{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:10:23Z","timestamp":1746331823827,"version":"3.32.0"},"reference-count":28,"publisher":"The Microbiological Society of Korea","issue":"10","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Microbiol."],"DOI":"10.1007\/s12275-022-1675-1","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T18:03:55Z","timestamp":1664301835000},"page":"1039-1047","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Core promoter mutation of nucleotides A1762T and G1764A of hepatitis B virus increases core promoter transactivation by hepatocyte nuclear factor 1"],"prefix":"10.71150","volume":"60","author":[{"given":"Mi So","family":"Seong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon Jeong","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ah","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Ah","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wah Wah","family":"Aung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Yi","family":"Kyaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JaeHun","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4586","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"1675_CR1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s12876-017-0726-2","volume":"17","author":"S Alonso","year":"2017","unstructured":"Alonso, S., Guerra, A.R., Carreira, L., Ferrer, J.\u00c1., Guti\u00e9rrez, M.L., and Fernandez-Rodriguez, C.M. 2017. Upcoming pharmacological developments in chronic hepatitis B: can we glimpse a cure on the horizon?. BMC Gastroenterol., 17, 168.","journal-title":"BMC Gastroenterol."},{"key":"1675_CR2","doi-asserted-by":"publisher","first-page":"12725","DOI":"10.1128\/JVI.78.23.12725-12734.2004","volume":"78","author":"MJ Bouchard","year":"2004","unstructured":"Bouchard, M.J. and Schneider, R.J. 2004. The enigmatic X gene of hepatitis B virus. J. Virol., 78, 12725\u201312734.","journal-title":"J. Virol."},{"key":"1675_CR3","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1111\/febs.12776","volume":"281","author":"HK Cho","year":"2014","unstructured":"Cho, H.K., Kim, S.Y., Yoo, S.K., Choi, Y.H., and Cheong, J. 2014. Fatty acids increase hepatitis B virus X protein stabilization and HBxinduced inflammatory gene expression. FEBS J., 281, 2228\u20132239.","journal-title":"FEBS J."},{"key":"1675_CR4","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1002\/jmv.21452","volume":"81","author":"JW Choi","year":"2009","unstructured":"Choi, J.W., Ahn, S.H., Park, J.Y., Chang, H.Y., Kim, J.K., Baatarkhuu, O., Kim, D.Y., Han, K.H., and Chon, C.Y. 2009. Hepatitis B e antigen-negative mutations in the precore and core promoter regions in Korean patients. J. Med. Virol., 81, 594\u2013601.","journal-title":"J. Med. Virol."},{"key":"1675_CR5","doi-asserted-by":"publisher","first-page":"e63585","DOI":"10.1371\/journal.pone.0063585","volume":"8","author":"S Faguer","year":"2013","unstructured":"Faguer, S., Mayeur, N., Casemayou, A., Pageaud, A.L., Courtellemont, C., Cartery, C., Fournie, G.J., Schanstra, J.P., Tack, I., Bascands, J.L., et al. 2013. Hnf-1\u03b2 transcription factor is an early Hif-1\u00b1-independent marker of epithelial hypoxia and controls renal repair. PLoS ONE, 8, e63585.","journal-title":"PLoS ONE"},{"key":"1675_CR6","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.devcel.2005.09.010","volume":"9","author":"MV Gustafsson","year":"2005","unstructured":"Gustafsson, M.V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J.L., Poellinger, L., Lendahl, U., and Bondesson, M. 2005. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev. Cell, 9, 617\u2013628.","journal-title":"Dev. Cell"},{"key":"1675_CR7","doi-asserted-by":"publisher","first-page":"469","DOI":"10.3390\/genes9100469","volume":"9","author":"E Hadziyannis","year":"2018","unstructured":"Hadziyannis, E. and Laras, A. 2018. Viral biomarkers in chronic HBeAg negative HBV infection. Genes, 9, 469.","journal-title":"Genes"},{"key":"1675_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000445319","volume":"59","author":"ZH Jiang","year":"2016","unstructured":"Jiang, Z.H., Chen, Q.Y., Harrison, T.J., Li, G.J., Wang, X.Y., Li, H., Hu, L.P., Li, K.W., Yang, Q.L., Tan, C., et al. 2016. Hepatitis B virus core promoter double mutations (A1762T, G1764A) are associated with lower levels of serum dihydrolipoyl dehydrogenase. Intervirology, 59, 1\u20137.","journal-title":"Intervirology"},{"key":"1675_CR9","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S1473-3099(02)00315-8","volume":"2","author":"JH Kao","year":"2002","unstructured":"Kao, J.H. and Chen, D.S. 2002. Global control of hepatitis B virus infection. Lancet Infect. Dis., 2, 395\u2013403.","journal-title":"Lancet Infect. Dis."},{"key":"1675_CR10","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s12072-017-9829-7","volume":"11","author":"P Karayiannis","year":"2017","unstructured":"Karayiannis, P. 2017. Hepatitis B virus: virology, molecular biology, life cycle and intrahepatic spread. Hepatol. Int., 11, 500\u2013508.","journal-title":"Hepatol. Int."},{"key":"1675_CR11","doi-asserted-by":"publisher","first-page":"7017","DOI":"10.3748\/wjg.v22.i31.7017","volume":"22","author":"DH Kim","year":"2016","unstructured":"Kim, D.H., Kang, H.S., and Kim, K.H. 2016. Roles of hepatocyte nuclear factors in hepatitis B virus infection. World J. Gastroenterol., 22, 7017\u20137029.","journal-title":"World J. Gastroenterol."},{"key":"1675_CR12","doi-asserted-by":"publisher","first-page":"163","DOI":"10.20517\/2394-5079.2016.05","volume":"2","author":"RJ Lamontagne","year":"2016","unstructured":"Lamontagne, R.J., Bagga, S., and Bouchard, M.J. 2016. Hepatitis B virus molecular biology and pathogenesis. Hepatoma Res., 2, 163\u2013186.","journal-title":"Hepatoma Res."},{"key":"1675_CR13","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.3389\/fmicb.2020.01653","volume":"11","author":"KCK Lau","year":"2020","unstructured":"Lau, K.C.K., Joshi, S.S., Mahoney, D.J., Mason, A.L., van Marle, G., Osiowy, C., and Coffin, C.S. 2020. Differences in HBV replication, APOBEC3 family expression, and inflammatory cytokine levels between wild-type HBV and pre-core (G1896A) or basal core promoter (A1762T\/G1764A) mutants. Front. Microbiol., 11, 1653.","journal-title":"Front. Microbiol."},{"key":"1675_CR14","doi-asserted-by":"publisher","first-page":"5875","DOI":"10.1128\/JVI.76.12.5875-5881.2002","volume":"76","author":"J Li","year":"2002","unstructured":"Li, J., Xu, Z., Zheng, Y., Johnson, D.L., and Ou, J.H. 2002. Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins. J. Virol., 76, 5875\u20135881.","journal-title":"J. Virol."},{"key":"1675_CR15","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1128\/JVI.75.8.3851-3858.2001","volume":"75","author":"CR Madden","year":"2001","unstructured":"Madden, C.R., Finegold, M.J., and Slagle, B.L. 2001. Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine induced preneoplastic lesions. J. Virol., 75, 3851\u20133858.","journal-title":"J. Virol."},{"key":"1675_CR16","doi-asserted-by":"publisher","first-page":"a021410","DOI":"10.1101\/cshperspect.a021410","volume":"5","author":"JH MacLachlan","year":"2015","unstructured":"MacLachlan, J.H. and Cowie, B.C. 2015. Hepatitis B virus epidemiology. Cold Spring Harb. Perspect. Med., 5, a021410.","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"1675_CR17","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ctrv.2008.01.006","volume":"34","author":"L Marignol","year":"2008","unstructured":"Marignol, L., Coffey, M., Lawler, M., and Hollywood, D. 2008. Hypoxia in prostate cancer: a powerful shield against tumour destruction?. Cancer Treat. Rev., 34, 313\u2013327.","journal-title":"Cancer Treat. Rev."},{"key":"1675_CR18","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1093\/emboj\/cdg263","volume":"22","author":"H Marusawa","year":"2003","unstructured":"Marusawa, H., Matsuzawa, S., Welsh, K., Zou, H., Armstrong, R., Tamm, I., and Reed, J.C. 2003. HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J., 22, 2729\u20132740.","journal-title":"EMBO J."},{"key":"1675_CR19","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.antiviral.2012.09.014","volume":"96","author":"S Mirandola","year":"2012","unstructured":"Mirandola, S., Sebastiani, G., Rossi, C., Velo, E., Erne, E.M., Vario, A., Tempesta, D., Romualdi, C., Campagnolo, D., and Alberti, A. 2012. Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy. Antiviral Res., 96, 422\u2013429.","journal-title":"Antiviral Res."},{"key":"1675_CR20","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.3390\/v13091691","volume":"13","author":"E Ohsaki","year":"2021","unstructured":"Ohsaki, E., Suwanmanee, Y., and Ueda, D. 2021. Chronic hepatitis B treatment strategies using polymerase inhibitor-based combination therapy. Viruses, 13, 1691.","journal-title":"Viruses"},{"key":"1675_CR21","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3748\/wjg.v20.i2.425","volume":"20","author":"J Quarleri","year":"2014","unstructured":"Quarleri, J. 2014. Core promoter: a critical region where the hepatitis B virus makes decisions. World J. Gastroenterol., 20, 425\u2013435.","journal-title":"World J. Gastroenterol."},{"key":"1675_CR22","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.biocel.2009.11.016","volume":"43","author":"VC Reese","year":"2011","unstructured":"Reese, V.C., Ondracek, C.R., Rushing, C.N., Li, L., Oropeza, C.E., and McLachlan, A. 2011. Multiple nuclear receptors may regulate hepatitis B virus biosynthesis during development. Int. J. Biochem. Cell Biol., 43, 230\u2013237.","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"1675_CR23","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1016\/S0140-6736(15)61412-X","volume":"386","author":"A Schweitzer","year":"2015","unstructured":"Schweitzer, A., Horn, J., Mikolajczyk, R.T., Krause, G., and Ott, J.J. 2015. Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet, 386, 1546\u20131555.","journal-title":"Lancet"},{"key":"1675_CR24","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1073\/pnas.98.4.1841","volume":"98","author":"H Tang","year":"2001","unstructured":"Tang, H. and McLachlan, A. 2001. Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism. Proc. Natl. Acad. Sci. USA, 98, 1841\u20131846.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"1675_CR25","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1038\/emi.2013.10","volume":"2","author":"S Tong","year":"2013","unstructured":"Tong, S., Li, J., Wands, J.R., and Wen, Y.M. 2013. Hepatitis B virus genetic variants: biological properties and clinical implications. Emerg. Microbes Infect., 2, e10.","journal-title":"Emerg. Microbes Infect."},{"key":"1675_CR26","doi-asserted-by":"publisher","first-page":"6908","DOI":"10.1128\/JVI.78.13.6908-6914.2004","volume":"78","author":"Y Zheng","year":"2004","unstructured":"Zheng, Y., Li, J., and Ou, J.H. 2004. Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein. J. Virol., 78, 6908\u20136914.","journal-title":"J. Virol."},{"key":"1675_CR27","first-page":"5830","volume":"59","author":"H Zhong","year":"1999","unstructured":"Zhong, H., De Marzo, A.M., Laughner, E., Lim, M., Hilton, D.A., Zagzag, D., Buechler, P., Isaacs, W.B., Semenza, G.L., and Simons, J.W. 1999. Overexpression of hypoxia-inducible factor 1\u03b1 in common human cancers and their metastases. Cancer Res., 59, 5830\u20135835.","journal-title":"Cancer Res."},{"key":"1675_CR28","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/cmi.2015.97","volume":"13","author":"Z Zhou","year":"2016","unstructured":"Zhou, Z., Xu, M.J., and Gao, B. 2016. Hepatocytes: a key cell type for innate immunity. Cell. Mol. Immunol., 13, 301\u2013315.","journal-title":"Cell. Mol. Immunol."}],"container-title":["Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12275-022-1675-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12275-022-1675-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12275-022-1675-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T17:51:28Z","timestamp":1735062688000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12275-022-1675-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,27]]},"references-count":28,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["1675"],"URL":"https:\/\/doi.org\/10.1007\/s12275-022-1675-1","relation":{},"ISSN":["1976-3794"],"issn-type":[{"type":"electronic","value":"1976-3794"}],"subject":[],"published":{"date-parts":[[2022,9,27]]},"assertion":[{"value":"31 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by Ethics Review Committee of Department of Medical Research. The approval number is 22\/ Ethics 2015, dated 25.3.2015. Informed consent was obtained from the study participants who were at or more than 16 years and from the parents\/guardians of the study participants who were under 16 years.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Statement"}}]}}