{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:08:46Z","timestamp":1784264926064,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,1,13]],"date-time":"2013-01-13T00:00:00Z","timestamp":1358035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s12311-012-0440-0","type":"journal-article","created":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T05:53:53Z","timestamp":1357970033000},"page":"475-484","source":"Crossref","is-referenced-by-count":42,"title":["Friedreich Ataxia: Dysarthria Profile and Clinical Data"],"prefix":"10.1007","volume":"12","author":[{"given":"Bettina","family":"Brendel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Ackermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Lindig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Sch\u00f6lderle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Sch\u00f6ls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,13]]},"reference":[{"key":"440_CR1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nrneurol.2009.26","volume":"5","author":"JB Schulz","year":"2009","unstructured":"Schulz JB, Boesch S, B\u00fcrk K, et al. Diagnosis and treatment of Friedreich ataxia: a European perspective. Nature Rev Neurol. 2009;5:222\u201334.","journal-title":"Nature Rev Neurol"},{"key":"440_CR2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nrn1474","volume":"5","author":"F Taroni","year":"2004","unstructured":"Taroni F, DiDonato S. Pathways to motor incoordination: the inherited ataxias. Nature Rev Neurosci. 2004;5:641\u201355.","journal-title":"Nature Rev Neurosci"},{"issue":"Suppl 1","key":"440_CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00415-009-1002-3","volume":"256","author":"M Pandolfo","year":"2009","unstructured":"Pandolfo M. Friedreich ataxia: the clinical picture. J Neurol. 2009;256 Suppl 1:3\u20138.","journal-title":"J Neurol"},{"key":"440_CR4","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1093\/brain\/120.12.2131","volume":"120","author":"L Sch\u00f6ls","year":"1997","unstructured":"Sch\u00f6ls L, Amoiridis G, Przuntek H, et al. Friedreich's ataxia\u2014revision of the phenotype according to molecular genetics. Brain. 1997;120:2131\u201340.","journal-title":"Brain"},{"key":"440_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.37.1.1","volume":"37","author":"MB Delatycki","year":"2000","unstructured":"Delatycki MB, Williamson R, Forrest SM. Friedreich ataxia: an overview. J Med Genet. 2000;37:1\u20138.","journal-title":"J Med Genet"},{"key":"440_CR6","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1001\/archneur.62.12.1865","volume":"62","author":"R Bhidayasiri","year":"2005","unstructured":"Bhidayasiri R, Perlman SL, Pulst SM, Geschwind DH. Late-onset Friedreich ataxia. Phenotypic analysis, magnetic resonance imaging findings, and review of the literature. Arch Neurol. 2005;62:1865\u20139.","journal-title":"Arch Neurol"},{"key":"440_CR7","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1136\/jnnp.2007.124297","volume":"79","author":"R Della Nave","year":"2008","unstructured":"Della Nave R, Ginestroni A, Giannelli M, et al. Brain structural damage in Friedreich\u2019s ataxia. J Neurol Neurosurg Psychiatry. 2008;79:82\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"440_CR8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuroimage.2007.11.050","volume":"40","author":"R Della Nave","year":"2008","unstructured":"Della Nave R, Ginestroni A, Tessa C, et al. Brain white matter tracts degeneration in Friedreich ataxia: an in vivo MRI study using tract-based spatial statistics and voxel-based morphometry. NeuroImage. 2008;40:19\u201325.","journal-title":"NeuroImage"},{"key":"440_CR9","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1159\/000327751","volume":"8","author":"M Synofzik","year":"2011","unstructured":"Synofzik M, Godau J, Lindig T, et al. Transcranial sonography reveals cerebellar, nigral, and forebrain abnormalities in Friedreich\u2019s ataxia. Neurodegener Dis. 2011;8:470\u20135.","journal-title":"Neurodegener Dis"},{"key":"440_CR10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00401-011-0844-9","volume":"122","author":"AH Koeppen","year":"2011","unstructured":"Koeppen AH, Davis AN, Morral JA. The cerebellar component of Friedreich's ataxia. Acta Neuropathol. 2011;122:323\u201330.","journal-title":"Acta Neuropathol"},{"key":"440_CR11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/brain\/104.3.589","volume":"104","author":"AE Harding","year":"1981","unstructured":"Harding AE. Friedreich\u2019s ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features. Brain. 1981;104:589\u2013620.","journal-title":"Brain"},{"key":"440_CR12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1055\/s-2007-999122","volume":"60","author":"H Ackermann","year":"1992","unstructured":"Ackermann H, Ziegler W. Cerebellar dysarthria\u2014a review [German]. Fortschr Neurol Psychiatr. 1992;60:28\u201340.","journal-title":"Fortschr Neurol Psychiatr"},{"key":"440_CR13","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1056\/NEJM199610173351601","volume":"335","author":"A D\u00fcrr","year":"1996","unstructured":"D\u00fcrr A, Cossee M, Agid Y, et al. Clinical and genetic abnormalities in patients with Friedreich\u2019s ataxia. N Engl J Med. 1996;335:1169\u201375.","journal-title":"N Engl J Med"},{"key":"440_CR14","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/(SICI)1096-8628(19991119)87:2<168::AID-AJMG8>3.0.CO;2-2","volume":"87","author":"MB Delatycki","year":"1999","unstructured":"Delatycki MB, Paris DBBP, McKinlay Gardner RJ, et al. Clinical and genetic study of Friedreich ataxia in an Australian population. Am J Med Genet. 1999;87:168\u201374.","journal-title":"Am J Med Genet"},{"key":"440_CR15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0093-934X(80)90036-X","volume":"10","author":"Y Joanette","year":"1980","unstructured":"Joanette Y, Dudley JG. Dysarthric symptomatology of Friedreich\u2019s ataxia. Brain Lang. 1980;10:39\u201350.","journal-title":"Brain Lang"},{"key":"440_CR16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000287207","volume":"62","author":"JE Folker","year":"2010","unstructured":"Folker JE, Murdoch BE, Cahill LM, et al. Dysarthria in Friedreich\u2019s ataxia: a perceptual analysis. Folia Phoniatr Logop. 2010;62:97\u2013103.","journal-title":"Folia Phoniatr Logop"},{"key":"440_CR17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/mds.22776","volume":"25","author":"A Singh","year":"2010","unstructured":"Singh A, Epstein E, Myers LM, et al. Clinical measures of dysarthria in Friedreich\u2019s ataxia. Mov Disord. 2010;25:108\u201311.","journal-title":"Mov Disord"},{"key":"440_CR18","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00415-011-6192-9","volume":"259","author":"A Eigentler","year":"2012","unstructured":"Eigentler A, Rhomberg J, Nachbauer W, et al. The scale for the assessment and rating of ataxia correlates with dysarthria assessment in Friedreich\u2019s ataxia. J Neurol. 2012;259:420\u20136.","journal-title":"J Neurol"},{"key":"440_CR19","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/0093-934X(90)90126-2","volume":"38","author":"M Gentil","year":"1990","unstructured":"Gentil M. Dysarthria in Friedreich disease. Brain Lang. 1990;38:438\u201348.","journal-title":"Brain Lang"},{"key":"440_CR20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/02699209308985545","volume":"7","author":"H Ackermann","year":"1993","unstructured":"Ackermann H, Hertrich I. Dysarthria in Friedreich\u2019s ataxia: timing of speech segments. Clin Linguist Phonet. 1993;7:75\u201391.","journal-title":"Clin Linguist Phonet"},{"key":"440_CR21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000266295","volume":"46","author":"H Ackermann","year":"1994","unstructured":"Ackermann H, Hertrich I. Speech rate and rhythm in cerebellar dysarthria\u2014an acoustic analysis of syllabic timing. Folia Phoniatr Logop. 1994;46:70\u20138.","journal-title":"Folia Phoniatr Logop"},{"key":"440_CR22","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1212\/WNL.47.1.208","volume":"47","author":"W Ziegler","year":"1996","unstructured":"Ziegler W, Wessel K. Speech timing in ataxic disorders: sentence production and rapid repetitive articulation. Neurology. 1996;47:208\u201314.","journal-title":"Neurology"},{"key":"440_CR23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3109\/02699206.2010.511760","volume":"25","author":"JE Folker","year":"2011","unstructured":"Folker JE, Murdoch BE, Cahill LM, et al. Kinematic analysis of lingual movements during consonant productions in dysarthric speakers with Friedreich\u2019s ataxia: a case-by-case analysis. Clin Linguist Phonet. 2011;25:66\u201379.","journal-title":"Clin Linguist Phonet"},{"key":"440_CR24","doi-asserted-by":"crossref","unstructured":"Synofzik M, Srulijes K, Godau J, et al. Characterizing POLG ataxia: clinics, electrophysiology and imaging. Cerebellum. 2012. doi: 10.1007\/s12311-012-0378-2 .","DOI":"10.1007\/s12311-012-0378-2"},{"key":"440_CR25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/729254892","volume":"17","author":"W Ziegler","year":"2003","unstructured":"Ziegler W. Speech motor control is task-specific. Evidence from dysarthria and apraxia of speech. Aphasiology. 2003;17:3\u201336.","journal-title":"Aphasiology"},{"key":"440_CR26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1055\/s-0028-1103390","volume":"29","author":"K Bunton","year":"2008","unstructured":"Bunton K. Speech versus nonspeech: different tasks. Different neural organization. Semin Speech Lang. 2008;29:267\u201375.","journal-title":"Semin Speech Lang"},{"key":"440_CR27","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1006\/brln.2001.2614","volume":"80","author":"W Ziegler","year":"2002","unstructured":"Ziegler W. Task-related factors in oral motor control: speech and oral diadochokinesis in dysarthria and apraxia of speech. Brain Lang. 2002;80:556\u201375.","journal-title":"Brain Lang"},{"key":"440_CR28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1136\/jnnp.54.1.74","volume":"54","author":"H Ackermann","year":"1991","unstructured":"Ackermann H, Ziegler W. Cerebellar voice tremor. J Neurol Neurosurg Psychiatry. 1991;54:74\u20136.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"440_CR29","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1212\/01.wnl.0000219042.60538.92","volume":"66","author":"T Schmitz-H\u00fcbsch","year":"2006","unstructured":"Schmitz-H\u00fcbsch T, du Montcel ST, Baliko L, et al. Scale for the assessment and rating of ataxia: development of a new clinical scale. Neurology. 2006;66:1717\u201320.","journal-title":"Neurology"},{"key":"440_CR30","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/mds.22660","volume":"24","author":"K B\u00fcrk","year":"2009","unstructured":"B\u00fcrk K, M\u00e4lzig U, Wolf S, et al. Comparison of three clinical rating scales in Friedreich\u2019s ataxia (FRDA). Mov Disord. 2009;24:1779\u201384.","journal-title":"Mov Disord"},{"key":"440_CR31","first-page":"242","volume-title":"Dysarthria: a physiological approach to assessment and treatment","author":"BE Murdoch","year":"1998","unstructured":"Murdoch BE, Theodoros DG. Ataxic dysarthria. In: Murdoch BE, editor. Dysarthria: a physiological approach to assessment and treatment. Cheltenham: Stanley Thornes; 1998. p. 242\u201365."},{"key":"440_CR32","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jcomdis.2008.05.001","volume":"41","author":"W Ziegler","year":"2008","unstructured":"Ziegler W, Zierdt A. Telediagnostic assessment of intelligibility in dysarthria: a pilot investigation of MVP-Online. J Commun Dis. 2008;41:553\u201377.","journal-title":"J Commun Dis"},{"key":"440_CR33","first-page":"14","volume":"18","author":"F Nicola","year":"2004","unstructured":"Nicola F, Ziegler W, Vogel M. The Bogenhausener Dysarthria Scales (BODYS): an instrument for clinical diagnostic of dysarthria [German]. Forum Logop\u00e4die. 2004;18:14\u201322.","journal-title":"Forum Logop\u00e4die"},{"key":"440_CR34","doi-asserted-by":"crossref","unstructured":"Ackermann H, Hertrich I, Ziegler W. Dysarthria. In: Damico JS, M\u00fcller N, Ball MJ, editors. The handbook of language and speech disorders. Hoboken: Wiley-Blackwell; 2010. pp. 362\u2013390.","DOI":"10.1002\/9781444318975.ch16"},{"key":"440_CR35","doi-asserted-by":"crossref","unstructured":"Levelt WJM. Speaking. From intention to articulation. Cambridge: MIT; 1989.","DOI":"10.7551\/mitpress\/6393.001.0001"},{"key":"440_CR36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/jpho.2000.0122","volume":"28","author":"RD Kent","year":"2000","unstructured":"Kent RD, Kent JF, Weismer G, Duffy JR. What dysarthrias can tell us about the neural control of speech. J Phon. 2000;28:273\u2013302.","journal-title":"J Phon"},{"key":"440_CR37","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/000348949410300203","volume":"103","author":"H Ackermann","year":"1994","unstructured":"Ackermann H, Ziegler W. Acoustic analysis of vocal instability in cerebellar dysfunction. Ann Otol Rhinol Laryngol. 1994;103:98\u2013104.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"440_CR38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000266338","volume":"47","author":"H Ackermann","year":"1995","unstructured":"Ackermann H, Hertrich I, Hehr T. Oral diadochokinesis in neurological dysarthrias. Folia Phoniatr Logop. 1995;47:15\u201323.","journal-title":"Folia Phoniatr Logop"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-012-0440-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12311-012-0440-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-012-0440-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T16:57:38Z","timestamp":1745945858000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12311-012-0440-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,13]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["440"],"URL":"https:\/\/doi.org\/10.1007\/s12311-012-0440-0","relation":{},"ISSN":["1473-4222","1473-4230"],"issn-type":[{"value":"1473-4222","type":"print"},{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,13]]}}}