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In this study, we performed evaluation of the changes in radiation dermatitis (RD) using quantitative and qualitative methods, and verified the validity of the conventional qualitative assessment for clinical use.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Forty-three breast cancer patients received conventional fractionated radiotherapy to whole breast after breast-conserving surgery. Erythema, pigmentation and skin dryness were evaluated qualitatively, and biophysical parameters of RD were measured using a Multi-Display Device MDD4 with a Corneometer for capacitance, a Tewameter for transepidermal water loss (TEWL), a Mexameter for erythema index and melanin index. Measurements were performed periodically until 1 year.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The quantitative manifestations developed serially from skin erythema followed by dryness and pigmentation. Quantitative measurements detected the effects of irradiation earlier than that of qualitative indices. However, the grades of the domains in RD by qualitative and quantitative assessment showed similar time courses and peak periods. However, no significant correlation was observed between the skin dryness grade and skin barrier function. In contrast to serial increase in pigmentation grades, melanin index showed initial decrease followed by marked increase with significant correlation with pigmentation grades.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Subjectively and objectively measured results of RD were almost similar course and peak points through the study. Therefore, validity of the conventional qualitative scoring for RD is confirmed by the present quantitative assessments. Instrumental evaluations revealed the presence of modest inflammatory changes before radiotherapy and long-lasting skin dryness, suggesting indication of intervention for RD.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s12282-020-01082-3","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T09:02:28Z","timestamp":1588496548000},"page":"861-870","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Non-invasive quantitative measures of qualitative grading effectiveness as the indices of acute radiation dermatitis in breast cancer patients"],"prefix":"10.1007","volume":"27","author":[{"given":"Hiroshi","family":"Sekine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Kijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Itami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Igaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Nomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuko","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Nozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,3]]},"reference":[{"key":"1082_CR1","first-page":"147","volume":"54","author":"H Sekine","year":"2007","unstructured":"Sekine H, Fukuda I, Takagi S, Kobayashi M, Aoki M, Kanehira C. 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Yoshikazu Kijima has no conflicts of interest. Masao Kobayashi has no conflicts of interest. Jun Itami received personal fees from HekaBio, ItoChu, and Kay-J, which were unrelated to the submitted work. Kana Takahashi has no conflicts of interest. Hiroshi Igaki received a research grant from HekaBio and personal fees from ItoChu, which were unrelated to the submitted work. Yasuo Nakai received personal fees from ONO Pharmaceutical Co. LTD, Novartis Pharma K.K, and Jiho, Inc., which were unrelated to the submitted work. Hitoshi Mizutani received a grant from the Japan Agency for Medical Research and Development during the conduct of the study; currently serves as a consultant to Asahikasei Pharma Co. Ltd., Kao Corp., Celgene Co. Ltd., Tanabe Mitsubishi Co. Ltd., Kinoushokuhin Kenkyusho, Sato Pharma, Eli Lilly Japan K.K., Maruishi Pharma Co. Ltd., Leo Pharma, Kaken Pharma, and FUJIFILM Toyama Chemical Co., Ltd.; received lecture and consultant fees from Maruho Co. Ltd.; received lecture and transportation fees from Jansen Pharma; received consultancy and manuscript fees from Shionogi Pharma Co. Ltd., and Bayer Pharma.; and received lecture fees from Taiho Pharma, Grafa Laboratory, Kyorin Pharma, Inforward Co. Ltd., Astellas Pharma., Kaken Pharma., Novartis Pharma, Kyowa-Kirin Co. Ltd., Eisai Co. Ltd., Torii Co. Ltd., Absolute Co. Ltd., Tsumura Co. Ltd., Nippon Shinyaku Co. Ltd., POLA-Pharma, and Ushio Electric Co. Ltd., which were unrelated to the submitted work. Yoshihito Nomoto has no conflicts of interest. Katsuko Kikuchi received a grant and personal fees from POLA-Pharma and personal fees from Maruho Co. Ltd. and TOKIWA Pharmaceutical Co. Ltd., which were unrelated to the submitted work. Haruo Matsushita has no conflicts of interest. Keiko Nozawa has no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Review Board of each institute and conducted according to the 1964 Declaration of Helsinki and its later amendments, as well as the Ethical Guidelines for Medical Health Research Involving Human Subjects (2014) by the Japanese Ministry of Health and Welfare and the Ministry of Education, Culture, and Technology.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}