{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:57:47Z","timestamp":1790463467386,"version":"4.1.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hematopathol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary lymphomas of the urinary bladder are rare, most of which are low-grade B-cell lymphomas. Primary anaplastic large cell lymphoma (ALCL) with bladder involvement is extremely rare, with most cases seen in adult patients. Here, we report a case of ALK-positive ALCL in a 14-year-old male.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 14-year-old male presented with several months of gross hematuria that had become painful. Computed tomography (CT) urogram showed a mass-like thickening of the anterior bladder wall. Cystoscopy showed a 3.5-cm pedunculated lesion at the bladder dome; transurethral excision was performed. Histology revealed sheets of large pleomorphic cells with horseshoe-shaped nuclei and brisk mitotic activity. Tumor cells were positive for CD4, CD5, and CD30 (diffuse\/strong) and negative for CD45. ALK immunostain showed nuclear and cytoplasmic staining. A diagnosis of ALK + ALCL was made. Staging CT was negative for disease. The bone marrow was uninvolved. The patient received multi-agent chemotherapy including brentuximab vedotin. A 2-month follow-up cystoscopy showed a well-healed resection site. Seven months after completing therapy, the patient had recurrent hematuria. Cystoscopy revealed an ulcerated lesion, but biopsies were reactive and showed no lymphoma. The patient remains under surveillance with urology and oncology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Primary bladder ALK + ALCL is exceedingly rare in children. Uniform CD30 positivity and ALK positivity are the key diagnostic clues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12308-026-00737-y","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:16:33Z","timestamp":1790414193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary ALK-positive anaplastic large cell lymphoma of the urinary bladder in a pediatric patient: a case report and review of literature"],"prefix":"10.1007","volume":"19","author":[{"given":"Navdeep","family":"Kaur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhila","family":"Aravind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarika P.","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"issue":"1","key":"737_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1182\/blood.V85.1.1.bloodjournal8511","volume":"85","author":"B Falini","year":"1995","unstructured":"Falini B, Pileri S, Pizzolo G et al (1995) CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy. 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Blood 93(8):2697\u20132706","journal-title":"Blood"},{"key":"737_CR6","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/327917","volume":"2014","author":"AK Venyo","year":"2014","unstructured":"Venyo AK (2014) Lymphoma of the urinary bladder. Adv Urol 2014","journal-title":"Adv Urol"},{"issue":"6","key":"737_CR7","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1080\/10428190500079829","volume":"46","author":"M Hughes","year":"2005","unstructured":"Hughes M, Morrison A, Jackson R (2005) Primary bladder lymphoma: management and outcome of 12 patients with a review of the literature. Leuk Lymphoma 46(6):873\u2013877","journal-title":"Leuk Lymphoma"},{"key":"737_CR8","first-page":"1143","volume":"8","author":"X Liang","year":"2015","unstructured":"Liang X, Wang Y, Zhang J et al (2015) Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with involvement of the urinary bladder: a case report and review of the literature. Onco Targets Ther 8:1143\u20131147","journal-title":"Onco Targets Ther"},{"issue":"2","key":"737_CR9","first-page":"102","volume":"1","author":"Y Huang","year":"2016","unstructured":"Huang Y, Yuan J, He H et al (2016) ALK-positive anaplastic large cell lymphoma presenting as a solitary bladder neoplasm: a case report and review of the literature. Hematopathology 1(2):102\u2013107","journal-title":"Hematopathology"},{"key":"737_CR10","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13000-024-01585-z","volume":"19","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Qiu W, Weng X et al (2024) ALK-positive anaplastic large cell lymphoma involving the bladder: case report and review of the literature. Diagn Pathol 19:157","journal-title":"Diagn Pathol"}],"container-title":["Journal of Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-026-00737-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12308-026-00737-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12308-026-00737-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:01:43Z","timestamp":1790460103000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12308-026-00737-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["737"],"URL":"https:\/\/doi.org\/10.1007\/s12308-026-00737-y","relation":{},"ISSN":["1865-5785"],"issn-type":[{"value":"1865-5785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]},"assertion":[{"value":"13 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Institutional Review Board approval was not required for this single-patient, retrospective case report in accordance with institutional policy.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written authorization for the use of de-identified clinical information for research purposes was obtained in accordance with institutional policy.","order":2,"name":"Ethics","label":"Informed\u00a0Consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"59"}}