{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:34:24Z","timestamp":1772120064110,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T00:00:00Z","timestamp":1556323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T00:00:00Z","timestamp":1556323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["12GRNT12050110"],"award-info":[{"award-number":["12GRNT12050110"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL094465"],"award-info":[{"award-number":["HL094465"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematopathol"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s12308-019-00354-y","type":"journal-article","created":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T18:03:15Z","timestamp":1556388195000},"page":"57-65","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of S1PR1, pSTAT3, S1PR2, and FOXP1 expression in aggressive, mature B cell lymphomas"],"prefix":"10.1007","volume":"12","author":[{"given":"Mustafa","family":"Al-Kawaaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8570-3199","authenticated-orcid":false,"given":"Michael J.","family":"Kluk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,27]]},"reference":[{"key":"354_CR1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues. 4th edition","year":"2008","unstructured":"Swerdlow SH, Campo E, Harris NL et al (eds) (2008) WHO classification of tumours of haematopoietic and lymphoid tissues. 4th edition. International Agency for Research on Cancer, Lyon"},{"key":"354_CR2","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th edition","year":"2017","unstructured":"Swerdlow SH, Campo E, Harris NL et al (eds) (2017) WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th edition. International Agency for Research on Cancer, Lyon"},{"key":"354_CR3","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1182\/bloodadvances.2017014860","volume":"2","author":"AM Wasik","year":"2018","unstructured":"Wasik AM, Wu C, Mansouri L, Rosenquist R, Pan-Hammarstrom Q, Sander B (2018) Clinical and functional impact of recurrent S1PR1 mutations in mantle cell lymphoma. Blood Adv 2:621\u2013625","journal-title":"Blood Adv"},{"key":"354_CR4","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/modpathol.2009.194","volume":"23","author":"H Nishimura","year":"2010","unstructured":"Nishimura H, Akiyama T, Monobe Y, Matsubara K, Igarashi Y, Abe M, Sugihara T, Sadahira Y (2010) Expression of sphingosine-1-phosphate receptor 1 in mantle cell lymphoma. Mod Pathol 23:439\u2013449","journal-title":"Mod Pathol"},{"key":"354_CR5","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/bjh.14054","volume":"174","author":"R Koresawa","year":"2016","unstructured":"Koresawa R, Yamazaki K, Oka D, Fujiwara H, Nishimura H, Akiyama T, Hamasaki S, Wada H, Sugihara T, Sadahira Y (2016) Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and therapeutic target for patients with primary testicular diffuse large B-cell lymphoma. Br J Haematol 174:264\u2013274","journal-title":"Br J Haematol"},{"key":"354_CR6","doi-asserted-by":"publisher","first-page":"8686","DOI":"10.1158\/0008-5472.CAN-09-1110","volume":"69","author":"G Cattoretti","year":"2009","unstructured":"Cattoretti G, Mandelbaum J, Lee N, Chaves AH, Mahler AM, Chadburn A, Dalla-Favera R, Pasqualucci L, MacLennan AJ (2009) Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. Cancer Res 69:8686\u20138692","journal-title":"Cancer Res"},{"key":"354_CR7","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1182\/blood-2018-01-824540","volume":"131","author":"G Li","year":"2018","unstructured":"Li G, So AY, Sookram R et al (2018) Epigenetic silencing of miR-125b is required for normal B-cell development. Blood 131:1920\u20131930","journal-title":"Blood"},{"key":"354_CR8","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/labinvest.2013.7","volume":"93","author":"MJ Kluk","year":"2013","unstructured":"Kluk MJ, Ryan KP, Wang B, Zhang G, Rodig SJ, Sanchez T (2013) Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration. Lab Investig 93:462\u2013471","journal-title":"Lab Investig"},{"key":"354_CR9","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/leu.2017.275","volume":"32","author":"K Vrzalikova","year":"2018","unstructured":"Vrzalikova K, Ibrahim M, Vockerodt M, Perry T, Margielewska S, Lupino L, Nagy E, Soilleux E, Liebelt D, Hollows R, Last A, Reynolds G, Abdullah M, Curley H, Care M, Krappmann D, Tooze R, Allegood J, Spiegel S, Wei W, Woodman CBJ, Murray PG (2018) S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells. Leukemia 32:214\u2013223","journal-title":"Leukemia"},{"key":"354_CR10","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40164-015-0004-3","volume":"4","author":"S Middle","year":"2015","unstructured":"Middle S, Coupland SE, Taktak A, Kidgell V, Slupsky JR, Pettitt AR, Till KJ (2015) Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin\u2019s lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins. Exp Hematol Oncol 4:10","journal-title":"Exp Hematol Oncol"},{"key":"354_CR11","doi-asserted-by":"publisher","first-page":"97516","DOI":"10.18632\/oncotarget.22178","volume":"8","author":"H Kuusanmaki","year":"2017","unstructured":"Kuusanmaki H, Dufva O, Parri E et al (2017) Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK\/STAT3 signaling. Oncotarget 8:97516\u201397527","journal-title":"Oncotarget"},{"key":"354_CR12","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1182\/blood-2007-09-111948","volume":"111","author":"LT Lam","year":"2008","unstructured":"Lam LT, Wright G, Davis RE, Lenz G, Farinha P, Dang L, Chan JW, Rosenwald A, Gascoyne RD, Staudt LM (2008) Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma. Blood 111:3701\u20133713","journal-title":"Blood"},{"key":"354_CR13","first-page":"825","volume":"32","author":"G Petrakis","year":"2017","unstructured":"Petrakis G, Kostopoulos I, Venizelos I, Lambropoulou M, Vouras K, Vakalopoulou S, Mandala E, Tsatalas C, Papadopoulos N (2017) Expression of the activation markers Blimp1, Foxp1 and pStat3 in extranodal diffuse large B-cell lymphomas. Histol Histopathol 32:825\u2013834","journal-title":"Histol Histopathol"},{"key":"354_CR14","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1182\/blood-2007-04-087734","volume":"111","author":"BB Ding","year":"2008","unstructured":"Ding BB, Yu JJ, Yu RY, Mendez LM, Shaknovich R, Zhang Y, Cattoretti G, Ye BH (2008) Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood 111:1515\u20131523","journal-title":"Blood"},{"key":"354_CR15","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1038\/nm.2250","volume":"16","author":"H Lee","year":"2010","unstructured":"Lee H, Deng J, Kujawski M, Yang C, Liu Y, Herrmann A, Kortylewski M, Horne D, Somlo G, Forman S, Jove R, Yu H (2010) STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat Med 16:1421\u20131428","journal-title":"Nat Med"},{"key":"354_CR16","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1186\/1471-2407-14-911","volume":"14","author":"JH Paik","year":"2014","unstructured":"Paik JH, Nam SJ, Kim TM, Heo DS, Kim CW, Jeon YK (2014) Overexpression of sphingosine-1-phosphate receptor 1 and phospho-signal transducer and activator of transcription 3 is associated with poor prognosis in rituximab-treated diffuse large B-cell lymphomas. BMC Cancer 14:911","journal-title":"BMC Cancer"},{"key":"354_CR17","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1182\/blood-2011-12-399030","volume":"120","author":"Y Liu","year":"2012","unstructured":"Liu Y, Deng J, Wang L, Lee H, Armstrong B, Scuto A, Kowolik C, Weiss LM, Forman S, Yu H (2012) S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma. Blood 120:1458\u20131465","journal-title":"Blood"},{"key":"354_CR18","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.bbrc.2017.05.031","volume":"488","author":"R Zeng","year":"2017","unstructured":"Zeng R, Tang Y, Zhou H, Liu Y, Huang J, Li L, Liu W, Feng Y, Zhou Y, Chen T, Zhang L, Zhong M (2017) STAT3 mediates multidrug resistance of Burkitt lymphoma cells by promoting antioxidant feedback. Biochem Biophys Res Commun 488:182\u2013188","journal-title":"Biochem Biophys Res Commun"},{"key":"354_CR19","doi-asserted-by":"publisher","first-page":"5113","DOI":"10.1158\/1078-0432.CCR-14-0683","volume":"20","author":"CY Ok","year":"2014","unstructured":"Ok CY, Chen J, Xu-Monette ZY, Tzankov A, Manyam GC, Li L, Visco C, Montes-Moreno S, Dybkaer K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WWL, van Krieken JH, Huh J, Zhao X, Ponzoni M, Ferreri AJM, Bertoni F, Farnen JP, Moller MB, Piris MA, Winter JN, Medeiros LJ, Young KH (2014) Clinical implications of phosphorylated STAT3 expression in De novo diffuse large B-cell lymphoma. Clin Cancer Res 20:5113\u20135123","journal-title":"Clin Cancer Res"},{"key":"354_CR20","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1080\/10428194.2016.1228932","volume":"58","author":"DM Gascoyne","year":"2017","unstructured":"Gascoyne DM, Banham AH (2017) The significance of FOXP1 in diffuse large B-cell lymphoma. Leuk Lymphoma 58:1037\u20131051","journal-title":"Leuk Lymphoma"},{"key":"354_CR21","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1097\/PAS.0000000000000434","volume":"39","author":"W Wang","year":"2015","unstructured":"Wang W, Hu S, Lu X, Young KH, Medeiros LJ (2015) Triple-hit B-cell lymphoma with MYC, BCL2, and BCL6 translocations\/rearrangements: clinicopathologic features of 11 cases. Am J Surg Pathol 39:1132\u20131139","journal-title":"Am J Surg Pathol"},{"key":"354_CR22","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1182\/blood-2015-08-662635","volume":"127","author":"M Flori","year":"2016","unstructured":"Flori M, Schmid CA, Sumrall ET, Tzankov A, Law CW, Robinson MD, Muller A (2016) The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling. Blood 127:1438\u20131448","journal-title":"Blood"},{"key":"354_CR23","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/ni.2047","volume":"12","author":"JA Green","year":"2011","unstructured":"Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CDC, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG (2011) The sphingosine 1-phosphate receptor S1P(2) maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol 12:672\u2013680","journal-title":"Nat Immunol"},{"key":"354_CR24","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/nature13765","volume":"516","author":"JR Muppidi","year":"2014","unstructured":"Muppidi JR, Schmitz R, Green JA, Xiao W, Larsen AB, Braun SE, An J, Xu Y, Rosenwald A, Ott G, Gascoyne RD, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Vaidehi N, Staudt LM, Cyster JG (2014) Loss of signalling via Galpha13 in germinal centre B-cell-derived lymphoma. Nature 516:254\u2013258","journal-title":"Nature"},{"key":"354_CR25","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1182\/blood-2013-02-483727","volume":"122","author":"RD Morin","year":"2013","unstructured":"Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA (2013) Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood 122:1256\u20131265","journal-title":"Blood"},{"key":"354_CR26","doi-asserted-by":"publisher","first-page":"4520","DOI":"10.1200\/JCO.2012.45.6004","volume":"31","author":"X Huang","year":"2013","unstructured":"Huang X, Meng B, Iqbal J, Ding BB, Perry AM, Cao W, Smith LM, Bi C, Jiang C, Greiner TC, Weisenburger DD, Rimsza L, Rosenwald A, Ott G, Delabie J, Campo E, Braziel RM, Gascoyne RD, Cook JR, Tubbs RR, Jaffe ES, Armitage JO, Vose JM, Staudt LM, McKeithan TW, Chan WC, Ye BH, Fu K (2013) Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol 31:4520\u20134528","journal-title":"J Clin Oncol"},{"key":"354_CR27","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1756-8722-4-31","volume":"4","author":"ZL Wu","year":"2011","unstructured":"Wu ZL, Song YQ, Shi Y, Zhu J (2011) High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma. J Hematol Oncol 4:31","journal-title":"J Hematol Oncol"},{"key":"354_CR28","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/modpathol.2011.85","volume":"24","author":"A Yemelyanova","year":"2011","unstructured":"Yemelyanova A, Vang R, Kshirsagar M, Lu D, Marks MA, Shih IM, Kurman RJ (2011) Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis. Mod Pathol 24:1248\u20131253","journal-title":"Mod Pathol"},{"key":"354_CR29","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1038\/s41598-017-01800-6","volume":"7","author":"M Kazantseva","year":"2017","unstructured":"Kazantseva M, Hung NA, Mehta S, Roth I, Eiholzer R, Rich AM, Seo B, Baird MA, Braithwaite AW, Slatter TL (2017) Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Sci Rep 7:1566","journal-title":"Sci Rep"},{"key":"354_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s11883-016-0586-1","volume":"18","author":"T Sanchez","year":"2016","unstructured":"Sanchez T (2016) Sphingosine-1-phosphate signaling in endothelial disorders. Curr Atheroscler Rep 18:31","journal-title":"Curr Atheroscler Rep"}],"container-title":["Journal of Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-019-00354-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12308-019-00354-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-019-00354-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T13:38:58Z","timestamp":1589636338000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12308-019-00354-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,27]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["354"],"URL":"https:\/\/doi.org\/10.1007\/s12308-019-00354-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/472449","asserted-by":"object"}]},"ISSN":["1868-9256","1865-5785"],"issn-type":[{"value":"1868-9256","type":"print"},{"value":"1865-5785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,27]]},"assertion":[{"value":"28 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"MAK, TS, and MJK declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}