{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:45:46Z","timestamp":1780494346253,"version":"3.54.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Essential tremor (ET) is a common movement disorder, and while ventral intermediate nucleus deep brain stimulation (VIM-DBS) is a well-established treatment, its precise mechanisms or modulatory effects, particularly in relation to cerebellar oscillations, remain unclear. In this study, we hypothesized that VIM-DBS would modulate cerebellar oscillatory activity across both resting and motor task conditions, reflecting its impact on cerebello-thalamic pathways. Ten patients diagnosed with ET participated in this study. We examined the effects of VIM-DBS on mid-cerebellar oscillations during resting-state and lower-limb pedaling motor tasks. Frequency analysis was conducted on the resting-state signal and time-frequency analysis was performed on motor task-related signals. We explored the modulatory effects of VIM-DBS on oscillatory activity across delta, theta, alpha, beta, and gamma frequency bands. We found that ON VIM-DBS increased mid-cerebellar relative theta power during resting-state conditions, with no significant changes in other frequency bands. During a pedaling motor task, VIM-DBS led to significant reductions in theta, alpha, and gamma power, highlighting the frequency-specific effects of stimulation. VIM-DBS also increased peak acceleration of leg movements during the pedaling task. Furthermore, VIM-DBS selectively increased mid-frontal relative theta and beta power as well as mid-occipital relative theta power during resting condition, suggesting localized mid-cerebellar modulation. Moreover, similarity analyses between mid-cerebellar and nearby mid-occipital signals revealed differences in coherence, phase coherence, and cross-spectrum phase coherence. Overall, these results support the role of VIM-DBS in modulating mid-cerebellar oscillations in ET and provide new insights into the neural mechanisms underlying DBS efficacy.<\/jats:p>","DOI":"10.1007\/s12311-025-01787-1","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T09:06:08Z","timestamp":1738400768000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cerebellar Oscillatory Patterns in Essential Tremor: Modulatory Effects of VIM-DBS"],"prefix":"10.1007","volume":"24","author":[{"given":"Taylor J.","family":"Bosch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Groth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo I.","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Bharmauria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Flouty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4273-542X","authenticated-orcid":false,"given":"Arun","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,1]]},"reference":[{"key":"1787_CR1","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/S0140-6736(07)60544-3","volume":"369","author":"J Benito-Leon","year":"2007","unstructured":"Benito-Leon J, Louis ED. 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The research protocols received approval from the University of Iowa.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"40"}}