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All patients provided their written informed consent to participate in the study and for the use of their biopsy tissues and clinical data, in accordance with Spanish law. We followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Yes.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}