{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:46:48Z","timestamp":1773064008627,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Bari Aldo Moro"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Musculoskelet Surg"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Supraspinatus tendinosis (ST) refers to the intratendinous degeneration of the supraspinatus tendon. Platelet-Rich Plasma (PRP) is one of the possible conservative treatments for supraspinatus tendinosis. This prospective observational study aims to evaluate the efficacy and safety of a single ultrasound-guided PRP injection in the treatment of supraspinatus tendinosis and to assess its non-inferiority to the widely used shockwave therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Seventy-two amateur athletes (35 male, mean age: 43.75\u2009\u00b1\u200910.82, range 21\u201358\u00a0years old) with ST were finally included in the study. All the patients underwent clinical evaluation at baseline, (T0) and at 1-month (T1), 3-month (T2) and 6-month (T3) follow-up using the following clinical scales: the Visual Analogue Scale for pain (VAS), Constant Score and the Disabilities of the Arm, Shoulder and Hand Score (DASH). A T0 and T3 ultrasound examination was also performed. The findings observed in the recruited patients were compared to the clinical results observed in a retrospective control group made up of 70 patients (32 male, mean age\u2009=\u200941.29\u2009\u00b1\u200913.85, range 20\u201365\u00a0years old) treated by extracorporeal shockwave therapy (ESWT).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>VAS, DASH and Constant scores significantly improved from T0 to T1; the improvement in clinical scores was kept until T3. No local nor systemic adverse events were observed. An improvement in the tendon structure was observed on ultrasound examination. PRP showed a non-statistical inferiority, in terms of efficacy and safety, compared to ESWT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The PRP one-shot injection is a valid conservative treatment to reduce pain, and improve both quality of life and functional scores in patients with supraspinatus tendinosis. Furthermore, the PRP intratendinous one-shot injection showed a non-inferiority in terms of efficacy at the 6-month follow-up, compared to ESWT.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12306-023-00778-x","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T21:50:55Z","timestamp":1679867455000},"page":"455-462","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["One-shot platelet-rich plasma (PRP) injection is non-inferior to extracorporeal shockwave therapy in the management of supraspinatus tendinosis"],"prefix":"10.1007","volume":"107","author":[{"given":"L.","family":"Moretti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-2333","authenticated-orcid":false,"given":"D.","family":"Bizzoca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. D.","family":"Cassano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Coviello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Franchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,11]]},"reference":[{"key":"778_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/03009740310004667","volume":"33","author":"JJ Luime","year":"2004","unstructured":"Luime JJ, Koes BW, Hendriksen IJ et al (2004) Prevalence and incidence of shoulder pain in the general population; a systematic review. Scand J Rheumatol 33:73\u201381","journal-title":"Scand J Rheumatol"},{"key":"778_CR2","doi-asserted-by":"publisher","first-page":"923","DOI":"10.2519\/jospt.2015.5941","volume":"45","author":"J Lewis","year":"2015","unstructured":"Lewis J, Mccreesh K, Roy JS, Ginn K (2015) Rotator cuff tendinopathy: navigating the diagnosis-management conundrum. J Orthop Sport Phys 45:923\u2013937","journal-title":"J Orthop Sport Phys"},{"key":"778_CR3","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1114\/1.1509765","volume":"30","author":"LJ Soslowsky","year":"2002","unstructured":"Soslowsky LJ, Thomopoulos S, Esmail A et al (2002) Rotator cuff tendinosis in an animal model: role of extrinsic and overuse factors. Ann Biomed Eng 30:1057\u20131063","journal-title":"Ann Biomed Eng"},{"issue":"5","key":"778_CR4","doi-asserted-by":"publisher","first-page":"330","DOI":"10.2519\/jospt.2015.5455","volume":"45","author":"A Desjardins-Charbonneau","year":"2015","unstructured":"Desjardins-Charbonneau A, Roy JS, Dionne CE et al (2015) The efficacy of manual therapy for rotator cuff tendinopathy: a systematic review and meta-analysis. J Orthop Sports Phys Ther 45(5):330\u2013350. https:\/\/doi.org\/10.2519\/jospt.2015.5455","journal-title":"J Orthop Sports Phys Ther"},{"key":"778_CR5","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ptsp.2014.09.004","volume":"16","author":"F Desmeules","year":"2015","unstructured":"Desmeules F, Boudreault J, Roy JS et al (2015) The efficacy of therapeutic ultrasound for rotator cuff tendinopathy: a systematic review and metaanalysis. Phys Ther Sport 16:276\u2013284","journal-title":"Phys Ther Sport"},{"key":"778_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.math.2011.02.005","volume":"16","author":"BM Huisstede","year":"2011","unstructured":"Huisstede BM, Gebremariam L, van der Sande R et al (2011) Evidence for effectiveness of extracorporal shock-wave therapy (ESWT) to treat calcific and noncalcific rotator cuff tendinosis \u2013 a systematic review. Man Ther 16:419\u2013433","journal-title":"Man Ther"},{"key":"778_CR7","first-page":"CD012225","volume":"2016","author":"MJ Page","year":"1996","unstructured":"Page MJ, Green S, Mrocki MA et al (1996) Electrotherapy modalities for rotator cuff disease. Cochrane Database Syst Rev 2016:CD012225","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"778_CR8","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1016\/j.arthro.2019.12.006","volume":"36","author":"RN Puzzitiello","year":"2020","unstructured":"Puzzitiello RN, Patel BH, Nwachukwu BU et al (2020) Adverse impact of corticosteroid injection on rotator cuff tendon health and repair: a systematic review. Arthroscopy 36(5):1468\u20131475. https:\/\/doi.org\/10.1016\/j.arthro.2019.12.006","journal-title":"Arthroscopy"},{"issue":"2","key":"778_CR9","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.apmr.2018.06.028","volume":"100","author":"MT Lin","year":"2019","unstructured":"Lin MT, Chiang CF, Wu CH et al (2019) Comparative effectiveness of injection therapies in rotator cuff tendinopathy: a systematic review, pairwise and network meta-analysis of randomized controlled trials. Arch Phys Med Rehabil 100(2):336-349.e15. https:\/\/doi.org\/10.1016\/j.apmr.2018.06.028","journal-title":"Arch Phys Med Rehabil"},{"issue":"9","key":"778_CR10","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.3390\/jcm11092640","volume":"11","author":"L Moretti","year":"2022","unstructured":"Moretti L, Maccagnano G, Coviello M, Cassano GD, Franchini A, Laneve A, Moretti B (2022) Platelet rich plasma injections for knee osteoarthritis treatment: a prospective clinical study. J Clin Med 11(9):2640. https:\/\/doi.org\/10.3390\/jcm11092640","journal-title":"J Clin Med"},{"issue":"8","key":"778_CR11","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1177\/0363546517743746","volume":"46","author":"X Chen","year":"2018","unstructured":"Chen X, Jones IA, Park C, Vangsness CT Jr (2018) The efficacy of platelet-rich plasma on tendon and ligament healing: a systematic review and meta-analysis with bias assessment. Am J Sports Med 46(8):2020\u20132032. https:\/\/doi.org\/10.1177\/0363546517743746","journal-title":"Am J Sports Med"},{"key":"778_CR12","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1097\/00003086-198701000-00023","volume":"214","author":"CR Constant","year":"1987","unstructured":"Constant CR, Murley AH (1987) A clinical method of functional assessment of the shoulder. Clin Orthop Relat Res 214:160\u2013164","journal-title":"Clin Orthop Relat Res"},{"key":"778_CR13","doi-asserted-by":"publisher","unstructured":"Hudak PL, Amadio PC, Bombardier C (1996) Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG). Am J Ind Med. 1996 Jun;29(6):602\u20138. doi: https:\/\/doi.org\/10.1002\/(SICI)1097-0274(199606)29:6<602::AID-AJIM4>3.0.CO;2-L. Erratum in: Am J Ind Med 1996 Sep;30(3):372","DOI":"10.1002\/(SICI)1097-0274(199606)29:6<602::AID-AJIM4>3.0.CO;2-L"},{"issue":"4","key":"778_CR14","doi-asserted-by":"publisher","first-page":"270","DOI":"10.11138\/mltj\/2015.5.4.270","volume":"5","author":"L Osti","year":"2016","unstructured":"Osti L, Buda M, Buono AD et al (2016) Clinical evidence in the treatment of rotator cuff tears with hyaluronic acid. Muscles Ligaments Tendons J 5(4):270\u2013275. https:\/\/doi.org\/10.11138\/mltj\/2015.5.4.270","journal-title":"Muscles Ligaments Tendons J"},{"issue":"7","key":"778_CR15","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1002\/acr.20174","volume":"62","author":"S Saito","year":"2010","unstructured":"Saito S, Furuya T, Kotake S (2010) Therapeutic effects of hyaluronate injections in patients with chronic painful shoulder: a meta-analysis of randomized controlled trials. Arthritis Care Res (Hoboken) 62(7):1009\u20131018. https:\/\/doi.org\/10.1002\/acr.20174","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"8","key":"778_CR16","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s40279-014-0195-5","volume":"44","author":"TM McCarrel","year":"2014","unstructured":"McCarrel TM, Mall NA, Lee AS et al (2014) Considerations for the use of platelet-rich plasma in orthopedics. Sports Med 44(8):1025\u20131036. https:\/\/doi.org\/10.1007\/s40279-014-0195-5","journal-title":"Sports Med"},{"issue":"2","key":"778_CR17","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1177\/0363546510390780","volume":"39","author":"R Castricini","year":"2011","unstructured":"Castricini R, Longo UG, De Benedetto M et al (2011) Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial. Am J Sports Med 39(2):258\u2013265. https:\/\/doi.org\/10.1177\/0363546510390780","journal-title":"Am J Sports Med"},{"issue":"4","key":"778_CR18","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.jse.2011.02.008","volume":"20","author":"P Randelli","year":"2011","unstructured":"Randelli P, Arrigoni P, Ragone V et al (2011) Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up. J Shoulder Elbow Surg 20(4):518\u2013528. https:\/\/doi.org\/10.1016\/j.jse.2011.02.008","journal-title":"J Shoulder Elbow Surg"},{"issue":"10","key":"778_CR19","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1177\/0363546514541777","volume":"42","author":"EA Malavolta","year":"2014","unstructured":"Malavolta EA, Gracitelli ME, Ferreira Neto AA et al (2014) Platelet-rich plasma in rotator cuff repair: a prospective randomized study. Am J Sports Med 42(10):2446\u20132454. https:\/\/doi.org\/10.1177\/0363546514541777","journal-title":"Am J Sports Med"},{"issue":"11","key":"778_CR20","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1177\/0363546513496542","volume":"41","author":"S Kesikburun","year":"2013","unstructured":"Kesikburun S, Tan AK, Yilmaz B et al (2013) Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up. Am J Sports Med 41(11):2609\u20132616. https:\/\/doi.org\/10.1177\/0363546513496542","journal-title":"Am J Sports Med"},{"issue":"5","key":"778_CR21","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.arthro.2018.10.115","volume":"35","author":"ET Hurley","year":"2019","unstructured":"Hurley ET, Hannon CP, Pauzenberger L et al (2019) Nonoperative treatment of rotator cuff disease with platelet-rich plasma: a systematic review of randomized controlled trials. Arthroscopy 35(5):1584\u20131591. https:\/\/doi.org\/10.1016\/j.arthro.2018.10.115","journal-title":"Arthroscopy"},{"issue":"2","key":"778_CR22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.5397\/cise.2019.22.2.61","volume":"22","author":"HW Lee","year":"2019","unstructured":"Lee HW, Choi KH, Kim JY et al (2019) Prospective clinical research of the efficacy of platelet-rich plasma in the outpatient-based treatment of rotator cuff tendinopathy. Clin Shoulder Elb 22(2):61\u201369. https:\/\/doi.org\/10.5397\/cise.2019.22.2.61","journal-title":"Clin Shoulder Elb"},{"issue":"2","key":"778_CR23","doi-asserted-by":"publisher","first-page":"e0147842","DOI":"10.1371\/journal.pone.0147842","volume":"11","author":"M Wesner","year":"2016","unstructured":"Wesner M, Defreitas T, Bredy H et al (2016) A pilot study evaluating the effectiveness of platelet-rich plasma therapy for treating degenerative tendinopathies: a randomized control trial with synchronous observational cohort. PLoS ONE 11(2):e0147842. https:\/\/doi.org\/10.1371\/journal.pone.0147842","journal-title":"PLoS ONE"},{"key":"778_CR24","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1177\/0269215512448388","volume":"27","author":"DW Rha","year":"2013","unstructured":"Rha DW, Park GY, Kim YK et al (2013) Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial. Clin Rehabil 27:113\u2013122","journal-title":"Clin Rehabil"},{"issue":"1","key":"778_CR25","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1186\/s13018-019-1406-4","volume":"14","author":"SJ Kim","year":"2019","unstructured":"Kim SJ et al (2019) Effect of platelet-rich plasma on the degenerative rotator cuff tendinopathy according to the compositions. J Orthop Surg Res 14(1):408. https:\/\/doi.org\/10.1186\/s13018-019-1406-4","journal-title":"J Orthop Surg Res"},{"issue":"2","key":"778_CR26","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1249\/MSS.0000000000001781","volume":"51","author":"YU Cai","year":"2019","unstructured":"Cai YU, Sun Z, Liao B et al (2019) Sodium hyaluronate and platelet-rich plasma for partial-thickness rotator cuff tears. Med Sci Sports Exerc 51(2):227\u2013233. https:\/\/doi.org\/10.1249\/MSS.0000000000001781","journal-title":"Med Sci Sports Exerc"},{"issue":"11","key":"778_CR27","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.3390\/medicina57111206","volume":"57","author":"L Moretti","year":"2021","unstructured":"Moretti L, Bizzoca D, Giancaspro GA, Cassano GD, Moretti F, Setti S, Moretti B (2021) Biophysical stimulation in athletes\u2019 joint degeneration: a narrative review. Medicina (Kaunas) 57(11):1206. https:\/\/doi.org\/10.3390\/medicina57111206","journal-title":"Medicina (Kaunas)"},{"issue":"6 Suppl. 1","key":"778_CR28","first-page":"23","volume":"32","author":"G Vicenti","year":"2018","unstructured":"Vicenti G, Bizzoca D, Nappi VS, Moretti F, Carrozzo M, Belviso V, Moretti B (2018) Biophysical stimulation of the knee with PEMFs: from bench to bedside. J Biol Regul Homeost Agents 32(6 Suppl. 1):23\u201328 (PMID: 30644277)","journal-title":"J Biol Regul Homeost Agents"},{"issue":"4","key":"778_CR29","first-page":"1195","volume":"30","author":"A Notarnicola","year":"2016","unstructured":"Notarnicola A, Moretti L, Maccagnano G, Tafuri S, Moretti B (2016) Tendonitis of the rotator cuff treated with extracorporeal shock wave therapy: radiographic monitoring to identify prognostic factors for disintegration. J Biol Regul Homeost Agents 30(4):1195\u20131202","journal-title":"J Biol Regul Homeost Agents"},{"issue":"35","key":"778_CR30","doi-asserted-by":"publisher","first-page":"e7940","DOI":"10.1097\/MD.0000000000007940","volume":"96","author":"W Li","year":"2017","unstructured":"Li W, Zhang SX, Yang Q, Li BL, Meng QG, Guo ZG (2017) Effect of extracorporeal shock-wave therapy for treating patients with chronic rotator cuff tendonitis. Medicine (Baltimore) 96(35):e7940. https:\/\/doi.org\/10.1097\/MD.0000000000007940. (PMID: 28858120 PMCID: PMC5585514)","journal-title":"Medicine (Baltimore)"},{"issue":"6 Suppl. 1","key":"778_CR31","first-page":"15","volume":"32","author":"G Vicenti","year":"2018","unstructured":"Vicenti G, Bizzoca D, Caruso I, Nappi VS, Giancaspro G, Carrozzo M, Moretti B (2018) New insights into the treatment of non-healing diabetic foot ulcers. J Biol Regul Homeost Agents 32(6 Suppl. 1):15\u201321","journal-title":"J Biol Regul Homeost Agents"},{"issue":"7","key":"778_CR32","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.jse.2017.12.017","volume":"27","author":"R Gilat","year":"2018","unstructured":"Gilat R, Atoun E, Cohen O, Tsvieli O, Rath E, Lakstein D, Levy O (2018) Recurrent rotator cuff tear: is ultrasound imaging reliable? J Shoulder Elbow Surg 27(7):1263\u20131267. https:\/\/doi.org\/10.1016\/j.jse.2017.12.017. (Epub 2018 Feb 3)","journal-title":"J Shoulder Elbow Surg"},{"key":"778_CR33","unstructured":"Vicenti G, Bizzoca D, Solarino G, Moretti F, Ottaviani G, Simone F, Zavattini G, Maccagnano G, Noia G, Moretti B. 2020 The role of biophysical stimulation with pemfs in fracture healing: from bench to bedside. J Biol Regul Homeost Agents. 34(5 Suppl. 1):131\u2013135. IORS Special Issue on Orthopedics"},{"key":"778_CR34","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1302\/0301-620X.89B3.18249","volume":"89-B","author":"JD Albert","year":"2007","unstructured":"Albert JD, Meadeb J, Guggenbuhl P et al (2007) High-energy extracorporeal shockwave therapy for calcifying tendinitis of the rotator cuff: a randomised trial. J Bone Joint Surg Br 89-B:335\u2013341","journal-title":"J Bone Joint Surg Br"},{"key":"778_CR35","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.jse.2011.09.026","volume":"21","author":"DA Van Kampen","year":"2012","unstructured":"Van Kampen DA, van Beers LW, Scholtes VA et al (2012) Validation of the dutch version of the simple shoulder test. J Shoulder Elbow Surg 21:808\u2013814","journal-title":"J Shoulder Elbow Surg"},{"issue":"2","key":"778_CR36","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00132-013-2249-z","volume":"43","author":"P Diehl","year":"2014","unstructured":"Diehl P, Gollwitzer H, Schauwecker J, Tischer T, Gerdesmeyer L (2014) Konservative therapie der chronischen enthesiopathien [conservative treatment of chronic tendinopathies]. Orthopade 43(2):183\u2013193. https:\/\/doi.org\/10.1007\/s00132-013-2249-z","journal-title":"Orthopade"}],"container-title":["MUSCULOSKELETAL SURGERY"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12306-023-00778-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12306-023-00778-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12306-023-00778-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T17:17:45Z","timestamp":1702055865000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12306-023-00778-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,11]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["778"],"URL":"https:\/\/doi.org\/10.1007\/s12306-023-00778-x","relation":{},"ISSN":["2035-5106","2035-5114"],"issn-type":[{"value":"2035-5106","type":"print"},{"value":"2035-5114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,11]]},"assertion":[{"value":"10 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous three years; and no other relationships or activities that could appear to have influenced the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of Azienda Ospedaliero Universitaria Policlinico di Bari (protocol code 0104, 22\/01\/2021). The study was also registered on ClinicalTrials.gov (NCT04851951).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}