{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:27:43Z","timestamp":1770528463281,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s12311-015-0650-3","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T22:25:53Z","timestamp":1422311153000},"page":"284-291","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Vestibular Performance During High-Acceleration Stimuli Correlates with Clinical Decline in SCA6"],"prefix":"10.1007","volume":"14","author":[{"given":"Young Eun","family":"Huh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beom Seok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Whan","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Zee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"650_CR1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/ana.410420616","volume":"42","author":"CM Gomez","year":"1997","unstructured":"Gomez CM, Thompson RM, Gammack JT, Perlman SL, Dobyns WB, Truwit CL, et al. Spinocerebellar ataxia type 6: gaze-evoked and vertical nystagmus, Purkinje cell degeneration, and variable age of onset. Ann Neurol. 1997;42:933\u201350.","journal-title":"Ann Neurol."},{"key":"650_CR2","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1212\/WNL.54.4.860","volume":"54","author":"N Takeichi","year":"2000","unstructured":"Takeichi N, Fukushima K, Sasaki H, Yabe I, Tashiro K, Inuyama Y. Dissociation of smooth pursuit and vestibulo-ocular reflex cancellation in SCA-6. Neurology. 2000;54:860\u20136.","journal-title":"Neurology."},{"key":"650_CR3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s00415-003-1020-5","volume":"250","author":"I Yabe","year":"2003","unstructured":"Yabe I, Sasaki H, Takeichi N, Takei A, Hamada T, Fukushima K, et al. Positional vertigo and macroscopic downbeat positioning nystagmus in spinocerebellar ataxia type 6 (SCA6). J Neurol. 2003;250:440\u20133.","journal-title":"J Neurol."},{"key":"650_CR4","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1001\/archneur.55.10.1353","volume":"55","author":"N Buttner","year":"1998","unstructured":"Buttner N, Geschwind D, Jen JC, Perlman S, Pulst SM, Baloh RW. Oculomotor phenotypes in autosomal dominant ataxias. Arch Neurol. 1998;55:1353\u20137.","journal-title":"Arch Neurol."},{"key":"650_CR5","doi-asserted-by":"crossref","unstructured":"Kim JS, Youn J, Seo DW, Jeong Y, Kang JH, Park JH, et al. Ocular motor characteristics of different subtypes of spinocerebellar ataxia: distinguishing features. Mov Disord. 2013.","DOI":"10.1002\/mds.25464"},{"key":"650_CR6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/brain\/99.2.207","volume":"99","author":"DS Zee","year":"1976","unstructured":"Zee DS, Yee RD, Cogan DG, Robinson DA, Engel WK. Ocular motor abnormalities in hereditary cerebellar ataxia. Brain. 1976;99:207\u201334.","journal-title":"Brain."},{"key":"650_CR7","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1136\/jnnp.74.10.1403","volume":"74","author":"CR Gordon","year":"2003","unstructured":"Gordon CR, Joffe V, Vainstein G, Gadoth N. Vestibulo-ocular arreflexia in families with spinocerebellar ataxia type 3 (Machado-Joseph disease). J Neurol Neurosurg Psychiatry. 2003;74:1403\u20136.","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"650_CR8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00415-009-0068-2","volume":"256","author":"P Yu-Wai-Man","year":"2009","unstructured":"Yu-Wai-Man P, Gorman G, Bateman DE, Leigh RJ, Chinnery PF. Vertigo and vestibular abnormalities in spinocerebellar ataxia type 6. J Neurol. 2009;256:78\u201382.","journal-title":"J Neurol."},{"key":"650_CR9","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s002219900266","volume":"130","author":"BT Crane","year":"2000","unstructured":"Crane BT, Tian JR, Demer JL. Initial vestibulo-ocular reflex during transient angular and linear acceleration in human cerebellar dysfunction. Exp Brain Res. 2000;130:486\u201396.","journal-title":"Exp Brain Res."},{"key":"650_CR10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3389\/fneur.2012.00162","volume":"3","author":"O Kremmyda","year":"2012","unstructured":"Kremmyda O, Kirchner H, Glasauer S, Brandt T, Jahn K, Strupp M. False-positive head-impulse test in cerebellar ataxia. Front Neurol. 2012;3:162.","journal-title":"Front Neurol."},{"key":"650_CR11","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1007\/s00415-013-6837-y","volume":"260","author":"HK Park","year":"2013","unstructured":"Park HK, Kim JS, Strupp M, Zee DS. Isolated floccular infarction: impaired vestibular responses to horizontal head impulse. J Neurol. 2013;260:1576\u201382.","journal-title":"J Neurol."},{"key":"650_CR12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1196\/annals.1325.040","volume":"1039","author":"SH Ying","year":"2005","unstructured":"Ying SH, Choi SI, Lee M, Perlman SL, Baloh RW, Toga AW, et al. Relative atrophy of the flocculus and ocular motor dysfunction in SCA2 and SCA6. Ann N Y Acad Sci. 2005;1039:430\u20135.","journal-title":"Ann N Y Acad Sci."},{"key":"650_CR13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ana.410430306","volume":"43","author":"S Rivaud-Pechoux","year":"1998","unstructured":"Rivaud-Pechoux S, Durr A, Gaymard B, Cancel G, Ploner CJ, Agid Y, et al. Eye movement abnormalities correlate with genotype in autosomal dominant cerebellar ataxia type I. Ann Neurol. 1998;43:297\u2013302.","journal-title":"Ann Neurol."},{"key":"650_CR14","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.20220","volume":"56","author":"L Velazquez-Perez","year":"2004","unstructured":"Velazquez-Perez L, Seifried C, Santos-Falcon N, Abele M, Ziemann U, Almaguer LE, et al. Saccade velocity is controlled by polyglutamine size in spinocerebellar ataxia 2. Ann Neurol. 2004;56:444\u20137.","journal-title":"Ann Neurol."},{"key":"650_CR15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s004150050456","volume":"246","author":"K Burk","year":"1999","unstructured":"Burk K, Fetter M, Abele M, Laccone F, Brice A, Dichgans J, et al. Autosomal dominant cerebellar ataxia type I: oculomotor abnormalities in families with SCA1, SCA2, and SCA3. J Neurol. 1999;246:789\u201397.","journal-title":"J Neurol."},{"key":"650_CR16","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1212\/01.wnl.0000276958.91986.89","volume":"69","author":"J Hubner","year":"2007","unstructured":"Hubner J, Sprenger A, Klein C, Hagenah J, Rambold H, Zuhlke C, et al. Eye movement abnormalities in spinocerebellar ataxia type 17 (SCA17). Neurology. 2007;69:1160\u20138.","journal-title":"Neurology."},{"key":"650_CR17","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1093\/brain\/awr269","volume":"134","author":"YE Huh","year":"2011","unstructured":"Huh YE, Kim JS. Patterns of spontaneous and head-shaking nystagmus in cerebellar infarction: imaging correlations. Brain. 2011;134:3662\u201371.","journal-title":"Brain."},{"key":"650_CR18","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s12311-011-0316-8","volume":"11","author":"JA Saute","year":"2012","unstructured":"Saute JA, Donis KC, Serrano-Munuera C, Genis D, Ramirez LT, Mazzetti P, et al. Ataxia rating scales\u2014psychometric profiles, natural history and their application in clinical trials. Cerebellum. 2012;11:488\u2013504.","journal-title":"Cerebellum."},{"key":"650_CR19","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s10038-004-0142-7","volume":"49","author":"H Takahashi","year":"2004","unstructured":"Takahashi H, Ishikawa K, Tsutsumi T, Fujigasaki H, Kawata A, Okiyama R, et al. A clinical and genetic study in a large cohort of patients with spinocerebellar ataxia type 6. J Hum Genet. 2004;49:256\u201364.","journal-title":"J Hum Genet."},{"key":"650_CR20","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/brain\/awm323","volume":"131","author":"MC Fahey","year":"2008","unstructured":"Fahey MC, Cremer PD, Aw ST, Millist L, Todd MJ, White OB, et al. Vestibular, saccadic and fixation abnormalities in genetically confirmed Friedreich ataxia. Brain. 2008;131:1035\u201345.","journal-title":"Brain."},{"key":"650_CR21","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1152\/jn.1996.76.6.4009","volume":"76","author":"ST Aw","year":"1996","unstructured":"Aw ST, Haslwanter T, Halmagyi GM, Curthoys IS, Yavor RA, Todd MJ. Three-dimensional vector analysis of the human vestibuloocular reflex in response to high-acceleration head rotations. I. Responses in normal subjects. J Neurophysiol. 1996;76:4009\u201320.","journal-title":"J Neurophysiol"},{"key":"650_CR22","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1152\/jn.1996.76.6.4021","volume":"76","author":"ST Aw","year":"1996","unstructured":"Aw ST, Halmagyi GM, Haslwanter T, Curthoys IS, Yavor RA, Todd MJ. Three-dimensional vector analysis of the human vestibuloocular reflex in response to high-acceleration head rotations. II. Responses in subjects with unilateral vestibular loss and selective semicircular canal occlusion. J Neurophysiol. 1996;76:4021\u201330.","journal-title":"J Neurophysiol"},{"key":"650_CR23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0079-6123(08)00625-0","volume":"171","author":"GM Halmagyi","year":"2008","unstructured":"Halmagyi GM, Weber KP, Aw ST, Todd MJ, Curthoys IS. Impulsive testing of semicircular canal function. Prog Brain Res. 2008;171:187\u201394.","journal-title":"Prog Brain Res."},{"issue":"Pt 4","key":"650_CR24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/brain\/121.4.699","volume":"121","author":"PD Cremer","year":"1998","unstructured":"Cremer PD, Halmagyi GM, Aw ST, Curthoys IS, McGarvie LA, Todd MJ, et al. Semicircular canal plane head impulses detect absent function of individual semicircular canals. Brain. 1998;121(Pt 4):699\u2013716.","journal-title":"Brain"},{"key":"650_CR25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/MAO.0b013e3182995227","volume":"35","author":"Y Agrawal","year":"2014","unstructured":"Agrawal Y, Schubert MC, Migliaccio AA, Zee DS, Schneider E, Lehnen N, et al. Evaluation of quantitative head impulse testing using search coils versus video-oculography in older individuals. Otol Neurotol. 2014;35:283\u20138.","journal-title":"Otol Neurotol."},{"key":"650_CR26","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1152\/jn.1984.52.6.1140","volume":"52","author":"SG Lisberger","year":"1984","unstructured":"Lisberger SG, Miles FA, Zee DS. Signals used to compute errors in monkey vestibuloocular reflex: possible role of flocculus. J Neurophysiol. 1984;52:1140\u201353.","journal-title":"J Neurophysiol."},{"key":"650_CR27","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.1523\/JNEUROSCI.21-23-09185.2001","volume":"21","author":"ES Piedras-Renteria","year":"2001","unstructured":"Piedras-Renteria ES, Watase K, Harata N, Zhuchenko O, Zoghbi HY, Lee CC, et al. Increased expression of alpha 1A Ca2+ channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6. J Neurosci. 2001;21:9185\u201393.","journal-title":"J Neurosci."},{"key":"650_CR28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(00)81877-2","volume":"88","author":"DL Burgess","year":"1997","unstructured":"Burgess DL, Jones JM, Meisler MH, Noebels JL. Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell. 1997;88:385\u201392.","journal-title":"Cell."},{"key":"650_CR29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1152\/jn.01004.2003","volume":"92","author":"K Tully","year":"2004","unstructured":"Tully K, Treistman SN. Distinct intracellular calcium profiles following influx through N- versus L-type calcium channels: role of Ca2\u2009+\u2009-induced Ca2+ release. J Neurophysiol. 2004;92:135\u201343.","journal-title":"J Neurophysiol."},{"key":"650_CR30","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s12311-010-0182-9","volume":"11","author":"A Kasumu","year":"2012","unstructured":"Kasumu A, Bezprozvanny I. Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias. Cerebellum. 2012;11:630\u20139.","journal-title":"Cerebellum."},{"key":"650_CR31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0896-6273(00)00099-4","volume":"28","author":"M Miyata","year":"2000","unstructured":"Miyata M, Finch EA, Khiroug L, Hashimoto K, Hayasaka S, Oda SI, et al. Local calcium release in dendritic spines required for long-term synaptic depression. Neuron. 2000;28:233\u201344.","journal-title":"Neuron."},{"key":"650_CR32","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI200420216","volume":"113","author":"VG Shakkottai","year":"2004","unstructured":"Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, et al. Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia. J Clin Invest. 2004;113:582\u201390.","journal-title":"J Clin Invest."},{"key":"650_CR33","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.brainres.2003.09.048","volume":"994","author":"J Strahlendorf","year":"2003","unstructured":"Strahlendorf J, Box C, Attridge J, Diertien J, Finckbone V, Henne WM, et al. AMPA-induced dark cell degeneration of cerebellar Purkinje neurons involves activation of caspases and apparent mitochondrial dysfunction. Brain Res. 2003;994:146\u201359.","journal-title":"Brain Res."},{"key":"650_CR34","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1152\/jn.00318.2005","volume":"95","author":"JS Stahl","year":"2006","unstructured":"Stahl JS, James RA, Oommen BS, Hoebeek FE, De Zeeuw CI. Eye movements of the murine P\/Q calcium channel mutant tottering, and the impact of aging. J Neurophysiol. 2006;95:1588\u2013607.","journal-title":"J Neurophysiol."},{"key":"650_CR35","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1152\/jn.1995.74.5.2051","volume":"74","author":"CI Zeeuw De","year":"1995","unstructured":"De Zeeuw CI, Wylie DR, Stahl JS, Simpson JI. Phase relations of Purkinje cells in the rabbit flocculus during compensatory eye movements. J Neurophysiol. 1995;74:2051\u201364.","journal-title":"J Neurophysiol."},{"key":"650_CR36","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1152\/jn.1995.73.4.1396","volume":"73","author":"JS Stahl","year":"1995","unstructured":"Stahl JS, Simpson JI. Dynamics of rabbit vestibular nucleus neurons and the influence of the flocculus. J Neurophysiol. 1995;73:1396\u2013413.","journal-title":"J Neurophysiol."},{"key":"650_CR37","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1152\/jn.1999.82.3.1254","volume":"82","author":"LB Minor","year":"1999","unstructured":"Minor LB, Lasker DM, Backous DD, Hullar TE. Horizontal vestibuloocular reflex evoked by high-acceleration rotations in the squirrel monkey. I. Normal responses. J Neurophysiol. 1999;82:1254\u201370.","journal-title":"J Neurophysiol."},{"key":"650_CR38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/PL00005650","volume":"114","author":"C Chen-Huang","year":"1997","unstructured":"Chen-Huang C, McCrea RA, Goldberg JM. Contributions of regularly and irregularly discharging vestibular-nerve inputs to the discharge of central vestibular neurons in the alert squirrel monkey. Exp Brain Res. 1997;114:405\u201322.","journal-title":"Exp Brain Res."},{"key":"650_CR39","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2990.2009.01015.x","volume":"35","author":"K Gierga","year":"2009","unstructured":"Gierga K, Schelhaas HJ, Brunt ER, Seidel K, Scherzed W, Egensperger R, et al. Spinocerebellar ataxia type 6 (SCA6): neurodegeneration goes beyond the known brain predilection sites. Neuropathol Appl Neurobiol. 2009;35:515\u201327.","journal-title":"Neuropathol Appl Neurobiol."},{"key":"650_CR40","volume-title":"The neurology of eye movements","author":"RJ Leigh","year":"2006","unstructured":"Leigh RJ, Zee DS. The neurology of eye movements. New York: Oxford University Press; 2006."}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-015-0650-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12311-015-0650-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-015-0650-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:36:40Z","timestamp":1566261400000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12311-015-0650-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["650"],"URL":"https:\/\/doi.org\/10.1007\/s12311-015-0650-3","relation":{},"ISSN":["1473-4222","1473-4230"],"issn-type":[{"value":"1473-4222","type":"print"},{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,28]]}}}