{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:41:36Z","timestamp":1792734096596,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Friedreich\u2019s Ataxia Research Alliance Postdoctoral Fellowship"},{"name":"Kavli Distinguished PhD Fellowship"},{"name":"Klingenstein Simons Fellowship"},{"name":"Sloan Fellowship"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"DOI":"10.1007\/s12311-026-02068-1","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T04:35:41Z","timestamp":1786509341000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Generation and Validation of an Acan-Cre Mouse Line to Selectively Label Class-B Excitatory Neurons of the Cerebellar Nuclei"],"prefix":"10.1007","volume":"25","author":[{"given":"Julian","family":"Cheron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Lowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"M-G Anant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Siauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justus M.","family":"Kebschull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"2068_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-022-01506-0","author":"JM Kebschull","year":"2023","unstructured":"Kebschull JM, Casoni F, Consalez GG, Goldowitz D, Hawkes R, Ruigrok TJH, Schilling K, Wingate R, Wu J, Yeung J, Uusisaari MY. Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum. Cerebellum Lond Engl. 2023. https:\/\/doi.org\/10.1007\/s12311-022-01506-0.","journal-title":"Cerebellum Lond Engl"},{"key":"2068_CR2","doi-asserted-by":"publisher","first-page":"7554","DOI":"10.1523\/JNEUROSCI.1451-23.2023","volume":"43","author":"S Rudolph","year":"2023","unstructured":"Rudolph S, Badura A, Lutzu S, Pathak SS, Thieme A, Verpeut JL, Wagner MJ, Yang Y-M, Fioravante D. Cognitive-Affective Functions of the Cerebellum. J Neurosci. 2023;43:7554\u201364. https:\/\/doi.org\/10.1523\/JNEUROSCI.1451-23.2023.","journal-title":"J Neurosci"},{"key":"2068_CR3","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1113\/jphysiol.2010.201582","volume":"589","author":"M Uusisaari","year":"2011","unstructured":"Uusisaari M, De Schutter E. The mysterious microcircuitry of the cerebellar nuclei. J Physiol. 2011;589:3441\u201357. https:\/\/doi.org\/10.1113\/jphysiol.2010.201582.","journal-title":"J Physiol"},{"key":"2068_CR4","doi-asserted-by":"publisher","first-page":"eabd5059","DOI":"10.1126\/science.abd5059","volume":"370","author":"JM Kebschull","year":"2020","unstructured":"Kebschull JM, Richman EB, Ringach N, Friedmann D, Albarran E, Kolluru SS, Jones RC, Allen WE, Wang Y, Cho SW, Zhou H, Ding JB, Chang HY, Deisseroth K, Quake SR, Luo L. Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set. Science. 2020;370:eabd5059. https:\/\/doi.org\/10.1126\/science.abd5059.","journal-title":"Science"},{"key":"2068_CR5","doi-asserted-by":"publisher","first-page":"e58613","DOI":"10.7554\/eLife.58613","volume":"9","author":"H Fujita","year":"2020","unstructured":"Fujita H, Kodama T, du Lac S. Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis. eLife. 2020;9:e58613. https:\/\/doi.org\/10.7554\/eLife.58613.","journal-title":"eLife"},{"key":"2068_CR6","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1152\/jn.00974.2006","volume":"97","author":"M Uusisaari","year":"2007","unstructured":"Uusisaari M, Obata K, Kn\u00f6pfel T. Morphological and Electrophysiological Properties of GABAergic and Non-GABAergic Cells in the Deep Cerebellar Nuclei. J Neurophysiol. 2007;97:901\u201311. https:\/\/doi.org\/10.1152\/jn.00974.2006.","journal-title":"J Neurophysiol"},{"key":"2068_CR7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00401-011-0844-9","volume":"122","author":"AH Koeppen","year":"2011","unstructured":"Koeppen AH, Davis AN, Morral JA. The cerebellar component of Friedreich\u2019s ataxia. Acta Neuropathol (Berl). 2011;122:323\u201330. https:\/\/doi.org\/10.1007\/s00401-011-0844-9.","journal-title":"Acta Neuropathol (Berl)"},{"key":"2068_CR8","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neuron.2011.05.028","volume":"71","author":"L Vong","year":"2011","unstructured":"Vong L, Ye C, Yang Z, Choi B, Chua S, Lowell BB. Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons. Neuron. 2011;71:142\u201354. https:\/\/doi.org\/10.1016\/j.neuron.2011.05.028.","journal-title":"Neuron"},{"key":"2068_CR9","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.cell.2013.04.025","volume":"153","author":"H Wang","year":"2013","unstructured":"Wang H, Yang H, Shivalila CS, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R. One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR\/Cas-Mediated Genome Engineering. Cell. 2013;153:910\u20138. https:\/\/doi.org\/10.1016\/j.cell.2013.04.025.","journal-title":"Cell"},{"key":"2068_CR10","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.cell.2013.08.022","volume":"154","author":"H Yang","year":"2013","unstructured":"Yang H, Wang H, Shivalila CS, Cheng AW, Shi L, Jaenisch R. One-step generation of mice carrying reporter and conditional alleles by CRISPR\/Cas-mediated genome engineering. Cell. 2013;154:1370\u20139. https:\/\/doi.org\/10.1016\/j.cell.2013.08.022.","journal-title":"Cell"},{"key":"2068_CR11","doi-asserted-by":"publisher","unstructured":"Qi H, Anant MM-G, Faltine-Gonzalez DZ, Hu R, Wei L, Workman CD, Shi C, Rosario ID, Kebschull JM. 2026. BARseq3: a modular system for integrating spatial multi-omics and cellular barcoding in single cells. https:\/\/doi.org\/10.64898\/2026.05.13.724900","DOI":"10.64898\/2026.05.13.724900"},{"key":"2068_CR12","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/s41586-023-06812-z","volume":"624","author":"Z Yao","year":"2023","unstructured":"Yao Z, van Velthoven CTJ, Kunst M, Zhang M, McMillen D, Lee C, Jung W, Goldy J, Abdelhak A, Aitken M, Baker K, Baker P, Barkan E, Bertagnolli D, Bhandiwad A, Bielstein C, Bishwakarma P, Campos J, Carey D, Casper T, Chakka AB, Chakrabarty R, Chavan S, Chen M, Clark M, Close J, Crichton K, Daniel S, DiValentin P, Dolbeare T, Ellingwood L, Fiabane E, Fliss T, Gee J, Gerstenberger J, Glandon A, Gloe J, Gould J, Gray J, Guilford N, Guzman J, Hirschstein D, Ho W, Hooper M, Huang M, Hupp M, Jin K, Kroll M, Lathia K, Leon A, Li S, Long B, Madigan Z, Malloy J, Malone J, Maltzer Z, Martin N, McCue R, McGinty R, Mei N, Melchor J, Meyerdierks E, Mollenkopf T, Moonsman S, Nguyen TN, Otto S, Pham T, Rimorin C, Ruiz A, Sanchez R, Sawyer L, Shapovalova N, Shepard N, Slaughterbeck C, Sulc J, Tieu M, Torkelson A, Tung H, Valera Cuevas N, Vance S, Wadhwani K, Ward K, Levi B, Farrell C, Young R, Staats B, Wang M-QM, Thompson CL, Mufti S, Pagan CM, Kruse L, Dee N, Sunkin SM, Esposito L, Hawrylycz MJ, Waters J, Ng L, Smith K, Tasic B, Zhuang X, Zeng H. A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain. Nature. 2023;624:317\u201332. https:\/\/doi.org\/10.1038\/s41586-023-06812-z.","journal-title":"Nature"},{"key":"2068_CR13","doi-asserted-by":"publisher","first-page":"100341","DOI":"10.1016\/j.jgeb.2023.100341","volume":"22","author":"HA Ahmed","year":"2024","unstructured":"Ahmed HA, Elhossini R, Aglan M, Amr K. Aggrecan-related bone disorders; a novel heterozygous ACAN variant associated with spondyloepimetaphyseal dysplasia expanding the phenotypic spectrum and review of literature. J Genet Eng Biotechnol. 2024;22:100341. https:\/\/doi.org\/10.1016\/j.jgeb.2023.100341.","journal-title":"J Genet Eng Biotechnol"},{"key":"2068_CR14","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13023-016-0459-2","volume":"11","author":"BG Gibson","year":"2016","unstructured":"Gibson BG, Briggs MD. The aggrecanopathies; an evolving phenotypic spectrum of human genetic skeletal diseases. Orphanet J Rare Dis. 2016;11:86. https:\/\/doi.org\/10.1186\/s13023-016-0459-2.","journal-title":"Orphanet J Rare Dis"},{"key":"2068_CR15","doi-asserted-by":"publisher","first-page":"e2711","DOI":"10.1210\/clinem\/dgab088","volume":"106","author":"L Lin","year":"2021","unstructured":"Lin L, Li M, Luo J, Li P, Zhou S, Yang Y, Chen K, Weng Y, Ge X, Mireguli M, Wei H, Yang H, Li G, Sun Y, Cui L, Zhang S, Chen J, Zeng G, Xu L, Luo X, Shen Y. A High Proportion of Novel ACAN Mutations and Their Prevalence in a Large Cohort of Chinese Short Stature Children. J Clin Endocrinol Metab. 2021;106:e2711\u20139. https:\/\/doi.org\/10.1210\/clinem\/dgab088.","journal-title":"J Clin Endocrinol Metab"},{"key":"2068_CR16","doi-asserted-by":"publisher","first-page":"10102","DOI":"10.1523\/JNEUROSCI.1122-18.2018","volume":"38","author":"D Rowlands","year":"2018","unstructured":"Rowlands D, Lensj\u00f8 KK, Dinh T, Yang S, Andrews MR, Hafting T, Fyhn M, Fawcett JW, Dick G. Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity. J Neurosci. 2018;38:10102\u201313. https:\/\/doi.org\/10.1523\/JNEUROSCI.1122-18.2018.","journal-title":"J Neurosci"},{"key":"2068_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fnana.2017.00041","volume":"11","author":"A Noguchi","year":"2017","unstructured":"Noguchi A, Matsumoto N, Morikawa S, Tamura H, Ikegaya Y. Juvenile Hippocampal CA2 Region Expresses Aggrecan. Front Neuroanat. 2017;11:41. https:\/\/doi.org\/10.3389\/fnana.2017.00041.","journal-title":"Front Neuroanat"},{"key":"2068_CR18","doi-asserted-by":"publisher","first-page":"e23070","DOI":"10.1002\/dvg.23070","volume":"55","author":"H Rashid","year":"2017","unstructured":"Rashid H, Chen H, Hassan Q, Javed A. Dwarfism in homozygous Agc1CreERT mice is associated with decreased expression of aggrecan. genesis. 2017;55:e23070. https:\/\/doi.org\/10.1002\/dvg.23070.","journal-title":"genesis"},{"key":"2068_CR19","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1002\/dvg.20564","volume":"47","author":"SP Henry","year":"2009","unstructured":"Henry SP, Jang C-W, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B. Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage. Genesis. 2009;47:805\u201314. https:\/\/doi.org\/10.1002\/dvg.20564.","journal-title":"Genesis"},{"key":"2068_CR20","doi-asserted-by":"publisher","first-page":"10104","DOI":"10.1523\/JNEUROSCI.2087-09.2009","volume":"29","author":"MW Bagnall","year":"2009","unstructured":"Bagnall MW, Zingg B, Sakatos A, Moghadam SH, Zeilhofer HU, du Lac S. Glycinergic Projection Neurons of the Cerebellum. J Neurosci. 2009;29:10104\u201310. https:\/\/doi.org\/10.1523\/JNEUROSCI.2087-09.2009.","journal-title":"J Neurosci"},{"key":"2068_CR21","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s12311-010-0240-3","volume":"10","author":"M Uusisaari","year":"2011","unstructured":"Uusisaari M, Kn\u00f6pfel T. Functional Classification of Neurons in the Mouse Lateral Cerebellar Nuclei. Cerebellum. 2011;10:637\u201346. https:\/\/doi.org\/10.1007\/s12311-010-0240-3.","journal-title":"Cerebellum"},{"key":"2068_CR22","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.neuroscience.2008.07.060","volume":"156","author":"M Uusisaari","year":"2008","unstructured":"Uusisaari M, Kn\u00f6pfel T. GABAergic synaptic communication in the GABAergic and non-GABAergic cells in the deep cerebellar nuclei. Neuroscience. 2008;156:537\u201349. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.07.060.","journal-title":"Neuroscience"},{"key":"2068_CR23","doi-asserted-by":"publisher","unstructured":"Fenno LE, Mattis J, Ramakrishnan C, Deisseroth K. INTRSECT: targeting specific cell types in the nervous System. Curr Protoc Neurosci. 2017;80(391). https:\/\/doi.org\/10.1002\/cpns.30.","DOI":"10.1002\/cpns.30"},{"key":"2068_CR24","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/nmeth.2996","volume":"11","author":"LE Fenno","year":"2014","unstructured":"Fenno LE, Mattis J, Ramakrishnan C, Hyun M, Lee SY, He M, Tucciarone J, Selimbeyoglu A, Berndt A, Grosenick L, Zalocusky KA, Bernstein H, Swanson H, Perry C, Diester I, Boyce FM, Bass CE, Neve R, Huang ZJ, Deisseroth K. Targeting cells with single vectors using multiple-feature Boolean logic. Nat Methods. 2014;11:763\u201372. https:\/\/doi.org\/10.1038\/nmeth.2996.","journal-title":"Nat Methods"},{"key":"2068_CR25","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1038\/s41593-024-01659-7","volume":"27","author":"AC Hughes","year":"2024","unstructured":"Hughes AC, Pittman BG, Xu B, Gammons JW, Webb CM, Nolen HG, Chapman P, Bikoff JB, Schwarz LA. A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function. Nat Neurosci. 2024;27:1400\u201310. https:\/\/doi.org\/10.1038\/s41593-024-01659-7.","journal-title":"Nat Neurosci"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-026-02068-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12311-026-02068-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-026-02068-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:37:01Z","timestamp":1792733821000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12311-026-02068-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["2068"],"URL":"https:\/\/doi.org\/10.1007\/s12311-026-02068-1","relation":{},"ISSN":["1473-4230"],"issn-type":[{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"21 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"125"}}