{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:41:19Z","timestamp":1781091679993,"version":"3.54.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002911","name":"Universidad Complutense de Madrid","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with cognitive deficits have a prolonged latency and reduced amplitude of the P300 wave. However, no study has correlated P300 wave alterations with the cognitive performance of patients with cerebellar lesions. We aimed to determine if the cognitive status of these patients was associated with P300 wave alterations. We recruited 30 patients with cerebellar lesions from the wards of the N.R.S. Medical College, Kolkata, in West Bengal (India). The Kolkata Cognitive Screening Battery tasks and the Frontal Assessment Battery (FAB)\u00a0were used to assess the cognitive status and the International Cooperative Ataxia Rating Scale (ICARS)\u00a0for cerebellar signs. We compared the results with the normative data of the Indian population. Patients had P300 wave alterations with a significant increase in latency and a non-significant trend in amplitude. In a multivariate model, P300 wave latency was positively associated with the ICARS kinetic subscale (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005) and age (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009), regardless of sex and years of education. In the model that included cognitive variables, P300 wave latency was negatively associated with performance in phonemic fluency (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035) and construction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009). Furthermore, P300 wave amplitude was positively associated with the FAB total score (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In closing,\u00a0patients with cerebellar lesions had an increase in latency and a decrease in the amplitude of the P300 wave. These P300 wave alterations were also associated with worse cognitive performance and some of the subscales of the\u00a0ICARS, reinforcing that the cerebellum has motor, cognitive, and affective functions.\n                  <\/jats:p>","DOI":"10.1007\/s12311-023-01570-0","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T06:02:27Z","timestamp":1685080947000},"page":"1304-1312","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions"],"prefix":"10.1007","volume":"23","author":[{"given":"Sourav","family":"Nanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Lape\u00f1a-Motilva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar Kumar","family":"Misra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Guha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinjan","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumit","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Benito-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"1570_CR1","doi-asserted-by":"crossref","unstructured":"Mesulam M. 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The study was conducted following the principles of the Helsinki Declaration of 1975 and was approved by the ethical standards committee on human experimentation at NRS Medical College, Kolkata, in West Bengal (India).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Sourav Nanda (drsouravnanda@gmail.com) reports no relevant disclosures.Jos\u00e9 Lape\u00f1a-Motilva (joselapemo@gmail.com) reports no relevant disclosures.Amar Kumar Misra (drakm62@gmail.com) reports no relevant disclosures.Gautam Guha (drgguha@gmail.com) reports no relevant disclosures.Sinjan Ghosh (drsinjan@gmail.com) reports no relevant disclosures.Akash Manna (akashmanna756@gmail.com) reports no relevant disclosures.Soumit Roy (soroy746@gmail.com) reports no relevant disclosures.Juli\u00e1n Benito-Le\u00f3n (jbenitol67@gmail.com) reports no relevant disclosures.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}