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However, data regarding the partner genes, concurrent rearrangements, and ultimate diagnoses in these patients is scarce compared to that in adult cohorts. We aimed to characterize the spectrum of <jats:italic>MYC<\/jats:italic>-rearranged (<jats:italic>MYC<\/jats:italic>-R) mature, aggressive BCL in the pediatric\/YA population. A retrospective study of morphologic, immunophenotypic, and fluorescence in situ hybridization (FISH) results of patients age\u2009\u2264\u200930\u00a0years with suspected Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell lymphoma (HGBCL), and a <jats:italic>MYC<\/jats:italic>-R by FISH between 2013\u20132022 was performed. Two-hundred fifty-eight cases (129 (50%) pediatric (&lt;\u200918\u00a0years) and 129 (50%) YA (18\u201330\u00a0years)) were included. Most <jats:italic>MYC<\/jats:italic>-R BCL in pediatric (89%) and YA (66%) cases were BL. While double-hit (DH) cytogenetics (<jats:italic>MYC<\/jats:italic> with <jats:italic>BCL2<\/jats:italic> and\/or <jats:italic>BCL6<\/jats:italic>-R, HGBCL-DH) was rare in the pediatric population (2\/129, 2%), HGBCL-DH increased with age and was identified in 17\/129 (13%) of YA cases. Most HGBCL-DH had <jats:italic>MYC<\/jats:italic> and <jats:italic>BCL6<\/jats:italic>-R, while <jats:italic>BCL2<\/jats:italic>-R were rare in both groups (3\/258, 1%). <jats:italic>MYC<\/jats:italic>-R without an IG partner was more common in the YA group (14\/116 (12%) vs 2\/128 (2%), <jats:italic>p<\/jats:italic>\u2009=\u20090.001). The pediatric to YA transition is characterized by decreasing frequency in BL and increasing genetic heterogeneity of <jats:italic>MYC<\/jats:italic>-R BCL, with emergence of DH-BCL with <jats:italic>MYC<\/jats:italic> and <jats:italic>BCL6<\/jats:italic>-R. FISH to evaluate for <jats:italic>BCL2<\/jats:italic> and <jats:italic>BCL6<\/jats:italic> rearrangements is likely not warranted in the pediatric population but should continue to be applied in YA BCL.<\/jats:p>","DOI":"10.1007\/s12308-024-00579-6","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T04:44:50Z","timestamp":1712033090000},"page":"51-61","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cytogenetic and pathologic characterization of MYC-rearranged B-cell lymphomas in pediatric and young adult patients"],"prefix":"10.1007","volume":"17","author":[{"given":"Marie-France","family":"Gagnon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frido K.","family":"Bruehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Sill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid G.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia T.","family":"Greipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Hoppman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda B.","family":"Baughn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess F.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen D.","family":"McPhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhett P.","family":"Ketterling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-0226","authenticated-orcid":false,"given":"Rebecca L.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"579_CR1","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1182\/blood.2022015851","volume":"140","author":"E Campo","year":"2022","unstructured":"Campo E, Jaffe ES, Cook JR, Quintanilla-Martinez L, Swerdlow SH, Anderson KC, Brousset P, Cerroni L, de Leval L, Dirnhofer S, Dogan A, Feldman AL, Fend F, Friedberg JW, Gaulard P, Ghia P, Horwitz SM, King RL, Salles G, San-Miguel J, Seymour JF, Treon SP, Vose JM, Zucca E, Advani R, Ansell S, Au WY, Barrionuevo C, Bergsagel L, Chan WC, Cohen JI, d\u2019Amore F, Davies A, Falini B, Ghobrial IM, Goodlad JR, Gribben JG, Hsi ED, Kahl BS, Kim WS, Kumar S, LaCasce AS, Laurent C, Lenz G, Leonard JP, Link MP, Lopez-Guillermo A, Mateos MV, Macintyre E, Melnick AM, Morschhauser F, Nakamura S, Narbaitz M, Pavlovsky A, Pileri SA, Piris M, Pro B, Rajkumar V, Rosen ST, Sander B, Sehn L, Shipp MA, Smith SM, Staudt LM, Thieblemont C, Tousseyn T, Wilson WH, Yoshino T, Zinzani PL, Dreyling M, Scott DW, Winter JN, Zelenetz AD (2022) The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. 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