{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:23:35Z","timestamp":1792783415098,"version":"4.5.0"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn","id":[{"id":"https:\/\/ror.org\/041nas322","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tumor Necrosis Factor-Induced Protein 1 (TNIP1) is a well-known ubiquitin-binding signaling molecule involved in innate and adaptive inflammatory processes. It has been implicated in diverse immunological diseases, but also associated with various neuro-psychiatric conditions, including Alzheimer\u2019s disease, glioma formation, and demyelination. However, a systematic analysis of TNIP1 expression and function in the central nervous system is missing. Here, we combine immunohistochemical staining, Western blotting, quantitative PCR and the re-analysis of publicly available single cell- and in situ hybridization-mRNA datasets to document the expression of TNIP1 in the developing and adult murine cerebellum. We document that TNIP1 is broadly expressed in cerebellar neurons and macroglial cells, where it is localized to discrete puncta within cell nuclei and somata, including Purkinje cell dendrites. Both TNIP1 and its mRNA are developmentally regulated in the early postnatal cerebellum, and levels of the latter vary systematically across the cell cycle. Consistently, overexpression of TNIP1 in human embryonic kidney cells inhibits proliferation and activates cleaved caspase-3 expression. These observations support a role for TNIP1 in neur(on)al development and function and establish a paradigm to study the mechanistic basis of its function in the normal and diseased nervous system.<\/jats:p>","DOI":"10.1007\/s12311-026-02080-5","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:34:26Z","timestamp":1788939266000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TNIP1 As A Potential Factor In Neuronal Survival, Growth and Differentiation in the Cerebellar Cortex"],"prefix":"10.1007","volume":"25","author":[{"given":"Carolina","family":"G\u00f6ttsche Esperan\u00e7a Clara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spoelgen","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian P.","family":"Roeser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan L.","family":"Baader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"2080_CR1","doi-asserted-by":"crossref","unstructured":"Oshima S, Turer EE, Callahan JA, Chai S, Advincula R, Barrera J, Shifrin N, Lee B, Benedict Yen TS, Yen B, Woo T, Malynn BA, Ma A. ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature 2009;457(7231):906\u20139.","DOI":"10.1038\/nature07575"},{"key":"2080_CR2","doi-asserted-by":"crossref","unstructured":"Shamilov R, Vinogradova O, Aneskievich BJ. The Anti-Inflammatory Protein TNIP1 Is Intrinsically Disordered with Structural Flexibility Contributed by Its AHD1-UBAN Domain. Biomolecules 2020;10(11):1531.","DOI":"10.3390\/biom10111531"},{"key":"2080_CR3","doi-asserted-by":"crossref","unstructured":"Li M, Liu Y, Xu C, Zhao Q, Liu J, Xing M, Li X, Zhang H, Wu X, Wang L, Ou Y, Wu X, Zhao X, Liu H, Qiu L, Li F, Li J, Rong W, Luo Y, Deng J, Wang X, Wang Z, Zhao Y, Lv A, Li Q, Zhang H. Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development. Cell Death Differ. 2022;29(10):2034\u201345.","DOI":"10.1038\/s41418-022-00994-1"},{"key":"2080_CR4","doi-asserted-by":"crossref","unstructured":"Le Guerrou\u00e9 F, Bunker EN, Rosencrans WM, Nguyen JT, Basar MA, Werner A, Chou T-F, Wang C, Youle RJ. TNIP1 inhibits selective autophagy via bipartite interaction with LC3\/GABARAP and TAX1BP1. Mol. Cell 2023;83(6):927\u2013941.e8.","DOI":"10.1016\/j.molcel.2023.02.023"},{"key":"2080_CR5","doi-asserted-by":"crossref","unstructured":"Verstrepen L, Carpentier I, Verhelst K, Beyaert R. ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling. Biochem. Pharmacol. 2009;78(2):105\u201314.","DOI":"10.1016\/j.bcp.2009.02.009"},{"key":"2080_CR6","doi-asserted-by":"crossref","unstructured":"van Quickelberghe E, Sutter D de, van Loo G, Eyckerman S, Gevaert K. A protein-protein interaction map of the TNF-induced NF-\u03baB signal transduction pathway. Sci. 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Arthritis Rheum. 2012;64(11):3695\u2013705.","journal-title":"Arthritis Rheum"},{"key":"2080_CR8","doi-asserted-by":"crossref","unstructured":"Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta M-L, Brun JG, G\u00f8ransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnstr\u00f6m M, Jazebi H, Cunninghame Graham DS, Grandits ME, Nazmul-Hossain ANM, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, R\u00f6nnblom L, Nordmark G, Ng W-F, Mariette X, Anaya J-M, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Sivils KL. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sj\u00f6gren\u2019s syndrome. Nat. Genet. 2013;45(11):1284\u201392.","DOI":"10.1038\/ng.2792"},{"key":"2080_CR9","doi-asserted-by":"crossref","unstructured":"Baurecht H, Hotze M, Brand S, B\u00fcning C, Cormican P, Corvin A, Ellinghaus D, Ellinghaus E, Esparza-Gordillo J, F\u00f6lster-Holst R, Franke A, Gieger C, Hubner N, Illig T, Irvine AD, Kabesch M, Lee YAE, Lieb W, Marenholz I, McLean WHI, Morris DW, Mrowietz U, Nair R, N\u00f6then MM, Novak N, O\u2019Regan GM, Schreiber S, Smith C, Strauch K, Stuart PE, Trembath R, Tsoi LC, Weichenthal M, Barker J, Elder JT, Weidinger S, Cordell HJ, Brown SJ. Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am. J. Hum. 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Immun. 2025;126:214\u201324.","DOI":"10.1016\/j.bbi.2025.02.015"},{"key":"2080_CR15","doi-asserted-by":"crossref","unstructured":"Pottier C, K\u00fc\u00e7\u00fckali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, Coster W de, Wynants S, van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, van Rooij JG, Mol MO, Hsiung G-YR, Graff C, \u00d6ijerstedt L, Neumann M, Asmann Y, McDonnell SK, Baheti S, Josephs KA, Whitwell JL, Bieniek KF, Forsberg L, Heuer H, Lago AL, Geier EG, Yokoyama JS, Oddi AP, Flanagan M, Mao Q, Hodges JR, Kwok JB, Domoto-Reilly K, Synofzik M, Wilke C, Onyike C, Dickerson BC, Evers BM, Dugger BN, Munoz DG, Keith J, Zinman L, Rogaeva E, Suh E, Gefen T, Geula C, Weintraub S, Diehl-Schmid J, Farlow MR, Edbauer D, Woodruff BK, Caselli RJ, Donker Kaat LL, Huey ED, Reiman EM, Mead S, King A, Roeber S, Nana AL, Ertekin-Taner N, Knopman DS, Petersen RC, Petrucelli L, Uitti RJ, Wszolek ZK, Ramos EM, Grinberg LT, Tempini MLG, Rosen HJ, Spina S, Piguet O, Grossman M, Trojanowski JQ, Keene CD, Jin L-W, Prudlo J, Geschwind DH, Rissman RA, Cruchaga C, Ghetti B, Halliday GM, Beach TG, Serrano GE, Arzberger T, Herms J, Boxer AL, Honig LS, Vonsattel JP, Lopez OL, Kofler J, White CL, Gearing M, Glass J, Rohrer JD, Irwin DJ, Lee EB, van Deerlin V, Castellani R, Mesulam MM, Tartaglia MC, Finger EC, Troakes C, Al-Sarraj S, Dalgard CL, Miller BL, Seelaar H, Graff-Radford NR, Boeve BF, Mackenzie IR, van Swieten JC, Seeley WW, Sleegers K, Dickson DW, Biernacka JM, Rademakers R. Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing. Nat. Commun. 2025;16(1):3914.","DOI":"10.1038\/s41467-025-59216-0"},{"key":"2080_CR16","doi-asserted-by":"crossref","unstructured":"Terzi U, Ates I, Erden A, Suzen S, Irham LM, Yilmaz S. Investigation of the pathogenic variants induced Sjogren\u2019s syndrome in Turkish population. Open Med. (Wars) 2025;20(1):20251294.","DOI":"10.1515\/med-2025-1294"},{"key":"2080_CR17","doi-asserted-by":"crossref","unstructured":"17. G\u2019Sell RT, Gaffney PM, Powell DW. A20-Binding Inhibitor of NF-\u03baB Activation 1 is a Physiologic Inhibitor of NF-\u03baB: A Molecular Switch for Inflammation and Autoimmunity. Arthritis Rheumatol. 2015;67(9):2292\u2013302.","DOI":"10.1002\/art.39245"},{"key":"2080_CR18","doi-asserted-by":"crossref","unstructured":"Stelzer G, Rosen N, Plaschkes I, Zimmerman S, Twik M, Fishilevich S, Stein TI, Nudel R, Lieder I, Mazor Y, Kaplan S, Dahary D, Warshawsky D, Guan-Golan Y, Kohn A, Rappaport N, Safran M, Lancet D. The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses. Curr. Protoc. Bioinformatics 2016;54:1.30.1\u20131.30.33.","DOI":"10.1002\/cpbi.5"},{"key":"2080_CR19","volume-title":"Development of the Cerebellum from Molecular Aspects to Diseases","year":"2023","unstructured":"Marzban H, editor. Development of the Cerebellum from Molecular Aspects to Diseases. 2nd edn. Cham: Springer International Publishing; 2023.","edition":"2nd edn"},{"key":"2080_CR20","doi-asserted-by":"crossref","unstructured":"Kadota K, Mori M, Yanagimachi M, Miyamae T, Hara T, Kanetaka T, Nozawa T, Kikuchi M, Hara R, Imagawa T, Kaneko T, Yokota S. Analysis of gender differences in genetic risk: association of TNFAIP3 polymorphism with male childhood-onset systemic lupus erythematosus in the Japanese population. PLoS ONE 2013;8(8):e72551.","DOI":"10.1371\/journal.pone.0072551"},{"key":"2080_CR21","doi-asserted-by":"crossref","unstructured":"Ippagunta SK, Gangwar R, Finkelstein D, Vogel P, Pelletier S, Gingras S, Redecke V, H\u00e4cker H. Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function. Proc. Natl. Acad. Sci. 2016;113(41):E6162-E6171.","DOI":"10.1073\/pnas.1606996113"},{"key":"2080_CR22","doi-asserted-by":"crossref","unstructured":"Kozareva V, Martin C, Osorno T, Rudolph S, Guo C, Vanderburg C, Nadaf N, Regev A, Regehr WG, Macosko E. A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types. 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Cellular distribution of metastasis suppressor 1 and the shape of cell bodies are temporarily altered in Engrailed-2 overexpressing cerebellar Purkinje cells. Neuroscience 2011;189:68\u201378.","DOI":"10.1016\/j.neuroscience.2011.05.038"},{"key":"2080_CR26","doi-asserted-by":"crossref","unstructured":"Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Ramaswamy V, Mack SC, Lee JJY, Kumar S, Przelicki D, Michealraj A, Juraschka K, Skowron P, Luu B, Suzuki H, Morrissy A. Sorana, Cavalli FM, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Pugh T, Notta F, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD, Sundaravadanam Y, Hendrikse LD, Mack SC, Fong V, Morrissy AS, Cavalli FMG, Heisler L, Ng K, Thompson EM. Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs \/\/ Childhood cerebellar tumours mirror conserved fetal transcriptional programs. 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Classifying cell cycle states and a quiescent-like G0 state using single-cell transcriptomics. bioRxiv 2025.","DOI":"10.1101\/2024.04.16.589816"},{"key":"2080_CR34","doi-asserted-by":"crossref","unstructured":"34. Baader SL, Schilling K. Glutamate receptors mediate dynamic regulation of nitric oxide synthase expression in cerebellar granule cells. J. Neurosci. 1996;16(4):1440\u20139.","DOI":"10.1523\/JNEUROSCI.16-04-01440.1996"},{"key":"2080_CR35","doi-asserted-by":"crossref","unstructured":"35. Holst MI, Maercker C, Pintea B, Masseroli M, Liebig C, Jankowski J, Miething A, Martini J, Schwaller B, Oberdick J, Schilling K, Baader SL. Engrailed-2 regulates genes related to vesicle formation and transport in cerebellar Purkinje cells. Mol. Cell. Neurosci. 2008;38(4):495\u2013504.","DOI":"10.1016\/j.mcn.2008.04.010"},{"key":"2080_CR36","doi-asserted-by":"crossref","unstructured":"Bahaaeldin M, B\u00fclte C, Luelsberg F, Kumar S, Kappler J, V\u00f6lker C, Schilling K, Baader SL. 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