{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:42:27Z","timestamp":1790451747986,"version":"4.1.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematopathol"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s12308-023-00535-w","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T12:03:12Z","timestamp":1677672192000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mixed-phenotype acute leukemia, T\/megakaryoblastic: does it really exist?"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-0694","authenticated-orcid":false,"given":"Neelum","family":"Mansoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Javed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naila","family":"Rafiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anila","family":"Aali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Meraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"issue":"3","key":"535_CR1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/cyto.b.21155","volume":"86","author":"M Borowitz","year":"2014","unstructured":"Borowitz M (2014) Mixed phenotype acute leukemia. Cytometry B Clin Cytom 86(3):152. https:\/\/doi.org\/10.1002\/cyto.b.21155","journal-title":"Cytometry B Clin Cytom"},{"issue":"2","key":"535_CR2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/cyto.b.21072","volume":"84","author":"W van den Ancker","year":"2013","unstructured":"van den Ancker W, Westers TM, de Leeuw DC, van der Veeken YF, Loonen A, van Beckhoven E et al (2013) A threshold of 10% for myeloperoxidase by flow cytometry is valid to classify acute leukemia of ambiguous and myeloid origin. Cytometry B Clin Cytom 84(2):114\u2013118. https:\/\/doi.org\/10.1002\/cyto.b.21072","journal-title":"Cytometry B Clin Cytom"},{"issue":"16","key":"535_CR3","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1182\/blood-2014-10-551465","volume":"125","author":"O Wolach","year":"2015","unstructured":"Wolach O, Stone RM (2015) How I treat mixed-phenotype acute leukemia. Blood 125(16):2477\u20132485. https:\/\/doi.org\/10.1182\/blood-2014-10-551465","journal-title":"Blood"},{"key":"535_CR4","doi-asserted-by":"publisher","unstructured":"Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, et al 2022 The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms. Leukemia 36(7):1703\u20131719 https:\/\/doi.org\/10.1038\/s41375-022-01613-1","DOI":"10.1038\/s41375-022-01613-1"},{"issue":"7","key":"535_CR5","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/leu.2010.119","volume":"24","author":"W Van den Ancker","year":"2010","unstructured":"Van den Ancker W, Terwijn M, Westers T, Merle P, Van Beckhoven E, Dr\u00e4ger A et al (2010) Acute leukemias of ambiguous lineage: diagnostic consequences of the WHO2008 classification. Leukemia 24(7):1392\u20131396. https:\/\/doi.org\/10.1038\/leu.2010.119","journal-title":"Leukemia"},{"issue":"6","key":"535_CR6","doi-asserted-by":"publisher","first-page":"928","DOI":"10.3324\/haematol.2009.014506","volume":"95","author":"E Mejstrikova","year":"2010","unstructured":"Mejstrikova E, Volejnikova J, Fronkova E, Zdrahalova K, Kalina T, Sterba J et al (2010) Prognosis of children with mixed phenotype acute leukemia treated on the basis of consistent immunophenotypic criteria. Haematologica. 95(6):928. https:\/\/doi.org\/10.3324\/haematol.2009.014506","journal-title":"Haematologica."},{"issue":"3","key":"535_CR7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.4172\/2161-0681.1000111","volume":"2","author":"G Devika","year":"2012","unstructured":"Devika G, Chatterjee T, Srishti G, Ajay S (2012) A rare case of a mixed phenotypic acute leukemia (Mpal)-report from a tertiary care hospital. J Clinic Experiment Pathol 2(3):111. https:\/\/doi.org\/10.4172\/2161-0681.1000111","journal-title":"J Clinic Experiment Pathol"},{"issue":"6","key":"535_CR8","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1007\/s00277-018-3297-6","volume":"97","author":"M Khan","year":"2018","unstructured":"Khan M, Siddiqi R, Naqvi K (2018) An update on classification, genetics, and clinical approach to mixed phenotype acute leukemia (MPAL). Ann Hematol 97(6):945\u2013953. https:\/\/doi.org\/10.1007\/s00277-018-3297-6","journal-title":"Ann Hematol"},{"issue":"20","key":"535_CR9","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","volume":"127","author":"DA Arber","year":"2016","unstructured":"Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127(20):2391\u20132405. https:\/\/doi.org\/10.1182\/blood-2016-03-643544","journal-title":"Blood"},{"issue":"22","key":"535_CR10","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1182\/blood-2018-09-871194","volume":"132","author":"MM Klairmont","year":"2018","unstructured":"Klairmont MM, Choi JK (2018) Mixed-phenotype acute leukemia, T\/megakaryoblastic. Blood 132(22):2418\u20132418. https:\/\/doi.org\/10.1182\/blood-2018-09-871194","journal-title":"Blood"},{"issue":"1","key":"535_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13000-022-01257-w","volume":"17","author":"Y Jia","year":"2022","unstructured":"Jia Y, Lin D, Wang Z, Li C, Wang H, Wang J et al (2022) Diagnostic challenge in mixed phenotype acute leukemia with T\/megakaryocyte or T\/myeloid lineages accompanied by t (3; 3). Diagn Pathol 17(1):1\u20137. https:\/\/doi.org\/10.1186\/s13000-022-01257-w","journal-title":"Diagn Pathol"},{"key":"535_CR12","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.leukres.2018.05.009","volume":"71","author":"JG Rossi","year":"2018","unstructured":"Rossi JG, Rubio P, Alonso CN, Bernasconi AR, Sajaroff EO, Digiorge J et al (2018) Cytoplasmic CD3 expression in infant acute megakaryoblastic leukemia: a new ambiguous lineage subtype? Leuk Res 71:6\u201312. https:\/\/doi.org\/10.1016\/j.leukres.2018.05.009","journal-title":"Leuk Res"}],"container-title":["Journal of Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-023-00535-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12308-023-00535-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-023-00535-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T01:03:12Z","timestamp":1709254992000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12308-023-00535-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["535"],"URL":"https:\/\/doi.org\/10.1007\/s12308-023-00535-w","relation":{},"ISSN":["1868-9256","1865-5785"],"issn-type":[{"value":"1868-9256","type":"print"},{"value":"1865-5785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"25 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate\/informed consent"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}