{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:43:18Z","timestamp":1790340198159,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:00:00Z","timestamp":1326153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s12311-011-0352-4","type":"journal-article","created":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T09:07:49Z","timestamp":1326100069000},"page":"872-879","source":"Crossref","is-referenced-by-count":37,"title":["High Width Variability during Spiral Drawing: Further Evidence of Cerebellar Dysfunction in Essential Tremor"],"prefix":"10.1007","volume":"11","author":[{"given":"Elan D.","family":"Louis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Gillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Boschung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth L.","family":"Pullman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,10]]},"reference":[{"key":"352_CR1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/mds.22838","volume":"25","author":"ED Louis","year":"2010","unstructured":"Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25:534\u201341.","journal-title":"Mov Disord"},{"key":"352_CR2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/mds.10376","volume":"18","author":"J Benito-Leon","year":"2003","unstructured":"Benito-Leon J, Bermejo-Pareja F, Morales JM, Vega S, Molina JA. Prevalence of essential tremor in three elderly populations of Central Spain. Mov Disord. 2003;18:389\u201394.","journal-title":"Mov Disord"},{"key":"352_CR3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/mds.22370","volume":"24","author":"ED Louis","year":"2009","unstructured":"Louis ED, Frucht SJ, Rios E. Intention tremor in essential tremor: prevalence and association with disease duration. Mov Disord. 2009;24:626\u20137.","journal-title":"Mov Disord"},{"key":"352_CR4","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/mds.21079","volume":"21","author":"J Leegwater-Kim","year":"2006","unstructured":"Leegwater-Kim J, Louis ED, Pullman SL, Floyd AG, Borden S, Moskowitz CB, et al. Intention tremor of the head in patients with essential tremor. Mov Disord. 2006;21:2001\u20135.","journal-title":"Mov Disord"},{"key":"352_CR5","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1093\/brain\/124.11.2278","volume":"124","author":"H Stolze","year":"2001","unstructured":"Stolze H, Petersen G, Raethjen J, Wenzelburger R, Deuschl G. The gait disorder of advanced essential tremor. Brain. 2001;124:2278\u201386.","journal-title":"Brain"},{"key":"352_CR6","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/mds.23144","volume":"25","author":"ED Louis","year":"2010","unstructured":"Louis ED, Rios E, Rao AK. Tandem gait performance in essential tremor: clinical correlates and association with midline tremors. Mov Disord. 2010;25:1633\u20138.","journal-title":"Mov Disord"},{"key":"352_CR7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.gaitpost.2011.03.013","volume":"34","author":"AK Rao","year":"2011","unstructured":"Rao AK, Gillman A, Louis ED. Quantitative gait analysis in essential tremor reveals impairments that are maintained into advanced age. Gait Posture. 2011;34:65\u201370.","journal-title":"Gait Posture"},{"key":"352_CR8","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/brain\/awg132","volume":"126","author":"C Helmchen","year":"2003","unstructured":"Helmchen C, Hagenow A, Miesner J, Sprenger A, Rambold H, Wenzelburger R, et al. Eye movement abnormalities in essential tremor may indicate cerebellar dysfunction. Brain. 2003;126:1319\u201332.","journal-title":"Brain"},{"key":"352_CR9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/mds.20729","volume":"21","author":"P Trillenberg","year":"2006","unstructured":"Trillenberg P, Fuhrer J, Sprenger A, Hagenow A, Kompf D, Wenzelburger R, et al. Eye\u2013hand coordination in essential tremor. Mov Disord. 2006;21:373\u20139.","journal-title":"Mov Disord"},{"key":"352_CR10","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/mds.20934","volume":"21","author":"Z Farkas","year":"2006","unstructured":"Farkas Z, Szirmai I, Kamondi A. Impaired rhythm generation in essential tremor. Mov Disord. 2006;21:1196\u20139.","journal-title":"Mov Disord"},{"key":"352_CR11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s12311-009-0133-5","volume":"9","author":"M Bares","year":"2010","unstructured":"Bares M, Lungu OV, Husarova I, Gescheidt T. Predictive motor timing performance dissociates between early diseases of the cerebellum and Parkinson's disease. Cerebellum. 2010;9:124\u201335.","journal-title":"Cerebellum"},{"key":"352_CR12","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1093\/brain\/awm081","volume":"130","author":"M Kronenbuerger","year":"2007","unstructured":"Kronenbuerger M, Gerwig M, Brol B, Block F, Timmann D. Eyeblink conditioning is impaired in subjects with essential tremor. Brain. 2007;130:1538\u201351.","journal-title":"Brain"},{"key":"352_CR13","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.3174\/ajnr.A1190","volume":"29","author":"A Quattrone","year":"2008","unstructured":"Quattrone A, Cerasa A, Messina D, Nicoletti G, Hagberg GE, Lemieux L, et al. Essential head tremor is associated with cerebellar vermis atrophy: a volumetric and voxel-based morphometry MR imaging study. AJNR Am J Neuroradiol. 2008;29:1692\u20137.","journal-title":"AJNR Am J Neuroradiol"},{"key":"352_CR14","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1212\/WNL.0b013e3181d5a460","volume":"74","author":"G Nicoletti","year":"2010","unstructured":"Nicoletti G, Manners D, Novellino F, Condino F, Malucelli E, Barbiroli B, et al. Diffusion tensor MRI changes in cerebellar structures of patients with familial essential tremor. Neurology. 2010;74:988\u201394.","journal-title":"Neurology"},{"key":"352_CR15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(02)00966-7","volume":"333","author":"ED Louis","year":"2002","unstructured":"Louis ED, Shungu DC, Chan S, Mao X, Jurewicz EC, Watner D. Metabolic abnormality in the cerebellum in patients with essential tremor: a proton magnetic resonance spectroscopic imaging study. Neurosci Lett. 2002;333:17\u201320.","journal-title":"Neurosci Lett"},{"key":"352_CR16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jns.2009.08.037","volume":"287","author":"J Benito-Leon","year":"2009","unstructured":"Benito-Leon J, Alvarez-Linera J, Hernandez-Tamames JA, Alonso-Navarro H, Jimenez-Jimenez FJ, Louis ED. Brain structural changes in essential tremor: voxel-based morphometry at 3-tesla. J Neurol Sci. 2009;287:138\u201342.","journal-title":"J Neurol Sci"},{"key":"352_CR17","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3174\/ajnr.A1544","volume":"30","author":"A Cerasa","year":"2009","unstructured":"Cerasa A, Messina D, Nicoletti G, Novellino F, Lanza P, Condino F, et al. Cerebellar atrophy in essential tremor using an automated segmentation method. AJNR Am J Neuroradiol. 2009;30:1240\u20133.","journal-title":"AJNR Am J Neuroradiol"},{"key":"352_CR18","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1093\/brain\/awr164","volume":"134","author":"L Passamonti","year":"2011","unstructured":"Passamonti L, Novellino F, Cerasa A, Chiriaco C, Rocca F, Matina MS, et al. Altered cortical-cerebellar circuits during verbal working memory in essential tremor. Brain. 2011;134:2274\u201386.","journal-title":"Brain"},{"key":"352_CR19","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1136\/jnnp.2010.213330","volume":"82","author":"SH Kuo","year":"2011","unstructured":"Kuo SH, Erickson-Davis C, Gillman A, Faust PL, Vonsattel JP, Louis ED. Increased number of heterotopic Purkinje cells in essential tremor. J Neurol Neurosurg Psychiatry. 2011;82:1038\u201340.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"352_CR20","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S1474-4422(10)70090-9","volume":"9","author":"ED Louis","year":"2010","unstructured":"Louis ED. Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry. Lancet Neurol. 2010;9:613\u201322.","journal-title":"Lancet Neurol"},{"key":"352_CR21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00401-010-0776-9","volume":"121","author":"SH Kuo","year":"2011","unstructured":"Kuo SH, Faust PL, Vonsattel JP, Ma K, Louis ED. Parallel fiber counts and parallel fiber integrated density are similar in essential tremor cases and controls. Acta Neuropathol. 2011;121:287\u20139.","journal-title":"Acta Neuropathol"},{"key":"352_CR22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/NEN.0b013e3181d1ad04","volume":"69","author":"CR Erickson-Davis","year":"2010","unstructured":"Erickson-Davis CR, Faust PL, Vonsattel JP, Gupta S, Honig LS, Louis ED. \"Hairy baskets\" associated with degenerative Purkinje cell changes in essential tremor. J Neuropathol Exp Neurol. 2010;69:262\u201371.","journal-title":"J Neuropathol Exp Neurol"},{"key":"352_CR23","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1007\/s12311-011-0291-0","volume":"4","author":"ED Louis","year":"2011","unstructured":"Louis ED, Faust PL, Ma KJ, Yu M, Cortes E, Vonsattel JP. Torpedoes in the cerebellar vermis in essential tremor cases vs controls. Cerebellum. 2011;4:812\u20139.","journal-title":"Cerebellum"},{"issue":"Suppl 3","key":"352_CR24","first-page":"8589","volume":"13","author":"SL Pullman","year":"1998","unstructured":"Pullman SL. Spiral analysis: a new technique for measuring tremor with a digitizing tablet. Mov Disord. 1998;13 Suppl 3:8589.","journal-title":"Mov Disord"},{"key":"352_CR25","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/mds.20915","volume":"21","author":"ED Louis","year":"2006","unstructured":"Louis ED, Yu Q, Floyd AG, Moskowitz C, Pullman SL. Axis is a feature of handwritten spirals in essential tremor. Mov Disord. 2006;21:1294\u20135.","journal-title":"Mov Disord"},{"key":"352_CR26","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/mds.22744","volume":"24","author":"AW Hsu","year":"2009","unstructured":"Hsu AW, Piboolnurak PA, Floyd AG, Yu QP, Wraith JE, Patterson MC, et al. Spiral analysis in Niemann\u2013Pick disease type C. Mov Disord. 2009;24:1984\u201390.","journal-title":"Mov Disord"},{"key":"352_CR27","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/brain\/awm266","volume":"130","author":"ED Louis","year":"2007","unstructured":"Louis ED, Faust PL, Vonsattel JP, Honig LS, Rajput A, Robinson CA, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain. 2007;130:3297\u2013307.","journal-title":"Brain"},{"key":"352_CR28","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/mds.20583","volume":"20","author":"ED Louis","year":"2005","unstructured":"Louis ED, Borden S, Moskowitz CB. Essential tremor centralized brain repository: diagnostic validity and clinical characteristics of a highly selected group of essential tremor cases. Mov Disord. 2005;20:1361\u20135.","journal-title":"Mov Disord"},{"key":"352_CR29","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/mds.22749","volume":"24","author":"ED Louis","year":"2009","unstructured":"Louis ED, Rios E, Henchcliffe C. Mirror movements in patients with essential tremor. Mov Disord. 2009;24:2211\u20137.","journal-title":"Mov Disord"},{"key":"352_CR30","unstructured":"Fahn S, Elton R, Members of the UPDRS Development Committee in Fahn S, Marsden C, Goldtein M, Calne DB (ed) (1987) Recent developments in Parkinson's disease. Florham Park, NJ, Macmillan Health Care Information. pp 153\u201363."},{"key":"352_CR31","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.humov.2006.05.005","volume":"25","author":"MG Longstaff","year":"2006","unstructured":"Longstaff MG, Heath RA. Spiral drawing performance as an indicator of fine motor function in people with multiple sclerosis. Hum Mov Sci. 2006;25:474\u201391.","journal-title":"Hum Mov Sci"},{"key":"352_CR32","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000109681","volume":"16","author":"ED Louis","year":"1997","unstructured":"Louis ED, Ottman R, Ford B, Pullman S, Martinez M, Fahn S, et al. The Washington Heights-Inwood Genetic Study of essential tremor: methodologic issues in essential tremor research. Neuroepidemiology. 1997;16:124\u201333.","journal-title":"Neuroepidemiology"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-011-0352-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12311-011-0352-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-011-0352-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T03:53:58Z","timestamp":1559447638000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12311-011-0352-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["352"],"URL":"https:\/\/doi.org\/10.1007\/s12311-011-0352-4","relation":{},"ISSN":["1473-4222","1473-4230"],"issn-type":[{"value":"1473-4222","type":"print"},{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,10]]}}}