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Since then, modulation of the activity of cerebellar neurons by the monoamine systems has been studied extensively, as well as their reorganization and modifications during development, plasticity, and disease. The discovery of noradrenergic and serotoninergic innervation of the cerebellum has been a crucial step in understanding the neurochemical relationships between brainstem nuclei and the cerebellum, and the attempts to treat cerebellar ataxias pharmacologically. The large neurochemical repertoire of the cerebellum represents one of the complexities and challenges in the modern appraisal of cerebellar disorders.<\/jats:p>","DOI":"10.1007\/s12311-022-01480-7","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T09:02:58Z","timestamp":1663923778000},"page":"1045-1051","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Discovery of the Monoaminergic Innervation of the Cerebellum: Convergence of Divergent and Point-to-Point Systems"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6544-5738","authenticated-orcid":false,"given":"Lazaros C.","family":"Triarhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6034-4380","authenticated-orcid":false,"given":"Mario","family":"Manto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"1480_CR1","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1073\/pnas.83.4.1135","volume":"83","author":"C Sotelo","year":"1986","unstructured":"Sotelo C, Alvarado-Mallart RM. 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