{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:44:06Z","timestamp":1793724246018,"version":"4.6.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T00:00:00Z","timestamp":1357948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s12311-012-0447-6","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T06:24:05Z","timestamp":1357885445000},"page":"310-312","source":"Crossref","is-referenced-by-count":64,"title":["Expression of Expanded CAG Transcripts Triggers Nucleolar Stress in Huntington's Disease"],"prefix":"10.1007","volume":"12","author":[{"given":"Ho","family":"Tsoi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Yin Edwin","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,12]]},"reference":[{"key":"447_CR1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/sj.embor.7400250","volume":"5","author":"C Landles","year":"2004","unstructured":"Landles C, Bates GP. Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series. EMBO Rep. 2004;5:958\u201363.","journal-title":"EMBO Rep"},{"key":"447_CR2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-5-40","volume":"5","author":"RA Roos","year":"2010","unstructured":"Roos RA. Huntington's disease: a clinical review. Orphanet J Rare Dis. 2010;5:40.","journal-title":"Orphanet J Rare Dis"},{"key":"447_CR3","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1007\/s00018-006-6242-0","volume":"63","author":"M Borrell-Pages","year":"2006","unstructured":"Borrell-Pages M, Zala D, Humbert S, Saudou F. Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies. Cell Mol Life Sci. 2006;63:2642\u201360.","journal-title":"Cell Mol Life Sci"},{"key":"447_CR4","doi-asserted-by":"crossref","first-page":"e1002481","DOI":"10.1371\/journal.pgen.1002481","volume":"8","author":"M Banez-Coronel","year":"2012","unstructured":"Banez-Coronel M, Porta S, Kagerbauer B, Mateu-Huertas E, Pantano L, Ferrer I, et al. A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity. PLoS Genet. 2012;8:e1002481.","journal-title":"PLoS Genet"},{"key":"447_CR5","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/nature06909","volume":"453","author":"LB Li","year":"2008","unstructured":"Li LB, Yu Z, Teng X, Bonini NM. RNA toxicity is a component of ataxin-3 degeneration in Drosophila. Nature. 2008;453:1107\u201311.","journal-title":"Nature"},{"key":"447_CR6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ccr.2009.09.024","volume":"16","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Lu H. Signaling to p53: ribosomal proteins find their way. Cancer Cell. 2009;16:369\u201377.","journal-title":"Cancer Cell"},{"key":"447_CR7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.tcb.2009.10.002","volume":"20","author":"D Speidel","year":"2010","unstructured":"Speidel D. Transcription-independent p53 apoptosis: an alternative route to death. Trends Cell Biol. 2010;20:14\u201324.","journal-title":"Trends Cell Biol"},{"key":"447_CR8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1126\/science.1079447","volume":"299","author":"D Ruggero","year":"2003","unstructured":"Ruggero D, Grisendi S, Piazza F, Rego E, Mari F, Rao PH, et al. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science. 2003;299:259\u201362.","journal-title":"Science"},{"key":"447_CR9","doi-asserted-by":"crossref","first-page":"12759","DOI":"10.1523\/JNEUROSCI.2439-08.2008","volume":"28","author":"R Parlato","year":"2008","unstructured":"Parlato R, Kreiner G, Erdmann G, Rieker C, Stotz S, Savenkova E, et al. Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci. 2008;28:12759\u201364.","journal-title":"J Neurosci"},{"key":"447_CR10","doi-asserted-by":"crossref","first-page":"e22585","DOI":"10.1371\/journal.pone.0022585","volume":"6","author":"M Pietrzak","year":"2011","unstructured":"Pietrzak M, Rempala G, Nelson PT, Zheng JJ, Hetman M. Epigenetic silencing of nucleolar rRNA genes in Alzheimer's disease. PLoS One. 2011;6:e22585.","journal-title":"PLoS One"},{"key":"447_CR11","doi-asserted-by":"crossref","first-page":"13428","DOI":"10.1073\/pnas.1204089109","volume":"109","author":"H Tsoi","year":"2012","unstructured":"Tsoi H, Lau TC, Tsang SY, Lau KF, Chan HY. CAG expansion induces nucleolar stress in polyglutamine diseases. Proc Natl Acad Sci U S A. 2012;109:13428\u201333.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"447_CR12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrc1015","volume":"3","author":"D Ruggero","year":"2003","unstructured":"Ruggero D, Pandolfi PP. Does the ribosome translate cancer? Nat Rev Cancer. 2003;3:179\u201392.","journal-title":"Nat Rev Cancer"},{"key":"447_CR13","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1128\/MCB.25.7.2539-2546.2005","volume":"25","author":"R Santoro","year":"2005","unstructured":"Santoro R, Grummt I. Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation. Mol Cell Biol. 2005;25:2539\u201346.","journal-title":"Mol Cell Biol"},{"key":"447_CR14","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1038\/cdd.2011.38","volume":"18","author":"J Lee","year":"2011","unstructured":"Lee J, Hwang YJ, Boo JH, Han D, Kwon OK, Todorova K, et al. Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease. Cell Death Differ. 2011;18:1726\u201335.","journal-title":"Cell Death Differ"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-012-0447-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12311-012-0447-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-012-0447-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T07:54:01Z","timestamp":1559462041000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12311-012-0447-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,12]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["447"],"URL":"https:\/\/doi.org\/10.1007\/s12311-012-0447-6","relation":{},"ISSN":["1473-4222","1473-4230"],"issn-type":[{"value":"1473-4222","type":"print"},{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,12]]}}}