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Our recent study in drug-naive children with TS and OCD provided evidence of cerebellar involvement in both disorders. In addition, cerebellar functional connectivity (FC) was similar in TS patients without comorbidities (TSpure) and TS patients with OCD comorbidity (TS\u2009+\u2009OCD), but differed in pure OCD patients. To investigate in detail the cerebellar involvement in the pathophysiology of TS and OCD, we explored cerebellar structural and functional abnormalities in drug-naive children with TSpure, TS\u2009+\u2009OCD, and OCD and assessed possible correlations with severity scores. We examined 53 drug-naive children, classified as TSpure (<jats:italic>n<\/jats:italic>\u2009=\u200916), TS\u2009+\u2009OCD (<jats:italic>n<\/jats:italic>\u2009=\u200914), OCD (<jats:italic>n<\/jats:italic>\u2009=\u200911), or controls (<jats:italic>n<\/jats:italic>\u2009=\u200912). All subjects underwent a multimodal 3T magnetic resonance imaging examination. Cerebellar lobular volumes and quantitative diffusion tensor imaging parameters of cerebellar peduncles were used as measures of structural integrity. The dentate nucleus was selected as a region of interest to examine cerebello-cerebral functional connectivity alterations. Structural analysis revealed that both TSpure and TS\u2009+\u2009OCD patients had higher fractional anisotropy in cerebellar peduncles than controls. Conversely, OCD patients were characterized by lower fractional anisotropy than both controls and TSpure and TS\u2009+\u2009OCD patients. Lastly, cerebellar functional connectivity analysis revealed significant alterations in the cerebello-thalamo-cortical circuit in TSpure, TS\u2009+\u2009OCD, and OCD patients. Early cerebellar structural and functional changes in drug-naive pediatric TSpure, TS\u2009+\u2009OCD, and OCD patients support a primary role of the cerebellum in the pathophysiology of these disorders.<\/jats:p>","DOI":"10.1007\/s12311-021-01327-7","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T23:10:28Z","timestamp":1633043428000},"page":"867-878","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Cerebellum in Drug-naive Children with Tourette Syndrome and Obsessive\u2013Compulsive Disorder"],"prefix":"10.1007","volume":"21","author":[{"given":"Sankalp","family":"Tikoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Suppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Tommasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Giann\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Conte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Mirabella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Pantano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"1327_CR1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013","unstructured":"American Psychiatric Association. 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