{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T22:11:47Z","timestamp":1772575907282,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematopathol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tularemia is a rare zoonotic infection most often acquired through exposure to infected animals, arthropods, or contaminated food or water. Diagnosis typically involves serologic or PCR testing, but histopathologic findings can be a clue to the diagnosis. Here, we present a case of inguinal lymphadenopathy in an adolescent patient with a history of multiple animal exposures and possible tick bite. Excisional lymph node biopsy showed necrotizing granulomatous inflammation, and the clinical history, histologic findings, and serologic results together led to the diagnosis of ulceroglandular tularemia. This report adds to the limited available literature on the histopathologic findings of tularemia lymphadenitis and discusses the importance of including this entity in the differential diagnosis for necrotizing granulomatous disease.<\/jats:p>","DOI":"10.1007\/s12308-026-00687-5","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:42:12Z","timestamp":1772574132000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histopathologic findings of tularemia lymphadenitis"],"prefix":"10.1007","volume":"19","author":[{"given":"Anna","family":"Dar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily F.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"issue":"2","key":"687_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.rr7402a1","volume":"74","author":"CA Nelson","year":"2025","unstructured":"Nelson CA et al (2025) Tularemia antimicrobial treatment and prophylaxis: CDC recommendations for naturally acquired infections and bioterrorism response - United States, 2025. MMWR Recomm Rep 74(2):1\u201333","journal-title":"MMWR Recomm Rep"},{"issue":"5152","key":"687_CR2","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.15585\/mmwr.mm735152a1","volume":"73","author":"SN Rich","year":"2025","unstructured":"Rich SN et al (2025) Tularemia - United States, 2011\u20132022. MMWR Morb Mortal Wkly Rep 73(5152):1152\u20131156","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"687_CR3","unstructured":"Centers for Disease Control and Prevention. How tularemia spreads. [cited 2025 December 12]; Available from: https:\/\/www.cdc.gov\/tularemia\/causes\/index.html."},{"key":"687_CR4","unstructured":"Centers for Disease Control and Prevention. Signs and symptoms of tularemia. [cited 2025 December 12]; Available from: https:\/\/www.cdc.gov\/tularemia\/signs-symptoms\/index.html."},{"issue":"4","key":"687_CR5","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1128\/CMR.15.4.631-646.2002","volume":"15","author":"J Ellis","year":"2002","unstructured":"Ellis J et al (2002) Tularemia. Clin Microbiol Rev 15(4):631\u2013646","journal-title":"Clin Microbiol Rev"},{"issue":"5","key":"687_CR6","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/modpathol.3800087","volume":"17","author":"LW Lamps","year":"2004","unstructured":"Lamps LW et al (2004) Histologic and molecular diagnosis of tularemia: a potential bioterrorism agent endemic to North America. Mod Pathol 17(5):489\u2013495","journal-title":"Mod Pathol"},{"issue":"6","key":"687_CR7","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00428-012-1246-7","volume":"460","author":"S Asano","year":"2012","unstructured":"Asano S et al (2012) Temporal differences of onset between primary skin lesions and regional lymph node lesions for tularemia in Japan: a clinicopathologic and immunohistochemical study of 19 skin cases and 54 lymph node cases. Virchows Arch 460(6):651\u2013658","journal-title":"Virchows Arch"},{"issue":"7","key":"687_CR8","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.arcped.2021.08.005","volume":"28","author":"J Cognard","year":"2021","unstructured":"Cognard J et al (2021) Tularemia: a rare cause of pediatric lymph nodes adenitis. Arch Pediatr 28(7):580\u2013582","journal-title":"Arch Pediatr"},{"issue":"12","key":"687_CR9","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1007\/s00405-011-1722-8","volume":"268","author":"S Cagli","year":"2011","unstructured":"Cagli S et al (2011) Tularemia: a rare cause of neck mass, evaluation of 33 patients. Eur Arch Otorhinolaryngol 268(12):1699\u20131704","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"1","key":"687_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3960\/jslrt.52.1","volume":"52","author":"S Asano","year":"2012","unstructured":"Asano S (2012) Granulomatous lymphadenitis. J Clin Exp Hematop 52(1):1\u201316","journal-title":"J Clin Exp Hematop"},{"key":"687_CR11","first-page":"153","volume-title":"Hematopathology","author":"ED Hsi","year":"2017","unstructured":"Hsi ED, Schnitzer B (2017) Reactive lymphadenopathies. In: Jaffe JS, Arber DA, Campo E, Quintanilla-Fend L, Orazi A (eds) Hematopathology, 2nd edn. Elsevier, pp 153\u2013178","edition":"2"},{"issue":"3","key":"687_CR12","doi-asserted-by":"publisher","first-page":"104277","DOI":"10.1016\/j.lpm.2025.104277","volume":"55","author":"P Berche","year":"2025","unstructured":"Berche P (2025) Laboratory-associated infections and biosafety. Presse Med 55(3):104277","journal-title":"Presse Med"},{"issue":"8","key":"687_CR13","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s10096-016-2657-1","volume":"35","author":"N Wurtz","year":"2016","unstructured":"Wurtz N et al (2016) Survey of laboratory-acquired infections around the world in biosafety level 3 and 4 laboratories. Eur J Clin Microbiol Infect Dis 35(8):1247\u20131258","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"687_CR14","unstructured":"Tularemia, in Red Book: 2024\u20132027 Report of the Committee on Infectious Diseases, American Academy of Pediatrics, D.W. Kimberlin, et al., Editors. 2024."},{"key":"687_CR15","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fcimb.2017.00122","volume":"7","author":"Y Caspar","year":"2017","unstructured":"Caspar Y, Maurin M (2017) Francisella tularensis susceptibility to antibiotics: a comprehensive review of the data obtained in vitro and in animal models. Front Cell Infect Microbiol 7:122","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Journal of Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-026-00687-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12308-026-00687-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-026-00687-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:42:17Z","timestamp":1772574137000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12308-026-00687-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["687"],"URL":"https:\/\/doi.org\/10.1007\/s12308-026-00687-5","relation":{},"ISSN":["1865-5785"],"issn-type":[{"value":"1865-5785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"assertion":[{"value":"31 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No funding was received for conducting this study or preparing this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The requirement for formal Institutional Review Board approval was waived for this single-patient, retrospective case-report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, informed consent is not required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"For this type of study, consent for publication is not required.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"9"}}