{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:39:02Z","timestamp":1787841542800,"version":"build-2784847793"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012330","name":"Okayama University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012330","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s12282-026-01884-x","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:40:25Z","timestamp":1782283225000},"page":"1093-1101","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Breast ultrasound screening in young adult women undergoing infertility treatment at an infertility clinic: a retrospective observational study"],"prefix":"10.1007","volume":"33","author":[{"given":"Kanako","family":"Nakano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-5512","authenticated-orcid":false,"given":"Tadahiko","family":"Shien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Doihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reina","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Saji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motomi","family":"Yukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuka","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyu","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Habara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"1884_CR1","doi-asserted-by":"publisher","first-page":"e12552","DOI":"10.1002\/rmb2.12552","volume":"23","author":"Y Katagiri","year":"2024","unstructured":"Katagiri Y, Jwa SC, Kuwahara A, Iwasa T, On M, Kato K, et al. Assisted reproductive technology in Japan: A summary report for 2021 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology. Reprod Med Biol. 2024;23:e12552. https:\/\/doi.org\/10.1002\/rmb2.12552.","journal-title":"Reprod Med Biol"},{"key":"1884_CR2","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1093\/humrep\/deaa293","volume":"36","author":"JF Barcroft","year":"2021","unstructured":"Barcroft JF, Galazis N, Jones BP, et al. Fertility treatment and cancers\u2014the eternal conundrum: a systematic review and meta-analysis. Hum Reprod. 2021;36:1093\u2013107. https:\/\/doi.org\/10.1093\/humrep\/deaa293.","journal-title":"Hum Reprod"},{"key":"1884_CR3","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.fertnstert.2021.01.044","volume":"116","author":"Y Beebeejaun","year":"2021","unstructured":"Beebeejaun Y, Athithan A, Copeland TP, et al. Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis. Fertil Steril. 2021;116:198\u2013207. https:\/\/doi.org\/10.1016\/j.fertnstert.2021.01.044.","journal-title":"Fertil Steril"},{"key":"1884_CR4","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1093\/humupd\/dmt034","volume":"20","author":"TN Sergentanis","year":"2014","unstructured":"Sergentanis TN, Diamantaras AA, Perlepe C, et al. IVF and breast cancer risk: a meta-analysis. Hum Reprod Update. 2014;20:106\u201323. https:\/\/doi.org\/10.1093\/humupd\/dmt034.","journal-title":"Hum Reprod Update"},{"key":"1884_CR5","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1001\/jama.2016.9389","volume":"316","author":"AW van den Belt-Dusebout","year":"2016","unstructured":"van den Belt-Dusebout AW, Spaan M, Lambalk CB, et al. Ovarian stimulation for in vitro fertilization and long-term risk of breast cancer. JAMA. 2016;316:300\u201312. https:\/\/doi.org\/10.1001\/jama.2016.9389.","journal-title":"JAMA"},{"key":"1884_CR6","doi-asserted-by":"publisher","first-page":"k2644","DOI":"10.1136\/bmj.k2644","volume":"362","author":"CL Williams","year":"2018","unstructured":"Williams CL, Jones ME, Swerdlow AJ, et al. Risks of ovarian, breast, and corpus uteri cancer in women treated with assisted reproductive technology in Great Britain, 1991\u20132010. BMJ. 2018;362:k2644. https:\/\/doi.org\/10.1136\/bmj.k2644.","journal-title":"BMJ"},{"key":"1884_CR7","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3109\/09513599709152560","volume":"11","author":"A Brzezinski","year":"1997","unstructured":"Brzezinski A, Schenker JG. Induction of ovulation and risk of breast cancer: an overview and perspectives. Gynecol Endocrinol. 1997;11:357\u201364. https:\/\/doi.org\/10.3109\/09513599709152560.","journal-title":"Gynecol Endocrinol"},{"key":"1884_CR8","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3389\/fendo.2019.00313","volume":"10","author":"Z Momenimovahed","year":"2019","unstructured":"Momenimovahed Z, Taheri S, Tiznobaik A, Salehiniya H. Do fertility drugs increase the risk of cancer? A review study. Front Endocrinol (Lausanne). 2019;10:313. https:\/\/doi.org\/10.3389\/fendo.2019.00313.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1884_CR9","first-page":"209","volume":"43","author":"B MacMahon","year":"1970","unstructured":"MacMahon B, Cole P, Lin TM, et al. Age at first birth and breast cancer risk. Bull World Health Organ. 1970;43:209\u201321.","journal-title":"Bull World Health Organ"},{"key":"1884_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12916-015-0545-7","volume":"14","author":"M Lambertini","year":"2016","unstructured":"Lambertini M, Del Mastro L, Pescio MC, et al. Cancer and fertility preservation: international recommendations from an expert meeting. BMC Med. 2016;14:1. https:\/\/doi.org\/10.1186\/s12916-015-0545-7.","journal-title":"BMC Med"},{"key":"1884_CR11","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s12282-013-0463-5","volume":"21","author":"T Shien","year":"2014","unstructured":"Shien T, Nakatsuka M, Doihara H. Fertility preservation in breast cancer patients. Breast Cancer. 2014;21:651\u20135. https:\/\/doi.org\/10.1007\/s12282-013-0463-5.","journal-title":"Breast Cancer"},{"key":"1884_CR12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.18926\/AMO\/55854","volume":"72","author":"Y Takahashi","year":"2018","unstructured":"Takahashi Y, Shien T, Sakamoto A, et al. Current multidisciplinary approach to fertility preservation for breast cancer patients. Acta Med Okayama. 2018;72:137\u201342. https:\/\/doi.org\/10.18926\/AMO\/55854.","journal-title":"Acta Med Okayama"},{"key":"1884_CR13","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.2214\/AJR.12.8842","volume":"199","author":"CD Lehman","year":"2012","unstructured":"Lehman CD, Lee CI, Loving VA, et al. Accuracy and value of breast ultrasound for primary imaging evaluation of symptomatic women 30\u201339 years of age. AJR Am J Roentgenol. 2012;199:1169\u201377. https:\/\/doi.org\/10.2214\/AJR.12.8842.","journal-title":"AJR Am J Roentgenol"},{"key":"1884_CR14","doi-asserted-by":"publisher","first-page":"268","DOI":"10.7326\/M15-1789","volume":"164","author":"J Melnikow","year":"2016","unstructured":"Melnikow J, Fenton JJ, Whitlock EP, et al. Supplemental screening for breast cancer in women with dense breasts: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2016;164:268\u201378. https:\/\/doi.org\/10.7326\/M15-1789.","journal-title":"Ann Intern Med"},{"key":"1884_CR15","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0140-6736(15)00774-6","volume":"387","author":"N Ohuchi","year":"2016","unstructured":"Ohuchi N, Suzuki A, Sobue T, et al. Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial. Lancet. 2016;387:341\u20138. https:\/\/doi.org\/10.1016\/S0140-6736(15)00774-6.","journal-title":"Lancet"},{"key":"1884_CR16","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1001\/jama.299.18.2151","volume":"299","author":"WA Berg","year":"2008","unstructured":"Berg WA, Blume JD, Cormack JB, et al. Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer. JAMA. 2008;299:2151\u201363. https:\/\/doi.org\/10.1001\/jama.299.18.2151.","journal-title":"JAMA"},{"key":"1884_CR17","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.ejca.2010.12.002","volume":"47","author":"V Corsetti","year":"2011","unstructured":"Corsetti V, Houssami N, Ghirardi M, et al. Evidence of the effect of adjunct ultrasound screening in women with mammography-negative dense breasts: interval breast cancers at 1 year follow-up. Eur J Cancer. 2011;47:1021\u20136. https:\/\/doi.org\/10.1016\/j.ejca.2010.12.002.","journal-title":"Eur J Cancer"},{"key":"1884_CR18","doi-asserted-by":"publisher","first-page":"e222531","DOI":"10.1148\/radiol.222531","volume":"307","author":"SH Kim","year":"2023","unstructured":"Kim SH, Chang JM, Cho N, Park JS, Moon WK. Glandular tissue component and breast cancer risk in mammographically dense breasts at screening breast US. Radiology. 2023;307:e222531. https:\/\/doi.org\/10.1148\/radiol.222531.","journal-title":"Radiology"},{"key":"1884_CR19","volume-title":"BI-RADS Atlas","author":"American College of Radiology","year":"2013","unstructured":"American College of Radiology. BI-RADS Atlas. 5th ed. Reston, VA: American College of Radiology; 2013.","edition":"5"},{"key":"1884_CR20","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1093\/jbi\/wbab060","volume":"3","author":"WA Berg","year":"2021","unstructured":"Berg WA. BI-RADS 3 on Screening Breast Ultrasound: What Is It and What Is the Appropriate Management? J Breast Imaging. 2021;3:527\u201338.","journal-title":"J Breast Imaging"},{"key":"1884_CR21","doi-asserted-by":"publisher","first-page":"20170787","DOI":"10.1259\/bjr.20170787","volume":"91","author":"SM Ha","year":"2018","unstructured":"Ha SM, Chae EY, Cha JH, et al. Growing BI-RADS category 3 lesions on follow-up breast ultrasound: malignancy rates and worrisome features. Br J Radiol. 2018;91:20170787.","journal-title":"Br J Radiol"},{"key":"1884_CR22","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1002\/jum.16142","volume":"42","author":"DS Polat","year":"2023","unstructured":"Polat DS, Merchant K, Hayes J, et al. Outcome of Imaging and Biopsy of BI-RADS Category 3 Lesions: Follow-Up Compliance, Biopsy, and Malignancy Rates in a Large Patient Cohort. J Ultrasound Med. 2023;42:1285\u201396.","journal-title":"J Ultrasound Med"},{"key":"1884_CR23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1177\/08465371221121706","volume":"74","author":"J Common","year":"2023","unstructured":"Common J, Abdullah P, Alabousi A. A Single-Center Audit of BI-RADS 3 Assessment Category Utilization in Mammography and Breast Ultrasound. Can Assoc Radiol J. 2023;74:69\u201377.","journal-title":"Can Assoc Radiol J"},{"key":"1884_CR24","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s12282-019-01018-6","volume":"27","author":"K Nishiyama","year":"2020","unstructured":"Nishiyama K, Taira N, Mizoo T, et al. Influence of breast density on breast cancer risk: a case control study in Japanese women. Breast Cancer. 2020;27:277\u201383.","journal-title":"Breast Cancer"},{"key":"1884_CR25","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/S0140-6736(11)61092-1","volume":"379","author":"F Amant","year":"2012","unstructured":"Amant F, Loibl S, Neven P, Van Calsteren K. Breast cancer in pregnancy. Lancet. 2012;379:570\u20139.","journal-title":"Lancet"},{"key":"1884_CR26","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1093\/jjco\/hyz213","volume":"50","author":"T Shien","year":"2020","unstructured":"Shien T, Iwata H. Adjuvant and neoadjuvant therapy for breast cancer. Jpn J Clin Oncol. 2020;50:225\u20139.","journal-title":"Jpn J Clin Oncol"}],"container-title":["Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12282-026-01884-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12282-026-01884-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12282-026-01884-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:59:12Z","timestamp":1787839152000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12282-026-01884-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["1884"],"URL":"https:\/\/doi.org\/10.1007\/s12282-026-01884-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9125907\/v1","asserted-by":"object"}]},"ISSN":["1340-6868","1880-4233"],"issn-type":[{"value":"1340-6868","type":"print"},{"value":"1880-4233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]},"assertion":[{"value":"14 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}