{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T04:13:13Z","timestamp":1744431193961,"version":"3.40.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Hematol Blood Transfus"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s12288-024-01852-5","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T13:02:20Z","timestamp":1724936540000},"page":"422-426","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Revisiting the Real-World Prognosis of Intensive Chemotherapy in Elderly Acute Myeloid Leukemia Patients: A Retrospective Analysis from Tokyo"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-9641","authenticated-orcid":false,"given":"Takeshi","family":"Hagino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reina","family":"Saga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Hidai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Murai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayuri","family":"Motomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"1852_CR1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/ejh.13752","volume":"108","author":"RJ Stubbins","year":"2022","unstructured":"Stubbins RJ, Stamenkovic M, Roy C, Rodrigo J, Chung S, Kuchenbauer FC et al (2022) Incidence and socioeconomic factors in older adults with acute myeloid leukaemia: real-world outcomes from a population-based cohort. Eur J Haematol 108:437\u2013445","journal-title":"Eur J Haematol"},{"issue":"9","key":"1852_CR2","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1182\/blood-2005-09-3724","volume":"107","author":"FR Appelbaum","year":"2006","unstructured":"Appelbaum FR, Gundacker H, Head DR, Slovak ML, Willman CL, Godwin JE et al (2006) Age and acute myeloid leukemia. Blood 107(9):3481\u20133485","journal-title":"Blood"},{"key":"1852_CR3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/bjh.12750","volume":"165","author":"R Liersch","year":"2014","unstructured":"Liersch R, M\u00fcller-Tidow C, Berdel WE, Krug U (2014) Prognostic factors for acute myeloid leukaemia in adults\u2013biological significance and clinical use. Br J Haematol 165:17\u201338","journal-title":"Br J Haematol"},{"issue":"4","key":"1852_CR4","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1182\/blood-2016-08-733196","volume":"129","author":"H D\u00f6hner","year":"2017","unstructured":"D\u00f6hner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, B\u00fcchner T et al (2017) Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood 129(4):424\u2013447","journal-title":"Blood"},{"unstructured":"Cancer stat facts: Leukemia-Acute Myeloid Leukemia (AML) [(accessed on 18 May 2022)]; Available online: https:\/\/seer.cancer.gov\/statfacts\/html\/amyl.html","key":"1852_CR5"},{"issue":"12","key":"1852_CR6","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1007\/s00277-017-3150-3","volume":"96","author":"G Nagel","year":"2017","unstructured":"Nagel G, Weber D, Fromm E, Erhardt S, L\u00fcbbert M, Fiedler W et al (2017) Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO). Ann Hematol 96(12):1993\u20132003","journal-title":"Ann Hematol"},{"issue":"18","key":"1852_CR7","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.1182\/blood-2008-07-172007","volume":"113","author":"G Juliusson","year":"2009","unstructured":"Juliusson G, Antunovic P, Derolf A, Lehmann S, M\u00f6llg\u00e5rd L, Stockelberg D et al (2009) Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry. Blood 113(18):4179\u20134187","journal-title":"Blood"},{"issue":"8518","key":"1852_CR8","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/S0140-6736(86)92674-7","volume":"2","author":"JK Rees","year":"1986","unstructured":"Rees JK, Gray RG, Swirsky D, Hayhoe FG (1986) Principal results of the Medical Research Council\u2019s 8th acute myeloid leukaemia trial. Lancet 2(8518):1236\u20131241","journal-title":"Lancet"},{"issue":"23","key":"1852_CR9","doi-asserted-by":"publisher","first-page":"3849","DOI":"10.1200\/JCO.2008.21.0856","volume":"27","author":"RD Portugal","year":"2009","unstructured":"Portugal RD, Garnica M, Nucci M (2009) Index to predict invasive mold infection in high-risk neutropenic patients based on the area over the neutrophil curve. J Clin Oncol 27(23):3849\u20133854","journal-title":"J Clin Oncol"},{"issue":"2","key":"1852_CR10","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28763","volume":"68","author":"S Matsushima","year":"2021","unstructured":"Matsushima S, Kobayashi R, Sano H, Hori D, Yanagi M, Kodama K et al (2021) Comparison of myelosuppression using the D-index between children and adolescents\/young adults with acute lymphoblastic leukemia during induction chemotherapy. Pediatr Blood Cancer 68(2):e28763","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"1852_CR11","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","volume":"71","author":"JP Donnelly","year":"2020","unstructured":"Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE et al (2020) Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis 71(6):1367\u20131376","journal-title":"Clin Infect Dis"},{"issue":"3","key":"1852_CR12","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y (2013) Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant 48(3):452\u2013458","journal-title":"Bone Marrow Transplant"},{"key":"1852_CR13","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1002\/1097-0142(20001001)89:7<1611::AID-CNCR27>3.0.CO;2-B","volume":"89","author":"Y Kanda","year":"2000","unstructured":"Kanda Y, Yamamoto R, Chizuka A, Hamaki T, Suguro M, Arai C et al (2000) Prophylactic action of oral fluconazole against fungal infection in neutropenic patients. A meta-analysis of 16 randomized, controlled trials. Cancer 89:1611\u201325","journal-title":"Cancer"},{"key":"1852_CR14","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1200\/JCO.1990.8.2.272","volume":"8","author":"H Tilly","year":"1990","unstructured":"Tilly H, Castaigne S, Bordessoule D, Casassus P, Pris PYL, Tertian G et al (1990) Low-dose cytarabine versus intensive chemotherapy in the treatment of acute nonlympho-cytic leukemia in the elderly. J Clin Oncol 8:272\u2013279","journal-title":"J Clin Oncol"},{"key":"1852_CR15","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1200\/JCO.1984.2.8.865","volume":"2","author":"SB Kahn","year":"1984","unstructured":"Kahn SB, Begg CB, Mazza JJ, Bennett JM, Bonner H, Glick JH (1984) Full dose versus attenuated dose daunorubicin, cytosine arabinoside, and 6-thioguanine in the treatment of acute nonlymphocytic leukemia in the elderly. J Clin Oncol. 2:865\u201370","journal-title":"J Clin Oncol."},{"key":"1852_CR16","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1634\/theoncologist.2014-0093","volume":"19","author":"ME Hamaker","year":"2014","unstructured":"Hamaker ME, Stauder R, van Munster BC (2014) Exclusion of older patients from ongoing clinical trials for hematological malignancies: an evaluation of the National Institutes of Health clinical trial registry. Oncologist 19:1069\u20131075","journal-title":"Oncologist"},{"issue":"8","key":"1852_CR17","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1002\/1097-0142(19851015)56:8<1913::AID-CNCR2820560803>3.0.CO;2-W","volume":"56","author":"K Kimura","year":"1985","unstructured":"Kimura K, Ohno R, Amaki I, Hattori K, Hirota Y, Hoshino A et al (1985) Treatment of acute myelogenous leukemia in adults with N4-behenoyl-1-beta-D-arabinofuranosylcytosine. Cancer 56(8):1913\u20131917","journal-title":"Cancer"},{"issue":"12","key":"1852_CR18","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1200\/JCO.1986.4.12.1740","volume":"4","author":"R Ohno","year":"1986","unstructured":"Ohno R, Kato Y, Nagura E, Murase T, Okumura M, Yamada H et al (1986) Behenoyl cytosine arabinoside, daunorubicin, 6-mercaptopurine, and prednisolone combination therapy for acute myelogenous leukemia in adults and prognostic factors related to remission duration and survival length. J Clin Oncol 4(12):1740\u20131747","journal-title":"J Clin Oncol"},{"issue":"1","key":"1852_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0609.1989.tb01243.x","volume":"43","author":"M Yoshida","year":"1989","unstructured":"Yoshida M, Suda K, Tsuboyama A, Sasaki R, Kitagawa S, Kano Y et al (1989) Behenoyl cytosine arabinoside, aclacinomycin A, 6-mercaptopurine, and prednisolone combination therapy for acute non-lymphocytic leukaemia in adults. Eur J Haematol 43(1):1\u20136","journal-title":"Eur J Haematol"},{"issue":"7","key":"1852_CR20","first-page":"3412","volume":"43","author":"T Ueda","year":"1983","unstructured":"Ueda T, Nakamura T, Ando S, Kagawa D, Sasada M, Uchino H et al (1983) Pharmacokinetics of N4-behenoyl-1-beta-D-arabinofuranosylcytosine in patients with acute leukemia. Cancer Res. 43(7):3412\u20136","journal-title":"Cancer Res."}],"container-title":["Indian Journal of Hematology and Blood Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12288-024-01852-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12288-024-01852-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12288-024-01852-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T16:02:15Z","timestamp":1744387335000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12288-024-01852-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["1852"],"URL":"https:\/\/doi.org\/10.1007\/s12288-024-01852-5","relation":{},"ISSN":["0971-4502","0974-0449"],"issn-type":[{"type":"print","value":"0971-4502"},{"type":"electronic","value":"0974-0449"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"assertion":[{"value":"19 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest in association with the present study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}},{"value":"This study was approved by the Ethics Committee of the Tokyo Metropolitan Tama-Hokubu Medical Center (No. 4\u201328) and was conducted in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}