{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T01:34:25Z","timestamp":1780882465621,"version":"3.54.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s12311-015-0692-6","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T07:03:22Z","timestamp":1435647802000},"page":"235-242","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Linking Essential Tremor to the Cerebellum: Neuropathological Evidence"],"prefix":"10.1007","volume":"15","author":[{"given":"Elan D.","family":"Louis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"692_CR1","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1212\/01.wnl.0000218162.80315.b9","volume":"66","author":"ED Louis","year":"2006","unstructured":"Louis ED, Vonsattel JP, Honig LS, Ross GW, Lyons KE, Pahwa R. Neuropathologic findings in essential tremor. Neurology. 2006;66:1756\u20139.","journal-title":"Neurology"},{"key":"692_CR2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1212\/01.WNL.0000115145.18830.1A","volume":"62","author":"A Rajput","year":"2004","unstructured":"Rajput A, Robinson CA, Rajput AH. Essential tremor course and disability: a clinicopathologic study of 20 cases. Neurology. 2004;62:932\u20136.","journal-title":"Neurology"},{"key":"692_CR3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.parkreldis.2012.01.013","volume":"18","author":"AH Rajput","year":"2012","unstructured":"Rajput AH, Robinson CA, Rajput ML, Robinson SL, Rajput A. Essential tremor is not dependent upon cerebellar Purkinje cell loss. Parkinsonism Relat Disord. 2012;18:626\u20138.","journal-title":"Parkinsonism Relat Disord"},{"key":"692_CR4","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.parkreldis.2012.06.017","volume":"18","author":"ED Louis","year":"2012","unstructured":"Louis ED, Faust PL, Vonsattel JP. Purkinje cell loss is a characteristic of essential tremor: towards a more mature understanding of pathogenesis. Parkinsonism Relat Disord. 2012;18:1003\u20134.","journal-title":"Parkinsonism Relat Disord"},{"key":"692_CR5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1468-1331.2011.03598.x","volume":"19","author":"M Yu","year":"2012","unstructured":"Yu M, Ma K, Faust PL, Honig LS, Cortes E, Vonsattel JP, et al. Increased number of Purkinje cell dendritic swellings in essential tremor. Eur J Neurol. 2012;19:625\u201330.","journal-title":"Eur J Neurol"},{"key":"692_CR6","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1093\/brain\/awu314","volume":"137","author":"ED Louis","year":"2014","unstructured":"Louis ED, Lee M, Babij R, Ma K, Cortes E, Vonsattel JP, et al. Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor. Brain. 2014;137:3142\u20138.","journal-title":"Brain"},{"key":"692_CR7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1001\/archneurol.2007.8","volume":"65","author":"JE Axelrad","year":"2008","unstructured":"Axelrad JE, Louis ED, Honig LS, Flores I, Ross GW, Pahwa R, et al. Reduced Purkinje cell number in essential tremor: a postmortem study. Arch Neurol. 2008;65:101\u20137.","journal-title":"Arch Neurol"},{"key":"692_CR8","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/brain\/awm266","volume":"130","author":"ED Louis","year":"2007","unstructured":"Louis ED, Faust PL, Vonsattel JP, Honig LS, Rajput A, Robinson CA, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain. 2007;130:3297\u2013307.","journal-title":"Brain"},{"key":"692_CR9","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1136\/jnnp.2010.213330","volume":"82","author":"SH Kuo","year":"2011","unstructured":"Kuo SH, Erickson-Davis C, Gillman A, Faust PL, Vonsattel JP, Louis ED. Increased number of heterotopic Purkinje cells in essential tremor. J Neurol Neurosurg Psychiatry. 2011;82:1038\u201340.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"692_CR10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/NEN.0b013e3181d1ad04","volume":"69","author":"CR Erickson-Davis","year":"2010","unstructured":"Erickson-Davis CR, Faust PL, Vonsattel JP, Gupta S, Honig LS, Louis ED. \u201cHairy baskets\u201d associated with degenerative Purkinje cell changes in essential tremor. J Neuropathol Exp Neurol. 2010;69:262\u201371.","journal-title":"J Neuropathol Exp Neurol"},{"key":"692_CR11","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00401-013-1108-7","volume":"125","author":"SH Kuo","year":"2013","unstructured":"Kuo SH, Tang G, Louis ED, Ma K, Babji R, Balatbat M, et al. Lingo-1 expression is increased in essential tremor cerebellum and is present in the basket cell pinceau. Acta Neuropathol. 2013;125:879\u201389.","journal-title":"Acta Neuropathol"},{"key":"692_CR12","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1093\/brain\/awu281","volume":"137","author":"CY Lin","year":"2014","unstructured":"Lin CY, Louis ED, Faust PL, Koeppen AH, Vonsattel JP, Kuo SH. Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum. Brain. 2014;137:3149\u201359.","journal-title":"Brain"},{"key":"692_CR13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s40478-014-0157-z","volume":"2","author":"M Lee","year":"2014","unstructured":"Lee M, Cheng MM, Lin CY, Louis ED, Faust PL, Kuo SH. Decreased EAAT2 protein expression in the essential tremor cerebellar cortex. Acta Neuropathol Commun. 2014;2:157.","journal-title":"Acta Neuropathol Commun"},{"key":"692_CR14","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1002\/mds.25645","volume":"28","author":"G Grimaldi","year":"2013","unstructured":"Grimaldi G, Manto M. Is essential tremor a Purkinjopathy? The role of the cerebellar cortex in its pathogenesis. Mov Disord. 2013;28:1759\u201361.","journal-title":"Mov Disord"},{"key":"692_CR15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s12311-013-0545-0","volume":"13","author":"ED Louis","year":"2014","unstructured":"Louis ED. From neurons to neuron neighborhoods: the rewiring of the cerebellar cortex in essential tremor. Cerebellum. 2014;13:501\u201312.","journal-title":"Cerebellum"},{"issue":"Suppl1","key":"692_CR16","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1016\/S1353-8020(13)70023-3","volume":"20","author":"E Louis","year":"2014","unstructured":"Louis E. Re-thinking the biology of essential tremor: from models to morphology. Parkinsonism Relat Disord. 2014;20(Suppl1):S88\u201393.","journal-title":"Parkinsonism Relat Disord"},{"key":"692_CR17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1096-9861(19990607)408:3<399::AID-CNE7>3.0.CO;2-2","volume":"408","author":"I Dusart","year":"1999","unstructured":"Dusart I, Morel MP, Wehrle R, Sotelo C. Late axonal sprouting of injured Purkinje cells and its temporal correlation with permissive changes in the glial scar. J Comp Neurol. 1999;408:399\u2013418.","journal-title":"J Comp Neurol"},{"key":"692_CR18","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s12311-014-0560-9","volume":"13","author":"ED Louis","year":"2014","unstructured":"Louis ED, Lee M, Cortes E, Vonsattel JP, Faust PL. Matching asymmetry of tremor with asymmetry of postmortem cerebellar hemispheric changes in essential tremor. Cerebellum. 2014;13:462\u201370.","journal-title":"Cerebellum"},{"key":"692_CR19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2217\/nmt.12.23","volume":"2","author":"AH Rajput","year":"2012","unstructured":"Rajput AH, Adler CH, Shill HA, Rajput A. Essential tremor is not a neurodegenerative disease. Neurodegener Dis Manag. 2012;2:259\u201368.","journal-title":"Neurodegener Dis Manag"},{"key":"692_CR20","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/mds.25845","volume":"29","author":"C Symanski","year":"2014","unstructured":"Symanski C, Shill HA, Dugger B, Hentz JG, Adler CH, Jacobson SA, et al. Essential tremor is not associated with cerebellar Purkinje cell loss. Mov Disord. 2014;29:496\u2013500.","journal-title":"Mov Disord"},{"key":"692_CR21","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.parkreldis.2011.05.004","volume":"17","author":"ED Louis","year":"2011","unstructured":"Louis ED, Faust PL, Vonsattel JP. Purkinje cell loss is a characteristic of essential tremor. Parkinsonism Relat Disord. 2011;17:406\u20139.","journal-title":"Parkinsonism Relat Disord"},{"key":"692_CR22","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/mds.22838","volume":"25","author":"ED Louis","year":"2010","unstructured":"Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25:534\u201341.","journal-title":"Mov Disord"},{"key":"692_CR23","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1093\/brain\/awt238","volume":"136","author":"R Babij","year":"2013","unstructured":"Babij R, Lee M, Cortes E, Vonsattel JP, Faust PL, Louis ED. Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains. Brain. 2013;136:3051\u201361.","journal-title":"Brain"},{"key":"692_CR24","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1523\/JNEUROSCI.15-03-02040.1995","volume":"15","author":"F Rossi","year":"1995","unstructured":"Rossi F, Jankovski A, Sotelo C. Target neuron controls the integrity of afferent axon phenotype: a study on the Purkinje cell-climbing fiber system in cerebellar mutant mice. J Neurosci. 1995;15:2040\u201356.","journal-title":"J Neurosci"},{"key":"692_CR25","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1212\/01.wnl.0000310425.76205.02","volume":"70","author":"HA Shill","year":"2008","unstructured":"Shill HA, Adler CH, Sabbagh MN, Connor DJ, Caviness JN, Hentz JG, et al. Pathologic findings in prospectively ascertained essential tremor subjects. Neurology. 2008;70:1452\u20135.","journal-title":"Neurology"},{"key":"692_CR26","first-page":"1004","volume":"62","author":"ED Louis","year":"2005","unstructured":"Louis ED, Honig LS, Vonsattel JP, Maraganore DM, Borden S, Moskowitz CB. Essential tremor associated with focal nonnigral Lewy bodies: a clinicopathologic study. Arch Neurol. 2005;62:1004\u20137.","journal-title":"Arch Neurol"},{"key":"692_CR27","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s11910-014-0450-z","volume":"14","author":"ED Louis","year":"2014","unstructured":"Louis ED. Understanding essential tremor: progress on the biological front. Curr Neurol Neurosci Rep. 2014;14:450.","journal-title":"Curr Neurol Neurosci Rep"},{"key":"692_CR28","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/mds.870120620","volume":"12","author":"JP Hubble","year":"1997","unstructured":"Hubble JP, Busenbark KL, Pahwa R, Lyons K, Koller WC. Clinical expression of essential tremor: effects of gender and age. Mov Disord. 1997;12:969\u201372.","journal-title":"Mov Disord"},{"key":"692_CR29","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.apmr.2006.07.255","volume":"87","author":"SL Parisi","year":"2006","unstructured":"Parisi SL, Heroux ME, Culham EG, Norman KE. Functional mobility and postural control in essential tremor. Arch Phys Med Rehabil. 2006;87:1357\u201364.","journal-title":"Arch Phys Med Rehabil"},{"key":"692_CR30","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/mds.23144","volume":"25","author":"ED Louis","year":"2010","unstructured":"Louis ED, Rios E, Rao AK. Tandem gait performance in essential tremor: clinical correlates and association with midline tremors. Mov Disord. 2010;25:1633\u20138.","journal-title":"Mov Disord"},{"key":"692_CR31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.gaitpost.2011.03.013","volume":"34","author":"AK Rao","year":"2011","unstructured":"Rao AK, Gillman A, Louis ED. Quantitative gait analysis in essential tremor reveals impairments that are maintained into advanced age. Gait Posture. 2011;34:65\u201370.","journal-title":"Gait Posture"},{"key":"692_CR32","doi-asserted-by":"crossref","unstructured":"Louis ED. Essential tremor and other forms of kinetic tremor. In: Grimaldi G, Manto M, editors. Mechanisms and emerging therapies of tremor disorders. Humana Press; 2012. p. 219\u2013234.","DOI":"10.1007\/978-1-4614-4027-7_10"},{"key":"692_CR33","doi-asserted-by":"crossref","unstructured":"Louis ED, Galecki M, Rao AK. Four essential tremor cases with moderately impaired gait: how impaired can gait be in this disease? Tremor Other Hyperkinet Mov (N Y) 2013;3. pii: tre-03-200-4597-1.","DOI":"10.5334\/tohm.138"},{"key":"692_CR34","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1093\/brain\/123.8.1568","volume":"123","author":"G Deuschl","year":"2000","unstructured":"Deuschl G, Wenzelburger R, Loffler K, Raethjen J, Stolze H. Essential tremor and cerebellar dysfunction clinical and kinematic analysis of intention tremor. Brain. 2000;123:1568\u201380.","journal-title":"Brain"},{"key":"692_CR35","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/mds.21079","volume":"21","author":"J Leegwater-Kim","year":"2006","unstructured":"Leegwater-Kim J, Louis ED, Pullman SL, Floyd AG, Borden S, Moskowitz CB, et al. Intention tremor of the head in patients with essential tremor. Mov Disord. 2006;21:2001\u20135.","journal-title":"Mov Disord"},{"key":"692_CR36","doi-asserted-by":"crossref","unstructured":"Gitchel GT, Wetzel PA, Baron MS. Slowed saccades and increased square wave jerks in essential tremor. Tremor Other Hyperkinet Mov (N Y) 2013;3. pii: tre-03-178-4116-2.","DOI":"10.5334\/tohm.127"},{"key":"692_CR37","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/brain\/awg132","volume":"126","author":"C Helmchen","year":"2003","unstructured":"Helmchen C, Hagenow A, Miesner J, Sprenger A, Rambold H, Wenzelburger R, et al. Eye movement abnormalities in essential tremor may indicate cerebellar dysfunction. Brain. 2003;126:1319\u201332.","journal-title":"Brain"},{"key":"692_CR38","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1111\/j.1460-9568.2009.06984.x","volume":"30","author":"L Avanzino","year":"2009","unstructured":"Avanzino L, Bove M, Tacchino A, Ruggeri P, Giannini A, Trompetto C, et al. Cerebellar involvement in timing accuracy of rhythmic finger movements in essential tremor. Eur J Neurosci. 2009;30:1971\u20139.","journal-title":"Eur J Neurosci"},{"key":"692_CR39","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/mds.20729","volume":"21","author":"P Trillenberg","year":"2006","unstructured":"Trillenberg P, Fuhrer J, Sprenger A, Hagenow A, Kompf D, Wenzelburger R, et al. Eye-hand coordination in essential tremor. Mov Disord. 2006;21:373\u20139.","journal-title":"Mov Disord"},{"key":"692_CR40","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s12311-009-0133-5","volume":"9","author":"M Bares","year":"2010","unstructured":"Bares M, Lungu OV, Husarova I, Gescheidt T. Predictive motor timing performance dissociates between early diseases of the cerebellum and Parkinson\u2019s disease. Cerebellum. 2010;9:124\u201335.","journal-title":"Cerebellum"},{"key":"692_CR41","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/mds.20934","volume":"21","author":"Z Farkas","year":"2006","unstructured":"Farkas Z, Szirmai I, Kamondi A. Impaired rhythm generation in essential tremor. Mov Disord. 2006;21:1196\u20139.","journal-title":"Mov Disord"},{"key":"692_CR42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/mds.870040210","volume":"4","author":"MJ Dupuis","year":"1989","unstructured":"Dupuis MJ, Delwaide PJ, Boucquey D, Gonsette RE. Homolateral disappearance of essential tremor after cerebellar stroke. Mov Disord. 1989;4:183\u20137.","journal-title":"Mov Disord"},{"key":"692_CR43","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1212\/01.wnl.0000335270.73346.60","volume":"71","author":"AH Rajput","year":"2008","unstructured":"Rajput AH, Maxood K, Rajput A. Classic essential tremor changes following cerebellar hemorrhage. Neurology. 2008;71:1739\u201340.","journal-title":"Neurology"},{"key":"692_CR44","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1056\/NEJM200002173420703","volume":"342","author":"PR Schuurman","year":"2000","unstructured":"Schuurman PR, Bosch DA, Bossuyt PM, Bonsel GJ, van Someren EJ, de Bie RM, et al. A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl J Med. 2000;342:461\u20138.","journal-title":"N Engl J Med"},{"key":"692_CR45","first-page":"39","volume":"58","author":"AL Benabid","year":"1993","unstructured":"Benabid AL, Pollak P, Seigneuret E, Hoffmann D, Gay E, Perret J. Chronic VIM thalamic stimulation in Parkinson\u2019s disease, essential tremor and extra-pyramidal dyskinesias. Acta Neurochir Suppl (Wien). 1993;58:39\u201344.","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"692_CR46","doi-asserted-by":"crossref","unstructured":"Passamonti L, Cerasa A, Quattrone A. Neuroimaging of essential tremor: what is the evidence for cerebellar involvement? Tremor Other Hyperkinet Mov (N Y) 2012;2. pii: 02-67-421-3.","DOI":"10.5334\/tohm.105"},{"key":"692_CR47","doi-asserted-by":"crossref","unstructured":"Louis ED, Huang CC, Dyke JP, Long Z, Dydak U. Neuroimaging studies of essential tremor: how well do these studies support\/refute the neurodegenerative hypothesis? Tremor Other Hyperkinet Mov (N Y) 2014;4:235.","DOI":"10.5334\/tohm.224"},{"key":"692_CR48","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ana.410410108","volume":"41","author":"SF Bucher","year":"1997","unstructured":"Bucher SF, Seelos KC, Dodel RC, Reiser M, Oertel WH. Activation mapping in essential tremor with functional magnetic resonance imaging. Ann Neurol. 1997;41:32\u201340.","journal-title":"Ann Neurol"},{"key":"692_CR49","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ana.410340115","volume":"34","author":"IH Jenkins","year":"1993","unstructured":"Jenkins IH, Bain PG, Colebatch JG, Thompson PD, Findley LJ, Frackowiak RS, et al. A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections. Ann Neurol. 1993;34:82\u201390.","journal-title":"Ann Neurol"},{"key":"692_CR50","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/ana.410360413","volume":"36","author":"AJ Wills","year":"1994","unstructured":"Wills AJ, Jenkins IH, Thompson PD, Findley LJ, Brooks DJ. Red nuclear and cerebellar but no olivary activation associated with essential tremor: a positron emission tomographic study. Ann Neurol. 1994;36:636\u201342.","journal-title":"Ann Neurol"},{"key":"692_CR51","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/0140-6736(90)92489-5","volume":"336","author":"JG Colebatch","year":"1990","unstructured":"Colebatch JG, Findley LJ, Frackowiak RS, Marsden CD, Brooks DJ. Preliminary report: activation of the cerebellum in essential tremor. Lancet. 1990;336:1028\u201330.","journal-title":"Lancet"},{"key":"692_CR52","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(02)00966-7","volume":"333","author":"ED Louis","year":"2002","unstructured":"Louis ED, Shungu DC, Chan S, Mao X, Jurewicz EC, Watner D. Metabolic abnormality in the cerebellum in patients with essential tremor: a proton magnetic resonance spectroscopic imaging study. Neurosci Lett. 2002;333:17\u201320.","journal-title":"Neurosci Lett"},{"key":"692_CR53","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1212\/01.WNL.0000065885.15875.0D","volume":"60","author":"FL Pagan","year":"2003","unstructured":"Pagan FL, Butman JA, Dambrosia JM, Hallett M. Evaluation of essential tremor with multi-voxel magnetic resonance spectroscopy. Neurology. 2003;60:1344\u20137.","journal-title":"Neurology"},{"key":"692_CR54","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3174\/ajnr.A0744","volume":"29","author":"DH Shin","year":"2008","unstructured":"Shin DH, Han BS, Kim HS, Lee PH. Diffusion tensor imaging in patients with essential tremor. AJNR Am J Neuroradiol. 2008;29:151\u20133.","journal-title":"AJNR Am J Neuroradiol"},{"key":"692_CR55","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/hbm.21077","volume":"32","author":"JC Klein","year":"2011","unstructured":"Klein JC, Lorenz B, Kang JS, Baudrexel S, Seifried C, van de Loo S, et al. Diffusion tensor imaging of white matter involvement in essential tremor. Hum Brain Mapp. 2011;32:896\u2013904.","journal-title":"Hum Brain Mapp"},{"key":"692_CR56","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1212\/WNL.0b013e3181d5a460","volume":"74","author":"G Nicoletti","year":"2010","unstructured":"Nicoletti G, Manners D, Novellino F, Condino F, Malucelli E, Barbiroli B, et al. Diffusion tensor MRI changes in cerebellar structures of patients with familial essential tremor. Neurology. 2010;74:988\u201394.","journal-title":"Neurology"},{"key":"692_CR57","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jns.2009.08.037","volume":"287","author":"J Benito-Leon","year":"2009","unstructured":"Benito-Leon J, Alvarez-Linera J, Hernandez-Tamames JA, Alonso-Navarro H, Jimenez-Jimenez FJ, Louis ED. Brain structural changes in essential tremor: voxel-based morphometry at 3-Tesla. J Neurol Sci. 2009;287:138\u201342.","journal-title":"J Neurol Sci"},{"key":"692_CR58","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.3174\/ajnr.A1190","volume":"29","author":"A Quattrone","year":"2008","unstructured":"Quattrone A, Cerasa A, Messina D, Nicoletti G, Hagberg GE, Lemieux L, et al. Essential head tremor is associated with cerebellar vermis atrophy: a volumetric and voxel-based morphometry MR imaging study. Am J Neuroradiol. 2008;29:1692\u20137.","journal-title":"Am J Neuroradiol"},{"key":"692_CR59","doi-asserted-by":"crossref","first-page":"254","DOI":"10.5334\/tohm.229","volume":"4","author":"A Gironell","year":"2014","unstructured":"Gironell A. The GABA hypothesis in essential tremor: lights and shadows. Tremor Other Hyperkinet Mov. 2014;4:254. doi: 10.7916\/D8SF2T9C . eCollection 2014.","journal-title":"Tremor Other Hyperkinet Mov"},{"key":"692_CR60","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12311-014-0556-5","volume":"13","author":"ED Louis","year":"2014","unstructured":"Louis ED, Kuo SH, Vonsattel JP, Faust PL. Torpedo formation and Purkinje cell loss: modeling their relationship in cerebellar disease. Cerebellum. 2014;13:433\u20139.","journal-title":"Cerebellum"},{"key":"692_CR61","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.parkreldis.2014.08.014","volume":"20","author":"RJ Louis","year":"2014","unstructured":"Louis RJ, Lee M, Kuo SH, Vonsattel JP, Louis ED, Faust PL. Cellular density in the cerebellar molecular layer in essential tremor, spinocerebellar ataxia, and controls. Parkinsonism Relat Disord. 2014;20:1270\u20133.","journal-title":"Parkinsonism Relat Disord"},{"key":"692_CR62","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1001\/archneurol.2009.217","volume":"66","author":"ED Louis","year":"2009","unstructured":"Louis ED. Essential tremors: a family of neurodegenerative disorders? Arch Neurol. 2009;66:1202\u20138.","journal-title":"Arch Neurol"},{"key":"692_CR63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000356351","volume":"42","author":"ED Louis","year":"2014","unstructured":"Louis ED. \u2018Essential tremor\u2019 or \u2018the essential tremors\u2019: is this one disease or a family of diseases? Neuroepidemiology. 2014;42:81\u20139.","journal-title":"Neuroepidemiology"},{"key":"692_CR64","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1002\/mds.22755","volume":"24","author":"G Deuschl","year":"2009","unstructured":"Deuschl G, Elble R. Essential tremor\u2014neurodegenerative or nondegenerative disease towards a working definition of ET. Mov Disord. 2009;24:2033\u201341.","journal-title":"Mov Disord"},{"key":"692_CR65","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archneur.63.8.1189","volume":"63","author":"ED Louis","year":"2006","unstructured":"Louis ED, Vonsattel JP, Honig LS, Lawton A, Moskowitz C, Ford B, et al. Essential tremor associated with pathologic changes in the cerebellum. Arch Neurol. 2006;63:1189\u201393.","journal-title":"Arch Neurol"},{"key":"692_CR66","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5414\/NP300414","volume":"31","author":"ED Louis","year":"2012","unstructured":"Louis ED, Mazzoni P, Ma KJ, Moskowitz CB, Lawton A, Garber A, et al. Essential tremor with ubiquitinated intranuclear inclusions and cerebellar degeneration. Clin Neuropathol. 2012;31:119\u201326.","journal-title":"Clin Neuropathol"},{"issue":"Suppl 3","key":"692_CR67","first-page":"35","volume":"13","author":"RJ Elble","year":"1998","unstructured":"Elble RJ. Animal models of action tremor. Mov Disord. 1998;13 Suppl 3:35\u20139.","journal-title":"Mov Disord"},{"key":"692_CR68","doi-asserted-by":"crossref","unstructured":"Testa CM. Key issues in essential tremor genetics research: where are we now and how can we move forward? Tremor Other Hyperkinet Mov (N Y) 2013;3. pii: tre-03-105-1843-1.","DOI":"10.5334\/tohm.160"},{"key":"692_CR69","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1468-1331.2008.02226.x","volume":"15","author":"EK Tan","year":"2008","unstructured":"Tan EK, Schapira AH. Hunting for genes in essential tremor. Eur J Neurol. 2008;15:889\u201390.","journal-title":"Eur J Neurol"},{"key":"692_CR70","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/brain\/awr301","volume":"135","author":"S Paris-Robidas","year":"2012","unstructured":"Paris-Robidas S, Brochu E, Sintes M, Emond V, Bousquet M, Vandal M, et al. Defective dentate nucleus GABA receptors in essential tremor. Brain. 2012;135:105\u201316.","journal-title":"Brain"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-015-0692-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12311-015-0692-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-015-0692-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T08:15:06Z","timestamp":1599207306000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12311-015-0692-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,1]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["692"],"URL":"https:\/\/doi.org\/10.1007\/s12311-015-0692-6","relation":{},"ISSN":["1473-4222","1473-4230"],"issn-type":[{"value":"1473-4222","type":"print"},{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,1]]}}}