{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:56:25Z","timestamp":1793393785993,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T00:00:00Z","timestamp":1227052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"},{"start":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T00:00:00Z","timestamp":1227052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematopathol"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1007\/s12308-008-0020-x","type":"journal-article","created":{"date-parts":[[2008,11,18]],"date-time":"2008-11-18T09:28:21Z","timestamp":1227000501000},"page":"9-19","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Efficient shRNA delivery into B and T lymphoma cells using lentiviral vector-mediated transfer"],"prefix":"10.1007","volume":"2","author":[{"given":"Nata\u0161a","family":"Anastasov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Klier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Angermeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"H\u00f6fler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falko","family":"Fend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Quintanilla-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,11,19]]},"reference":[{"issue":"11","key":"20_CR1","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.exphem.2005.07.006","volume":"33","author":"H Guven","year":"2005","unstructured":"Guven H, Konstantinidis KV, Alici E et al (2005) Efficient gene transfer into primary human natural killer cells by retroviral transduction. Exp Hematol 33(11):1320\u20131328","journal-title":"Exp Hematol"},{"issue":"1\u20132","key":"20_CR2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0022-1759(98)00088-X","volume":"215","author":"H Huang","year":"1998","unstructured":"Huang H, Pannetier C, Hu-Li J et al (1998) Transient transfection of primary T helper cells by particle-mediated gene transfer. J Immunol Methods 215(1\u20132):173\u2013177","journal-title":"J Immunol Methods"},{"issue":"5556","key":"20_CR3","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1126\/science.1067081","volume":"295","author":"C Lois","year":"2002","unstructured":"Lois C, Hong EJ, Pease S et al (2002) Germ line transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295(5556):868\u2013872","journal-title":"Science"},{"issue":"Pt 6","key":"20_CR4","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1042\/BST0320952","volume":"32","author":"CA Sledz","year":"2004","unstructured":"Sledz CA, Williams BR (2004) RNA interference and double-stranded-RNA-activated pathways. Biochem Soc Trans 32(Pt 6):952\u2013956","journal-title":"Biochem Soc Trans"},{"issue":"9","key":"20_CR5","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/ncb1038","volume":"5","author":"CA Sledz","year":"2003","unstructured":"Sledz CA, Holko M, de Veer MJ et al (2003) Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5(9):834\u2013839","journal-title":"Nat Cell Biol"},{"issue":"5567","key":"20_CR6","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1126\/science.1068999","volume":"296","author":"TR Brummelkamp","year":"2002","unstructured":"Brummelkamp TR, Bernards R, Agami R (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science 296(5567):550\u2013553","journal-title":"Science"},{"issue":"8","key":"20_CR7","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1101\/gad.981002","volume":"16","author":"PJ Paddison","year":"2002","unstructured":"Paddison PJ, Caudy AA, Bernstein E et al (2002) Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev 16(8):948\u2013958","journal-title":"Genes Dev"},{"issue":"3","key":"20_CR8","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1182\/blood-2004-12-4643","volume":"106","author":"CA Sledz","year":"2005","unstructured":"Sledz CA, Williams BR (2005) RNA interference in biology and disease. Blood 106(3):787\u2013794","journal-title":"Blood"},{"issue":"6","key":"20_CR9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrm1129","volume":"4","author":"DM Dykxhoorn","year":"2003","unstructured":"Dykxhoorn DM, Novina CD, Sharp PA (2003) Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol 4(6):457\u2013467","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"18","key":"20_CR10","doi-asserted-by":"publisher","first-page":"15991","DOI":"10.1074\/jbc.M300714200","volume":"278","author":"EA Bohula","year":"2003","unstructured":"Bohula EA, Salisbury AJ, Sohail M et al (2003) The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript. J Biol Chem 278(18):15991\u201315997","journal-title":"J Biol Chem"},{"issue":"9","key":"20_CR11","doi-asserted-by":"publisher","first-page":"7108","DOI":"10.1074\/jbc.M210326200","volume":"278","author":"TA Vickers","year":"2003","unstructured":"Vickers TA, Koo S, Bennett CF et al (2003) Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis. J Biol Chem 278(9):7108\u20137118","journal-title":"J Biol Chem"},{"issue":"4","key":"20_CR12","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.jmb.2005.03.011","volume":"348","author":"S Schubert","year":"2005","unstructured":"Schubert S, Grunweller A, Erdmann VA et al (2005) Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions. J Mol Biol 348(4):883\u2013893","journal-title":"J Mol Biol"},{"issue":"6836","key":"20_CR13","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/35078107","volume":"411","author":"SM Elbashir","year":"2001","unstructured":"Elbashir SM, Harborth J, Lendeckel W et al (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411(6836):494\u2013498","journal-title":"Nature"},{"issue":"2","key":"20_CR14","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1101\/gad.862301","volume":"15","author":"SM Elbashir","year":"2001","unstructured":"Elbashir SM, Lendeckel W, Tuschl T (2001) RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15(2):188\u2013200","journal-title":"Genes Dev"},{"issue":"5","key":"20_CR15","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0002-9440(10)64278-2","volume":"162","author":"L Quintanilla-Martinez","year":"2003","unstructured":"Quintanilla-Martinez L, Kremer M, Specht K et al (2003) Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events. Am J Pathol 162(5):1449\u20131461","journal-title":"Am J Pathol"},{"issue":"4","key":"20_CR16","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1182\/blood-2003-11-3837","volume":"104","author":"K Specht","year":"2004","unstructured":"Specht K, Haralambieva E, Bink K et al (2004) Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels. Blood 104(4):1120\u20131126","journal-title":"Blood"},{"issue":"6","key":"20_CR17","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nm1249","volume":"11","author":"R Chiarle","year":"2005","unstructured":"Chiarle R, Simmons WJ, Cai H et al (2005) Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Nat Med 11(6):623\u2013629","journal-title":"Nat Med"},{"issue":"8","key":"20_CR18","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1101\/gad.11.8.957","volume":"11","author":"JA Diehl","year":"1997","unstructured":"Diehl JA, Zindy F, Sherr CJ (1997) Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin\u2013proteasome pathway. Genes Dev 11(8):957\u2013972","journal-title":"Genes Dev"},{"issue":"3","key":"20_CR19","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1745-7254.2005.00053.x","volume":"26","author":"LF Gao","year":"2005","unstructured":"Gao LF, Xu DQ, Wen LJ et al (2005) Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells. Acta Pharmacol Sin 26(3):377\u2013383","journal-title":"Acta Pharmacol Sin"},{"issue":"6","key":"20_CR20","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1182\/blood-2005-10-014258","volume":"108","author":"L Quintanilla-Martinez","year":"2006","unstructured":"Quintanilla-Martinez L, Pittaluga S, Miething C et al (2006) NPM-ALK-dependent expression of the transcription factor CCAAT\/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma. Blood 108(6):2029\u20132036","journal-title":"Blood"},{"issue":"10","key":"20_CR21","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1261\/rna.546207","volume":"13","author":"Y Shao","year":"2007","unstructured":"Shao Y, Chan CY, Maliyekkel A et al (2007) Effect of target secondary structure on RNAi efficiency. RNA 13(10):1631\u20131640","journal-title":"RNA"},{"issue":"10","key":"20_CR22","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1261\/rna.599107","volume":"13","author":"L Li","year":"2007","unstructured":"Li L, Lin X, Khvorova A et al (2007) Defining the optimal parameters for hairpin-based knockdown constructs. RNA 13(10):1765\u20131774","journal-title":"RNA"},{"issue":"10","key":"20_CR23","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1089\/hum.2004.15.976","volume":"15","author":"AC Logan","year":"2004","unstructured":"Logan AC, Nightingale SJ, Haas DL et al (2004) Factors influencing the titer and infectivity of lentiviral vectors. Hum Gene Ther 15(10):976\u2013988","journal-title":"Hum Gene Ther"},{"key":"20_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2199-5-9","volume":"5","author":"RJ Fish","year":"2004","unstructured":"Fish RJ, Kruithof EK (2004) Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors. BMC Mol Biol 5:9","journal-title":"BMC Mol Biol"},{"issue":"2","key":"20_CR25","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1182\/blood-2005-05-2125","volume":"107","author":"R Piva","year":"2006","unstructured":"Piva R, Chiarle R, Manazza AD et al (2006) Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. Blood 107(2):689\u2013697","journal-title":"Blood"}],"container-title":["Journal of Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-008-0020-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12308-008-0020-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s12308-008-0020-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-008-0020-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T20:14:31Z","timestamp":1630440871000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12308-008-0020-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,19]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["20"],"URL":"https:\/\/doi.org\/10.1007\/s12308-008-0020-x","relation":{},"ISSN":["1865-5785","1865-5785"],"issn-type":[{"value":"1865-5785","type":"print"},{"value":"1865-5785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,19]]},"assertion":[{"value":"30 June 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}