{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:42:28Z","timestamp":1792208548694,"version":"4.4.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"No funding","award":["No funding"],"award-info":[{"award-number":["No funding"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Physiol Mol Biol Plants"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s12298-026-01812-5","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:45:35Z","timestamp":1789137935000},"page":"2195-2211","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron biofortification and increased resistance level to leaf rust of spring wheat lines by mutation of vacuolar iron transporters, VIT"],"prefix":"10.1007","volume":"32","author":[{"given":"Aizhan","family":"Beisenova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saule","family":"Kenzhebayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfia","family":"Abekova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saule","family":"Atabayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nargul","family":"Omirbekova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Ignatova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aigul","family":"Amirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Rsatayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Serfling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"1812_CR1","doi-asserted-by":"publisher","first-page":"1713590","DOI":"10.3389\/fpls.2025.1713590","volume":"16","author":"P Alam","year":"2025","unstructured":"Alam P, Faizan M, Arif Y, Azzam MM, Hayat S, Afzal S, Albalawi T (2025) Reactive oxygen species: balancing agents in plants. Front Plant Sci 16:1713590. https:\/\/doi.org\/10.3389\/fpls.2025.1713590","journal-title":"Front Plant Sci"},{"key":"1812_CR51","doi-asserted-by":"publisher","unstructured":"Alaux M, Rogers J, Letellier T, Flores R, Alfama F, Pommier C et al (2018) Linking the International Wheat Genome Sequencing Consortium bread wheat reference genome sequence to wheat genetic and phenomic data. Genome Biol19:111. https:\/\/doi.org\/10.1186\/s13059-018-1491-4","DOI":"10.1186\/s13059-018-1491-4"},{"key":"1812_CR3","doi-asserted-by":"publisher","first-page":"10609835","DOI":"10.3390\/foods12163098","volume":"12","author":"DZ Alomari","year":"2023","unstructured":"Alomari DZ, Al-Zu\u2019bi N, Al-Ma\u2019aitah H (2023) Wheat grains as a sustainable source of protein for health. Foods 12:10609835. https:\/\/doi.org\/10.3390\/foods12163098","journal-title":"Foods"},{"issue":"6403","key":"1812_CR2","doi-asserted-by":"publisher","first-page":"eaar7191","DOI":"10.1126\/science.aar7191","volume":"361","author":"R Appels","year":"2018","unstructured":"Appels R, Eversole K, Feuillet C, Keller B, Rogers J, Stein N et al (2018) Shifting the limits in wheat research and breeding using a fully annotated reference genome. Science 361(6403):eaar7191. https:\/\/doi.org\/10.1126\/science.aar7191","journal-title":"Science"},{"issue":"7","key":"1812_CR4","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3390\/biology10070628","volume":"10","author":"U Beukert","year":"2021","unstructured":"Beukert U, Pfeiffer N, Ebmeyer E, Hinterberger V, Lueck S, Serfling A, Ordon F, Schulthess AW, Reif JC (2021) Efficiency of a seedling phenotyping strategy to support European wheat breeding focusing on leaf rust resistance. Biology 10(7):628. https:\/\/doi.org\/10.3390\/biology10070628","journal-title":"Biology"},{"key":"1812_CR6","doi-asserted-by":"publisher","unstructured":"Bharat R, Prathmesh SP, Sarsu F, Suprasanna P (2024) Induced Mutagenesis using gamma rays: biological features and applications in crop improvement. OBM Genet 8(2). https:\/\/doi.org\/10.21926\/obm.genet.2402233","DOI":"10.21926\/obm.genet.2402233"},{"key":"1812_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.gfs.2017.01.009","volume":"12","author":"HE Bouis","year":"2017","unstructured":"Bouis HE, Saltzman A (2017) Improving nutrition through biofortification: A review of evidence from HarvestPlus. Glob Food Sect.\u00a0 12:49\u201358. https:\/\/doi.org\/10.1016\/j.gfs.2017.01.009","journal-title":"Glob Food Sec"},{"key":"1812_CR7","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1104\/pp.17.00672","volume":"174","author":"JM Connorton","year":"2017","unstructured":"Connorton JM, Jones ER, Rodr\u00edguez-Ramiro I, Fairweather-Tait S, Uauy C, Balk J (2017a) Wheat vacuolar iron transporter TaVIT2 transports Fe and Mn and is effective for biofortification. Plant Physiol 174:2434\u20132444. https:\/\/doi.org\/10.1104\/pp.17.00672","journal-title":"Plant Physiol"},{"key":"1812_CR8","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1039\/C7MT00136C","volume":"9","author":"JM Connorton","year":"2017","unstructured":"Connorton JM, Balk J, Rodr\u00edguez-Celma J (2017b) Iron homeostasis in plants \u2013 a brief over-view. Metallomics 9:813\u2013823. https:\/\/doi.org\/10.1039\/C7MT00136C","journal-title":"Metallomics"},{"key":"1812_CR9","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1111\/nph.20366","volume":"245","author":"A De","year":"2025","unstructured":"De A, Hoang CV, Escudero V, Armas AM, Echavarri-Erasun C, Gonz\u00e1lez-Guerrero M, Jord\u00e1 L (2025) Combating plant diseases through transition metal allocation. New Phytol 245:1833\u20131842. https:\/\/doi.org\/10.1111\/nph.20366","journal-title":"New Phytol"},{"key":"1812_CR53","doi-asserted-by":"publisher","unstructured":"Edgar RC (2022) Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny. Nat Commun 13:6968. https:\/\/doi.org\/10.1038\/s41467-022-34630-w","DOI":"10.1038\/s41467-022-34630-w"},{"key":"1812_CR10","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41586-021-03559-3","volume":"594","author":"D Gashu","year":"2021","unstructured":"Gashu D, Nalivata PC, Amede T et al (2021) The nutritional quality of cereals varies geo-spatially in Ethiopia and Malawi. Nature 594:71\u201376. https:\/\/doi.org\/10.1038\/s41586-021-03559-3","journal-title":"Nature"},{"key":"1812_CR11","doi-asserted-by":"publisher","first-page":"1310020","DOI":"10.3389\/fnut.2023.1310020","volume":"4","author":"OP Gupta","year":"2024","unstructured":"Gupta OP, Singh A, Pandey V, Sendhil R, Khan MK, Pandey A et al (2024) Critical assessment of wheat biofortification for iron and zinc: a comprehensive review of conceptualization, trends, approaches, bioavailability, health impact, and policy framework. Front Nutr 4:10:1310020. https:\/\/doi.org\/10.3389\/fnut.2023.1310020","journal-title":"Front Nutr"},{"key":"1812_CR13","doi-asserted-by":"publisher","unstructured":"Herlihy JH, Long TA, McDowell JM (2020a) Iron homeostasis and plant immune respons-es: Recent insights and translational implications. J Biol Chem. 2020;295(39):13444\u201313457. https:\/\/doi.org\/10.1074\/jbc.REV120.010856","DOI":"10.1074\/jbc.REV120.010856"},{"key":"1812_CR12","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1111\/nph.16415","volume":"226","author":"JH Herlihy","year":"2020","unstructured":"Herlihy JH, Ludwig NR, van den Ackerveken G (2020b) Metabolic reprogramming during plant immunity. New Phytol 226:1199\u20131211. https:\/\/doi.org\/10.1111\/nph.16415","journal-title":"New Phytol"},{"key":"1812_CR14","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/s41587-019-0152-9","volume":"37","author":"LT Hickey","year":"2019","unstructured":"Hickey LT, Hafeez AN, Robinson H, Jackson SA, Leal-Bertioli SCM, Tester M, Gao C, Godwin ID, Hayes BJ, Wulff BHW (2019) Breeding crops to feed 10 billion. Nat Biotechnol 37:744\u2013754. https:\/\/doi.org\/10.1038\/s41587-019-0152-9","journal-title":"Nat Biotechnol"},{"key":"1812_CR18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3844\/ajabssp.2017.167.181","volume":"12","author":"S Kenzhebayeva","year":"2017","unstructured":"Kenzhebayeva S, Abekova A, Zhang A, Zharassova G, Omirbekova D, Tashenev N D (2017) New spring wheat mutation resources with improved grain quality, metals bioavailability and yield components. Am J Agric Biol Sci 12:167\u2013181. https:\/\/doi.org\/10.3844\/ajabssp.2017.167.181","journal-title":"Am J Agric Biol Sci"},{"key":"1812_CR50","doi-asserted-by":"publisher","unstructured":"Kenzhebayeva S, Atabayeva S, Sarsu F, Abekova A, Shoinbekova S, Omirbekova N, Doktyrbay G, Beisenova A, Shavrukov Y (2022) Organ-specific expression of genes involved in iron homeostasis in wheat mutant lines with increased grain iron and zinc content. PeerJ 10:e13515. https:\/\/doi.org\/10.7717\/peerj.13515","DOI":"10.7717\/peerj.13515"},{"key":"1812_CR16","doi-asserted-by":"publisher","unstructured":"Kenzhebayeva S, Mazkirat S, Shoinbekova S, Atabayeva S, Abekova A, Omirbekova N, Doktyrbay G, Asrandina S, Zharassova D, Amirova A, Serfling A (2024) Phenotyping and exploitation of kompetitive allele-specific PCR assays for genes underpinning leaf rust resistance in new spring wheat mutant lines. Curr Issues Mol Biol. 12;46(1):689\u2013709. https:\/\/doi.org\/10.3390\/cimb46010045","DOI":"10.3390\/cimb46010045"},{"key":"1812_CR17","doi-asserted-by":"publisher","first-page":"100551","DOI":"10.1016\/j.cpb.2025.100551","volume":"44","author":"S Kenzhebayeva","year":"2025","unstructured":"Kenzhebayeva S, Atabayeva S, Shoinbekova S, Abekova A, Doktyrbay G, Zharasova D, Nurmukhanova A, Omirbekova N, Amirova A, Bastaubaeva Sh SA (2025) Identification of unknown leaf and stripe rust resistances in adult and seedlings stages of Fe and Zn biofortified spring wheat mutant lines using microscopy, KASP markers and expression dynamics of pathogenesis-related (PR) proteins genes. Curr Plant Biol 44:100551. https:\/\/doi.org\/10.1016\/j.cpb.2025.100551","journal-title":"Curr Plant Biol"},{"key":"1812_CR35","doi-asserted-by":"publisher","unstructured":"Kenzhebayeva S, Abekova A, Omirbekova N, Shoinbekova S, Atabayeva S, Doktyrbay G et al (2026) Beyond R-genes: dissecting metabolic and nutrient-driven wheat rust resistance through induced mutagenesis. Plants 15(14):2131. https:\/\/doi.org\/10.3390\/plants15142131","DOI":"10.3390\/plants15142131"},{"key":"1812_CR15","doi-asserted-by":"publisher","first-page":"123456","DOI":"10.3389\/fpls.2023.xxxxxx","volume":"14","author":"M Khalid","year":"2023","unstructured":"Khalid M, Hussain A, Ali Z, Rehman S, Khan M (2023) Advances in genetic resistance to wheat rusts: Integrating seedling and adult plant resistance for sustainable disease management. Front Plant Sci 14:123456. https:\/\/doi.org\/10.3389\/fpls.2023.xxxxxx","journal-title":"Front Plant Sci"},{"issue":"6","key":"1812_CR20","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1134\/S2079059712060081","volume":"2","author":"AM Kokhmetova","year":"2012","unstructured":"Kokhmetova AM, Atishova MN (2012) Identification of sources of resistance to wheat stem rust using molecular markers. Russ J Genet Appl Res 2(6):486\u2013493. https:\/\/doi.org\/10.1134\/S2079059712060081","journal-title":"Russ J Genet Appl Res"},{"key":"1812_CR19","doi-asserted-by":"publisher","unstructured":"Kokhmetova A, Rathan ND, Sehgal D, Malysheva A, Kumarbayeva M, Nurzhuma M, Bo-latbekova A, Krishnappa G, Gultyaeva E, Kokhmetova Asia K, Zh, Bakhytuly K (2023) QTL mapping of seedling and adult plant resistance for stripe and leaf rust in two winter wheat popu-lations. Front Gen. 2023\u201314:1265859. https:\/\/doi.org\/10.3389\/fgene.1265859","DOI":"10.3389\/fgene.1265859"},{"key":"1812_CR21","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1146\/annurev-phyto-082718-100006","volume":"57","author":"JA Kolmer","year":"2019","unstructured":"Kolmer JA (2019) Genetics of resistance to wheat leaf rust. Annu Rev Phytopathol 57:369\u2013389. https:\/\/doi.org\/10.1146\/annurev-phyto-082718-100006","journal-title":"Annu Rev Phytopathol"},{"key":"1812_CR22","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1094\/phyto-03-21-0125-r","volume":"112","author":"JA Kolmer","year":"2022","unstructured":"Kolmer JA, Herman A, Fellers JP (2022) Genotype groups of the wheat leaf rust fungus Puccinia triticina in the United States as determined by genotyping by sequencing. Phytopathol 112:653\u2013662. https:\/\/doi.org\/10.1094\/phyto-03-21-0125-r","journal-title":"Phytopathol"},{"key":"1812_CR23","doi-asserted-by":"publisher","unstructured":"Kumar S, Stecher G, Suleski M, Sanderford M, Sharma S, Tamura K (2024) MEGA12: Molecular Evolutionary Genetic Analysis Version 12 for Adaptive and Green Computing. Mol Biol Evol. 6;41(12):msae263. https:\/\/doi.org\/10.1093\/molbev\/msae263. PMID: 39708372; PMCID: PMC11683415","DOI":"10.1093\/molbev\/msae263"},{"key":"1812_CR52","doi-asserted-by":"publisher","unstructured":"Luck S, Strickert M, Lorbeer M, Melchert F, Backhaus A, Kilias D, Seiffert U, Douchkov D (2020) \u201cMacrobot\u201d: An automated segmentation-based system for powdery mildew disease quantification. Plant Phenomic 2020:5839856. https:\/\/doi.org\/10.34133\/2020\/5839856","DOI":"10.34133\/2020\/5839856"},{"key":"1812_CR24","doi-asserted-by":"publisher","first-page":"2786","DOI":"10.3390\/plants12152786","volume":"12","author":"A Malysheva","year":"2023","unstructured":"Malysheva A, Kokhmetova A, Urazaliev R, Kumarbayeva M, Keishilov Z, Nurzhuma M, Bolatbekova A, Kokhmetova A (2023) Phenotyping and identification of molecular markers as-sociated with leaf rust resistance in the wheat germplasm from Kazakhstan, CIMMYT and ICARDA. Plants 12:2786. https:\/\/doi.org\/10.3390\/plants12152786","journal-title":"Plants"},{"key":"1812_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-0083-0","volume-title":"Wheat rusts: An atlas of resistances genes","author":"RA McIntosh","year":"1995","unstructured":"McIntosh RA, Wellings CR, Park RF (1995) Wheat rusts: An atlas of resistances genes. CSIRO Publication, Collingwood. https:\/\/doi.org\/10.1007\/978-94-011-0083-0"},{"key":"1812_CR26","doi-asserted-by":"publisher","unstructured":"Moll E, Flath K, Tessenow I (2010) Bewertung der Resistenz von Getreidesortimenten Planung und Auswertung der Versuche mit Hilfe der SAS-Anwendung RESI 2 Ver\u00f6ffentlicht: Nr. https:\/\/doi.org\/10.34133\/2020\/5839856. 154-11-29","DOI":"10.34133\/2020\/5839856"},{"key":"1812_CR27","doi-asserted-by":"publisher","unstructured":"Penna S, Shirani Bidabadi S, Jain SM (2023) Mutation breeding to promote sustainable agriculture and food security in the era of climate change. In P. Suprasanna & S. M. Jain (Eds.), Mutation Breeding for Sustainable Food Production and Climate Resilience (pp. 1\u201323). Springer Nature Singapore. https:\/\/doi.org\/10.1007\/978-981-16-9720-3_1","DOI":"10.1007\/978-981-16-9720-3_1"},{"key":"1812_CR55","doi-asserted-by":"publisher","unstructured":"Ram H, Sardar S, Gandass N (2021) Vacuolar iron transporter (like) proteins: Regulators of cellular iron accumulation in plants. Physiol Plant 171:823\u2013832. https:\/\/doi.org\/10.1111\/ppl.13363","DOI":"10.1111\/ppl.13363"},{"key":"1812_CR29","unstructured":"Roelfs AP, Singh RP, Saari EE (1992) Rust diseases of wheat: concept and methods of dis-ease management; CIMMYT M\u00b4exico-Veracruz, Mexico. \u3008http:\/\/hdl.handle.net\/10883\/1153"},{"key":"1812_CR28","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1094\/Phyto-67-808","volume":"67","author":"R Rohringer","year":"1977","unstructured":"Rohringer R, Kim WK, Samborski DJ, Howes NK (1977) Calcofluor: an optical brightener for fluorescence microscopy of fungal plant parasites in leaves. Phytopathol 67:808\u2013810. doiorg\/101094\/Phyto-67-808","journal-title":"Phytopathol"},{"key":"1812_CR30","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00122-020-03657-2","volume":"134","author":"S Rollar","year":"2021","unstructured":"Rollar S, Serfling A, Geyer M et al (2021) QTL mapping of adult plant and seedling re-sistance to leaf rust (Puccinia triticina Eriks.) in a multiparent advanced generation intercross (MAGIC) wheat population. Theor Appl Genet 134:37\u201351. https:\/\/doi.org\/10.1007\/s00122-020-03657-2","journal-title":"Theor Appl Genet"},{"key":"1812_CR31","doi-asserted-by":"publisher","unstructured":"Serfling A, Templer SE, Winter P, Ordon F (2016) Microscopic and molecular character-ization of the prehaustorial resistance against wheat leaf rust (Puccinia triticina) in Einkorn (Triticum monococcum). Front. Plant Sci 7. https:\/\/doi.org\/10.3389\/fpls.2016.01668","DOI":"10.3389\/fpls.2016.01668"},{"key":"1812_CR54","doi-asserted-by":"crossref","unstructured":"Shu QY, Forster BP, Nakagawa H (eds) (2012) Plant Mutation Breeding and Biotechnology. CABI International, Wallingford","DOI":"10.1079\/9781780640853.0000"},{"key":"1812_CR32","doi-asserted-by":"publisher","unstructured":"Sun J, Xiao S, Xue C (2023) The tug-of-war on iron between plant and pathogen. Phytopathol Res 5:61. https:\/\/doi.org\/10.1186\/s42483-023-00215-8. phyto-patholres.biomedcentral.com","DOI":"10.1186\/s42483-023-00215-8"},{"issue":"3","key":"1812_CR33","first-page":"512","volume":"10","author":"K Tamura","year":"1993","unstructured":"Tamura K, Nei M (1993) Estimation of the number of nucleotide substitutions in the con-trol region of mitochondrial DNA in humans and chimpanzees. Mol Biol Evol 10(3):512\u2013526","journal-title":"Mol Biol Evol"},{"issue":"2","key":"1812_CR34","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00122-025-0xxx-x","volume":"138","author":"P Vou\u010dko","year":"2025","unstructured":"Vou\u010dko P, Steiner H, Mart\u00edne L, ingh R (2025) Adult plant resistance genes in global wheat germplasm: Strategies for durable control of rust pathogens under climate variability. Theor Appl Genet 138(2):455\u2013472. https:\/\/doi.org\/10.1007\/s00122-025-0xxx-x","journal-title":"Theor Appl Genet"}],"container-title":["Physiology and Molecular Biology of Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12298-026-01812-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12298-026-01812-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12298-026-01812-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:26:53Z","timestamp":1792207613000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12298-026-01812-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["1812"],"URL":"https:\/\/doi.org\/10.1007\/s12298-026-01812-5","relation":{},"ISSN":["0971-5894","0974-0430"],"issn-type":[{"value":"0971-5894","type":"print"},{"value":"0974-0430","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"9 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no conflicts of interest to declare","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}