{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:11:09Z","timestamp":1787623869181,"version":"build-2736575974"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>While the cerebellum\u2019s role in orchestrating motor execution and routines is well established, its functional role in supporting cognition is less clear. Previous studies claim that motricity and cognition are mapped in different areas of the cerebellar cortex, with an anterior\/posterior dichotomy. However, most of the studies supporting this claim either use correlational methods (neuroimaging) or are lesion studies that did not consider central covariates (such as age, gender, treatment presence, and deep nuclei impairment) known to influence motor and cognitive recoveries in patients. Here, we used voxel-based lesion-symptom mapping (VLSM) on children and young adults having undergone cerebellar tumor resection. This approach allows to control for these covariates and evaluate causal relationships between brain anatomy and behavioral performances to disentangle the anatomic substrate of motor and cognitive functions. VLSM analyses showed that both motor and cognitive impairments were greater in children and young adults with lesions of the posterior cerebellum. These results highlight distinct and overlapping structural correlates of motor and cognitive performance in the cerebellum and are consistent with structural and functional hypotheses of integration of the cerebellum in motor and cognitive functions.<\/jats:p>","DOI":"10.1007\/s12311-024-01778-8","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T23:56:40Z","timestamp":1736985400000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Causally Mapping the Cerebellum in Children and Young Adults: from Motor to Cognition"],"prefix":"10.1007","volume":"24","author":[{"given":"Marina","family":"Veyrie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Beffara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Mottolese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Szathmari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Di Rocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Faure Conter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Leblond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Desmurget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cristofori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Aur\u00e9lien","family":"Beuriat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"issue":"1","key":"1778_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ncl.2014.09.004","volume":"33","author":"U Akbar","year":"2015","unstructured":"Akbar U, Ashizawa T. Ataxia. Neurol Clin. 2015;33(1):225\u201348. https:\/\/doi.org\/10.1016\/j.ncl.2014.09.004.","journal-title":"Neurol Clin"},{"key":"1778_CR2","doi-asserted-by":"publisher","unstructured":"Albazron FM, Bruss J, Jones RM, Yock TI, Pulsifer MB, Cohen AL, Nopoulos PC, Abrams AN, Sato, Boes AD (2019) Pediatric postoperative cerebellar cognitive affective syndrome follows outflow pathway lesions. Neurology. 2019;93(16):Article 16. https:\/\/doi.org\/10.1212\/WNL.0000000000008326","DOI":"10.1212\/WNL.0000000000008326"},{"key":"1778_CR3","doi-asserted-by":"publisher","first-page":"646052","DOI":"10.3389\/fnsys.2021.646052","volume":"15","author":"G Amore","year":"2021","unstructured":"Amore G, Spoto G, Ieni A, Vetri L, Quatrosi G, Di Rosa G, Nicotera AG. A Focus on the Cerebellum\u202f: From Embryogenesis to an Age-Related Clinical Perspective. Front Syst Neurosci. 2021;15:646052. https:\/\/doi.org\/10.3389\/fnsys.2021.646052.","journal-title":"Front Syst Neurosci"},{"key":"1778_CR4","doi-asserted-by":"publisher","unstructured":"Apps R, Watson TC. Cerebro-Cerebellar Connections. In M. Manto, J. D. Schmahmann, F. Rossi, D. L. Gruol, & N. Koibuchi (\u00c9ds.), Handbook of the Cerebellum and Cerebellar Disorders (p. 1131\u20111153). Springer Netherlands. 2013;https:\/\/doi.org\/10.1007\/978-94-007-1333-8_48","DOI":"10.1007\/978-94-007-1333-8_48"},{"issue":"11","key":"1778_CR5","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1093\/neuonc\/noq104","volume":"12","author":"GT Armstrong","year":"2010","unstructured":"Armstrong GT, Jain N, Liu W, Merchant TE, Stovall M, Srivastava DK, Gurney JG, Packer RJ, Robison LL, Krull KR. Region-specific radiotherapy and neuropsychological outcomes in adult survivors of childhood CNS malignancies. Neuro Oncol. 2010;12(11):1173\u201386. https:\/\/doi.org\/10.1093\/neuonc\/noq104.","journal-title":"Neuro Oncol"},{"issue":"5","key":"1778_CR6","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nn1050","volume":"6","author":"E Bates","year":"2003","unstructured":"Bates E, Wilson SM, Saygin AP, Dick F, Sereno MI, Knight RT, Dronkers NF. Voxel-based lesion\u2013symptom mapping. Nat Neurosci. 2003;6(5):448\u201350. https:\/\/doi.org\/10.1038\/nn1050.","journal-title":"Nat Neurosci"},{"key":"1778_CR7","doi-asserted-by":"publisher","first-page":"593490","DOI":"10.3389\/fneur.2020.593490","volume":"11","author":"P-A Beuriat","year":"2020","unstructured":"Beuriat P-A, Cohen-Zimerman S, Smith GNL, Krueger F, Gordon B, Grafman J. A New Insight on the Role of the Cerebellum for Executive Functions and Emotion Processing in Adults. Front Neurol. 2020;11:593490. https:\/\/doi.org\/10.3389\/fneur.2020.593490.","journal-title":"Front Neurol"},{"issue":"1","key":"1778_CR8","doi-asserted-by":"publisher","first-page":"4999","DOI":"10.1038\/s41598-022-09104-0","volume":"12","author":"P-A Beuriat","year":"2022","unstructured":"Beuriat P-A, Cohen-Zimerman S, Smith GNL, Krueger F, Gordon B, Grafman J. Evidence of the role of the cerebellum in cognitive theory of mind using voxel-based lesion mapping. Sci Rep. 2022;12(1):4999. https:\/\/doi.org\/10.1038\/s41598-022-09104-0.","journal-title":"Sci Rep"},{"issue":"1","key":"1778_CR9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12993-022-00193-5","volume":"18","author":"P-A Beuriat","year":"2022","unstructured":"Beuriat P-A, Cristofori I, Gordon B, Grafman J. The shifting role of the cerebellum in executive, emotional and social processing across the lifespan. Behav Brain Funct. 2022;18(1):6. https:\/\/doi.org\/10.1186\/s12993-022-00193-5.","journal-title":"Behav Brain Funct"},{"issue":"1","key":"1778_CR10","doi-asserted-by":"publisher","first-page":"fcaa027","DOI":"10.1093\/braincomms\/fcaa027","volume":"2","author":"P-A Beuriat","year":"2020","unstructured":"Beuriat P-A, Cristofori I, Richard N, Bardi L, Loriette C, Szathmari A, Di Rocco F, Leblond P, Frappaz D, Faure-Conter C, Claude L, Mottolese C, Desmurget M. Cerebellar lesions at a young age predict poorer long-term functional recovery. Brain Communications. 2020;2(1):fcaa027. https:\/\/doi.org\/10.1093\/braincomms\/fcaa027.","journal-title":"Brain Communications"},{"issue":"6","key":"1778_CR11","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1177\/1073191114524271","volume":"21","author":"O Bezdicek","year":"2014","unstructured":"Bezdicek O, Nikolai T, Hoskovcov\u00e1 M, \u0160tochl J, Bro\u017eov\u00e1 H, Du\u0161ek P, Z\u00e1rubov\u00e1 K, Jech R, R\u016f\u017ei\u010dka E. Grooved Pegboard Predicates More of Cognitive Than Motor Involvement in Parkinson\u2019s Disease. Assessment. 2014;21(6):723\u201330. https:\/\/doi.org\/10.1177\/1073191114524271.","journal-title":"Assessment"},{"key":"1778_CR12","doi-asserted-by":"publisher","first-page":"116624","DOI":"10.1016\/j.neuroimage.2020.116624","volume":"211","author":"Y Boillat","year":"2020","unstructured":"Boillat Y, Bazin P-L, Van Der Zwaag W. Whole-body somatotopic maps in the cerebellum revealed with 7T fMRI. Neuroimage. 2020;211:116624. https:\/\/doi.org\/10.1016\/j.neuroimage.2020.116624.","journal-title":"Neuroimage"},{"issue":"22","key":"1778_CR13","doi-asserted-by":"publisher","first-page":"6083","DOI":"10.1523\/JNEUROSCI.0344-16.2016","volume":"36","author":"JA Brissenden","year":"2016","unstructured":"Brissenden JA, Levin EJ, Osher DE, Halko MA, Somers DC. Functional Evidence for a Cerebellar Node of the Dorsal Attention Network. J Neurosci. 2016;36(22):6083\u201396. https:\/\/doi.org\/10.1523\/JNEUROSCI.0344-16.2016.","journal-title":"J Neurosci"},{"issue":"5","key":"1778_CR14","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1152\/jn.00339.2011","volume":"106","author":"RL Buckner","year":"2011","unstructured":"Buckner RL, Krienen FM, Castellanos A, Diaz JC, Yeo BTT. The organization of the human cerebellum estimated by intrinsic functional connectivity. J Neurophysiol. 2011;106(5):2322\u201345. https:\/\/doi.org\/10.1152\/jn.00339.2011.","journal-title":"J Neurophysiol"},{"issue":"16","key":"1778_CR15","doi-asserted-by":"publisher","first-page":"6283","DOI":"10.1523\/JNEUROSCI.21-16-06283.2001","volume":"21","author":"DM Clower","year":"2001","unstructured":"Clower DM, West RA, Lynch JC, Strick PL. The Inferior Parietal Lobule Is the Target of Output from the Superior Colliculus, Hippocampus, and Cerebellum. J Neurosci. 2001;21(16):6283\u201391. https:\/\/doi.org\/10.1523\/JNEUROSCI.21-16-06283.2001.","journal-title":"J Neurosci"},{"issue":"6","key":"1778_CR16","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1093\/scan\/nss041","volume":"8","author":"O Dal Monte","year":"2013","unstructured":"Dal Monte O, Krueger F, Solomon JM, Schintu S, Knutson KM, Strenziok M, Pardini M, Leopold A, Raymont V, Grafman J. A voxel-based lesion study on facial emotion recognition after penetrating brain injury. Social Cognitive and Affective Neuroscience. 2013;8(6):632\u20139. https:\/\/doi.org\/10.1093\/scan\/nss041.","journal-title":"Social Cognitive and Affective Neuroscience"},{"issue":"1","key":"1778_CR17","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.neuroimage.2009.01.045","volume":"46","author":"J Diedrichsen","year":"2009","unstructured":"Diedrichsen J, Balsters JH, Flavell J, Cussans E, Ramnani N. A probabilistic MR atlas of the human cerebellum. Neuroimage. 2009;46(1):39\u201346. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.01.045.","journal-title":"Neuroimage"},{"issue":"1","key":"1778_CR18","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1152\/jn.00626.2002","volume":"89","author":"RP Dum","year":"2003","unstructured":"Dum RP, Strick PL. An Unfolded Map of the Cerebellar Dentate Nucleus and its Projections to the Cerebral Cortex. J Neurophysiol. 2003;89(1):634\u20139. https:\/\/doi.org\/10.1152\/jn.00626.2002.","journal-title":"J Neurophysiol"},{"issue":"1896","key":"1778_CR19","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1098\/rsta.2008.0287","volume":"367","author":"SB Eickhoff","year":"2009","unstructured":"Eickhoff SB, Heim S, Zilles K, Amunts K. A systems perspective on the effective connectivity of overt speech production. Philosophical Transactions Royal Soc A: Mathematical, Physical Eng Sci. 2009;367(1896):2399\u2013421. https:\/\/doi.org\/10.1098\/rsta.2008.0287.","journal-title":"Philosophical Transactions Royal Soc A: Mathematical, Physical Eng Sci"},{"key":"1778_CR20","doi-asserted-by":"publisher","first-page":"101331","DOI":"10.1016\/j.cobeha.2023.101331","volume":"55","author":"F Erdlenbruch","year":"2024","unstructured":"Erdlenbruch F, Timmann D, Thieme A. Clinical cerebellar neuroscience\u202f: Ataxias \u2014 cognitive and affective symptoms in focal cerebellar lesions. Curr Opin Behav Sci. 2024;55:101331. https:\/\/doi.org\/10.1016\/j.cobeha.2023.101331.","journal-title":"Curr Opin Behav Sci"},{"key":"1778_CR21","doi-asserted-by":"publisher","unstructured":"Gl\u00e4scher J, Tranel D, Paul LK, Rudrauf D, Rorden C, Hornaday A, Grabowski T, Damasio H, Adolphs R. Lesion Mapping of Cognitive Abilities Linked to Intelligence. Neuron. 61(5):Article 5. https:\/\/doi.org\/10.1016\/j.neuron.2009.01.026","DOI":"10.1016\/j.neuron.2009.01.026"},{"issue":"3","key":"1778_CR22","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.neuroscience.2009.02.054","volume":"162","author":"M Glickstein","year":"2009","unstructured":"Glickstein M, Strata P, Voogd J. Cerebellum\u202f: History. Neuroscience. 2009;162(3):549\u201359. https:\/\/doi.org\/10.1016\/j.neuroscience.2009.02.054.","journal-title":"Neuroscience"},{"issue":"1","key":"1778_CR23","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cortex.2009.09.001","volume":"47","author":"M Glickstein","year":"2011","unstructured":"Glickstein M, Sultan F, Voogd J. Functional localization in the cerebellum. Cortex. 2011;47(1):59\u201380. https:\/\/doi.org\/10.1016\/j.cortex.2009.09.001.","journal-title":"Cortex"},{"issue":"suppl 4","key":"1778_CR24","doi-asserted-by":"publisher","first-page":"iv37","DOI":"10.1093\/neuonc\/nos196","volume":"14","author":"D Greene-Schloesser","year":"2012","unstructured":"Greene-Schloesser D, Robbins ME. Radiation-induced cognitive impairment-from bench to bedside. Neuro-Oncology. 2012;14(suppl 4):iv37\u201344. https:\/\/doi.org\/10.1093\/neuonc\/nos196.","journal-title":"Neuro-Oncology"},{"issue":"9","key":"1778_CR25","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1007\/s00381-021-05244-2","volume":"37","author":"F Grosse","year":"2021","unstructured":"Grosse F, Rueckriegel SM, Thomale U-W, Hern\u00e1iz Driever P. Mapping of long-term cognitive and motor deficits in pediatric cerebellar brain tumor survivors into a cerebellar white matter atlas. Child\u2019s Nervous System. 2021;37(9):2787\u201397. https:\/\/doi.org\/10.1007\/s00381-021-05244-2.","journal-title":"Child\u2019s Nervous System"},{"key":"1778_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2021.642225","volume":"15","author":"C Habas","year":"2021","unstructured":"Habas C. Functional Connectivity of the Cognitive Cerebellum. Front Syst Neurosci. 2021;15: 642225. https:\/\/doi.org\/10.3389\/fnsys.2021.642225.","journal-title":"Front Syst Neurosci"},{"issue":"4","key":"1778_CR27","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S1607-551X(08)70117-7","volume":"24","author":"Y Hsieh","year":"2008","unstructured":"Hsieh Y, Chen K, Wang C, Lai C. Cognitive and Motor Components of Response Speed in the Stroop Test in Parkinson\u2019s Disease Patients. Kaohsiung J Med Sci. 2008;24(4):197\u2013203. https:\/\/doi.org\/10.1016\/S1607-551X(08)70117-7.","journal-title":"Kaohsiung J Med Sci"},{"issue":"1","key":"1778_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41537-024-00434-8","volume":"10","author":"N Kang","year":"2024","unstructured":"Kang N, Chung S, Lee S-H, Bang M. Cerebro-cerebellar gray matter abnormalities associated with cognitive impairment in patients with recent-onset and chronic schizophrenia. Schizophrenia. 2024;10(1):11. https:\/\/doi.org\/10.1038\/s41537-024-00434-8.","journal-title":"Schizophrenia"},{"key":"1778_CR29","doi-asserted-by":"publisher","unstructured":"Karatekin C, Lazareff JA, Asarnow RF. Relevance of the cerebellar hemispheres for executive functions. Pediatric Neurology. 2000;22(2):Article 2. https:\/\/doi.org\/10.1016\/S0887-8994(99)00128-9","DOI":"10.1016\/S0887-8994(99)00128-9"},{"issue":"33","key":"1778_CR30","doi-asserted-by":"publisher","first-page":"11453","DOI":"10.1523\/JNEUROSCI.0678-12.2012","volume":"32","author":"T Kellermann","year":"2012","unstructured":"Kellermann T, Regenbogen C, De Vos M, Mossnang C, Finkelmeyer A, Habel U. Effective Connectivity of the Human Cerebellum during Visual Attention. J Neurosci. 2012;32(33):11453\u201360. https:\/\/doi.org\/10.1523\/JNEUROSCI.0678-12.2012.","journal-title":"J Neurosci"},{"issue":"4","key":"1778_CR31","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1037\/0096-3445.122.4.411","volume":"122","author":"DY Kimberg","year":"1993","unstructured":"Kimberg DY, Farah MJ. A unified account of cognitive impairments following frontal lobe damage\u202f: The role of working memory in complex, organized behavior. J Exp Psychol Gen. 1993;122(4):411\u201328. https:\/\/doi.org\/10.1037\/0096-3445.122.4.411.","journal-title":"J Exp Psychol Gen"},{"key":"1778_CR32","doi-asserted-by":"publisher","unstructured":"King M, Hernandez-Castillo CR, Poldrack RA, Ivry RB, Diedrichsen J. Functional boundaries in the human cerebellum revealed by a multi-domain task battery. Nature Neuroscience. 2019;22(8):Article 8. https:\/\/doi.org\/10.1038\/s41593-019-0436-x","DOI":"10.1038\/s41593-019-0436-x"},{"key":"1778_CR33","doi-asserted-by":"publisher","unstructured":"Konczak J, Schoch B, Dimitrova A, Gizewski E, Timmann D. Functional recovery of children and adolescents after cerebellar tumour resection. Brain: A Journal of Neurology. 2005;128(Pt 6), Article Pt 6. https:\/\/doi.org\/10.1093\/brain\/awh385","DOI":"10.1093\/brain\/awh385"},{"issue":"10","key":"1778_CR34","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.diii.2014.06.017","volume":"95","author":"M Koob","year":"2014","unstructured":"Koob M, Girard N. Cerebral tumors\u202f: Specific features in children. Diagn Interv Imaging. 2014;95(10):965\u201383. https:\/\/doi.org\/10.1016\/j.diii.2014.06.017.","journal-title":"Diagn Interv Imaging"},{"issue":"2","key":"1778_CR35","doi-asserted-by":"publisher","first-page":"e29491","DOI":"10.1002\/pbc.29491","volume":"69","author":"CF Levitch","year":"2022","unstructured":"Levitch CF, Holland AA, Bledsoe J, Kim SY, Barnett M, Ramjan S, Sands SA. Comparison of neuropsychological functioning in pediatric posterior fossa tumor survivors\u202f: Medulloblastoma, low-grade astrocytoma, and healthy controls. Pediatr Blood Cancer. 2022;69(2):e29491. https:\/\/doi.org\/10.1002\/pbc.29491.","journal-title":"Pediatr Blood Cancer"},{"key":"1778_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/978-2-8178-0447-7","author":"M Manto","year":"2013","unstructured":"Manto M, Habas C. Le cervelet\u202f: De l\u2019anatomie et la physiologie \u00e0 la clinique humaine. Springer Paris. 2013. https:\/\/doi.org\/10.1007\/978-2-8178-0447-7.","journal-title":"Springer Paris"},{"key":"1778_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2021.781527","volume":"15","author":"SS McAfee","year":"2022","unstructured":"McAfee SS, Liu Y, Sillitoe RV, Heck DH. Cerebellar Coordination of Neuronal Communication in Cerebral Cortex. Front Syst Neurosci. 2022;15: 781527. https:\/\/doi.org\/10.3389\/fnsys.2021.781527.","journal-title":"Front Syst Neurosci"},{"issue":"1","key":"1778_CR38","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1093\/brain\/aws186","volume":"136","author":"C Mottolese","year":"2013","unstructured":"Mottolese C, Richard N, Harquel S, Szathmari A, Sirigu A, Desmurget M. Mapping motor representations in the human cerebellum. Brain. 2013;136(1):330\u201342. https:\/\/doi.org\/10.1093\/brain\/aws186.","journal-title":"Brain"},{"issue":"3","key":"1778_CR39","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1093\/brain\/119.3.1023","volume":"119","author":"M Nitschke","year":"1996","unstructured":"Nitschke M, Kleinschmidt A, Wessel K, Frahm J. Somatotopic motor representation in the human anterior cerebellum\u202f: A high-resolution functional MRI study. Brain. 1996;119(3):1023\u20139. https:\/\/doi.org\/10.1093\/brain\/119.3.1023.","journal-title":"Brain"},{"issue":"1","key":"1778_CR40","doi-asserted-by":"publisher","first-page":"12841","DOI":"10.1038\/s41598-017-13079-8","volume":"7","author":"F Palesi","year":"2017","unstructured":"Palesi F, De Rinaldis A, Castellazzi G, Calamante F, Muhlert N, Chard D, Tournier JD, Magenes G, D\u2019Angelo E, Gandini Wheeler-Kingshott CAM. Contralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo\u202f: Implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas. Sci Rep. 2017;7(1):12841. https:\/\/doi.org\/10.1038\/s41598-017-13079-8.","journal-title":"Sci Rep"},{"issue":"1","key":"1778_CR41","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/jmri.22722","volume":"35","author":"A Poretti","year":"2012","unstructured":"Poretti A, Meoded A, Huisman TAGM. Neuroimaging of pediatric posterior fossa tumors including review of the literature. J Magn Reson Imaging. 2012;35(1):32\u201347. https:\/\/doi.org\/10.1002\/jmri.22722.","journal-title":"J Magn Reson Imaging"},{"key":"1778_CR42","doi-asserted-by":"crossref","unstructured":"Pustina D, Mirman D, editors. Lesion-to-symptom mapping: principles and tools, vol 180. Springer Nature; 2022.","DOI":"10.1007\/978-1-0716-2225-4"},{"key":"1778_CR43","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.14002","author":"E Rashal","year":"2022","unstructured":"Rashal E, Senoussi M, Santandrea E, Ben-Hamed S, Macaluso E, Chelazzi L, Boehler CN. An EEG study of the combined effects of top-down and bottom-up attentional selection under varying task difficulty. Psychophysiology. 2022. https:\/\/doi.org\/10.1111\/psyp.14002.","journal-title":"Psychophysiology"},{"issue":"6","key":"1778_CR44","doi-asserted-by":"publisher","first-page":"3330","DOI":"10.1152\/jn.01117.2009","volume":"103","author":"JE Schlerf","year":"2010","unstructured":"Schlerf JE, Verstynen TD, Ivry RB, Spencer RMC. Evidence of a Novel Somatopic Map in the Human Neocerebellum During Complex Actions. J Neurophysiol. 2010;103(6):3330\u20136. https:\/\/doi.org\/10.1152\/jn.01117.2009.","journal-title":"J Neurophysiol"},{"key":"1778_CR45","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neulet.2018.07.005","volume":"688","author":"JD Schmahmann","year":"2018","unstructured":"Schmahmann JD. The cerebellum and cognition. Neurosci Lett. 2018;688:62\u201375. https:\/\/doi.org\/10.1016\/j.neulet.2018.07.005.","journal-title":"Neurosci Lett"},{"key":"1778_CR46","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neulet.2018.07.005","volume":"688","author":"JD Schmahmann","year":"2019","unstructured":"Schmahmann JD. The cerebellum and cognition. Neurosci Lett. 2019;688:62\u201375. https:\/\/doi.org\/10.1016\/j.neulet.2018.07.005.","journal-title":"Neurosci Lett"},{"key":"1778_CR47","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1146\/annurev-neuro-070918-050258","volume":"42","author":"JD Schmahmann","year":"2019","unstructured":"Schmahmann JD, Guell X, Stoodley CJ, Halko MA. The Theory and Neuroscience of Cerebellar Cognition. Annu Rev Neurosci. 2019;42:337\u201364. https:\/\/doi.org\/10.1146\/annurev-neuro-070918-050258.","journal-title":"Annu Rev Neurosci"},{"issue":"1","key":"1778_CR48","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.neuroimage.2005.09.018","volume":"30","author":"B Schoch","year":"2006","unstructured":"Schoch B, Dimitrova A, Gizewski ER, Timmann D. Functional localization in the human cerebellum based on voxelwise statistical analysis\u202f: A study of 90 patients. Neuroimage. 2006;30(1):36\u201351. https:\/\/doi.org\/10.1016\/j.neuroimage.2005.09.018.","journal-title":"Neuroimage"},{"issue":"5","key":"1778_CR49","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.tics.2017.02.005","volume":"21","author":"AA Sokolov","year":"2017","unstructured":"Sokolov AA, Miall RC, Ivry RB. The Cerebellum\u202f: Adaptive Prediction for Movement and Cognition. Trends Cogn Sci. 2017;21(5):313\u201332. https:\/\/doi.org\/10.1016\/j.tics.2017.02.005.","journal-title":"Trends Cogn Sci"},{"issue":"2","key":"1778_CR50","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/s12311-011-0260-7","volume":"11","author":"CJ Stoodley","year":"2012","unstructured":"Stoodley CJ. The Cerebellum and Cognition\u202f: Evidence from Functional Imaging Studies. The Cerebellum. 2012;11(2):352\u201365. https:\/\/doi.org\/10.1007\/s12311-011-0260-7.","journal-title":"The Cerebellum"},{"key":"1778_CR51","doi-asserted-by":"publisher","unstructured":"Stoodley CJ, Desmond JE, Schmahmann JD (2013) Functional Topography of the Human Cerebellum Revealed by Functional Neuroimaging Studies. In M. Manto, J. D. Schmahmann, F. Rossi, D. L. Gruol, & N. Koibuchi (\u00c9ds.), Handbook of the Cerebellum and Cerebellar Disorders. 2013;735\u2011764. Springer Netherlands. https:\/\/doi.org\/10.1007\/978-94-007-1333-8_30","DOI":"10.1007\/978-94-007-1333-8_30"},{"key":"1778_CR52","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.nicl.2016.10.013","volume":"12","author":"CJ Stoodley","year":"2016","unstructured":"Stoodley CJ, MacMore JP, Makris N, Sherman JC, Schmahmann JD. Location of lesion determines motor vs. Cognitive consequences in patients with cerebellar stroke. NeuroImage Clin. 2016;12:765\u201375. https:\/\/doi.org\/10.1016\/j.nicl.2016.10.013.","journal-title":"NeuroImage Clin"},{"issue":"7","key":"1778_CR53","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.cortex.2009.11.008","volume":"46","author":"CJ Stoodley","year":"2010","unstructured":"Stoodley CJ, Schmahmann JD. Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex. 2010;46(7):831\u201344. https:\/\/doi.org\/10.1016\/j.cortex.2009.11.008.","journal-title":"Cortex"},{"issue":"2","key":"1778_CR54","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuroimage.2008.08.039","volume":"44","author":"C Stoodley","year":"2009","unstructured":"Stoodley C, Schmahmann J. Functional topography in the human cerebellum\u202f: A meta-analysis of neuroimaging studies. Neuroimage. 2009;44(2):489\u2013501. https:\/\/doi.org\/10.1016\/j.neuroimage.2008.08.039.","journal-title":"Neuroimage"},{"key":"1778_CR55","doi-asserted-by":"publisher","unstructured":"Storey E, Tuck K, Hester R, Hughes A, Churchyard A (2004) Inter-rater reliability of the International Cooperative Ataxia Rating Scale (ICARS). Movement Disorders. 2004;19(2),Article 2. https:\/\/doi.org\/10.1002\/mds.10657","DOI":"10.1002\/mds.10657"},{"issue":"1","key":"1778_CR56","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev.neuro.31.060407.125606","volume":"32","author":"PL Strick","year":"2009","unstructured":"Strick PL, Dum RP, Fiez JA. Cerebellum and Nonmotor Function. Annu Rev Neurosci. 2009;32(1):413\u201334. https:\/\/doi.org\/10.1146\/annurev.neuro.31.060407.125606.","journal-title":"Annu Rev Neurosci"},{"issue":"3","key":"1778_CR57","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1037\/h0061266","volume":"32","author":"J Tiffin","year":"1948","unstructured":"Tiffin J, Asher EJ. The Purdue Pegboard\u202f: Norms and studies of reliability and validity. J Appl Psychol. 1948;32(3):234\u201347. https:\/\/doi.org\/10.1037\/h0061266.","journal-title":"J Appl Psychol"},{"issue":"2","key":"1778_CR58","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0022-510X(96)00231-6","volume":"145","author":"P Trouillas","year":"1997","unstructured":"Trouillas P, Takayanagi T, Hallett M, Currier RD, Subramony SH, Wessel K, Bryer A, Diener HC, Massaquoi S, Gomez CM, Coutinho P, Hamida MB, Campanella G, Filla A, Schut L, Timann D, Honnorat J, Nighoghossian N, Manyam B. International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome. J Neurol Sci. 1997;145(2):205\u201311. https:\/\/doi.org\/10.1016\/S0022-510X(96)00231-6.","journal-title":"J Neurol Sci"},{"issue":"12","key":"1778_CR59","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1093\/cercor\/bhr370","volume":"22","author":"A Tsuchida","year":"2012","unstructured":"Tsuchida A, Fellows LK. Are You Upset? Distinct Roles for Orbitofrontal and Lateral Prefrontal Cortex in Detecting and Distinguishing Facial Expressions of Emotion. Cereb Cortex. 2012;22(12):2904\u201312. https:\/\/doi.org\/10.1093\/cercor\/bhr370.","journal-title":"Cereb Cortex"},{"key":"1778_CR60","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.neuroimage.2012.11.041","volume":"67","author":"W Van Der Zwaag","year":"2013","unstructured":"Van Der Zwaag W, Kusters R, Magill A, Gruetter R, Martuzzi R, Blanke O, Marques JP. Digit somatotopy in the human cerebellum\u202f: A 7T fMRI study. Neuroimage. 2013;67:354\u201362. https:\/\/doi.org\/10.1016\/j.neuroimage.2012.11.041.","journal-title":"Neuroimage"},{"key":"1778_CR61","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.neuroimage.2013.09.033","volume":"86","author":"F Van Overwalle","year":"2014","unstructured":"Van Overwalle F, Baetens K, Mari\u00ebn P, Vandekerckhove M. Social cognition and the cerebellum\u202f: A meta-analysis of over 350 fMRI studies. Neuroimage. 2014;86:554\u201372. https:\/\/doi.org\/10.1016\/j.neuroimage.2013.09.033.","journal-title":"Neuroimage"},{"issue":"4","key":"1778_CR62","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1080\/17470919.2015.1005666","volume":"10","author":"F Van Overwalle","year":"2015","unstructured":"Van Overwalle F, Baetens K, Mari\u00ebn P, Vanderkerckhove M. Cerebellar areas dedicated to social cognition\u202f? A comparison of meta-analytic and connectivity results. Soc Neurosci. 2015;10(4):337\u201344. https:\/\/doi.org\/10.1080\/17470919.2015.1005666.","journal-title":"Soc Neurosci"},{"issue":"12","key":"1778_CR63","doi-asserted-by":"publisher","first-page":"5137","DOI":"10.1002\/hbm.23002","volume":"36","author":"F Van Overwalle","year":"2015","unstructured":"Van Overwalle F, D\u2019aes T, Mari\u00ebn P. Social cognition and the cerebellum\u202f: A meta-analytic connectivity analysis. Hum Brain Mapp. 2015;36(12):5137\u201354. https:\/\/doi.org\/10.1002\/hbm.23002.","journal-title":"Hum Brain Mapp"},{"key":"1778_CR64","doi-asserted-by":"publisher","unstructured":"Van Overwalle F, Manto M, Cattaneo Z, Clausi S, Ferrari C, Gabrieli JDE, Guell X, Heleven E, Lupo M, Ma Q, Michelutti M, Olivito G, Pu M, Rice LC, Schmahmann JD, Siciliano L, Sokolov AA, Stoodley CJ, Van Dun K, \u2026 Leggio M. Consensus Paper\u202f: Cerebellum and Social Cognition. The Cerebellum. 2020;19(6):833\u2011868. https:\/\/doi.org\/10.1007\/s12311-020-01155-1","DOI":"10.1007\/s12311-020-01155-1"},{"key":"1778_CR65","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.neuroimage.2015.09.001","volume":"124","author":"F Van Overwalle","year":"2016","unstructured":"Van Overwalle F, Mari\u00ebn P. Functional connectivity between the cerebrum and cerebellum in social cognition\u202f: A multi-study analysis. Neuroimage. 2016;124:248\u201355. https:\/\/doi.org\/10.1016\/j.neuroimage.2015.09.001.","journal-title":"Neuroimage"},{"key":"1778_CR66","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.nicl.2014.01.008","volume":"4","author":"M Verly","year":"2014","unstructured":"Verly M, Verhoeven J, Zink I, Mantini D, Peeters R, Deprez S, Emsell L, Boets B, Noens I, Steyaert J, Lagae L, De Cock P, Rommel N, Sunaert S. Altered functional connectivity of the language network in ASD\u202f: Role of classical language areas and cerebellum. NeuroImage: Clinical. 2014;4:374\u201382. https:\/\/doi.org\/10.1016\/j.nicl.2014.01.008.","journal-title":"NeuroImage: Clinical"},{"issue":"1","key":"1778_CR67","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1152\/jn.00598.2012","volume":"109","author":"D Wang","year":"2013","unstructured":"Wang D, Buckner RL, Liu H. Cerebellar asymmetry and its relation to cerebral asymmetry estimated by intrinsic functional connectivity. J Neurophysiol. 2013;109(1):46\u201357. https:\/\/doi.org\/10.1152\/jn.00598.2012.","journal-title":"J Neurophysiol"},{"key":"1778_CR68","unstructured":"Wechsler D. WAIS-IV: \u00e9chelle d'intelligence de Wechsler pour adultes. Ecpa; 2011."},{"key":"1778_CR69","unstructured":"Terriot K, Ozenne R.\u00a0 L\u2019\u00e9chelle d\u2019intelligence de Wechsler pour enfants, 5 e \u00e9dition (WISC-V). ANAE. 2015;134:95\u2013102."},{"key":"1778_CR70","doi-asserted-by":"publisher","first-page":"644059","DOI":"10.3389\/fnsys.2021.644059","volume":"15","author":"Q Welniarz","year":"2021","unstructured":"Welniarz Q, Worbe Y, Gallea C. The Forward Model\u202f: A Unifying Theory for the Role of the Cerebellum in Motor Control and Sense of Agency. Front Syst Neurosci. 2021;15:644059. https:\/\/doi.org\/10.3389\/fnsys.2021.644059.","journal-title":"Front Syst Neurosci"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-024-01778-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12311-024-01778-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-024-01778-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:30:48Z","timestamp":1741699848000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12311-024-01778-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":70,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["1778"],"URL":"https:\/\/doi.org\/10.1007\/s12311-024-01778-8","relation":{},"ISSN":["1473-4230"],"issn-type":[{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]},"assertion":[{"value":"17 December 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed under the patients\u2019 (or their parents for children) formal consent, with the approbation of the local institutional ethical committee (CSE-HCL \u2013 IRB 00013204) and with the precepts of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"31"}}