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NN and YY have received grants from Chugai Pharmaceutical Co. MM, YK. YY has received honorariums as a speaker or consultant\/advisory role. YY have received grants from Eli Lilly. MM, YK, NN, and YY have received honorariums as a speaker or consultant\/advisory role. YY have received grants from Eisai. NH, MM, YK, NN, and YY have received honorariums as a speaker or consultant\/advisory role from AstraZeneca. NH, MM, YK, NN, YY, and HK have received honorariums as a speaker or consultant\/advisory role. YY have received grants from Pfizer Japan Inc. MM, YK, and YY have received honorariums as a speaker or consultant\/advisory role. YY have received grants from Taiho Pharma. MM, YK, and YY have received honorariums as a speaker or consultant\/advisory role. YY has received grants from Daiichi-Sankyo. NH, YK, NN, and YY have received honorariums as a speaker or consultant\/advisory role. YY have received grants from Novartis Pharma. NH, YK, and YY have received honorariums as a speaker or consultant\/advisory role. YY has received grants, and MM has received non-financial support from Kyowa Hakko Kirin. YY has received grants and honorariums as a speaker or consultant\/advisory role from Takeda. YY has received grants and honorariums as a speaker or consultant\/advisory role from Sysmex. YY has received honorariums as a speaker or consultant\/advisory role from GE Health Care Japan. NN has received grants from Nippon Mediphysics, Daiichi-Sankyo, BMS, and MSD. YY has received grants and honorariums as a speaker or consultant\/advisory role from Nihon Kayaku. HK has received honorariums as a speaker or consultant\/advisory role from Mitsubishi Tanabe Pharma. NH has received honorariums as a speaker or consultant\/advisory role from Genomic Health Inc., Devicor Japan, and Allergan Japan. HK, HM, and UI report affiliation with the Department of Healthcare Quality Assessment at the University of Tokyo. The department is a social collaboration department supported by the National Clinical Database, Johnson & Johnson K.K., and the Nipro Corporation. YY and HJ are board members of the Japanese Breast Cancer Society. All of these declarations are outside the submitted work. The other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}