{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:07:38Z","timestamp":1793502458480,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"DOI":"10.1007\/s12311-023-01631-4","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T08:01:35Z","timestamp":1699603295000},"page":"1204-1210","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["\u201cHot Cross Bun\u201d Sign in a Patient with Glutamic Acid Decarboxylase 65-KDa Isoform Associated Cerebellar Ataxia: Case Report and Review of the Literature"],"prefix":"10.1007","volume":"23","author":[{"given":"Ruo-Nan","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Zhen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"1631_CR1","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1148\/radiol.2452041856","volume":"245","author":"A Shrivastava","year":"2007","unstructured":"Shrivastava A. The hot cross bun sign. Radiology. 2007;245:606\u20137. https:\/\/doi.org\/10.1148\/radiol.2452041856.","journal-title":"Radiology."},{"key":"1631_CR2","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1468-1331.2008.02524.x","volume":"16","author":"YC Lee","year":"2009","unstructured":"Lee YC, Liu CS, Wu HM, Wang PS, Chang MH, Soong BW. The \u2018hot cross bun\u2019 sign in the patients with spinocerebellar ataxia. Eur J Neurol. 2009;16:513\u20136. https:\/\/doi.org\/10.1111\/j.1468-1331.2008.02524.x.","journal-title":"Eur J Neurol."},{"key":"1631_CR3","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00415-002-0734-0","volume":"249","author":"Y Horimoto","year":"2002","unstructured":"Horimoto Y, Aiba I, Yasuda T, Ohkawa Y, Katayama T, Yokokawa Y, Goto A, Ito Y. Longitudinal MRI study of multiple system atrophy - when do the findings appear, and what is the course? J Neurol. 2002;249:847\u201354. https:\/\/doi.org\/10.1007\/s00415-002-0734-0.","journal-title":"J Neurol."},{"key":"1631_CR4","doi-asserted-by":"publisher","first-page":"592212","DOI":"10.3389\/fnagi.2020.592212","volume":"12","author":"S Zhu","year":"2020","unstructured":"Zhu S, Li H, Deng B, Zheng J, Huang Z, Chang Z, Huang Y, Wen Z, Liang Y, Yu M, Chan LL, Tan EK, Wang Q. Various diseases and clinical heterogeneity are associated with \u201chot cross bun\u201d. Front Aging Neurosci. 2020;12:592212. https:\/\/doi.org\/10.3389\/fnagi.2020.592212.","journal-title":"Front Aging Neurosci."},{"key":"1631_CR5","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1002\/mdc3.13596","volume":"9","author":"S Prasad","year":"2022","unstructured":"Prasad S, Rossi M. The hot cross bun sign: a journey across etiologies. Mov Disord Clin Pract. 2022;9:1018\u201320. https:\/\/doi.org\/10.1002\/mdc3.13596.","journal-title":"Mov Disord Clin Pract."},{"key":"1631_CR6","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1136\/jnnp-2020-325275","volume":"92","author":"A Budhram","year":"2021","unstructured":"Budhram A, Sechi E, Flanagan EP, Dubey D, Zekeridou A, Shah SS, Gadoth A, Naddaf E, McKeon A, Pittock SJ, Zalewski NL. Clinical spectrum of high-titre GAD65 antibodies. J Neurol Neurosurg Psychiatry. 2021;92:645\u201354. https:\/\/doi.org\/10.1136\/jnnp-2020-325275.","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"1631_CR7","doi-asserted-by":"publisher","first-page":"990553","DOI":"10.3389\/fneur.2022.990553","volume":"13","author":"L Bai","year":"2022","unstructured":"Bai L, Ren H, Liang M, Lu Q, Lin N, Liu M, Fan S, Cui R, Guan H. Neurological disorders associated with glutamic acid decarboxylase 65 antibodies: clinical spectrum and prognosis of a cohort from China. Front Neurol. 2022;13:990553. https:\/\/doi.org\/10.3389\/fneur.2022.990553.","journal-title":"Front Neurol."},{"key":"1631_CR8","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.mayocp.2021.11.024","volume":"97","author":"M Majed","year":"2022","unstructured":"Majed M, Madhavan AA, Pittock SJ, Dubey D. \u201cHot cross bun\u201d sign in a patient with Kelch-like protein 11 rhombencephalitis. Mayo Clin Proc. 2022;97:122\u20133. https:\/\/doi.org\/10.1016\/j.mayocp.2021.11.024.","journal-title":"Mayo Clin Proc."},{"key":"1631_CR9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1001\/jamaneurol.2022.4663","volume":"80","author":"Y Liu","year":"2023","unstructured":"Liu Y, Huang D, Wu L. Occult breast cancer with anti-ri antibody positivity and pontine hot cross bun sign. JAMA Neurol. 2023;80:207\u20138. https:\/\/doi.org\/10.1001\/jamaneurol.2022.4663.","journal-title":"JAMA Neurol."},{"key":"1631_CR10","doi-asserted-by":"publisher","first-page":"979203","DOI":"10.3389\/fneur.2022.979203","volume":"13","author":"M Liu","year":"2022","unstructured":"Liu M, Ren H, Lin N, Tan Y, Fan S, Guan H. The \u201chot cross bun sign\u201d in patients with autoimmune cerebellar ataxia: a case report and literature review. Front Neurol. 2022;13:979203. https:\/\/doi.org\/10.3389\/fneur.2022.979203.","journal-title":"Front Neurol."},{"key":"1631_CR11","doi-asserted-by":"publisher","unstructured":"Liu M, Ren H, Fan S, Zhang W, Xu Y, Zhao W, Guan H, Encephalitis CG. Neurological autoimmunity associated with Homer-3 antibody: a case series from China. Neurol Neuroimmunol Neuroinflamm. 2021:8. https:\/\/doi.org\/10.1212\/NXI.0000000000001077.","DOI":"10.1212\/NXI.0000000000001077"},{"key":"1631_CR12","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1111\/ene.15120","volume":"28","author":"H Ishikawa","year":"2021","unstructured":"Ishikawa H, Mandel-Brehm C, Shindo A, Cady MA, Mann SA, Niwa A, Miyashita K, Ii Y, Zorn KC, Taniguchi A, Maeda M, Wilson MR, DeRisi JL, Tomimoto H. Long-term MRI changes in a patient with Kelch-like protein 11-associated paraneoplastic neurological syndrome. Eur J Neurol. 2021;28:4261\u20136. https:\/\/doi.org\/10.1111\/ene.15120.","journal-title":"Eur J Neurol."},{"key":"1631_CR13","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/ane.12469","volume":"133","author":"H Ishikawa","year":"2016","unstructured":"Ishikawa H, Kawada N, Taniguchi A, Odachi K, Mizutani A, Asahi M, Tomimoto H. Paraneoplastic neurological syndrome due to burned-out testicular tumor showing hot cross-bun sign. Acta Neurol Scand. 2016;133:398\u2013402. https:\/\/doi.org\/10.1111\/ane.12469.","journal-title":"Acta Neurol Scand."},{"key":"1631_CR14","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jocn.2020.04.052","volume":"76","author":"E Schlapakow","year":"2020","unstructured":"Schlapakow E, Keil VC, Paus M, Kornblum C, Hattingen E, Klockgether T. Multiple system atrophy mimicry in MRI: watch out for paraneoplastic rhombencephalitis. J Clin Neurosci. 2020;76:238\u201340. https:\/\/doi.org\/10.1016\/j.jocn.2020.04.052.","journal-title":"J Clin Neurosci."},{"key":"1631_CR15","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/s1474-4422(15)00401-9","volume":"15","author":"F Graus","year":"2016","unstructured":"Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, Cortese I, Dale RC, Gelfand JM, Geschwind M, Glaser CA, Honnorat J, H\u00f6ftberger R, Iizuka T, Irani SR, Lancaster E, Leypoldt F, Pr\u00fcss H, Rae-Grant A, et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 2016;15:391\u2013404. https:\/\/doi.org\/10.1016\/s1474-4422(15)00401-9.","journal-title":"Lancet Neurol."},{"key":"1631_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/mus.25565","volume":"56","author":"A McKeon","year":"2017","unstructured":"McKeon A, Tracy JA. GAD65 neurological autoimmunity. Muscle Nerve. 2017;56:15\u201327. https:\/\/doi.org\/10.1002\/mus.25565.","journal-title":"Muscle Nerve"},{"key":"1631_CR17","doi-asserted-by":"publisher","first-page":"46","DOI":"10.2169\/internalmedicine.46.0514","volume":"2007","author":"M Takao","year":"1883","unstructured":"Takao M, Kadowaki T, Tomita Y, Yoshida Y, Mihara B. \u2018Hot-cross bun sign\u2019 of multiple system atrophy. Intern Med. 1883;2007:46. https:\/\/doi.org\/10.2169\/internalmedicine.46.0514.","journal-title":"Intern Med."},{"key":"1631_CR18","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1001\/jamaneurol.2020.2231","volume":"77","author":"D Dubey","year":"2020","unstructured":"Dubey D, Wilson MR, Clarkson B, Giannini C, Gandhi M, Cheville J, Lennon VA, Eggers S, Devine MF, Mandel-Brehm C, Kryzer T, Hinson SR, Khazaie K, Hales C, Kattah J, Pavelko KD, Andrews P, Eaton JE, Jitprapaikulsan J, et al. Expanded clinical phenotype, oncological associations, and immunopathologic insights of paraneoplastic Kelch-like protein-11 encephalitis. JAMA Neurol. 2020;77:1420\u20139. https:\/\/doi.org\/10.1001\/jamaneurol.2020.2231.","journal-title":"JAMA Neurol."},{"key":"1631_CR19","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1056\/NEJMra1708712","volume":"378","author":"J Dalmau","year":"2018","unstructured":"Dalmau J, Graus F. Antibody-mediated encephalitis. N Engl J Med. 2018;378:840\u201351. https:\/\/doi.org\/10.1056\/NEJMra1708712.","journal-title":"N Engl J Med."},{"key":"1631_CR20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.14802\/jmd.13009","volume":"6","author":"SYR H-sJ","year":"2013","unstructured":"H-sJ SYR, Kim YH. Hot cross bun sign following bilateral pontine infarction: a case report. Journal of. Mov Disord. 2013;6:37\u20139.","journal-title":"Mov Disord."},{"key":"1631_CR21","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1002\/acn3.51486","volume":"8","author":"A Dik","year":"2021","unstructured":"Dik A, Widman G, Schulte-Mecklenbeck A, Witt JA, Pitsch J, Golombeck KS, Wagner J, Gallus M, Strippel C, Hansen N, Monig C, Rauber S, Wiendl H, Elger CE, Surges R, Meuth SG, Helmstaedter C, Gross CC, Becker AJ, Melzer N. Impact of T cells on neurodegeneration in anti-GAD65 limbic encephalitis. Ann Clin Transl Neurol. 2021;8:2289\u2013301. https:\/\/doi.org\/10.1002\/acn3.51486.","journal-title":"Ann Clin Transl Neurol"},{"key":"1631_CR22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12883-020-01738-9","volume":"20","author":"A Sugiyama","year":"2020","unstructured":"Sugiyama A, Yokota H, Yamanaka Y, Mukai H, Yamamoto T, Hirano S, Koide K, Ito S, Kuwabara S. Vertical pons hyperintensity and hot cross bun sign in cerebellar-type multiple system atrophy and spinocerebellar ataxia type 3. BMC Neurol. 2020;20:157. https:\/\/doi.org\/10.1186\/s12883-020-01738-9.","journal-title":"BMC Neurol."},{"key":"1631_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41531-021-00159-w","volume":"7","author":"S Zhu","year":"2021","unstructured":"Zhu S, Deng B, Huang Z, Chang Z, Li H, Liu H, Huang Y, Pan Y, Wang Y, Chao YX, Chan LL, Wu YR, Tan EK, Wang Q. \u201cHot cross bun\u201d is a potential imaging marker for the severity of cerebellar ataxia in MSA-C. NPJ Parkinsons Dis. 2021;7:15. https:\/\/doi.org\/10.1038\/s41531-021-00159-w.","journal-title":"NPJ Parkinsons Dis."}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-023-01631-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12311-023-01631-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-023-01631-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T08:19:09Z","timestamp":1716020349000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12311-023-01631-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,10]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["1631"],"URL":"https:\/\/doi.org\/10.1007\/s12311-023-01631-4","relation":{},"ISSN":["1473-4230"],"issn-type":[{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,10]]},"assertion":[{"value":"31 October 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The patient gave written informed consent for publication of medical information and images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"None to declare","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}