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Here, we investigated multiunit activity (MUA) in the inferior olive (IO), dentate nucleus (DN), and Crus II of the cerebellum in a rat model of tract lesion-induced parkinsonism triggered by ventrolateral striatum (VLS) injury. Thirty-six male Wistar rats were divided into a Lesion group and an Intact group. Monopolar electrodes were implanted to record MUA in IO, DN, or Crus II for four consecutive weeks. Basal and tremor-associated signals were analyzed using generalized linear models and post hoc comparisons. In rats with VLS lesions, IO activity initially increased and then declined over time, whereas DN activity remained consistently elevated, suggesting compensatory upregulation. Crus II showed no significant shifts in baseline activity. During tremor episodes, all three structures exhibited distinct temporal fluctuations in MUA. These findings reveal cerebellar structure-specific responses to striatal injury and highlight the cerebellum\u2019s role in both the acute and chronic phases of Parkinsonian motor dysfunction. Careful consideration of possible inflammatory responses to electrode implantation remains essential for future studies.<\/jats:p>","DOI":"10.1007\/s12311-026-01971-x","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:41:56Z","timestamp":1774075316000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Compensatory and Dynamic Cerebellar Responses to Striatal Lesions in Experimental Parkinsonism"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-1919","authenticated-orcid":false,"given":"Luis I.","family":"Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4782-5504","authenticated-orcid":false,"given":"Gerardo","family":"Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6039-3745","authenticated-orcid":false,"given":"Cristofer","family":"Z\u00e1rate-Calder\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-1752","authenticated-orcid":false,"given":"Ira\u00eds","family":"Viveros-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8906-6850","authenticated-orcid":false,"given":"Mario E.","family":"Valerio-Nolasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4765-9051","authenticated-orcid":false,"given":"Luis","family":"Beltr\u00e1n-Parrazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-5787","authenticated-orcid":false,"given":"Donaji","family":"Chi-Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,21]]},"reference":[{"key":"1971_CR1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3390\/neuroglia5040030","volume":"5","author":"I Viveros-Mart\u00ednez","year":"2024","unstructured":"Viveros-Mart\u00ednez I, Zarate-Calderon C, Chi-Casta\u00f1eda D, Carrillo P, Aranda-Abreu GE, Mart\u00ednez AJ, et al. 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Burlington: Elsevier Academic; 2006.","edition":"6"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-026-01971-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12311-026-01971-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-026-01971-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:06:15Z","timestamp":1776686775000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12311-026-01971-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,21]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["1971"],"URL":"https:\/\/doi.org\/10.1007\/s12311-026-01971-x","relation":{},"ISSN":["1473-4230"],"issn-type":[{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,21]]},"assertion":[{"value":"29 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures involving laboratory animals were conducted in accordance with the ethical standards established by the Mexican Official Norm NOM-062-ZOO-1999 for the care and use of laboratory animals (experimental classification: category d), as well as the Guide for the Care and Use of Laboratory Animals (NOM\/GCUAL). All experimental protocols adhered to the policies on animal use outlined by the Society for Neuroscience, including the U.S. Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy) and the Guide for the Care and Use of Laboratory Animals. The experimental procedures were approved by the Institutional Animal Care and Use Committee of the Institute of Neuroscience of the Universidad Veracruzana (Approval No.: 2018-003). A limitation of the present study is the relatively small sample size per group (n\u2009=\u20096), which may have limited statistical power to detect subtle effects. Accordingly, the absence of statistically significant differences in some parameters should not be interpreted as definitive evidence of lack of effect.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"35"}}