{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:05:10Z","timestamp":1774616710100,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NINDS #R01 NS088257"],"award-info":[{"award-number":["NINDS #R01 NS088257"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s12311-015-0742-0","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T08:46:01Z","timestamp":1447404361000},"page":"726-731","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mapping Purkinje Cell Placement Along the Purkinje Cell Layer: an Analysis of Postmortem Tissue from Essential Tremor Patients vs. Controls"],"prefix":"10.1007","volume":"15","author":[{"given":"Elan D.","family":"Louis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Rabinowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Choe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Tate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey C.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Han","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis L.","family":"Faust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,13]]},"reference":[{"key":"742_CR1","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1136\/jnnp.2005.086579","volume":"77","author":"JD Putzke","year":"2006","unstructured":"Putzke JD, Whaley NR, Baba Y, Wszolek ZK, Uitti RJ. Essential tremor: predictors of disease progression in a clinical cohort. J Neurol Neurosurg Psychiatry. 2006;77:1235\u20137.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"742_CR2","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1136\/jnnp.2010.229740","volume":"82","author":"ED Louis","year":"2011","unstructured":"Louis ED, Agnew A, Gillman A, Gerbin M, Viner AS. Estimating annual rate of decline: prospective, longitudinal data on arm tremor severity in two groups of essential tremor cases. J Neurol Neurosurg Psychiatry. 2011;82:761\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"742_CR3","doi-asserted-by":"crossref","unstructured":"Bares M, Husarova I, Lungu OV. Essential tremor, the cerebellum, and motor timing: towards integrating them into one complex entity. Tremor Other Hyperkinet Mov (N Y) 2012;2.","DOI":"10.5334\/tohm.121"},{"key":"742_CR4","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1002\/mds.25645","volume":"28","author":"G Grimaldi","year":"2013","unstructured":"Grimaldi G, Manto M. Is essential tremor a Purkinjopathy? The role of the cerebellar cortex in its pathogenesis. Mov Disord. 2013;28:1759\u201361.","journal-title":"Mov Disord"},{"key":"742_CR5","doi-asserted-by":"crossref","unstructured":"Passamonti L, Cerasa A, Quattrone A. Neuroimaging of essential tremor: what is the evidence for cerebellar involvement? Tremor Other Hyperkinet Mov (N Y) 2012;2.","DOI":"10.5334\/tohm.105"},{"key":"742_CR6","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1093\/brain\/awt238","volume":"136","author":"R Babij","year":"2013","unstructured":"Babij R, Lee M, Cortes E, Vonsattel JP, Faust PL, Louis ED. Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains. Brain. 2013;136:3051\u201361.","journal-title":"Brain"},{"key":"742_CR7","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1093\/brain\/awu314","volume":"137","author":"ED Louis","year":"2014","unstructured":"Louis ED, Lee M, Babij R, Ma K, Cortes E, Vonsattel JP, et al. Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor. Brain. 2014;137:3142\u20138.","journal-title":"Brain"},{"key":"742_CR8","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/NEN.0b013e3181d1ad04","volume":"69","author":"CR Erickson-Davis","year":"2010","unstructured":"Erickson-Davis CR, Faust PL, Vonsattel JP, Gupta S, Honig LS, Louis ED. \u201cHairy baskets\u201d associated with degenerative Purkinje cell changes in essential tremor. J Neuropathol Exp Neurol. 2010;69:262\u201371.","journal-title":"J Neuropathol Exp Neurol"},{"key":"742_CR9","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1093\/brain\/awu281","volume":"137","author":"CY Lin","year":"2014","unstructured":"Lin CY, Louis ED, Faust PL, Koeppen AH, Vonsattel JP, Kuo SH. Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum. Brain. 2014;137:3149\u201359.","journal-title":"Brain"},{"key":"742_CR10","doi-asserted-by":"crossref","unstructured":"Louis ED. Essential tremor: a common disorder of Purkinje neurons? Neuroscientist. 2015 Jun 4.","DOI":"10.1177\/1073858415590351"},{"key":"742_CR11","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1093\/brain\/awm266","volume":"130","author":"ED Louis","year":"2007","unstructured":"Louis ED, Faust PL, Vonsattel JP, Honig LS, Rajput A, Robinson CA, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain. 2007;130:3297\u2013307.","journal-title":"Brain"},{"key":"742_CR12","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1002\/mds.25629","volume":"28","author":"ED Louis","year":"2013","unstructured":"Louis ED, Babij R, Lee M, Cortes E, Vonsattel JP. Quantification of cerebellar hemispheric Purkinje cell linear density: 32 ET cases versus 16 controls. Mov Disord. 2013;28:1854\u20139.","journal-title":"Mov Disord"},{"key":"742_CR13","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/mds.25845","volume":"29","author":"C Symanski","year":"2014","unstructured":"Symanski C, Shill HA, Dugger B, Hentz JG, Adler CH, Jacobson SA, et al. Essential tremor is not associated with cerebellar Purkinje cell loss. Mov Disord. 2014;29:496\u2013500.","journal-title":"Mov Disord"},{"key":"742_CR14","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.parkreldis.2012.01.013","volume":"18","author":"AH Rajput","year":"2012","unstructured":"Rajput AH, Robinson CA, Rajput ML, Robinson SL, Rajput A. Essential tremor is not dependent upon cerebellar Purkinje cell loss. Parkinsonism Relat Disord. 2012;18:626\u20138.","journal-title":"Parkinsonism Relat Disord"},{"key":"742_CR15","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/mds.25852","volume":"29","author":"KA Jellinger","year":"2014","unstructured":"Jellinger KA. Is there cerebellar pathology in essential tremor? Mov Disord. 2014;29:435\u20136.","journal-title":"Mov Disord"},{"key":"742_CR16","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.parkreldis.2012.06.017","volume":"18","author":"ED Louis","year":"2012","unstructured":"Louis ED, Faust PL, Vonsattel JP. Purkinje cell loss is a characteristic of essential tremor: towards a more mature understanding of pathogenesis. Parkinsonism Relat Disord. 2012;18:1003\u20134.","journal-title":"Parkinsonism Relat Disord"},{"key":"742_CR17","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s12311-014-0556-5","volume":"14","author":"ED Louis","year":"2014","unstructured":"Louis ED, Kuo SH, Vonsattel JP, Faust PL. Torpedo formation and Purkinje cell loss: modeling their relationship in cerebellar disease. Cerebellum. 2014;14:433\u20139.","journal-title":"Cerebellum"},{"key":"742_CR18","doi-asserted-by":"crossref","unstructured":"Choe M, Cort\u00e9s E, Vonsattel JPG, Kuo SH, Faust PL, Louis ED. Purkinje cell loss in essential tremor: random sampling quantification and nearest neighbor analysis. Mov Disord. 2015;in press.","DOI":"10.1002\/mds.26490"},{"key":"742_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22275","author":"KR Hamling","year":"2015","unstructured":"Hamling KR, Tobias ZJ, Weissman TA. Mapping the development of cerebellar Purkinje cells in zebrafish. Dev Neurobiol. 2015. doi: 10.1002\/dneu.22275 .","journal-title":"Dev Neurobiol"},{"key":"742_CR20","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/j.1530-0277.2001.tb02203.x","volume":"25","author":"JW Harasymiw","year":"2001","unstructured":"Harasymiw JW, Bean P. Identification of heavy drinkers by using the early detection of alcohol consumption score. Alcohol Clin Exp Res. 2001;25:228\u201335.","journal-title":"Alcohol Clin Exp Res"},{"key":"742_CR21","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuroimage.2008.08.039","volume":"44","author":"CJ Stoodley","year":"2009","unstructured":"Stoodley CJ, Schmahmann JD. Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage. 2009;44:489\u2013501.","journal-title":"Neuroimage"},{"key":"742_CR22","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1007\/s12311-011-0291-0","volume":"10","author":"ED Louis","year":"2011","unstructured":"Louis ED, Faust PL, Ma KJ, Yu M, Cortes E, Vonsattel JPG. Torpedoes in the cerebellar vermis in essential tremor cases vs. controls. Cerebellum. 2011;10:812\u20139.","journal-title":"Cerebellum"},{"key":"742_CR23","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1365-2990.1975.tb00652.x","volume":"1","author":"TCMA Hall","year":"1975","unstructured":"Hall TCMA, Corsellis JAN. Variations in the human Purkinje cell population according to age and sex. Neuropathol Appl Neurobiol. 1975;1:267\u201392.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"742_CR24","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrn3886","volume":"16","author":"NL Cerminara","year":"2015","unstructured":"Cerminara NL, Lang EJ, Sillitoe RV, Apps R. Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits. Nat Rev Neurosci. 2015;16:79\u201393.","journal-title":"Nat Rev Neurosci"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-015-0742-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12311-015-0742-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-015-0742-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-015-0742-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T09:46:38Z","timestamp":1599817598000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12311-015-0742-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,13]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["742"],"URL":"https:\/\/doi.org\/10.1007\/s12311-015-0742-0","relation":{},"ISSN":["1473-4222","1473-4230"],"issn-type":[{"value":"1473-4222","type":"print"},{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,13]]},"assertion":[{"value":"13 November 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}