{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:16:46Z","timestamp":1793125006007,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100015638","name":"Japanese Breast Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015638","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004721","name":"The University of Tokyo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Implant-based breast reconstruction is the most commonly performed reconstructive technique following mastectomy. With an increasing number of patients undergoing implant-based breast reconstruction, concerns have arisen regarding the safety of postmastectomy radiation therapy (PMRT) in reconstructed breasts. This study aimed to investigate the safety of PMRT in implant-based breast reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted for articles published up to March 2021. Eligible studies included clinical trials and observational studies comparing outcomes between patients with breast cancer undergoing immediate implant-based breast reconstruction with PMRT and those without PMRT. The primary outcomes included major complications, reconstruction failure, capsular contracture, and cosmetic outcomes. Pooled odds ratio (OR) with 95% confidence interval (CI) were calculated using a random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 23 studies were identified, comprising one case\u2013control study, one prospective cohort study, and 21 retrospective cohort studies. PMRT was significantly associated with increased rates of major complications (OR 2.62, 95% CI 1.82\u20133.77,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.00001), reconstruction failure (OR 2.53, 95% CI 2.00\u20133.20,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.00001), and capsular contracture (OR 9.63, 95% CI 5.77\u201316.06,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.00001). Furthermore, cosmetic outcomes were significantly poorer in patients undergoing PMRT compared with those not receiving PMRT (OR 3.55, 95% CI 1.80\u20136.98,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta-analysis demonstrated that PMRT in implant-based breast reconstruction is associated with a significantly increased risk of adverse outcomes. Given these risks, treatment decisions should involve through discussions with patients to ensure that they are fully informed of the potential benefits and complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12282-025-01788-2","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:22:38Z","timestamp":1759206158000},"page":"1169-1179","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Postmastectomy radiation therapy for implant-based breast reconstruction: a systematic review and meta-analysis for the 2022 Japanese Breast Cancer Society Clinical Practice Guideline"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1539-4298","authenticated-orcid":false,"given":"Mami","family":"Ogita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subaru","family":"Sawayanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Jinnouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Sanuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Hamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehira","family":"Saji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"1788_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.815498","volume":"12","author":"M Shiraishi","year":"2022","unstructured":"Shiraishi M, Sowa Y, Tsuge I, Kodama T, Inafuku N, Morimoto N. 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He is an advisory board member of AstraZeneca, MSD, Pfizer, and Daiichi Sankyo. SS received research grants from Taiho, Eisai, Chugai, Takeda, MSD, Astra Zeneca, Daiichi Sankyo, Gilead, Eli Lilly, and Sanofi, and honoraria from Chugai, Kyowa Kirin, MSD, Novartis, Eisai, Takeda, Daiichi Sankyo, Eli Lilly, Astra Zeneca, Pfizer, Taiho, Ono, Nipponkayaku, Gilead, and Exact Sciences. He is an advisory board member of Chugai\/Roche, Astra Zeneca, Eli Lilly, Pfizer, Kyowa Kirin, Daiichi Sankyo, and MSD, and an executive board member of JBCRG, JBCS, JSMO, and BIG. TT received honoraria from Chugai, Daiichi Sankyo, Pfizer, MSD, Lilly, Novartis, and Taiho. He has no conflict of interest. The other authors have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This article does not contain any studies involving human participants or animals conducted by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Informed consent was not required for this type of study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}