{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:27:31Z","timestamp":1768678051041,"version":"3.49.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nDepressive state is a common complication of spinocerebellar ataxia type 3 (SCA3). To the best of our knowledge, cases of SCA3 presenting with cenesthopathy have not been described. Here, we present a case of a severe depressive state with cenesthopathy and delusion in a young Japanese man with SCA3. A 43-year-old Japanese man with SCA3 developed a severe depressive state with associated cenesthopathy and delusion. He was treated with escitalopram (10\u00a0mg\/day) and olanzapine (2.5\u00a0mg\/day). Computed tomography showed atrophy of the cerebellum, bilateral superior cerebellar peduncle, and tegmentum of the pons. Single-photon emission computed tomography demonstrated reduced blood flow in the cerebellum, vermis, and brainstem. After 8\u00a0weeks, his depressive state and delusion improved; however, his cenesthopathy persisted. We encountered a case of a severe depressive state with cenesthopathy and delusion in a young Japanese man with SCA3. This case supports previous studies that the cerebellum could have a role beyond motor functions.<\/jats:p>","DOI":"10.1007\/s12311-021-01338-4","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T14:02:58Z","timestamp":1635343378000},"page":"1135-1138","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Young Japanese Patient with Spinocerebellar Ataxia Type 3 Presenting Depressive State with Cenesthopathy and Delusion: a Case Report"],"prefix":"10.1007","volume":"21","author":[{"given":"Naomichi","family":"Okamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-4608","authenticated-orcid":false,"given":"Atsuko","family":"Ikenouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Ide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiji","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"1338_CR1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s12311-015-0716-2","volume":"15","author":"P Braga-Neto","year":"2016","unstructured":"Braga-Neto P, Pedroso JL, Gadelha A, Laureano MR, de Souza Noto C, Garrido GJ, et al. Psychosis in Machado-Joseph disease: clinical correlates, pathophysiological discussion, and functional brain imaging. Expanding the Cerebellar Cognitive Affective Syndrome. Cerebellum. 2016;15:483\u201390.","journal-title":"Cerebellum"},{"key":"1338_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.parkreldis.2015.11.021","volume":"22","author":"RY Lo","year":"2016","unstructured":"Lo RY, Figueroa KP, Pulst SM, Perlman S, Wilmot G, Gomez C, et al. Depression and clinical progression in spinocerebellar ataxias. Parkinsonism Relat Disord. 2016;22:87\u201392.","journal-title":"Parkinsonism Relat Disord"},{"key":"1338_CR3","first-page":"19","volume":"10","author":"CR Cecchin","year":"2007","unstructured":"Cecchin CR, Pires AP, Rieder CR, Monte TL, Silveira I, Carvalho T, et al. Depressive symptoms in Machado-Joseph disease (SCA3) patients and their relatives. Community Genet. 2007;10:19\u201326.","journal-title":"Community Genet"},{"key":"1338_CR4","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/brain\/121.4.561","volume":"121","author":"JD Schmahmann","year":"1998","unstructured":"Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998;121:561\u201379.","journal-title":"Brain"},{"key":"1338_CR5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1159\/000486204","volume":"51","author":"N Jimeno","year":"2018","unstructured":"Jimeno N, Vargas ML. Cenesthopathy and subjective cognitive complaints: an exploratory study in schizophrenia. Psychopathology. 2018;51:47\u201356.","journal-title":"Psychopathology"},{"key":"1338_CR6","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1176\/appi.ajp.2018.18040429","volume":"176","author":"RO Brady","year":"2019","unstructured":"Brady RO, Gonsalvez I, Lee I, \u00d6ng\u00fcr D, Seidman LJ, Schmahmann JD, et al. Cerebellar-prefrontal network connectivity and negative symptoms in schizophrenia. Am J Psychiatry. 2019;176:512\u201320.","journal-title":"Am J Psychiatry"},{"key":"1338_CR7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s12311-017-0882-5","volume":"17","author":"KW Turk","year":"2018","unstructured":"Turk KW, Flanagan ME, Josephson S, Keene CD, Jayadev S, Bird TD. Psychosis in spinocerebellar ataxias: a case series and study of tyrosine hydroxylase in substantia nigra. Cerebellum. 2018;17:143\u201351.","journal-title":"Cerebellum"},{"key":"1338_CR8","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1001\/archneur.1991.00530230086029","volume":"48","author":"JD Schmahmann","year":"1991","unstructured":"Schmahmann JD. An emerging concept: the cerebellar contribution to higher function. Arch Neurol. 1991;48:1178\u201387.","journal-title":"Arch Neurol"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-021-01338-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12311-021-01338-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-021-01338-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T18:22:48Z","timestamp":1666722168000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12311-021-01338-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,27]]},"references-count":8,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1338"],"URL":"https:\/\/doi.org\/10.1007\/s12311-021-01338-4","relation":{},"ISSN":["1473-4230"],"issn-type":[{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,27]]},"assertion":[{"value":"20 October 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All of the actions described in this study have been conducted in accordance with ethical guidelines. Informed consent was obtained from the patient for the publication of his anonymous information in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}