449, 804\u2013810.","journal-title":"Nature"},{"key":"6474_CR27","first-page":"139","volume":"3","author":"I.R.I. Viorica Chetru\u015f","year":"2013","unstructured":"Viorica Chetru\u015f, I.R.I. 2013. Dental plaque\u2013classification, formation, and identification. IJMD 3, 139\u2013143.","journal-title":"IJMD"},{"key":"6474_CR28","first-page":"1145","volume":"7","author":"C. Xiao","year":"2016","unstructured":"Xiao, C., Ran, S., Huang, Z., and Liang, J. 2016. Bacterial diversity and community structure of supragingival plaques in adults with dental health or caries revealed by 16S pyrosequencing. Front. Microbiol. 7, 1145.","journal-title":"Front. Microbiol"},{"key":"6474_CR29","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/odi.12018","volume":"19","author":"B.C. Xin","year":"2013","unstructured":"Xin, B.C., Luo, A.H., Qin, J., Paster, B.J., Xu, Y.L., Li, Y.L., and Yang, D.Q. 2013. Microbial diversity in the oral cavity of healthy chinese han children. Oral Dis. 19, 401\u2013405.","journal-title":"Oral Dis."},{"key":"6474_CR30","doi-asserted-by":"crossref","first-page":"89269","DOI":"10.1371\/journal.pone.0089269","volume":"9","author":"H. Xu","year":"2014","unstructured":"Xu, H., Hao, W., Zhou, Q., Wang, W., Xia, Z., Liu, C., Chen, X., Qin, M., and Chen, F. 2014. Plaque bacterial microbiome diversity in children younger than 30 months with or without caries prior to eruption of second primary molars. PLoS One 9, e89269.","journal-title":"PLoS One"},{"key":"6474_CR31","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/1462-2920.12502","volume":"17","author":"X. Xu","year":"2015","unstructured":"Xu, X., He, J.Z., Xue, J., Wang, Y., Li, K., Zhang, K.K., Guo, Q., Liu, X.H., Zhou, Y., Cheng, L., et al. 2015. Oral cavity contains distinct niches with dynamic microbial communities. Environ. Microbiol. 17, 699\u2013710.","journal-title":"Environ. Microbiol."},{"key":"6474_CR32","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1177\/0022034513507065","volume":"92","author":"F. Yang","year":"2013","unstructured":"Yang, F., Huang, S., He, T., Catrenich, C., Teng, F., Bo, C., Chen, J., Liu, J., Li, J., Song, Y., et al. 2013. Microbial basis of oral malodor development in humans. J. Dent. Res. 92, 1106\u20131112.","journal-title":"J. Dent. Res."},{"key":"6474_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ismej.2011.71","volume":"6","author":"F. Yang","year":"2012","unstructured":"Yang, F., Zeng, X., Ning, K., Liu, K.L., Lo, C.C., Wang, W., Chen, J., Wang, D., Huang, R., Chang, X., et al. 2012. Saliva microbiomes distinguish caries-active from healthy human populations. ISME J. 6, 1\u201310.","journal-title":"ISME J."},{"key":"6474_CR34","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/ismej.2013.185","volume":"8","author":"Z. Zhang","year":"2014","unstructured":"Zhang, Z., Geng, J., Tang, X., Fan, H., Xu, J., Wen, X., Ma, Z.S., and Shi, P. 2014. Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota. ISME J. 8, 881\u2013893.","journal-title":"ISME J."}],"container-title":["Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12275-017-6474-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12275-017-6474-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12275-017-6474-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T17:48:09Z","timestamp":1735062489000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12275-017-6474-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,22]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["6474"],"URL":"https:\/\/doi.org\/10.1007\/s12275-017-6474-8","relation":{},"ISSN":["1225-8873","1976-3794"],"issn-type":[{"value":"1225-8873","type":"print"},{"value":"1976-3794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,22]]}}}