{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:35:08Z","timestamp":1789029308084,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"DIUMCE","award":["20-2022-FGI"],"award-info":[{"award-number":["20-2022-FGI"]}]},{"name":"DIUMCE","award":["20-2022-FGI"],"award-info":[{"award-number":["20-2022-FGI"]}]},{"name":"DIUMCE","award":["20-2022-FGI"],"award-info":[{"award-number":["20-2022-FGI"]}]},{"name":"DIUMCE","award":["20-2022-FGI"],"award-info":[{"award-number":["20-2022-FGI"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"DOI":"10.1007\/s12311-024-01748-0","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T01:01:59Z","timestamp":1729558919000},"page":"2487-2496","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Potentiation of Motor Adaptation Via Cerebellar tACS: Characterization of the Stimulation Frequency"],"prefix":"10.1007","volume":"23","author":[{"given":"Paulo","family":"Figueroa-Taiba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"\u00c1lvarez-Ruf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulette","family":"Ulloa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinidad","family":"Bruna-Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Espinoza-Maraboli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Ignacio","family":"Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J","family":"Mariman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"1748_CR1","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/81497","volume":"3","author":"DM Wolpert","year":"2000","unstructured":"Wolpert DM, Ghahramani Z. Computational principles of movement neuroscience. Nat Neurosci. 2000;3:1212\u20137.","journal-title":"Nat Neurosci"},{"issue":"9","key":"1748_CR2","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/S1364-6613(98)01221-2","volume":"2","author":"DM Wolpert","year":"1998","unstructured":"Wolpert DM, Miall RC, Kawato M. Internal models in the cerebellum. Trends Cogn Sci. 1998;2(9):338\u201347.","journal-title":"Trends Cogn Sci"},{"issue":"4","key":"1748_CR3","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/nrn2332","volume":"9","author":"M Ito","year":"2008","unstructured":"Ito M. Control of mental activities by internal models in the cerebellum. Nat Rev Neurosci. 2008;9(4):304\u201313.","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"1748_CR4","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/s12311-021-01281-4","volume":"21","author":"E Tzvi","year":"2022","unstructured":"Tzvi E, Loens S, Donchin O. Mini-review: the role of the Cerebellum in Visuomotor Adaptation. Cerebellum. 2022;21(2):306\u201313.","journal-title":"Cerebellum"},{"issue":"8","key":"1748_CR5","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1093\/cercor\/bhq246","volume":"21","author":"JM Galea","year":"2011","unstructured":"Galea JM, Vazquez A, Pasricha N, Orban De Xivry JJ, Celnik P. Dissociating the roles of the Cerebellum and Motor Cortex during adaptive learning: the Motor Cortex retains what the Cerebellum learns. Cereb Cortex. 2011;21(8):1761\u201370.","journal-title":"Cereb Cortex"},{"issue":"10","key":"1748_CR6","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1016\/j.neurobiolaging.2014.03.030","volume":"35","author":"RM Hardwick","year":"2014","unstructured":"Hardwick RM, Celnik PA. Cerebellar direct current stimulation enhances motor learning in older adults. Neurobiol Aging. 2014;35(10):2217\u201321.","journal-title":"Neurobiol Aging"},{"issue":"12","key":"1748_CR7","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/nrn3112","volume":"12","author":"DM Wolpert","year":"2011","unstructured":"Wolpert DM, Diedrichsen J, Flanagan JR. Principles of sensorimotor learning. Nat Rev Neurosci. 2011;12(12):739\u201351.","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"1748_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/35067550","volume":"2","author":"F Varela","year":"2001","unstructured":"Varela F, Lachaux JP, Rodriguez E, Martinerie J. The brainweb: phase synchronization and large-scale integration. Nat Rev Neurosci. 2001;2(4):229\u201339.","journal-title":"Nat Rev Neurosci"},{"issue":"49","key":"1748_CR9","doi-asserted-by":"publisher","first-page":"8472","DOI":"10.1523\/JNEUROSCI.2238-22.2023","volume":"43","author":"A Schwey","year":"2023","unstructured":"Schwey A, Battaglia D, Bahuguna J, Malfait N. Different faces of Medial Beta-Band Activity reflect distinct visuomotor feedback signals. J Neurosci. 2023;43(49):8472\u201386.","journal-title":"J Neurosci"},{"key":"1748_CR10","doi-asserted-by":"publisher","first-page":"1045940","DOI":"10.3389\/fnsys.2023.1045940","volume":"17","author":"JJ Mariman","year":"2023","unstructured":"Mariman JJ, Bruna-Melo T, Gutierrez-Rodriguez R, Maldonado PE, Burgos PI. Event-related (de)synchronization and potential in whole vs. part sensorimotor learning. Front Syst Neurosci. 2023;17:1045940.","journal-title":"Front Syst Neurosci"},{"key":"1748_CR11","doi-asserted-by":"crossref","unstructured":"Burgos PI, Mariman JJ, Makeig S, Rivera-Lillo G, Maldonado PE. Visuomotor coordination and cortical connectivity of modular motor learning. Hum Brain Mapp. 2018;(March):1\u201318.","DOI":"10.1002\/hbm.24215"},{"issue":"2","key":"1748_CR12","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.tics.2022.11.013","volume":"27","author":"M Wischnewski","year":"2023","unstructured":"Wischnewski M, Alekseichuk I, Opitz A. Neurocognitive, physiological, and biophysical effects of transcranial alternating current stimulation. Trends Cogn Sci. 2023;27(2):189\u2013205.","journal-title":"Trends Cogn Sci"},{"issue":"3","key":"1748_CR13","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.brs.2016.02.005","volume":"9","author":"A Naro","year":"2016","unstructured":"Naro A, Leo A, Russo M, Cannav\u00f2 A, Milardi D, Bramanti P, et al. Does Transcranial Alternating Current Stimulation Induce Cerebellum plasticity? Feasibility, Safety and Efficacy of a novel electrophysiological Approach. Brain Stimulat. 2016;9(3):388\u201395.","journal-title":"Brain Stimulat"},{"issue":"6","key":"1748_CR14","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1007\/s00429-016-1355-1","volume":"222","author":"A Naro","year":"2017","unstructured":"Naro A, Bramanti A, Leo A, Manuli A, Sciarrone F, Russo M, et al. Effects of cerebellar transcranial alternating current stimulation on motor cortex excitability and motor function. Brain Struct Funct. 2017;222(6):2891\u2013906.","journal-title":"Brain Struct Funct"},{"key":"1748_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.clinph.2023.12.129","volume":"158","author":"A Guerra","year":"2024","unstructured":"Guerra A, Paparella G, Passaretti M, Costa D, Birreci D, De Biase A, et al. Theta-tACS modulates cerebellar-related motor functions and cerebellar-cortical connectivity. Clin Neurophysiol. 2024;158:159\u201369.","journal-title":"Clin Neurophysiol"},{"key":"1748_CR16","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3389\/fnbeh.2018.00132","volume":"12","author":"S Miyaguchi","year":"2018","unstructured":"Miyaguchi S, Otsuru N, Kojima S, Saito K, Inukai Y, Masaki M, et al. Transcranial Alternating Current Stimulation with Gamma Oscillations over the Primary Motor Cortex and Cerebellar Hemisphere Improved Visuomotor performance. Front Behav Neurosci. 2018;12:132.","journal-title":"Front Behav Neurosci"},{"issue":"1","key":"1748_CR17","doi-asserted-by":"publisher","first-page":"11217","DOI":"10.1038\/s41598-020-68028-9","volume":"10","author":"MJ Wessel","year":"2020","unstructured":"Wessel MJ, Draaisma LR, De Boer AFW, Park C, hyun, Maceira-Elvira P, Durand-Ruel M, et al. Cerebellar transcranial alternating current stimulation in the gamma range applied during the acquisition of a novel motor skill. Sci Rep. 2020;10(1):11217.","journal-title":"Sci Rep"},{"issue":"6","key":"1748_CR18","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s12311-021-01255-6","volume":"20","author":"A Giustiniani","year":"2021","unstructured":"Giustiniani A, Tarantino V, Bracco M, Bonaventura RE, Oliveri M. Functional role of cerebellar Gamma frequency in motor sequences learning: a tACS study. Cerebellum. 2021;20(6):913\u201321.","journal-title":"Cerebellum"},{"issue":"1","key":"1748_CR19","doi-asserted-by":"publisher","first-page":"tgaa064","DOI":"10.1093\/texcom\/tgaa064","volume":"1","author":"G Mioni","year":"2020","unstructured":"Mioni G, Shelp A, Stanfield-Wiswell CT, Gladhill KA, Bader F, Wiener M. Modulation of individual alpha frequency with tACS shifts Time Perception. Cereb Cortex Commun. 2020;1(1):tgaa064.","journal-title":"Cereb Cortex Commun"},{"key":"1748_CR20","doi-asserted-by":"publisher","first-page":"147834","DOI":"10.1016\/j.brainres.2022.147834","volume":"1782","author":"SK Kemmerer","year":"2022","unstructured":"Kemmerer SK, Sack AT, De Graaf TA, Ten Oever S, De Weerd P, Schuhmann T. Frequency-specific transcranial neuromodulation of alpha power alters visuospatial attention performance. Brain Res. 2022;1782:147834.","journal-title":"Brain Res"},{"issue":"1","key":"1748_CR21","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s12311-021-01362-4","volume":"22","author":"MJ Wessel","year":"2022","unstructured":"Wessel MJ, Draaisma LR, Hummel FC. Mini-review: Transcranial Alternating Current Stimulation and the Cerebellum. Cerebellum. 2022;22(1):120\u20138.","journal-title":"Cerebellum"},{"issue":"1","key":"1748_CR22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1113\/jphysiol.1980.sp013357","volume":"305","author":"R Llin\u00e1s","year":"1980","unstructured":"Llin\u00e1s R, Sugimori M. Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J Physiol. 1980;305(1):171\u201395.","journal-title":"J Physiol"},{"issue":"3","key":"1748_CR23","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1109\/TNSRE.2014.2308997","volume":"22","author":"SM Rampersad","year":"2014","unstructured":"Rampersad SM, Janssen AM, Lucka F, Aydin U, Lanfer B, Lew S, et al. Simulating Transcranial Direct Current Stimulation with a detailed Anisotropic Human Head Model. IEEE Trans Neural Syst Rehabil Eng. 2014;22(3):441\u201352.","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"key":"1748_CR24","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.neures.2015.12.003","volume":"104","author":"T Ishikawa","year":"2016","unstructured":"Ishikawa T, Tomatsu S, Izawa J, Kakei S. The cerebro-cerebellum: could it be loci of forward models? Neurosci Res. 2016;104:72\u20139.","journal-title":"Neurosci Res"},{"key":"1748_CR25","doi-asserted-by":"publisher","first-page":"987472","DOI":"10.3389\/fnins.2022.987472","volume":"16","author":"R Herzog","year":"2022","unstructured":"Herzog R, Berger TM, Pauly MG, Xue H, Rueckert E, M\u00fcnchau A, et al. Cerebellar transcranial current stimulation \u2013 an intraindividual comparison of different techniques. Front Neurosci. 2022;16:987472.","journal-title":"Front Neurosci"},{"key":"1748_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.conb.2015.12.003","volume":"37","author":"DM Wolpert","year":"2016","unstructured":"Wolpert DM, Flanagan JR. Computations underlying sensorimotor learning. Curr Opin Neurobiol. 2016;37:7\u201311.","journal-title":"Curr Opin Neurobiol"},{"issue":"8","key":"1748_CR27","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.3390\/biomedicines11082218","volume":"11","author":"R Herzog","year":"2023","unstructured":"Herzog R, Bolte C, Radecke JO, Von M\u00f6ller K, Lencer R, Tzvi E, et al. Neuronavigated cerebellar 50 hz tACS: attenuation of Stimulation effects by Motor sequence learning. Biomedicines. 2023;11(8):2218.","journal-title":"Biomedicines"},{"issue":"5","key":"1748_CR28","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1152\/jn.1968.31.5.785","volume":"31","author":"WT Thach","year":"1968","unstructured":"Thach WT. Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movements in the monkey. J Neurophysiol. 1968;31(5):785\u201397.","journal-title":"J Neurophysiol"},{"issue":"12","key":"1748_CR29","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1038\/nn.3576","volume":"16","author":"TDB Nguyen-Vu","year":"2013","unstructured":"Nguyen-Vu TDB, Kimpo RR, Rinaldi JM, Kohli A, Zeng H, Deisseroth K, et al. Cerebellar Purkinje cell activity drives motor learning. Nat Neurosci. 2013;16(12):1734\u20136.","journal-title":"Nat Neurosci"},{"key":"1748_CR30","doi-asserted-by":"publisher","first-page":"118127","DOI":"10.1016\/j.neuroimage.2021.118127","volume":"237","author":"SE Paraskevopoulou","year":"2021","unstructured":"Paraskevopoulou SE, Coon WG, Brunner P, Miller KJ, Schalk G. Within-subject reaction time variability: role of cortical networks and underlying neurophysiological mechanisms. NeuroImage. 2021;237:118127.","journal-title":"NeuroImage"},{"issue":"1","key":"1748_CR31","doi-asserted-by":"publisher","first-page":"13465","DOI":"10.1038\/s41598-017-13766-6","volume":"7","author":"M Sartori","year":"2017","unstructured":"Sartori M, Yavuz U\u015e, Farina D. In vivo neuromechanics: Decoding Causal Motor Neuron Behavior with resulting Musculoskeletal function. Sci Rep. 2017;7(1):13465.","journal-title":"Sci Rep"},{"key":"1748_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.neulet.2018.11.015","volume":"694","author":"S Miyaguchi","year":"2019","unstructured":"Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, et al. Gamma tACS over M1 and cerebellar hemisphere improves motor performance in a phase-specific manner. Neurosci Lett. 2019;694:64\u20138.","journal-title":"Neurosci Lett"},{"key":"1748_CR33","doi-asserted-by":"publisher","first-page":"827353","DOI":"10.3389\/fnsys.2022.827353","volume":"16","author":"S Vogeti","year":"2022","unstructured":"Vogeti S, Boetzel C, Herrmann CS. Entrainment and spike-timing dependent plasticity \u2013 a review of proposed mechanisms of Transcranial Alternating Current Stimulation. Front Syst Neurosci. 2022;16:827353.","journal-title":"Front Syst Neurosci"},{"issue":"1","key":"1748_CR34","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1038\/s41467-021-23021-2","volume":"12","author":"WA Huang","year":"2021","unstructured":"Huang WA, Stitt IM, Negahbani E, Passey DJ, Ahn S, Davey M, et al. Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform. Nat Commun. 2021;12(1):3151.","journal-title":"Nat Commun"},{"issue":"6","key":"1748_CR35","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1016\/j.brs.2020.08.017","volume":"13","author":"AS Asan","year":"2020","unstructured":"Asan AS, Lang EJ, Sahin M. Entrainment of cerebellar purkinje cells with directional AC electric fields in anesthetized rats. Brain Stimulation noviembre de. 2020;13(6):1548\u201358.","journal-title":"Brain Stimulation noviembre de"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-024-01748-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12311-024-01748-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-024-01748-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T09:23:05Z","timestamp":1732353785000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12311-024-01748-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1748"],"URL":"https:\/\/doi.org\/10.1007\/s12311-024-01748-0","relation":{},"ISSN":["1473-4230"],"issn-type":[{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"23 September 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was revised and approved by the scientific ethics committee of the Universidad de Santiago de Chile N\u00b0 313\/2022 and followed the principles of the Helsinki Declaration. All participants signed the document of consent to participate before taking part in the procedures of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}