{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T05:43:27Z","timestamp":1786167807832,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010608","name":"Universit\u00e0 degli Studi di Urbino Carlo Bo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010608","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"DOI":"10.1007\/s12311-026-02046-7","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:32:58Z","timestamp":1782707578000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends and Disparities in Mortality from Hereditary Ataxia in United States, 2000\u20132020: A Retrospective Analysis with Projections to 2050"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3916-6414","authenticated-orcid":false,"given":"Muhammad Junaid","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6855-9687","authenticated-orcid":false,"given":"Fiza","family":"Wali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1559-473X","authenticated-orcid":false,"given":"Laraib","family":"Israr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Ullah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzala Ahmed","family":"Farooqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9015-619X","authenticated-orcid":false,"given":"Fatima","family":"Naveed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areeba","family":"Kabir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1018-6697","authenticated-orcid":false,"given":"Gianluca","family":"Morganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6333-5797","authenticated-orcid":false,"given":"Anastasia","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5206-6296","authenticated-orcid":false,"given":"Michele","family":"Menotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"2046_CR1","unstructured":"Perlman S. (2023) Hereditary ataxia overview. Genereviews\u00ae[internet]."},{"key":"2046_CR2","doi-asserted-by":"publisher","first-page":"1422442","DOI":"10.3389\/fnins.2024.1422442","volume":"18","author":"Z-T Cui","year":"2024","unstructured":"Cui Z-T, Mao Z-T, Yang R, Li J-J, Jia S-S, Zhao J-L, Zhong F-T, Yu P, Dong M. Spinocerebellar ataxias: From pathogenesis to recent therapeutic advances. Front NeuroSci. 2024;18:1422442.","journal-title":"Front NeuroSci"},{"issue":"5","key":"2046_CR3","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s00439-025-02744-y","volume":"144","author":"E Bregant","year":"2025","unstructured":"Bregant E, Betto E, Dal Secco C, Zucco J, Baldan F, Allegri L, Lonigro IR, Faletra F, Verriello L, Damante G. The molecular landscape of hereditary ataxia: a single-center study. Hum Genet. 2025;144(5):545\u201357.","journal-title":"Hum Genet"},{"key":"2046_CR4","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1016\/S1474-4422(16)30287-3","volume":"15","author":"K Reetz","year":"2016","unstructured":"Reetz K, Dogan I, Hilgers R-D, Giunti P, Mariotti C, Durr A, Boesch S, Klopstock T, de Rivera FJR, Sch\u00f6ls L, Klockgether T, B\u00fcrk K, Rai M, Pandolfo M, Schulz JB, Nachbauer W, Eigentler A, Depondt C, Benaich S, Charles P, Ewenczyk C, Monin M-L, Dafotakis M, Fedosov K, Didszun C, Ermis U, Giordano IA, Timmann D, Karin I, Neuhofer C, Stendel C, vom M\u00fcller J, Wolf J, Panzeri M, Nanetti L, Castaldo A, Arpa J, Sanz-Gallego I, Parkinson MH, Sweeney MG. Progression characteristics of the European Friedreich\u2019s Ataxia Consortium for Translational Studies (EFACTS): a 2 year cohort study. Lancet Neurol. 2016;15:1346\u201354.","journal-title":"Lancet Neurol"},{"issue":"4","key":"2046_CR5","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nrneurol.2009.26","volume":"5","author":"JB Schulz","year":"2009","unstructured":"Schulz JB, Boesch S, B\u00fcrk K, D\u00fcrr A, Giunti P, Mariotti C, Pousset F, Sch\u00f6ls L, Vankan P, Pandolfo M. Diagnosis and treatment of Friedreich ataxia: a European perspective. Nat Reviews Neurol. 2009;5(4):222\u201334.","journal-title":"Nat Reviews Neurol"},{"issue":"1","key":"2046_CR6","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13023-016-0543-7","volume":"11","author":"C Rothblum-Oviatt","year":"2016","unstructured":"Rothblum-Oviatt C, Wright J, Lefton-Greif MA, McGrath-Morrow SA, Crawford TO, Lederman HM. Ataxia telangiectasia: a review. Orphanet J Rare Dis. 2016;11(1):159.","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"2046_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4330\/wjc.v11.i1.1","volume":"11","author":"E Hanson","year":"2019","unstructured":"Hanson E, Sheldon M, Pacheco B, Alkubeysi M, Raizada V. Heart disease in Friedreich\u2019s ataxia. World J Cardiol. 2019;11(1):1\u201312.","journal-title":"World J Cardiol"},{"issue":"11","key":"2046_CR8","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1001\/jamaneurol.2015.1855","volume":"72","author":"F Pousset","year":"2015","unstructured":"Pousset F, Legrand L, Monin ML, Ewenczyk C, Charles P, Komajda M, Brice A, Pandolfo M, Isnard R, Tezenas du Montcel S, Durr A. A 22-Year Follow-up Study of Long-term Cardiac Outcome and Predictors of Survival in Friedreich Ataxia. JAMA Neurol. 2015;72(11):1334\u201341.","journal-title":"JAMA Neurol"},{"key":"2046_CR9","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s40120-025-00749-3","volume":"14:3","author":"K Gunther","year":"2025","unstructured":"Gunther K, Profeta V, Keita M, Park C, Wells M, Sharma S, Schadt K, Lynch DR. Safety Monitoring of Omaveloxolone in Friedreich Ataxia: Results from One Year of Clinical Treatment. Neurol Therapy. 2025;14:3:1105\u201314.","journal-title":"Neurol Therapy"},{"key":"2046_CR10","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/mds.29687","volume":"39","author":"E Indelicato","year":"2024","unstructured":"Indelicato E, Reetz K, Maier S, Nachbauer W, Amprosi M, Giunti P, Mariotti C, Durr A, de Rivera Garrido FJ, Klopstock T. Predictors of survival in Friedreich\u2019s ataxia: a prospective cohort study. Mov Disord. 2024;39:510\u20138.","journal-title":"Mov Disord"},{"key":"2046_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jns.2011.05.023","volume":"307","author":"AY Tsou","year":"2011","unstructured":"Tsou AY, Paulsen EK, Lagedrost SJ, Perlman SL, Mathews KD, Wilmot GR, Ravina B, Koeppen AH, Lynch DR. Mortality in Friedreich ataxia. J Neurol Sci. 2011;307:1\u20132.","journal-title":"J Neurol Sci"},{"issue":"3","key":"2046_CR12","doi-asserted-by":"publisher","first-page":"206","DOI":"10.14802\/jmd.22069","volume":"15","author":"A Stezin","year":"2022","unstructured":"Stezin A, Pal PK. Treatable ataxias: how to find the needle in the haystack? J Mov disorders. 2022;15(3):206.","journal-title":"J Mov disorders"},{"key":"2046_CR13","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.3390\/cells12182314","volume":"12","author":"T Bremova-Ertl","year":"2023","unstructured":"Bremova-Ertl T, Hofmann J, Stucki J, Vossenkaul A, Gautschi M. Inborn errors of metabolism with ataxia: Current and future treatment options. Cells. 2023;12:2314.","journal-title":"Cells"},{"key":"2046_CR14","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1002\/acn3.51370","volume":"8","author":"SM Brooker","year":"2021","unstructured":"Brooker SM, Edamakanti CR, Akasha SM, Kuo SH, Opal P. Spinocerebellar ataxia clinical trials: opportunities and challenges. Ann Clin Transl Neurol. 2021;8:1543\u201356.","journal-title":"Ann Clin Transl Neurol"},{"issue":"1","key":"2046_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1159\/000346275","volume":"41","author":"V Alonso","year":"2013","unstructured":"Alonso V, Villaverde-Hueso A, Hens MJ, Morales-Piga A, Abaitua I, de la Posada M. Epidemiology of Hereditary Ataxias in Spain: Hospital Discharge Registry and Population-Based Mortality Study. Neuroepidemiology. 2013;41(1):13\u20139.","journal-title":"Neuroepidemiology"},{"key":"2046_CR16","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S1474-4422(18)30042-5","volume":"17","author":"A Diallo","year":"2018","unstructured":"Diallo A, Jacobi H, Cook A, Labrum R, Durr A, Brice A, Charles P, Marelli C, Mariotti C, Nanetti L. Survival in patients with spinocerebellar ataxia types 1, 2, 3, and 6 (EUROSCA): a longitudinal cohort study. Lancet Neurol. 2018;17:327\u201334.","journal-title":"Lancet Neurol"},{"key":"2046_CR17","unstructured":"CDC. Multiple Cause of Death, 1999\u20132020. 2025 [cited 2025 19 June]; Available from: https:\/\/wonder.cdc.gov\/mcd-icd10.html"},{"issue":"12","key":"2046_CR18","doi-asserted-by":"publisher","first-page":"e008491","DOI":"10.1136\/bmjopen-2015-008491","volume":"5","author":"Y Lin","year":"2015","unstructured":"Lin Y, Chen M, Chen G, Wu X, Lin T. Application of an autoregressive integrated moving average model for predicting injury mortality in Xiamen, China. BMJ Open. 2015;5(12):e008491.","journal-title":"BMJ Open"},{"issue":"12","key":"2046_CR19","doi-asserted-by":"publisher","first-page":"e70057","DOI":"10.1002\/jgh3.70057","volume":"8","author":"H Ali","year":"2024","unstructured":"Ali H, Jahagirdar V, Blaney H, Dahiya DS, Gangwani MK, Patel P, Hayat U, Jaber F, Simonetto DA, Satapathy SK. Forecasting Alcohol-Related Liver Disease Mortality Trends in Younger Populations Using Advanced Time\u2010Series Models: A 1999\u20132030. Anal JGH Open. 2024;8(12):e70057.","journal-title":"Anal JGH Open"},{"issue":"3","key":"2046_CR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z","volume":"19","author":"HJ Kim","year":"2000","unstructured":"Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med. 2000;19(3):335\u201351.","journal-title":"Stat Med"},{"key":"2046_CR21","doi-asserted-by":"publisher","first-page":"908955","DOI":"10.3389\/fpubh.2022.908955","volume":"10","author":"B Zhu","year":"2022","unstructured":"Zhu B, Wu X, An W, Yao B, Liu Y. The systematic analysis and 10-year prediction on disease burden of childhood cancer in China. Front Public Health. 2022;10:908955.","journal-title":"Front Public Health"},{"key":"2046_CR22","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S1474-4422(07)70054-6","volume":"6:3","author":"BL Fogel","year":"2007","unstructured":"Fogel BL, Perlman S. Clinical features and molecular genetics of autosomal recessive cerebellar ataxias. Lancet Neurol. 2007;6:3:245\u201357.","journal-title":"Lancet Neurol"},{"key":"2046_CR23","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s00455-013-9450-4","volume":"28","author":"C Isono","year":"2013","unstructured":"Isono C, Hirano M, Sakamoto H, Ueno S, Kusunoki S, Nakamura Y. Differences in dysphagia between spinocerebellar ataxia type 3 and type 6. Dysphagia. 2013;28:413\u20138.","journal-title":"Dysphagia"},{"key":"2046_CR24","doi-asserted-by":"publisher","unstructured":"Vogel AP, Keage MJ, Johansson K, Schalling E. Treatment for dysphagia (swallowing difficulties) in hereditary ataxia. Cochrane Database Syst Rev. 2015 Nov 13;2015(11):CD010169. https:\/\/doi.org\/10.1002\/14651858.CD010169.pub2Vogel","DOI":"10.1002\/14651858.CD010169.pub2Vogel"},{"key":"2046_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1750-1172-6-23","volume":"6","author":"MA Lefton-Greif","year":"2011","unstructured":"Lefton-Greif MA, Crawford TO, McGrath-Morrow S, Carson KA, Lederman HM. Safety and caregiver satisfaction with gastrostomy in patients with Ataxia Telangiectasia. Orphanet J Rare Dis. 2011;6:1\u201310.","journal-title":"Orphanet J Rare Dis"},{"issue":"4","key":"2046_CR26","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1007\/s12311-023-01635-0","volume":"23","author":"ER Lowell","year":"2024","unstructured":"Lowell ER, Borders JC, Perry SE, Dakin AE, Sevitz JS, Kuo S-H, Troche MS. Sensorimotor cough dysfunction in cerebellar ataxias. Cerebellum. 2024;23(4):1338\u201347.","journal-title":"Cerebellum"},{"key":"2046_CR27","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1159\/000110182","volume":"8","author":"M Leone","year":"1989","unstructured":"Leone M, Chandra V, Schoenberg BS. Patterns of mortality from hereditary ataxias in the United States, 1971 and 1973\u20131978. Neuroepidemiology. 1989;8:193\u20139.","journal-title":"Neuroepidemiology"},{"key":"2046_CR28","doi-asserted-by":"crossref","unstructured":"Taylor CA. (2017) Deaths from alzheimer\u2019s disease\u2014United States, 1999\u20132014. MMWR. Morbidity and mortality weekly report 66.","DOI":"10.15585\/mmwr.mm6620a1"},{"issue":"2","key":"2046_CR29","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3233\/JAD-210225","volume":"82","author":"X Zhao","year":"2021","unstructured":"Zhao X, Li C, Ding G, Heng Y, Li A, Wang W, Hou H, Wen J, Zhang Y. The Burden of Alzheimer\u2019s Disease Mortality in the United States, 1999\u20132018. J Alzheimers Dis. 2021;82(2):803\u201313.","journal-title":"J Alzheimers Dis"},{"key":"2046_CR30","doi-asserted-by":"publisher","first-page":"105765","DOI":"10.1016\/j.msard.2024.105765","volume":"89","author":"ZA Nadeem","year":"2024","unstructured":"Nadeem ZA, Ashraf H, Nadeem A, Kareem R, Ashfaq H, Majid Z, Ashraf A. Trends in mortality due to multiple sclerosis in the United States: A retrospective analysis from 1999 to 2020. Multiple Scler Relat Disorders. 2024;89:105765.","journal-title":"Multiple Scler Relat Disorders"},{"key":"2046_CR31","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1111\/jce.16644","volume":"36","author":"MU Sohail","year":"2025","unstructured":"Sohail MU, Batool RM, Saad M, Waqas SA, Noushad MA, Sohail MO, Bates M, Ahmed R, Ripley D. Trends in mortality related to atrial fibrillation and dementia in older adults in the United States: a 2000\u20132020 analysis. J Cardiovasc Electrophys. 2025;36:1234\u201343.","journal-title":"J Cardiovasc Electrophys"},{"key":"2046_CR32","doi-asserted-by":"publisher","first-page":"107110","DOI":"10.1016\/j.parkreldis.2024.107110","volume":"127","author":"ZH Tharwani","year":"2024","unstructured":"Tharwani ZH, Deepak FNU, Arshad MS, Zaheer S, Kumar R, Bhimani RK, Jabbar M, Habib Z, Raja A, Shivani R. Temporal trends in Parkinson\u2019s disease among older adults in the United States from 1999 to 2020: Retrospective analysis from CDC WONDER database. Parkinsonism Relat Disord. 2024;127:107110.","journal-title":"Parkinsonism Relat Disord"},{"key":"2046_CR33","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1007\/s12311-023-01629-y","volume":"23","author":"RB Tenorio","year":"2024","unstructured":"Tenorio RB, Camargo CHF, Donis KC, Almeida CCB, Teive HAG. Diagnostic Yield of NGS Tests for Hereditary Ataxia: a Systematic Review. Cerebellum. 2024;23:1552\u201365.","journal-title":"Cerebellum"},{"issue":"11","key":"2046_CR34","doi-asserted-by":"publisher","first-page":"e0225147","DOI":"10.1371\/journal.pone.0225147","volume":"14","author":"RE Peverill","year":"2019","unstructured":"Peverill RE, Romanelli G, Donelan L, Hassam R, Corben LA, Delatycki MB. Left ventricular structural and functional changes in Friedreich ataxia - Relationship with body size, sex, age and genetic severity. PLoS ONE. 2019;14(11):e0225147.","journal-title":"PLoS ONE"},{"issue":"1","key":"2046_CR35","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1038\/s42003-024-06962-4","volume":"7","author":"L Salinas","year":"2024","unstructured":"Salinas L, Montgomery CB, Figueroa F, Thai PN, Chiamvimonvat N, Cortopassi G, Dedkova EN. Sexual dimorphism in a mouse model of Friedreich\u2019s ataxia with severe cardiomyopathy. Commun Biology. 2024;7(1):1250.","journal-title":"Commun Biology"},{"key":"2046_CR36","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/jhg.2015.131","volume":"61:3","author":"I Paradisi","year":"2016","unstructured":"Paradisi I, Ikonomu V, Arias S. Spinocerebellar ataxias in Venezuela: genetic epidemiology and their most likely ethnic descent. J Hum Genet. 2016;61:3:215\u201322.","journal-title":"J Hum Genet"},{"issue":"2","key":"2046_CR37","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00415-018-9076-4","volume":"266","author":"R Sullivan","year":"2019","unstructured":"Sullivan R, Yau WY, O\u2019Connor E, Houlden H. Spinocerebellar ataxia: an update. J Neurol. 2019;266(2):533\u201344.","journal-title":"J Neurol"},{"key":"2046_CR38","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/s41431-021-01022-5","volume":"30","author":"S Best","year":"2022","unstructured":"Best S, Vidic N, An K, Collins F, White SM. A systematic review of geographical inequities for accessing clinical genomic and genetic services for non-cancer related rare disease. Eur J Hum Genet. 2022;30:645\u201352.","journal-title":"Eur J Hum Genet"},{"key":"2046_CR39","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1007\/s12311-020-01109-7","volume":"19","author":"R Rodr\u00edguez-Labrada","year":"2020","unstructured":"Rodr\u00edguez-Labrada R, Martins AC, Maga\u00f1a JJ, Vazquez-Mojena Y, Medrano-Montero J, Fernandez-Ru\u00edz J, Cisneros B, Teive H, McFarland KN, Saraiva-Pereira ML, Cerecedo-Zapata CM, Gomez CM, Ashizawa T, Vel\u00e1zquez-P\u00e9rez L, Jardim LB. Founder Effects of Spinocerebellar Ataxias in the American Continents and the Caribbean. Cerebellum. 2020;19:446\u201358.","journal-title":"Cerebellum"},{"key":"2046_CR40","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1136\/adc.2006.094268","volume":"91","author":"TO Crawford","year":"2006","unstructured":"Crawford TO, Skolasky R, Fernandez R, Rosquist K, Lederman H. Survival probability in ataxia telangiectasia. Arch Dis Child. 2006;91:610\u20131.","journal-title":"Arch Dis Child"},{"issue":"1","key":"2046_CR41","doi-asserted-by":"publisher","first-page":"201661","DOI":"10.1016\/j.omta.2025.201661","volume":"34","author":"DM DuBreuil","year":"2026","unstructured":"DuBreuil DM, Fleming M, Parikh Y, Woo M, Bu J, Ayloo S, Langohr IM, Bangari DS, Mueller C, Ramachandran S. Development of a secretable frataxin for enhanced efficacy in treating Friedreich\u2019s Ataxia. Mol Therapy Adv. 2026;34(1):201661.","journal-title":"Mol Therapy Adv"},{"issue":"2","key":"2046_CR42","doi-asserted-by":"publisher","first-page":"102541","DOI":"10.1016\/j.omtn.2025.102541","volume":"36","author":"N Mozafari","year":"2025","unstructured":"Mozafari N, Milagres S, Umek T, Rocha CSJ, Vargiu CM, Freyberger F, Saher O, Napierala M, Napierala JS, Blomberg P, J\u00f8rgensen PT, Punga T, Smith CIE, Wengel J, Zain R. Anti-gene oligonucleotides targeting Friedreich\u2019s ataxia expanded GAA\u22c5TTC repeats increase Frataxin expression. Mol Therapy Nucleic Acids. 2025;36(2):102541.","journal-title":"Mol Therapy Nucleic Acids"},{"key":"2046_CR43","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.3390\/cells12081193","volume":"12","author":"A Benussi","year":"2023","unstructured":"Benussi A, Batsikadze G, Fran\u00e7a C, Cury RG, Maas RP. The therapeutic potential of non-invasive and invasive cerebellar stimulation techniques in hereditary ataxias. Cells. 2023;12:1193.","journal-title":"Cells"},{"issue":"8","key":"2046_CR44","doi-asserted-by":"publisher","first-page":"e031331","DOI":"10.1136\/bmjopen-2019-031331","volume":"9","author":"A Earnest","year":"2019","unstructured":"Earnest A, Evans SM, Sampurno F, Millar J. Forecasting annual incidence and mortality rate for prostate cancer in Australia until 2022 using autoregressive integrated moving average (ARIMA) models. BMJ Open. 2019;9(8):e031331.","journal-title":"BMJ Open"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-026-02046-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12311-026-02046-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-026-02046-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T05:09:53Z","timestamp":1786165793000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12311-026-02046-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["2046"],"URL":"https:\/\/doi.org\/10.1007\/s12311-026-02046-7","relation":{},"ISSN":["1473-4230"],"issn-type":[{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Aggregated mortality data are available from CDC WONDER. The processed dataset and study materials supporting the conclusions of this article are available in Supplementary Files online.","order":2,"name":"Ethics","label":"Supplementary data and materials","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was considered exempt from institutional review board approval because it used deidentified, publicly available government data and was conducted and reported in accordance with the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines. Data points suppressed in the CDC WONDER database for confidentiality reasons were excluded from analysis.","order":3,"name":"Ethics","label":"Ethics Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this manuscript, the authors used ChatGPT model 5.2 to in order to improve the readability and language of the manuscript. The authors reviewed, edited, and verified the content and all citations, and take full responsibility for the integrity of the work.","order":4,"name":"Ethics","label":"Declaration of Generative AI and AI-assisted technologies in the writing process","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"101"}}