{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:51:16Z","timestamp":1791229876793,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s12282-018-0891-3","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T02:51:03Z","timestamp":1530759063000},"page":"74-83","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Up-regulated lncRNA AFAP1-AS1 indicates a poor prognosis and promotes carcinogenesis of breast cancer"],"prefix":"10.1007","volume":"26","author":[{"given":"Dachang","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duoming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"891_CR1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1007\/s12254-017-0368-7","volume":"10","author":"R Bartsch","year":"2017","unstructured":"Bartsch R, Bergen E. ASCO 2017: highlights in breast cancer. Memo. 2017;10:228\u201332.","journal-title":"Memo"},{"key":"891_CR2","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/cas.13463","volume":"109","author":"SK Low","year":"2017","unstructured":"Low SK, Zembutsu H, Nakamura Y. Breast cancer: the translation of big genomic data to cancer precision medicine. Cancer Sci. 2017;109:497","journal-title":"Cancer Sci"},{"key":"891_CR3","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/bs.pmbts.2016.09.011","volume":"144","author":"M Kumar","year":"2016","unstructured":"Kumar M, DeVaux RS, Herschkowitz JI. Molecular and cellular changes in breast cancer and new roles of lncRNAs in breast cancer initiation and progression. Prog Mol Biol Transl Sci. 2016;144:563\u201386.","journal-title":"Prog Mol Biol Transl Sci"},{"key":"891_CR4","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/cgt.2017.29","volume":"24","author":"RK Li","year":"2017","unstructured":"Li RK, Gao J, Guo LH, Huang GQ, Luo WH. PTENP1 acts as a ceRNA to regulate PTEN by sponging miR-19b and explores the biological role of PTENP1 in breast cancer. Cancer Gene Ther. 2017;24:309\u201315.","journal-title":"Cancer Gene Ther"},{"key":"891_CR5","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.biopha.2017.09.019","volume":"95","author":"W Xu","year":"2017","unstructured":"Xu W, Chang J, Du X, Hou J. Long non-coding RNA PCAT-1 contributes to tumorigenesis by regulating FSCN1 via miR-145-5p in prostate cancer. Biomed Pharmacother. 2017;95:1112\u20138.","journal-title":"Biomed Pharmacother"},{"key":"891_CR6","doi-asserted-by":"crossref","first-page":"83727","DOI":"10.18632\/oncotarget.13384","volume":"7","author":"Y Zheng","year":"2016","unstructured":"Zheng Y, Song D, Xiao K, Yang C, Ding Y, Deng W, et al. LncRNA GAS5 contributes to lymphatic metastasis in colorectal cancer. Oncotarget. 2016;7:83727\u201334.","journal-title":"Oncotarget"},{"key":"891_CR7","doi-asserted-by":"crossref","first-page":"15663","DOI":"10.18632\/oncotarget.14933","volume":"8","author":"H Hui","year":"2017","unstructured":"Hui H, Zhai Y, Ao L, Cleveland JC Jr, Liu H, Fullerton DA, et al. Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget. 2017;8:15663\u201376.","journal-title":"Oncotarget"},{"key":"891_CR8","doi-asserted-by":"publisher","first-page":"4247","DOI":"10.2147\/OTT.S107188","volume":"9","author":"FT Liu","year":"2016","unstructured":"Liu FT, Xue QZ, Zhu PQ, Luo HL, Zhang Y, Hao T. Long noncoding RNA AFAP1-AS1, a potential novel biomarker to predict the clinical outcome of cancer patients: a meta-analysis. Onco Targets Ther. 2016;9:4247\u201354.","journal-title":"Onco Targets Ther"},{"key":"891_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s40659-016-0094-3","volume":"49","author":"X Han","year":"2016","unstructured":"Han X, Wang L, Ning Y, Li S, Wang Z. Long non-coding RNA AFAP1-AS1 facilitates tumor growth and promotes metastasis in colorectal cancer. Biol Res. 2016;49:36.","journal-title":"Biol Res"},{"key":"891_CR10","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12967-015-0490-4","volume":"13","author":"Y Ye","year":"2015","unstructured":"Ye Y, Chen J, Zhou Y, Fu Z, Zhou Q, Wang Y, et al. High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal adenocarcinoma. J Transl Med. 2015;13:137.","journal-title":"J Transl Med"},{"key":"891_CR11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.biopha.2015.07.003","volume":"75","author":"J Deng","year":"2015","unstructured":"Deng J, Liang Y, Liu C, He S, Wang S. The up-regulation of long non-coding RNA AFAP1-AS1 is associated with the poor prognosis of NSCLC patients. Biomed Pharmacother. 2015;75:8\u201311.","journal-title":"Biomed Pharmacother"},{"key":"891_CR12","doi-asserted-by":"publisher","first-page":"20404","DOI":"10.18632\/oncotarget.4057","volume":"6","author":"H Bo","year":"2015","unstructured":"Bo H, Gong Z, Zhang W, Li X, Zeng Y, Liao Q, et al. Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma. Oncotarget. 2015;6:20404\u201318.","journal-title":"Oncotarget"},{"key":"891_CR13","doi-asserted-by":"publisher","first-page":"761","DOI":"10.2147\/OTT.S97664","volume":"9","author":"F Yang","year":"2016","unstructured":"Yang F, Lyu S, Dong S, Liu Y, Zhang X, Wang O. Expression profile analysis of long noncoding RNA in HER-2-enriched subtype breast cancer by next-generation sequencing and bioinformatics. Onco Targets Ther. 2016;9:761\u201372.","journal-title":"Onco Targets Ther"},{"key":"891_CR14","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/j.1365-2559.1991.tb00229.x","volume":"19","author":"CW Elston","year":"1991","unstructured":"Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991;19:403\u201310.","journal-title":"Histopathology"},{"key":"891_CR15","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.5858\/134.7.e48","volume":"134","author":"ME Hammond","year":"2010","unstructured":"Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, et al. American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med. 2010;134:e48\u201372.","journal-title":"Arch Pathol Lab Med"},{"key":"891_CR16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5858\/2007-131-18-ASOCCO","volume":"131","author":"AC Wolff","year":"2007","unstructured":"Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, et al. American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med. 2007;131:18\u201343.","journal-title":"Arch Pathol Lab Med"},{"key":"891_CR17","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.lfs.2015.11.020","volume":"144","author":"WQ Li","year":"2016","unstructured":"Li WQ, Li XH, Wu YH, Du J, Wang AP, Li D, et al. Role of eukaryotic translation initiation factors 3a in hypoxia-induced right ventricular remodeling of rats. Life Sci. 2016;144:61\u20138.","journal-title":"Life Sci"},{"key":"891_CR18","doi-asserted-by":"publisher","first-page":"9699","DOI":"10.1007\/s13277-016-4858-8","volume":"37","author":"X Lu","year":"2016","unstructured":"Lu X, Zhou C, Li R, Liang Z, Zhai W, Zhao L, et al. Critical role for the long non-coding RNA AFAP1-AS1 in the proliferation and metastasis of hepatocellular carcinoma. Tumour Biol. 2016;37:9699\u2013707.","journal-title":"Tumour Biol"},{"key":"891_CR19","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.biopha.2016.04.009","volume":"81","author":"F Wang","year":"2016","unstructured":"Wang F, Ni H, Sun F, Li M, Chen L. Overexpression of lncRNA AFAP1-AS1 correlates with poor prognosis and promotes tumorigenesis in colorectal cancer. Biomed Pharmacother. 2016;81:152\u20139.","journal-title":"Biomed Pharmacother"},{"key":"891_CR20","first-page":"2764","volume":"41","author":"L Wang","year":"2018","unstructured":"Wang L, Cao J, Shi Z, Fan W, Liu H, Deng J, et al. Experimental study on the neurotoxic effect of beta-amyloid on the cytoskeleton of PC12 cells. Int J Mol Med. 2018;41:2764\u201370.","journal-title":"Int J Mol Med"},{"key":"891_CR21","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1042\/BCJ20170079","volume":"474","author":"O Slaby","year":"2017","unstructured":"Slaby O, Laga R, Sedlacek O. Therapeutic targeting of non-coding RNAs in cancer. Biochem J. 2017;474:4219\u201351.","journal-title":"Biochem J"},{"key":"891_CR22","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.3390\/ijms18122578","volume":"18","author":"M Giroud","year":"2017","unstructured":"Giroud M, Scheideler M. Long non-coding RNAs in metabolic organs and energy homeostasis. Int J Mol Sci. 2017;18:2578","journal-title":"Int J Mol Sci"},{"key":"891_CR23","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.biopha.2014.12.002","volume":"69","author":"N Xu","year":"2015","unstructured":"Xu N, Wang F, Lv M, Cheng L. Microarray expression profile analysis of long non-coding RNAs in human breast cancer: a study of Chinese women. Biomed Pharmacother. 2015;69:221\u20137.","journal-title":"Biomed Pharmacother"},{"key":"891_CR24","doi-asserted-by":"crossref","first-page":"21730","DOI":"10.18632\/oncotarget.4419","volume":"6","author":"X Shen","year":"2015","unstructured":"Shen X, Xie B, Ma Z, Yu W, Wang W, Xu D, et al. Identification of novel long non-coding RNAs in triple-negative breast cancer. Oncotarget. 2015;6:21730\u20139.","journal-title":"Oncotarget"},{"key":"891_CR25","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.3892\/ijo.2016.3385","volume":"48","author":"JY Zhang","year":"2016","unstructured":"Zhang JY, Weng MZ, Song FB, Xu YG, Liu Q, Wu JY, et al. Long noncoding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA\/Rac2 signaling. Int J Oncol. 2016;48:1590\u20138.","journal-title":"Int J Oncol"},{"key":"891_CR26","doi-asserted-by":"crossref","first-page":"39001","DOI":"10.18632\/oncotarget.16545","volume":"8","author":"Y Tang","year":"2017","unstructured":"Tang Y, He Y, Shi L, Yang L, Wang J, Lian Y, et al. Co-expression of AFAP1-AS1 and PD-1 predicts poor prognosis in nasopharyngeal carcinoma. Oncotarget. 2017;8:39001\u201311.","journal-title":"Oncotarget"},{"key":"891_CR27","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1002\/mc.22454","volume":"55","author":"XL Zhou","year":"2016","unstructured":"Zhou XL, Wang WW, Zhu WG, Yu CH, Tao GZ, Wu QQ, et al. High expression of long non-coding RNA AFAP1-AS1 predicts chemoradioresistance and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Mol Carcinog. 2016;55:2095\u2013105.","journal-title":"Mol Carcinog"},{"key":"891_CR28","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1007\/s10620-017-4584-0","volume":"62","author":"JQ Guo","year":"2017","unstructured":"Guo JQ, Li SJ, Guo GX. Long Noncoding. RNA AFAP1-AS1 promotes cell proliferation and apoptosis of gastric cancer cells via PTEN\/p-AKT pathway. Dig Dis Sci. 2017;62:2004\u201310.","journal-title":"Dig Dis Sci"},{"key":"891_CR29","doi-asserted-by":"publisher","first-page":"6607","DOI":"10.1038\/sj.onc.1204802","volume":"20","author":"JM Baisden","year":"2001","unstructured":"Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC. The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases. Oncogene. 2001;20:6607\u201316.","journal-title":"Oncogene"},{"key":"891_CR30","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1038\/onc.2014.205","volume":"34","author":"JM Cunnick","year":"2015","unstructured":"Cunnick JM, Kim S, Hadsell J, Collins S, Cerra C, Reiser P, et al. Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland. Oncogene. 2015;34:2640\u20139.","journal-title":"Oncogene"},{"key":"891_CR31","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1111\/jcmm.12770","volume":"20","author":"ZD Lv","year":"2016","unstructured":"Lv ZD, Kong B, Liu XP, Jin LY, Dong Q, Li FN, et al. miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer. J Cell Mol Med. 2016;20:864\u201373.","journal-title":"J Cell Mol Med"},{"key":"891_CR32","first-page":"956 e4","volume":"144","author":"W Wu","year":"2013","unstructured":"Wu W, Bhagat TD, Yang X, Song JH, Cheng Y, Agarwal R, et al. Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett\u2019s esophagus and esophageal adenocarcinoma. Gastroenterology. 2013;144:956 e4\u201366 e4.","journal-title":"Gastroenterology"},{"key":"891_CR33","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s13277-015-3860-x","volume":"37","author":"Z Zeng","year":"2016","unstructured":"Zeng Z, Bo H, Gong Z, Lian Y, Li X, Li X, et al. AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis. Tumour Biol. 2016;37:729\u201337.","journal-title":"Tumour Biol"}],"container-title":["Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12282-018-0891-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12282-018-0891-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12282-018-0891-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:09Z","timestamp":1661558409000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12282-018-0891-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["891"],"URL":"https:\/\/doi.org\/10.1007\/s12282-018-0891-3","relation":{},"ISSN":["1340-6868","1880-4233"],"issn-type":[{"value":"1340-6868","type":"print"},{"value":"1880-4233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,5]]},"assertion":[{"value":"2 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All patients had signed the informed consent before surgery.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Clinicopathological follow-up information from breast cancer patients was available. All clinical investigations in the present study were approved by the Human Ethics Committee in the First Hospital of Lanzhou University (Lanzhou, China) and conducted according to the principles expressed in Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}