{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:46:22Z","timestamp":1793162782678,"version":"4.5.0"},"reference-count":42,"publisher":"The Microbiological Society of Korea","issue":"5","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Microbiol."],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s12275-019-8539-3","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T07:51:34Z","timestamp":1549353094000},"page":"388-395","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Growth and differentiation properties of pikromycin-producing Streptomyces venezuelae ATCC15439"],"prefix":"10.71150","volume":"57","author":[{"given":"Ji-Eun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon-Sun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hye","family":"Roe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4586","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"8539_CR1","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/j.1365-2958.2012.08070.x","volume":"84","author":"M.J. Bibb","year":"2012","unstructured":"Bibb, M.J., Domonkos, A., Chandra, G., and Buttner, M.J. 2012. Expression of the chaplin and rodlin hydrophobic sheath proteins in Streptomyces venezuelae is controlled by \u03c3BldN and a cognate anti-sigma factor, RsbN. Mol. Microbiol. 84, 1033\u20131049.","journal-title":"Mol. Microbiol."},{"key":"8539_CR2","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/ja.2013.61","volume":"66","author":"J. Davies","year":"2013","unstructured":"Davies, J. 2013. Specialized microbial metabolites: functions and origins. J. Antibiot. 66, 361\u2013364.","journal-title":"J. Antibiot."},{"key":"8539_CR3","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1099\/00221287-135-9-2483","volume":"135","author":"A. Daza","year":"1989","unstructured":"Daza, A., Martin, J.F., Dominguez, A., and Gil, J.A. 1989. Sporulation of several species of Streptomyces in submerged cultures after nutritional downshift. Microbiology 135, 2483\u20132491.","journal-title":"Microbiology"},{"key":"8539_CR4","doi-asserted-by":"publisher","first-page":"150263","DOI":"10.1098\/rsob.150263","volume":"6","author":"M. Donczew","year":"2016","unstructured":"Donczew, M., Mackiewicz, P., Wrobel, A., Flardh, K., Zakrzewska-Czerwinska, J., and Jakimowicz, D. 2016. ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation. Open Biol. 6, 150263.","journal-title":"Open Biol."},{"key":"8539_CR5","doi-asserted-by":"publisher","first-page":"869","DOI":"10.7164\/antibiotics.46.869","volume":"46","author":"J.L. Doull","year":"1993","unstructured":"Doull, J.L., Singh, A.K., Hoare, M., and Ayer, S.W. 1993. Production of a novel polyketide antibiotic, jadomycin B, by Streptomyces venezuelae following heat shock. J. Antibiot. 46, 869\u2013871.","journal-title":"J. Antibiot."},{"key":"8539_CR6","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1101\/gad.264403","volume":"17","author":"M.A. Elliot","year":"2003","unstructured":"Elliot, M.A., Karoonuthaisiri, N., Huang, J., Bibb, M.J., Cohen, S.N., Kao, C.M., and Buttner, M.J. 2003. The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor. Genes Dev. 17, 1727\u20131740.","journal-title":"Genes Dev."},{"key":"8539_CR7","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nrmicro1968","volume":"7","author":"K. Fl\u00e4rdh","year":"2009","unstructured":"Fl\u00e4rdh, K. and Buttner, M.J. 2009. Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium. Nat. Rev. Microbiol. 7, 36\u201349.","journal-title":"Nat. Rev. Microbiol."},{"key":"8539_CR8","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1099\/00221287-136-3-581","volume":"136","author":"M.A. Glazebrook","year":"1990","unstructured":"Glazebrook, M.A., Doull, J.L., Stuttard, C., and Vining, L.C. 1990. Sporulation of Streptomyces venezuelae in submerged cultures. J. Gen. Microbiol. 136, 581\u2013588.","journal-title":"J. Gen. Microbiol."},{"key":"8539_CR9","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1128\/JB.187.9.3227-3237.2005","volume":"87","author":"N. Grantcharova","year":"2005","unstructured":"Grantcharova, N., Lustig, U., and Fl\u00e4rdh, K. 2005. Dynamics of FtsZ assembly during sporulation in Streptomyces coelicolor A3 (2). J. Bacteriol. 87, 3227\u20133237.","journal-title":"J. Bacteriol."},{"key":"8539_CR10","volume-title":"Molecular cloning: a laboratory manual","author":"M.R. Green","year":"2012","unstructured":"Green, M.R. and Sambrook, J. 2012. Molecular cloning: a laboratory manual, 4th ed. Cold Spring Harbor Laboratory Press, New York, N.Y., USA."},{"key":"8539_CR11","first-page":"e00337","volume":"4","author":"J. He","year":"2016","unstructured":"He, J., Sundararajan, A., Devitt, N.P., Schilkey, F.D., Ramaraj, T., and Melan\u00e7on, C.E. 2016. Complete genome sequence of Streptomyces venezuelae ATCC 15439, producer of the methymycin\/ pikromycin family of macrolide antibiotics, using PacBio technology. Genome Announc. 4, e00337\u201316.","journal-title":"Genome Announc."},{"key":"8539_CR12","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195150667.001.0001","volume-title":"Streptomyces in nature and medicine: the antibiotic makers","author":"D.A. Hopwood","year":"2007","unstructured":"Hopwood, D.A. 2007. Streptomyces in nature and medicine: the antibiotic makers. Oxford University Press."},{"key":"8539_CR13","first-page":"393","volume":"85","author":"D. Jakimowicz","year":"2012","unstructured":"Jakimowicz, D. and van Wezel, G.P. 2012. Cell division and DNA segregation in Streptomyces: how to build a septum in the middle of nowhere? Mol. Microbiol. 85, 393\u2013404.","journal-title":"Microbiol."},{"key":"8539_CR14","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s00253-006-0318-5","volume":"72","author":"W.S. Jung","year":"2006","unstructured":"Jung, W.S., Lee, S.K., Hong, J.S.J., Park, S.R., Jeong, S.J., Han, A.R., Sohng, J.K., Kim, B.G., Choi, C.Y., and Sherman, D.H. 2006. Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Appl. Microbiol. Biotechnol. 72, 763\u2013769.","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"8539_CR15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1128\/JB.155.1.357-366.1983","volume":"155","author":"K.E. Kendrick","year":"1983","unstructured":"Kendrick, K.E. and Ensign, J.C. 1983. Sporulation of Streptomyces griseus in submerged culture. J. Bacteriol. 155, 357\u2013366.","journal-title":"J. Bacteriol."},{"key":"8539_CR16","volume-title":"Practical Streptomyces genetics","author":"T. Kieser","year":"2000","unstructured":"Kieser, T., Bibb, M., Buttner, M., Chater, K., and Hopwood, D. 2000. Practical Streptomyces genetics. The John Innes Foundation, Norwich, UK."},{"key":"8539_CR17","first-page":"64","volume":"42","author":"Y.M. Kim","year":"2004","unstructured":"Kim, Y.M. and Kim, J.h. 2004. Formation and dispersion of mycelial pellets of Streptomyces coelicolor A3 (2). J. Microbiol. 42, 64\u201367.","journal-title":"J. Microbiol."},{"key":"8539_CR18","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1007\/s12272-015-0638-z","volume":"38","author":"E.J. Kim","year":"2015","unstructured":"Kim, E.J., Yang, I., and Yoon, Y.J. 2015. Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery. Arch. Pharm. Res. 38, 1606\u20131616.","journal-title":"Arch. Pharm. Res."},{"key":"8539_CR19","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/j.bmc.2008.10.082","volume":"17","author":"J.D. Kittendorf","year":"2009","unstructured":"Kittendorf, J.D. and Sherman, D.H. 2009. The methymycin\/pikromycin pathway: A model for metabolic diversity in natural product biosynthesis. Bioorg. Med. Chem. 17, 2137\u20132146.","journal-title":"Bioorg. Med. Chem."},{"key":"8539_CR20","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1111\/j.1365-2958.2010.07529.x","volume":"79","author":"E.M. Kleinschnitz","year":"2011","unstructured":"Kleinschnitz, E.M., Heichlinger, A., Schirner, K., Winkler, J., Latus, A., Maldener, I., Wohlleben, W., and Muth, G. 2011. Proteins encoded by the mre gene cluster in Streptomyces coelicolor A3 (2) cooperate in spore wall synthesis. Mol. Microbiol. 79, 1367\u20131379.","journal-title":"Mol. Microbiol."},{"key":"8539_CR21","first-page":"3131","volume":"139","author":"K.J. Lee","year":"1993","unstructured":"Lee, K.J. and Rho, Y.T. 1993. Characteristics of spores formed by surface and submerged cultures of Streptomyces albidoflavus SMF- 301. Microbiology 139, 3131\u20133137.","journal-title":"Microbiology"},{"key":"8539_CR22","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1128\/AEM.02715-07","volume":"74","author":"A. Manteca","year":"2008","unstructured":"Manteca, A., Alvarez, R., Salazar, N., Yag\u00fce, P., and Sanchez, J. 2008. Mycelium differentiation and antibiotic production in submerged cultures of Streptomyces coelicolor. Appl. Environ. Microbiol. 74, 3877\u20133886.","journal-title":"Appl. Environ. Microbiol."},{"key":"8539_CR23","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1111\/j.1365-2958.2006.05134.x","volume":"60","author":"P. Mazza","year":"2006","unstructured":"Mazza, P., Noens, E.E., Schirner, K., Grantcharova, N., Mommaas, A.M., Koerten, H.K., Muth, G., Fl\u00e4rdh, K., Van Wezel, G.P., and Wohlleben, W. 2006. MreB of Streptomyces coelicolor is not essential for vegetative growth but is required for the integrity of aerial hyphae and spores. Mol. Microbiol. 60, 838\u2013852.","journal-title":"Mol. Microbiol."},{"key":"8539_CR24","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1574-6976.2011.00317.x","volume":"36","author":"J.R. McCormick","year":"2012","unstructured":"McCormick, J.R. and Fl\u00e4rdh, K. 2012. Signals and regulators that govern Streptomyces development. FEMS Microbiol. Rev. 36, 206\u2013231.","journal-title":"FEMS Microbiol. Rev."},{"key":"8539_CR25","first-page":"137","volume":"27","author":"J.K. Morris","year":"1965","unstructured":"Morris, J.K. 1965. A formaldehyde glutaraldehyde fixative of high osmolality for use in electron microscopy. J. Cell Biol. 27, 137.","journal-title":"J. Cell Biol."},{"key":"8539_CR26","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1139\/m92-125","volume":"38","author":"I.S. Novella","year":"1992","unstructured":"Novella, I.S., Barb\u00e9s, C., and S\u00e1nchez, J. 1992. Sporulation of Streptomyces antibioticus ETHZ 7451 in submerged culture. Can. J. Microbiol. 38, 769\u2013773.","journal-title":"Can. J. Microbiol."},{"key":"8539_CR27","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1139\/w01-109","volume":"47","author":"B. Rueda","year":"2001","unstructured":"Rueda, B., Migu\u00e9lez, E.M., Hardisson, C., and Manzanal, M.B. 2001. Mycelial differentiation and spore formation by Streptomyces brasiliensis in submerged culture. Can. J. Microbiol. 47, 1042\u20131047.","journal-title":"Can. J. Microbiol."},{"key":"8539_CR28","doi-asserted-by":"publisher","first-page":"e00459","DOI":"10.1016\/j.heliyon.2017.e00459","volume":"3","author":"F. Santos-Beneit","year":"2017","unstructured":"Santos-Beneit, F., Gu, J.Y., Stimming, U., and Errington, J. 2017. ylmD and ylmE genes are dispensable for growth, cross-wall formation and sporulation in Streptomyces venezuelae. Heliyon 3, e00459.","journal-title":"Heliyon"},{"key":"8539_CR29","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/j.1365-2958.1997.mmi507.x","volume":"25","author":"J. Schwedock","year":"1997","unstructured":"Schwedock, J., McCormick, J., Angert, E., Nodwell, J., and Losick, R. 1997. Assembly of the cell division protein FtsZ into ladderlike structures in the aerial hyphae of Streptomyces coelicolor. Mol. Microbiol. 25, 847\u2013858.","journal-title":"Mol. Microbiol."},{"key":"8539_CR30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ijmm.2014.12.014","volume":"305","author":"S. Sigle","year":"2015","unstructured":"Sigle, S., Ladwig, N., Wohlleben, W., and Muth, G. 2015. Synthesis of the spore envelope in the developmental life cycle of Streptomyces coelicolor. Int. J. Med. Microbiol. 305, 183\u2013189.","journal-title":"Int. J. Med. Microbiol."},{"key":"8539_CR31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jbiotec.2015.12.028","volume":"219","author":"J.Y. Song","year":"2016","unstructured":"Song, J.Y., Yoo, Y.J., Lim, S.K., Cha, S.H., Kim, J.E., Roe, J.H., Kim, J.F., and Yoon, Y.J. 2016. Complete genome sequence of Streptomyces venezuelae ATCC 15439, a promising cell factory for production of secondary metabolites. J. Biotechnol. 219, 57\u201358.","journal-title":"J. Biotechnol."},{"key":"8539_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1099\/00221287-128-1-115","volume":"128","author":"C. Stuttard","year":"1982","unstructured":"Stuttard, C. 1982. Temperate phages of Streptomyces venezuelae: lysogeny and host specificity shown by phages SV1 and SV2. Microbiology 128, 115\u2013121.","journal-title":"Microbiology"},{"key":"8539_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-800259-9.00001-9","volume":"89","author":"D. Dissel van","year":"2014","unstructured":"van Dissel, D., Claessen, D., and van Wezel, G.P. 2014. Morphogenesis of Streptomyces in submerged cultures. Adv. Appl. Microbiol. 89, 1\u201345.","journal-title":"Adv. Appl. Microbiol."},{"key":"8539_CR34","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/B978-0-12-800259-9.00006-8","volume":"89","author":"G. Keulen van","year":"2014","unstructured":"van Keulen, G. and Dyson, P.J. 2014. Production of specialized metabolites by Streptomyces coelicolor A3 (2). Adv. Appl. Microbiol. 89, 217\u2013266.","journal-title":"Adv. Appl. Microbiol."},{"key":"8539_CR35","doi-asserted-by":"publisher","first-page":"5283","DOI":"10.1128\/AEM.00808-06","volume":"72","author":"G.P. Wezel van","year":"2006","unstructured":"van Wezel, G.P., Krabben, P., Traag, B.A., Keijser, B.J., Kerste, R., Vijgenboom, E., Heijnen, J.J., and Kraal, B. 2006. Unlocking Streptomyces spp. for use as sustainable industrial production platforms by morphological engineering. Appl. Environ. Microbiol. 72, 5283\u20135288.","journal-title":"Appl. Environ. Microbiol."},{"key":"8539_CR36","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1039\/c1np00003a","volume":"28","author":"G.P. Wezel van","year":"2011","unstructured":"van Wezel, G.P. and McDowall, K.J. 2011. The regulation of the secondary metabolism of Streptomyces: new links and experimental advances. Nat. Prod. Rep. 28, 1311\u20131333.","journal-title":"Nat. Prod. Rep."},{"key":"8539_CR37","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1128\/JB.183.11.3468-3475.2001","volume":"183","author":"D.J. Wilson","year":"2001","unstructured":"Wilson, D.J., Xue, Y., Reynolds, K.A., and Sherman, D.H. 2001. Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. J. Bacteriol. 183, 3468\u20133475.","journal-title":"J. Bacteriol."},{"key":"8539_CR38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1006\/mben.2000.0167","volume":"3","author":"Y. Xue","year":"2001","unstructured":"Xue, Y. and Sherman, D.H. 2001. Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae. Metab. Eng. 3, 15\u201326.","journal-title":"Metab. Eng."},{"key":"8539_CR39","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s10295-018-2024-6","volume":"45","author":"J.S. Yi","year":"2018","unstructured":"Yi, J.S., Kim, M., Kim, E.J., and Kim, B.G. 2018. Production of pikromycin using branched chain amino acid catabolism in Streptomyces venezuelae ATCC 15439. J. Ind. Microbiol. Biotechnol. 45, 293\u2013303.","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"8539_CR40","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.jcice.2008.04.008","volume":"39","author":"P. Yin","year":"2008","unstructured":"Yin, P., Wang, Y.H., Zhang, S.L., Chu, J., Zhuang, Y.P., Chen, N., Li, X.F., and Wu, Y.B. 2008. Effect of mycelial morphology on bioreactor performance and avermectin production of Streptomyces avermitilis in submerged cultivations. J. Chinese Inst. Chem. Eng. 39, 609\u2013615.","journal-title":"J. Chinese Inst. Chem. Eng."},{"key":"8539_CR41","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S1074-5521(02)00095-9","volume":"9","author":"Y.J. Yoon","year":"2002","unstructured":"Yoon, Y.J., Beck, B.J., Kim, B.S., Kang, H.Y., Reynolds, K.A., and Sherman, D.H. 2002. Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chem. Biol. 9, 203\u2013214.","journal-title":"Chem. Biol."},{"key":"8539_CR42","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s10482-017-0844-4","volume":"110","author":"S.H. Yoon","year":"2017","unstructured":"Yoon, S.H., Ha, S.M., Lim, J., Kwon, S., and Chun, J. 2017. A largescale evaluation of algorithms to calculate average nucleotide identity. Antonie van Leeuwenhoek 110, 1281\u20131286.","journal-title":"Antonie van Leeuwenhoek"}],"container-title":["Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12275-019-8539-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12275-019-8539-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12275-019-8539-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T17:49:21Z","timestamp":1735062561000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12275-019-8539-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["8539"],"URL":"https:\/\/doi.org\/10.1007\/s12275-019-8539-3","relation":{},"ISSN":["1225-8873","1976-3794"],"issn-type":[{"value":"1225-8873","type":"print"},{"value":"1976-3794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]},"assertion":[{"value":"27 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}