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Despite treatment, <jats:italic>C. albicans<\/jats:italic> remains the leading cause of life-threatening invasive infections. Consequently, antimicrobial peptides (AMPs) are potential alternatives as antifungal agents with excellent antifungal activity. We previously reported that Css54, found in the venom of <jats:italic>Centrurodies suffusus suffusus<\/jats:italic> (<jats:italic>C. s. suffusus<\/jats:italic>) showed antibacterial activity against zoonotic bacteria. However, the antifungal activity of Css54 has not yet been elucidated. The objective of this study was to identify the antifungal activity of Css54 against <jats:italic>C. albicans<\/jats:italic> and analyze its mechanism. Css54 showed high antifungal activity against <jats:italic>C. albicans<\/jats:italic>. Css54 also inhibited biofilm formation in fluconazole-resistant fungi. The antifungal mechanism of action of Css54 was investigated using membrane-related assays, including the membrane depolarization assay and analysis of the membrane integrity of <jats:italic>C. albicans<\/jats:italic> after treatment with Css54. Css54 induced reactive oxygen species (ROS) production in <jats:italic>C. albicans<\/jats:italic>, which affected its antifungal activity. Our results indicate that Css54 causes membrane damage in <jats:italic>C. albicans<\/jats:italic>, highlighting its value as a potential therapeutic agent against <jats:italic>C. albicans<\/jats:italic> infection.<\/jats:p>","DOI":"10.1007\/s12275-024-00113-4","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T16:01:51Z","timestamp":1712592111000},"page":"101-112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the Therapeutic Potential of Scorpion-Derived Css54 Peptide Against Candida albicans"],"prefix":"10.71150","volume":"62","author":[{"given":"Jonggwan","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeongsun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Dam","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-3080","authenticated-orcid":false,"given":"Yoonkyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4586","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"113_CR1","doi-asserted-by":"publisher","first-page":"8339","DOI":"10.3390\/ijms21218339","volume":"21","author":"FLL Aguiar","year":"2020","unstructured":"Aguiar, F. 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