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Recent treatment options like photodynamic nailing are a mini-invasive procedure that allows fractures stabilization and early recovery. We reviewed five studies following the PRISMA guidelines obtaining 148 patients treated with Photodynamic Bone Stabilization (PBS). Mean follow-up period after surgery was 10.5\u00a0months as reported in 4 of 5 studies (range 1.5\u201324\u00a0months). All patients evaluated have been treated due to metastasis from other primary tumors. IlluminOss\u00ae System demonstrated positive outcomes in the reviewed studies, decreasing mean VAS score from pre-surgery values (7.71) to post-surgery values (4.19). As reported in 3 of 5 studies evaluated, mean preoperatively MSTS score was 30.38% (27\u201340%), earliest postoperative MSTS was 61.59% (52\u201387.8%). Complications were reported in 27 patients (18.24%). Several complications were described: device rupture, thromboembolic events, aseptic dehiscence, and malunion, respectively, in 14 patients (9.45%), 3 patients (2.02%), 2 patients (1.35%), 2 patients (1.35%). Our analysis offers a preliminary overview of the outcomes and complications related to PDNs (IlluminOss\u00ae System). While classical intramedullary nailing is often linked to favorable functional outcomes, the risk of complications, such as: hardware failure, and the necessity for future hardware removal, should not be ignored. The results obtained from this analysis are promising;\u00a0however, further randomized studies will be necessary to determine the superiority of the method over current treatments.<\/jats:p>","DOI":"10.1007\/s12306-026-00964-7","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T05:08:09Z","timestamp":1784524089000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photodynamic bone stabilization: a novel approach to elderly metastatic patients"],"prefix":"10.1007","author":[{"given":"R.","family":"Totti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cavola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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