{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T18:14:26Z","timestamp":1764267266968,"version":"3.46.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematopathol"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s12308-023-00567-2","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T15:01:36Z","timestamp":1700751696000},"page":"227-234","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two cases of mycosis fungoides with large cell transformation with KMT2A rearrangements"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4562-7830","authenticated-orcid":false,"given":"Paul A.","family":"Wadsworth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos J.","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atif","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Khodadoust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerri E.","family":"Rieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0428-0199","authenticated-orcid":false,"given":"Sebastian","family":"Fernandez-Pol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"567_CR1","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/ajcp\/aqac045","volume":"158","author":"F Fei","year":"2022","unstructured":"Fei F, Natkunam Y, Zehnder JL et al (2022) Diagnostic impact of next-generation sequencing panels for lymphoproliferative neoplasms on small-volume biopsies. Am J Clin Pathol 158:345\u2013361. https:\/\/doi.org\/10.1093\/ajcp\/aqac045","journal-title":"Am J Clin Pathol"},{"key":"567_CR2","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature25795","volume":"555","author":"X Ma","year":"2018","unstructured":"Ma X, Liu Y, Liu Y et al (2018) Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. Nature 555:371\u2013376. https:\/\/doi.org\/10.1038\/nature25795","journal-title":"Nature"},{"key":"567_CR3","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/gcc.20174","volume":"43","author":"JF Fu","year":"2005","unstructured":"Fu JF, Hsu HC, Shih LY (2005) MLL is fused to EBI (MAPREI), which encodes a microtubule-associated protein, in a patient with acute lymphoblastic leukemia. Genes Chromosom Cancer 43:206\u2013210. https:\/\/doi.org\/10.1002\/gcc.20174","journal-title":"Genes Chromosom Cancer"},{"key":"567_CR4","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/ng.3356","volume":"47","author":"J Choi","year":"2015","unstructured":"Choi J, Goh G, Walradt T et al (2015) Genomic landscape of cutaneous T cell lymphoma. Nat Genet 47:1011\u20131019. https:\/\/doi.org\/10.1038\/ng.3356","journal-title":"Nat Genet"},{"key":"567_CR5","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1182\/blood-2010-09-305128","volume":"117","author":"MK Kie\u00dfling","year":"2011","unstructured":"Kie\u00dfling MK, Oberholzer PA, Mondal C et al (2011) High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS\/RAF\/MEK signaling cascade. Blood 117:2433\u20132440. https:\/\/doi.org\/10.1182\/blood-2010-09-305128","journal-title":"Blood"},{"key":"567_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jdermsci.2017.07.013","volume":"88","author":"T Yanagi","year":"2017","unstructured":"Yanagi T, Nishihara H, Fujii K et al (2017) Comprehensive cancer-related gene analysis reveals that active KRAS mutation is a prognostic mutation in mycosis fungoides. J Dermatol Sci 88:367\u2013370. https:\/\/doi.org\/10.1016\/j.jdermsci.2017.07.013","journal-title":"J Dermatol Sci"},{"key":"567_CR7","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1182\/blood-2017-02-768234","volume":"130","author":"J Park","year":"2017","unstructured":"Park J, Yang J, Wenzel AT et al (2017) Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E). Blood 130:1430\u20131440. https:\/\/doi.org\/10.1182\/blood-2017-02-768234","journal-title":"Blood"},{"key":"567_CR8","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1182\/blood-2013-05-504308","volume":"123","author":"JP Vaqu\u00e9","year":"2014","unstructured":"Vaqu\u00e9 JP, G\u00f3mez-L\u00f3pez G, Mons\u00e1lvez V et al (2014) PLCG1 mutations in cutaneous T-cell lymphomas. Blood 123:2034\u20132043. https:\/\/doi.org\/10.1182\/blood-2013-05-504308","journal-title":"Blood"},{"key":"567_CR9","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41408-020-00380-5","volume":"10","author":"KV Argyropoulos","year":"2020","unstructured":"Argyropoulos KV, Pulitzer M, Maura F et al (2020) Targeted genomic analysis of cutaneous T cell lymphomas identifies a subset with aggressive clinicopathological features. Blood Cancer J 10:116. https:\/\/doi.org\/10.1038\/s41408-020-00380-5","journal-title":"Blood Cancer J"},{"key":"567_CR10","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/leu.2017.213","volume":"32","author":"C Meyer","year":"2018","unstructured":"Meyer C, Burmeister T, Gr\u00f6ger D et al (2018) The MLL recombinome of acute leukemias in 2017. Leukemia 32:273\u2013284. https:\/\/doi.org\/10.1038\/leu.2017.213","journal-title":"Leukemia"},{"key":"567_CR11","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/nrc3929","volume":"15","author":"RC Rao","year":"2015","unstructured":"Rao RC, Dou Y (2015) Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer 15:334\u2013346. https:\/\/doi.org\/10.1038\/nrc3929","journal-title":"Nat Rev Cancer"},{"key":"567_CR12","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/378505a0","volume":"378","author":"BD Yu","year":"1995","unstructured":"Yu BD, Hess JL, Horning SE et al (1995) Altered Hox expression and segmental identity in Mll-mutant mice. Nature 378:505\u2013508. https:\/\/doi.org\/10.1038\/378505a0","journal-title":"Nature"},{"key":"567_CR13","doi-asserted-by":"publisher","first-page":"26340","DOI":"10.1073\/pnas.2014732117","volume":"117","author":"C Meyer","year":"2020","unstructured":"Meyer C, Burmeister T, Gr\u00f6ger D et al (2020) Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23\/KMT2A. Proc Natl Acad Sci USA 117:26340\u201326346. https:\/\/doi.org\/10.1073\/pnas.2014732117","journal-title":"Proc Natl Acad Sci USA"},{"key":"567_CR14","doi-asserted-by":"publisher","unstructured":"Issa GC, Aldoss I, DiPersio J et al (2023) The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia. Nature. https:\/\/doi.org\/10.1038\/s41586-023-05812-3","DOI":"10.1038\/s41586-023-05812-3"},{"key":"567_CR15","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/ng.907","volume":"43","author":"Y Gui","year":"2011","unstructured":"Gui Y, Guo G, Huang Y et al (2011) Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet 43:875\u2013878. https:\/\/doi.org\/10.1038\/ng.907","journal-title":"Nat Genet"},{"key":"567_CR16","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3324\/haematol.2017.182444","volume":"103","author":"M-M Ji","year":"2018","unstructured":"Ji M-M, Huang Y-H, Huang J-Y et al (2018) Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified. Haematologica 103:679\u2013687. https:\/\/doi.org\/10.3324\/haematol.2017.182444","journal-title":"Haematologica"},{"key":"567_CR17","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1038\/s41375-021-01218-0","volume":"35","author":"J Stomper","year":"2021","unstructured":"Stomper J, Rotondo JC, Greve G, L\u00fcbbert M (2021) Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies. Leukemia 35:1873\u20131889","journal-title":"Leukemia"},{"key":"567_CR18","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.1080\/10428194.2022.2116934","volume":"63","author":"BJ Ball","year":"2022","unstructured":"Ball BJ, Arslan S, Koller P et al (2022) Clinical experience with venetoclax and hypomethylating agents (HMA) in patients with newly diagnosed and relapsed or refractory KMT2A-Rearranged acute myeloid leukemia (AML). Leuk. Lymphoma 63:3232\u20133236","journal-title":"Leuk. Lymphoma"},{"key":"567_CR19","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nrc2253","volume":"7","author":"AV Krivtsov","year":"2007","unstructured":"Krivtsov AV, Armstrong SA (2007) MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 7:823\u2013833","journal-title":"Nat Rev Cancer"}],"container-title":["Journal of Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-023-00567-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12308-023-00567-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-023-00567-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T18:11:41Z","timestamp":1764267101000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12308-023-00567-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["567"],"URL":"https:\/\/doi.org\/10.1007\/s12308-023-00567-2","relation":{},"ISSN":["1868-9256","1865-5785"],"issn-type":[{"type":"print","value":"1868-9256"},{"type":"electronic","value":"1865-5785"}],"subject":[],"published":{"date-parts":[[2023,11,23]]},"assertion":[{"value":"28 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Evaluation and reporting of these cases were performed under research protocols approved by the institutional review board of Stanford University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The need for informed consent is waived for this type of study under the IRB-approved protocol.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"For this type of study\u00a0and under the IRB-approved protocol, consent for publication is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}