{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:04:52Z","timestamp":1792814692209,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1-3","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS076617"],"award-info":[{"award-number":["NS076617"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA180358"],"award-info":[{"award-number":["CA180358"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Microenvironment"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s12307-017-0197-6","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T12:35:42Z","timestamp":1503059742000},"page":"57-68","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche"],"prefix":"10.1007","volume":"10","author":[{"given":"Bradley N.","family":"Mills","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George P.","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-8565","authenticated-orcid":false,"given":"Marc W.","family":"Halterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"issue":"6","key":"197_CR1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/00005072-200606000-00001","volume":"65","author":"Y Rong","year":"2006","unstructured":"Rong Y et al (2006) 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol 65(6):529\u2013539","journal-title":"J Neuropathol Exp Neurol"},{"key":"197_CR2","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1100\/2011\/736480","volume":"11","author":"L Persano","year":"2011","unstructured":"Persano L et al (2011) The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications. Sci World J 11:1829\u20131841","journal-title":"Sci World J"},{"issue":"9","key":"197_CR3","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1093\/neuonc\/nou035","volume":"16","author":"A Vartanian","year":"2014","unstructured":"Vartanian A et al (2014) GBM's multifaceted landscape: highlighting regional and microenvironmental heterogeneity. Neuro-Oncology 16(9):1167\u20131175","journal-title":"Neuro-Oncology"},{"issue":"6","key":"197_CR4","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ccr.2009.03.018","volume":"15","author":"Z Li","year":"2009","unstructured":"Li Z et al (2009) Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15(6):501\u2013513","journal-title":"Cancer Cell"},{"key":"197_CR5","doi-asserted-by":"crossref","unstructured":"Li Z et al. (2009) Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. In: Cancer Cell. Elsevier Ltd. p 501\u2013513","DOI":"10.1016\/j.ccr.2009.03.018"},{"issue":"10","key":"197_CR6","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1093\/neuonc\/not084","volume":"15","author":"M Vitucci","year":"2013","unstructured":"Vitucci M et al (2013) Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis. Neuro-Oncology 15(10):1317\u20131329","journal-title":"Neuro-Oncology"},{"issue":"22","key":"197_CR7","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.1038\/sj.onc.1210392","volume":"26","author":"M Raman","year":"2007","unstructured":"Raman M, Chen W, Cobb MH (2007) Differential regulation and properties of MAPKs. Oncogene 26(22):3100\u20133112","journal-title":"Oncogene"},{"issue":"3","key":"197_CR8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1124\/pr.107.00106","volume":"60","author":"T Boutros","year":"2008","unstructured":"Boutros T, Chevet E, Metrakos P (2008) Mitogen-activated protein (MAP) kinase\/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev 60(3):261\u2013310","journal-title":"Pharmacol Rev"},{"issue":"3","key":"197_CR9","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1093\/neuonc\/nop068","volume":"12","author":"PC De Witt Hamer","year":"2010","unstructured":"De Witt Hamer PC (2010) Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies. Neuro-Oncology 12(3):304\u2013316","journal-title":"Neuro-Oncology"},{"issue":"3","key":"197_CR10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.4143\/crt.2012.44.3.195","volume":"44","author":"H Yu","year":"2012","unstructured":"Yu H et al (2012) Constitutive expression of MAP kinase phosphatase-1 confers multi-drug resistance in human glioblastoma cells. Cancer Res Treat 44(3):195\u2013201","journal-title":"Cancer Res Treat"},{"issue":"35","key":"197_CR11","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.1038\/onc.2011.99","volume":"30","author":"S Messina","year":"2011","unstructured":"Messina S et al (2011) Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas. Oncogene 30(35):3813\u20133820","journal-title":"Oncogene"},{"issue":"4","key":"197_CR12","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1158\/0008-5472.CAN-09-3218","volume":"70","author":"A Waha","year":"2010","unstructured":"Waha A et al (2010) Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells. Cancer Res 70(4):1689\u20131699","journal-title":"Cancer Res"},{"issue":"1\u20132","key":"197_CR13","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s11010-005-9089-z","volume":"286","author":"J Wayne","year":"2006","unstructured":"Wayne J et al (2006) ERK regulation upon contact inhibition in fibroblasts. Mol Cell Biochem 286(1\u20132):181\u2013189","journal-title":"Mol Cell Biochem"},{"issue":"38","key":"197_CR14","doi-asserted-by":"publisher","first-page":"39951","DOI":"10.1074\/jbc.M407353200","volume":"279","author":"H Sakaue","year":"2004","unstructured":"Sakaue H et al (2004) Role of MAPK phosphatase-1 (MKP-1) in adipocyte differentiation. J Biol Chem 279(38):39951\u201339957","journal-title":"J Biol Chem"},{"issue":"18","key":"197_CR15","doi-asserted-by":"publisher","first-page":"12890","DOI":"10.1074\/jbc.274.18.12890","volume":"274","author":"KR Laderoute","year":"1999","unstructured":"Laderoute KR et al (1999) Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase\/c-Jun N-terminal protein kinase activity. J Biol Chem 274(18):12890\u201312897","journal-title":"J Biol Chem"},{"issue":"1\u20133","key":"197_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2008.06.111","volume":"593","author":"YM Lin","year":"2008","unstructured":"Lin YM et al (2008) Dexamethasone reduced invasiveness of human malignant glioblastoma cells through a MAPK phosphatase-1 (MKP-1) dependent mechanism. Eur J Pharmacol 593(1\u20133):1\u20139","journal-title":"Eur J Pharmacol"},{"key":"197_CR17","unstructured":"Scarpace L et al. (2015) Data from REMBRANDT. The Cancer Imaging Archive. Available from: \n                    https:\/\/doi.org\/10.7937\/K9\/TCIA.2015.588OZUZB"},{"issue":"36","key":"197_CR18","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang Y et al (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34(36):11929\u201311947","journal-title":"J Neurosci"},{"key":"197_CR19","unstructured":"Ivy (2015) Ivy Glioblastoma Atlas Project Available from: \n                    http:\/\/glioblastoma.alleninstitute.org\/rnaseq"},{"key":"197_CR20","unstructured":"NCI (2015) The cancer genome atlas; Available from: \n                    https:\/\/www.cancer.gov\/"},{"issue":"19","key":"197_CR21","doi-asserted-by":"publisher","first-page":"7011","DOI":"10.1158\/0008-5472.CAN-04-1364","volume":"64","author":"R Galli","year":"2004","unstructured":"Galli R et al (2004) Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64(19):7011\u20137021","journal-title":"Cancer Res"},{"issue":"3","key":"197_CR22","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1006\/bbrc.1999.1734","volume":"265","author":"H Inuzuka","year":"1999","unstructured":"Inuzuka H et al (1999) Differential regulation of immediate early gene expression in preadipocyte cells through multiple signaling pathways. Biochem Biophys Res Commun 265(3):664\u2013668","journal-title":"Biochem Biophys Res Commun"},{"key":"197_CR23","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.compbiolchem.2016.07.006","volume":"64","author":"M Sahu","year":"2016","unstructured":"Sahu M, Mallick B (2016) An integrative approach predicted co-expression sub-networks regulating properties of stem cells and differentiation. Comput Biol Chem 64:250\u2013262","journal-title":"Comput Biol Chem"},{"issue":"2","key":"197_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148065","volume":"11","author":"T Boulding","year":"2016","unstructured":"Boulding T et al (2016) Differential roles for DUSP family members in epithelial-to-mesenchymal transition and cancer stem cell regulation in breast cancer. PLoS One 11(2):e0148065","journal-title":"PLoS One"},{"issue":"18","key":"197_CR25","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.4161\/cc.8.18.9504","volume":"8","author":"AM Bleau","year":"2009","unstructured":"Bleau AM, Huse JT, Holland EC (2009) The ABCG2 resistance network of glioblastoma. Cell Cycle 8(18):2936\u20132944","journal-title":"Cell Cycle"},{"issue":"11","key":"197_CR26","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/nn.2955","volume":"14","author":"AB Hjelmeland","year":"2011","unstructured":"Hjelmeland AB et al (2011) Twisted tango: brain tumor neurovascular interactions. Nat Neurosci 14(11):1375\u20131381","journal-title":"Nat Neurosci"},{"key":"197_CR27","first-page":"21","volume":"3","author":"A Bradshaw","year":"2016","unstructured":"Bradshaw A et al (2016) Cancer stem cell hierarchy in glioblastoma Multiforme. Front Surg 3:21","journal-title":"Front Surg"},{"issue":"9","key":"197_CR28","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1002\/glia.22699","volume":"62","author":"Z Martinez-Lozada","year":"2014","unstructured":"Martinez-Lozada Z et al (2014) Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium\/calmodulin-dependent kinase IIbeta's actin-binding\/\u2212stabilizing domain. Glia 62(9):1543\u20131558","journal-title":"Glia"},{"issue":"3","key":"197_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004779","volume":"4","author":"L Roybon","year":"2009","unstructured":"Roybon L et al (2009) Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis. PLoS One 4(3):e4779","journal-title":"PLoS One"},{"issue":"12","key":"197_CR30","doi-asserted-by":"publisher","first-page":"6033","DOI":"10.1158\/0008-5472.CAN-05-3878","volume":"66","author":"WH Shen","year":"2006","unstructured":"Shen WH et al (2006) Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis. Cancer Res 66(12):6033\u20136039","journal-title":"Cancer Res"},{"issue":"42","key":"197_CR31","doi-asserted-by":"publisher","first-page":"41059","DOI":"10.1074\/jbc.M307149200","volume":"278","author":"M Li","year":"2003","unstructured":"Li M et al (2003) The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation. J Biol Chem 278(42):41059\u201341068","journal-title":"J Biol Chem"},{"issue":"4","key":"197_CR32","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1158\/1541-7786.MCR-07-2019","volume":"6","author":"YX Liu","year":"2008","unstructured":"Liu YX et al (2008) DUSP1 is controlled by p53 during the cellular response to oxidative stress. Mol Cancer Res 6(4):624\u2013633","journal-title":"Mol Cancer Res"},{"issue":"7381","key":"197_CR33","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nature10760","volume":"481","author":"CJ Lord","year":"2012","unstructured":"Lord CJ, Ashworth A (2012) The DNA damage response and cancer therapy. Nature 481(7381):287\u2013294","journal-title":"Nature"},{"issue":"19","key":"197_CR34","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1056\/NEJM200011093431901","volume":"343","author":"M Esteller","year":"2000","unstructured":"Esteller M et al (2000) Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343(19):1350\u20131354","journal-title":"N Engl J Med"},{"issue":"10","key":"197_CR35","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1056\/NEJMoa043331","volume":"352","author":"ME Hegi","year":"2005","unstructured":"Hegi ME et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352(10):997\u20131003","journal-title":"N Engl J Med"},{"issue":"7","key":"197_CR36","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1002\/jcp.25248","volume":"231","author":"BS Ferguson","year":"2016","unstructured":"Ferguson BS et al (2016) Mitogen-dependent regulation of DUSP1 governs ERK and p38 signaling during early 3T3-L1 adipocyte differentiation. J Cell Physiol 231(7):1562\u20131574","journal-title":"J Cell Physiol"},{"issue":"21","key":"197_CR37","doi-asserted-by":"publisher","first-page":"4221","DOI":"10.1007\/s00018-014-1686-0","volume":"71","author":"DY Kim","year":"2014","unstructured":"Kim DY, Rhee I, Paik J (2014) Metabolic circuits in neural stem cells. Cell Mol Life Sci 71(21):4221\u20134241","journal-title":"Cell Mol Life Sci"},{"issue":"8","key":"197_CR38","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1440-169X.2006.00889.x","volume":"48","author":"Z Li","year":"2006","unstructured":"Li Z, Theus MH, Wei L (2006) Role of ERK 1\/2 signaling in neuronal differentiation of cultured embryonic stem cells. Develop Growth Differ 48(8):513\u2013523","journal-title":"Develop Growth Differ"},{"issue":"1","key":"197_CR39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.cmet.2006.05.010","volume":"4","author":"JJ Wu","year":"2006","unstructured":"Wu JJ et al (2006) Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metab 4(1):61\u201373","journal-title":"Cell Metab"},{"issue":"2","key":"197_CR40","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1242\/dev.02208","volume":"133","author":"K Meletis","year":"2006","unstructured":"Meletis K et al (2006) p53 suppresses the self-renewal of adult neural stem cells. Development 133(2):363\u2013369","journal-title":"Development"},{"issue":"7216","key":"197_CR41","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature07385","volume":"455","author":"Cancer Genome Atlas Research, N","year":"2008","unstructured":"Cancer Genome Atlas Research, N (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455(7216):1061\u20131068","journal-title":"Nature"},{"issue":"23","key":"197_CR42","doi-asserted-by":"publisher","first-page":"8213","DOI":"10.1128\/MCB.21.23.8213-8224.2001","volume":"21","author":"J Li","year":"2001","unstructured":"Li J et al (2001) Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. Mol Cell Biol 21(23):8213\u20138224","journal-title":"Mol Cell Biol"},{"issue":"5449","key":"197_CR43","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1126\/science.286.5449.2514","volume":"286","author":"J Brondello","year":"1999","unstructured":"Brondello J (1999) Reduced MAP kinase phosphatase-1 degradation after p42\/p44MAPK-dependent phosphorylation. Science 286(5449):2514\u20132517","journal-title":"Science"}],"container-title":["Cancer Microenvironment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12307-017-0197-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12307-017-0197-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12307-017-0197-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T07:15:53Z","timestamp":1589440553000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12307-017-0197-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,18]]},"references-count":43,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["197"],"URL":"https:\/\/doi.org\/10.1007\/s12307-017-0197-6","relation":{},"ISSN":["1875-2292","1875-2284"],"issn-type":[{"value":"1875-2292","type":"print"},{"value":"1875-2284","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,18]]},"assertion":[{"value":"30 April 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}