{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:56:41Z","timestamp":1789646201378,"version":"4.0.0"},"reference-count":30,"publisher":"The Microbiological Society of Korea","issue":"4","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Microbiol."],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s12275-021-0573-2","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T12:02:31Z","timestamp":1617019351000},"page":"417-425","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of multi-species probiotic supplementation on alcohol metabolism in rats"],"prefix":"10.71150","volume":"59","author":[{"given":"Tae-Joong","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghyun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hyun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Jun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4586","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"573_CR1","doi-asserted-by":"publisher","first-page":"5688","DOI":"10.1038\/s41598-019-42059-3","volume":"9","author":"SB Ahn","year":"2019","unstructured":"Ahn, S.B., Jun, D.W., Kang, B.K., Lim, J.H., Lim, S., and Chung, M.J. 2019. Randomized, double-blind, placebo-controlled study of a multispecies probiotic mixture in nonalcoholic fatty liver disease. Sci. Rep. 9, 5688.","journal-title":"Sci. Rep."},{"key":"573_CR2","first-page":"604","volume":"36","author":"YT Ahn","year":"2004","unstructured":"Ahn, Y.T., Kim, Y.H., Bae, J.S., Lim, K.S., Huh, C.S., Yang, W.Y., Kim, H.S., and Baek, Y.J. 2004. Effect of Lactobacillus brevis HY7401 intake on the serum ethanol concentration in rats. Korean J. Food Sci. Technol. 36, 604\u2013608.","journal-title":"Korean J. Food Sci. Technol."},{"key":"573_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.alcohol.2011.08.004","volume":"46","author":"CP Chiang","year":"2012","unstructured":"Chiang, C.P., Jao, S.W., Lee, S.P., Chen, P.C., Chung, C.C., Lee, S.L., Nieh, S., and Yin, S.J. 2012. Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer. Alcohol 46, 37\u201349.","journal-title":"Alcohol"},{"key":"573_CR4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fphar.2018.00083","volume":"9","author":"WH Chung","year":"2018","unstructured":"Chung, W.H., Kang, J., Lim, M.Y., Lim, T.J., Lim, S., Roh, S.W., and Nam, Y.D. 2018. Complete genome sequence and genomic characterization of Lactobacillus acidophilus LA1 (11869BP). Front. Pharmacol. 9, 83.","journal-title":"Front. Pharmacol."},{"key":"573_CR5","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1503\/cmaj.1040752","volume":"172","author":"EG Giannini","year":"2005","unstructured":"Giannini, E.G., Testa, R., and Savarino, V. 2005. Liver enzyme alteration: a guide for clinicians. CMAJ 172, 367\u2013379.","journal-title":"CMAJ"},{"key":"573_CR6","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1365-2672.1989.tb05105.x","volume":"66","author":"F Fuller","year":"1989","unstructured":"Fuller, F. 1989. Probiotics in man and animals. J. Appl. Bacteriol. 66, 365\u2013378.","journal-title":"J. Appl. Bacteriol."},{"key":"573_CR7","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1093\/ajcn\/39.5.756","volume":"39","author":"BR Goldin","year":"1984","unstructured":"Goldin, B.R. and Gorbach, S.L. 1984. The effect of milk and lactobacillus feeding on human intestinal bacterial enzyme activity. Am. J. Clin. Nutr. 39, 756\u2013761.","journal-title":"Am. J. Clin. Nutr."},{"key":"573_CR8","first-page":"267","volume":"124","author":"S Holt","year":"1981","unstructured":"Holt, S. 1981. Observations on the relation between alcohol absorption and the rate of gastric emptying. Can. Med. Assoc. J. 124, 267\u2013277.","journal-title":"Can. Med. Assoc. J."},{"key":"573_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/(SICI)1097-0215(20000415)86:2<169::AID-IJC4>3.0.CO;2-3","volume":"86","author":"N Homann","year":"2000","unstructured":"Homann, N., Tillonen, J., and Salaspuro, M. 2000. Microbially produced acetaldehyde from ethanol may increase the risk of colon cancer via folate deficiency. Int. J. Cancer 86, 169\u2013173.","journal-title":"Int. J. Cancer"},{"key":"573_CR10","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1007\/s00431-018-3253-4","volume":"177","author":"MD Ib\u00e1\u00f1ez","year":"2018","unstructured":"Ib\u00e1\u00f1ez, M.D., del R\u00edo, P.R., Alsina, D.G.S., and Iglesias, V.V. 2018. Effect of synbiotic supplementation on children with atopic dermatitis: an observational prospective study. Eur. J. Pediatr. 177, 1851\u20131858.","journal-title":"Eur. J. Pediatr."},{"key":"573_CR11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.nmni.2017.05.012","volume":"19","author":"J Kang","year":"2017","unstructured":"Kang, J., Chung, W.H., Lim, T.J., Lim, S., and Nam, Y.D. 2017a. Complete genome sequence of the Bifidobacterium animalis subspecies lactis BL3, preventive probiotics for acute colitis and colon cancer. New Microbes New Infect. 19, 34\u201337.","journal-title":"New Microbes New Infect."},{"key":"573_CR12","first-page":"413","volume":"8","author":"J Kang","year":"2017","unstructured":"Kang, J., Chung, W.H., Lim, T.J., Whon, T.W., Lim, S., and Nam, Y.D. 2017b. Complete genome sequence of Lactobacillus casei LC5, a potential probiotics for atopic dermatitis. Front. Immunol. 8, 413.","journal-title":"Front. Immunol."},{"key":"573_CR13","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jbiotec.2015.09.035","volume":"214","author":"MJ Kwak","year":"2015","unstructured":"Kwak, M.J., Yoon, J.K., Kwon, S.K., Chung, M.J., Seo, J.G., and Kim, J.F. 2015. Complete genome sequence of the probiotic bacterium Bifidobacterium breve KCTC 12201BP isolated from a healthy infant. J. Biotechnol. 214, 156\u2013157.","journal-title":"J. Biotechnol."},{"key":"573_CR14","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/j.1530-0277.1996.tb01091.x","volume":"20","author":"T Koivisto","year":"1996","unstructured":"Koivisto, T. and Salaspuro, M. 1996. Aldehyde dehydrogenases of the rat colon: comparison with other tissues of the alimentary tract and the liver. Alcohol. Clin. Exp. Res. 20, 551\u2013555.","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"573_CR15","doi-asserted-by":"publisher","first-page":"5713","DOI":"10.3168\/jds.2017-13992","volume":"101","author":"M Konkit","year":"2018","unstructured":"Konkit, M., Kim, K., Kim, J.H., and Kim, W. 2018. Protective effects of Lactococcus chungangensis CAU 28 on alcohol-metabolizing enzyme activity in rats. J. Dairy Sci. 101, 5713\u20135723.","journal-title":"J. Dairy Sci."},{"key":"573_CR16","doi-asserted-by":"publisher","first-page":"655","DOI":"10.9799\/ksfan.2016.29.5.655","volume":"29","author":"J Lee","year":"2016","unstructured":"Lee, J., Hwang, B.H., Song, H.J., Jang, S.H., and Choe, S.Y. 2016. Effect of black red ginseng mixture on alcohol metabolism in rats. Korean J. Food Nutr. 29, 655\u2013662.","journal-title":"Korean J. Food Nutr."},{"key":"573_CR17","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/0168-8278(91)90846-4","volume":"12","author":"CS Lieber","year":"1991","unstructured":"Lieber, C.S. and Decarli, L.M. 1991. Hepatotoxicity of ethanol. J. Hepatol. 12, 394\u2013401.","journal-title":"J. Hepatol."},{"key":"573_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","volume":"11","author":"R Morris","year":"1984","unstructured":"Morris, R. 1984. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11, 47\u201360.","journal-title":"J. Neurosci. Methods"},{"key":"573_CR19","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/oxfordjournals.alcalc.a008191","volume":"31","author":"T Nosova","year":"1996","unstructured":"Nosova, T., Jokelainen, K., Kaihovaara, P., Jousimies-Somer, H., Siitonen, A., Heine, R., and Salaspuro, M. 1996. Aldehyde dehydrogenase activity and acetate production by aerobic bacteria representing the normal flora of human large intestine. Alcohol Alcohol. 31, 555\u2013564.","journal-title":"Alcohol Alcohol."},{"key":"573_CR20","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/alcalc\/35.6.561","volume":"35","author":"T Nosova","year":"2000","unstructured":"Nosova, T., Jousimies-Somer, H., Jokelainen, K., Heine, R., and Salaspuro, M. 2000. Acetaldehyde production and metabolism by human indigenous and probiotic Lactobacillus and Bifidobacterium strains. Alcohol Alcohol. 35, 561\u2013568.","journal-title":"Alcohol Alcohol."},{"key":"573_CR21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/cancers10020038","volume":"10","author":"M Rossi","year":"2018","unstructured":"Rossi, M., Jahanzaib Anwar, M., Usman, A., Keshavarzian, A., and Bishehsari, F. 2018. Colorectal cancer and alcohol consumption-populations to molecules. Cancers 10, 38.","journal-title":"Cancers"},{"key":"573_CR22","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/13556219772840","volume":"2","author":"M Salaspuro","year":"1997","unstructured":"Salaspuro, M. 1997. Microbial metabolism of ethanol and acetaldehyde and clinical consequences. Addict. Biol. 2, 35\u201346.","journal-title":"Addict. Biol."},{"key":"573_CR23","doi-asserted-by":"publisher","first-page":"616","DOI":"10.9721\/KJFST.2014.46.5.616","volume":"46","author":"HM Sung","year":"2014","unstructured":"Sung, H.M., Jung, H.J., Yun, S.K., Kim, T.Y., Kim, K.M., and Wee, J.H. 2014. Effect of a soy-sprout beverage prepared with high-concentrated oxygen water on alcohol metabolism in rats. Korean J. Food Sci. Technol. 46, 616\u2013621.","journal-title":"Korean J. Food Sci. Technol."},{"key":"573_CR24","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1093\/alcalc\/agv135","volume":"51","author":"A Tsuruya","year":"2016","unstructured":"Tsuruya, A., Kuwahara, A., Saito, Y., Yamaguchi, H., Tenma, N., Inai, M., Takahashi, S., Tsutsumi, S., Suwa, Y., Totsuka, Y., et al. 2016. Major anaerobic bacteria responsible for the production of carcinogenic acetaldehyde from ethanol in the colon and rectum. Alcohol Alcohol. 51, 395\u2013401.","journal-title":"Alcohol Alcohol."},{"key":"573_CR25","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0065-2628(08)60121-4","volume":"6","author":"RH Vaughn","year":"1955","unstructured":"Vaughn, R.H. 1955. Bacterial spoilage of wines with special reference to California conditions. Adv. Food Res. 6, 67\u2013108.","journal-title":"Adv. Food Res."},{"key":"573_CR26","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1093\/alcalc\/37.4.322","volume":"37","author":"JP Visap\u00e4\u00e4","year":"2002","unstructured":"Visap\u00e4\u00e4, J.P., Tillonen, J., and Salaspuro, M. 2002. Microbes and mucosa in the regulation of intracolonic acetaldehyde concentration during ethanol challenge. Alcohol Alcohol. 37, 322\u2013326.","journal-title":"Alcohol Alcohol."},{"key":"573_CR27","doi-asserted-by":"publisher","first-page":"225","DOI":"10.5352\/JLS.2010.20.2.225","volume":"20","author":"ST Yang","year":"2010","unstructured":"Yang, S.T. 2010. Effects of aged black garlic extract on ethanol induced hangover in rats. J. Life Sci. 20, 225\u2013230.","journal-title":"J. Life Sci."},{"key":"573_CR28","first-page":"1699","volume":"16","author":"JH Yim","year":"2006","unstructured":"Yim, J.H., Kim, D.H., Ku, J.K., Kang, Y.S., Kim, M.Y., Kim, H.O., Chung, M.J., and Park, Y.M. 2006. Therapeutic effects of probiotics in patients with atopic dermatitis. J. Microbiol. Biotechnol. 16, 1699\u20131705.","journal-title":"J. Microbiol. Biotechnol."},{"key":"573_CR29","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1111\/j.1530-0277.1994.tb00115.x","volume":"18","author":"SJ Yin","year":"1994","unstructured":"Yin, S.J., Liao, C.S., Lee, Y.C., Wu, C.W., and Jao, S.W. 1994. Genetic polymorphism and activities of human colon alcohol and aldehyde dehydrogenases: no gender and age differences. Alcohol. Clin. Exp. Res. 18, 1256\u20131260.","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"573_CR30","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/jgh.12322","volume":"29","author":"JS Yoon","year":"2014","unstructured":"Yoon, J.S., Sohn, W., Lee, O.Y., Lee, S.P., Lee, K.N., Jun, D.W., Lee, H.L., Yoon, B.C., Choi, H.S., Chung W.S., et al. 2014. Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J. Gastroenterol. Hepatol. 29, 52\u201359.","journal-title":"J. Gastroenterol. Hepatol."}],"updated-by":[{"DOI":"10.1007\/s12275-021-0699-2","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000}}],"container-title":["Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12275-021-0573-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12275-021-0573-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12275-021-0573-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T17:50:58Z","timestamp":1735062658000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12275-021-0573-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,29]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["573"],"URL":"https:\/\/doi.org\/10.1007\/s12275-021-0573-2","relation":{"erratum":[{"id-type":"doi","id":"10.1007\/s12275-021-0699-2","asserted-by":"object"}]},"ISSN":["1225-8873","1976-3794"],"issn-type":[{"value":"1225-8873","type":"print"},{"value":"1976-3794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,29]]},"assertion":[{"value":"4 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2021","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Erratum","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"An Erratum to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12275-021-0699-2","URL":"https:\/\/doi.org\/10.1007\/s12275-021-0699-2","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}]}}