{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T14:17:28Z","timestamp":1770301048215,"version":"3.49.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematopathol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm arising from follicular dendritic cells (FDC) of lymphoid follicles. While the majority of FDC sarcoma cases arise within lymph nodes, approximately 30% manifest in extranodal sites. Only 4 prior occurrences of intra-parotid FDC sarcomas have been documented. We are reporting a rare case of FDC of the parotid gland in a 65-year-old male with a questionable history of B-cell lymphoma. The patient underwent a right total parotidectomy and bilateral neck dissection. A diagnosis of follicular dendritic cell (FDC) sarcoma was made, with one positive intra-parotid node. The malignant cells expressed the characteristic markers for FDC sarcoma but with positivity of the melanocytic marker PRAME. This is a case of FDC sarcoma with an unusual extranodal localization in the parotid gland. Immunohistochemistry was useful in making a diagnosis although the positivity for the melanocytic marker PRAME was unusual and unreported before.<\/jats:p>","DOI":"10.1007\/s12308-024-00605-7","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:01:41Z","timestamp":1728432101000},"page":"271-274","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME"],"prefix":"10.1007","volume":"17","author":[{"given":"Sumayya","family":"Aslam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ifegwu","family":"Ibe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roksolana","family":"Demianets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Truc","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Gamayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-2130","authenticated-orcid":false,"given":"Sherif A.","family":"Rezk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"605_CR1","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s13139-016-0465-2","volume":"51","author":"W Makis","year":"2017","unstructured":"Makis W, Hudson EW, Chiu B (2017) Recurrent follicular dendritic cell sarcoma of the parotid gland imaged with 18F-FDG PET\/CT. Nucl Med Mol Imaging 51:354\u2013356","journal-title":"Nucl Med Mol Imaging"},{"key":"605_CR2","doi-asserted-by":"publisher","unstructured":"McClelland E, Bashyam A, Derbyshire S, Di Palma S (2018) Follicular dendritic cell sarcoma presenting as a painless lump in the parotid. BMJ Case Reports 2018. https:\/\/doi.org\/10.1136\/bcr-2018-224301","DOI":"10.1136\/bcr-2018-224301"},{"key":"605_CR3","doi-asserted-by":"publisher","first-page":"e23588","DOI":"10.1097\/MD.0000000000023588","volume":"99","author":"C Qu","year":"2020","unstructured":"Qu C, Tian X, Ma Y, Xie X, Wang M, Dong Y, Zhang J, Liu P, Yang Y (2020) Multidisciplinary diagnosis and treatment of recurrent follicular dendritic cell sarcoma in abdomen: a case report. Medicine 99:e23588","journal-title":"Medicine"},{"key":"605_CR4","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.humpath.2012.10.005","volume":"44","author":"SA Rezk","year":"2013","unstructured":"Rezk SA, Nathwani BN, Zhao X, Weiss LM (2013) Follicular dendritic cells: origin, function, and different disease-associated patterns. Hum Pathol 44:937\u2013950","journal-title":"Hum Pathol"},{"key":"605_CR5","doi-asserted-by":"publisher","first-page":"117955491984453","DOI":"10.1177\/1179554919844531","volume":"13","author":"N Lopez-Hisijos","year":"2019","unstructured":"Lopez-Hisijos N, Omman R, Pambuccian S, Mirza K (2019) Follicular dendritic cell sarcoma or not? A series of 5 diagnostically challenging cases. Clin Med Insights Oncol 13:1179554919844531","journal-title":"Clin Med Insights Oncol"},{"key":"605_CR6","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/00000478-199402000-00004","volume":"18","author":"JK Chan","year":"1994","unstructured":"Chan JK, Tsang WY, Ng CS, Tang SK, Yu HC, Lee AW (1994) Follicular dendritic cell tumors of the oral cavity. Am J Surg Pathol 18:148\u2013157","journal-title":"Am J Surg Pathol"},{"key":"605_CR7","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/ajcp\/103.1.90","volume":"103","author":"K Hollowood","year":"1995","unstructured":"Hollowood K, Stamp G, Zouvani I, Fletcher CD (1995) Extranodal follicular dendritic cell sarcoma of the gastrointestinal tract. Morphologic, immunohistochemical and ultrastructural analysis of two cases. Am J Clin Pathol 103:90\u201397","journal-title":"Am J Clin Pathol"},{"key":"605_CR8","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1097\/00000478-200106000-00003","volume":"25","author":"W Cheuk","year":"2001","unstructured":"Cheuk W, Chan JK, Shek TW, Chang JH, Tsou MH, Yuen NW, Ng WF, Chan AC, Prat J (2001) Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association. Am J Surg Pathol 25:721\u2013731","journal-title":"Am J Surg Pathol"},{"key":"605_CR9","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1097\/01.pas.0000112536.76973.7f","volume":"28","author":"KL Grogg","year":"2004","unstructured":"Grogg KL, Lae ME, Kurtin PJ, Macon WR (2004) Clusterin expression distinguishes follicular dendritic cell tumors from other dendritic cell neoplasms: report of a novel follicular dendritic cell marker and clinicopathologic data on 12 additional follicular dendritic cell tumors and 6 additional interdigitating dendritic cell tumors. Am J Surg Pathol 28:988\u2013998","journal-title":"Am J Surg Pathol"},{"key":"605_CR10","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.path.2021.01.001","volume":"14","author":"C Lezcano","year":"2021","unstructured":"Lezcano C, Jungbluth AA, Busam KJ (2021) PRAME immunohistochemistry as an Ancillary Test for the assessment of melanocytic lesions. Surg Pathol Clin 14:165\u2013175","journal-title":"Surg Pathol Clin"},{"issue":"3","key":"605_CR11","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/01.pai.0000213113.50849.9e","volume":"15","author":"AL Padilla-Rodr\u00edguez","year":"2007","unstructured":"Padilla-Rodr\u00edguez AL, Bembassat M, Lazaro M, Ortiz-Hidalgo C (2007) Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. Appl Immunohistochem Mol Morphol 15(3):346\u2013352","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"605_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s12308-014-0216-1","volume":"7","author":"S Fratoni","year":"2014","unstructured":"Fratoni S, Niscola P, Cupelli L et al (2014) An unusual case of follicular dendritic cell sarcoma of the omentum with pleomorphous morphology and aberrant cytokeratin expression. J Hematopathol 7:177\u2013180","journal-title":"J Hematopathol"},{"issue":"11","key":"605_CR13","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/j.1440-1827.2009.02449.x","volume":"59","author":"Y Yamada","year":"2009","unstructured":"Yamada Y, Haga H, Hernandez M, Kubota KC, Orii F, Nagashima K, Matsuno Y (2009) Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression. Pathol Int 59(11):809\u2013812","journal-title":"Pathol Int"},{"key":"605_CR14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.anndiagpath.2016.05.003","volume":"23","author":"A Agaimy","year":"2016","unstructured":"Agaimy A, Michal M, Hadravsky L, Michal M (2016) Follicular dendritic cell sarcoma: clinicopathologic study of 15 cases with emphasis on novel expression of MDM2, somatostatin receptor 2A, and PD-L1. Ann Diagn Pathol 23:21\u201328","journal-title":"Ann Diagn Pathol"},{"key":"605_CR15","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/his.12416","volume":"65","author":"H Go","year":"2014","unstructured":"Go H, Jeon YK, Huh J, Choi SJ, Choi YD, Cha HJ, Kim HJ, Park G, Min S, Kim JE (2014) Frequent detection of BRAF(V600E) mutations in histiocytic and dendritic cell neoplasms. Histopathology 65:261\u2013272","journal-title":"Histopathology"},{"key":"605_CR16","first-page":"67","volume":"29","author":"GK Griffin","year":"2016","unstructured":"Griffin GK, Sholl LM, Lindeman NI, Fletcher CD, Hornick JL (2016) Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-kappaB regulatory genes. Modern: Pathol Off J United States Can Acad Pathol, Inc 29:67\u201374","journal-title":"Modern: Pathol Off J United States Can Acad Pathol, Inc"},{"key":"605_CR17","doi-asserted-by":"publisher","first-page":"e13413","DOI":"10.1097\/MD.0000000000013413","volume":"97","author":"W Ren","year":"2018","unstructured":"Ren W, Sun Q, Wu PY, Huang B, Yang J, Yan J, Liu BR (2018) Profiles of genomic alterations in primary esophageal follicular dendritic cell sarcoma: a case report. Medicine 97:e13413","journal-title":"Medicine"}],"container-title":["Journal of Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-024-00605-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12308-024-00605-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-024-00605-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T04:48:19Z","timestamp":1733978899000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12308-024-00605-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["605"],"URL":"https:\/\/doi.org\/10.1007\/s12308-024-00605-7","relation":{},"ISSN":["1868-9256","1865-5785"],"issn-type":[{"value":"1868-9256","type":"print"},{"value":"1865-5785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"16 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"For this type of study consent for publication is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}