{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:40:26Z","timestamp":1792795226635,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Huizhi Talent Project of Xuanwu Hospital, Capital Medical University (Support Program for Top-notch Talents\uff09","award":["HZ2025ZCBJ004"],"award-info":[{"award-number":["HZ2025ZCBJ004"]}],"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Huizhi Talent Project of Xuanwu Hospital, Capital Medical University (Support Program for Top-notch Talents\uff09","award":["HZ2025ZCBJ004"],"award-info":[{"award-number":["HZ2025ZCBJ004"]}],"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Huizhi Talent Project of Xuanwu Hospital, Capital Medical University (Support Program for Top-notch Talents\uff09","award":["HZ2025ZCBJ004"],"award-info":[{"award-number":["HZ2025ZCBJ004"]}],"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Huizhi Talent Project of Xuanwu Hospital, Capital Medical University (Support Program for Top-notch Talents\uff09","award":["HZ2025ZCBJ004"],"award-info":[{"award-number":["HZ2025ZCBJ004"]}],"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Huizhi Talent Project of Xuanwu Hospital, Capital Medical University (Support Program for Top-notch Talents\uff09","award":["HZ2025ZCBJ004"],"award-info":[{"award-number":["HZ2025ZCBJ004"]}],"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Huizhi Talent Project of Xuanwu Hospital, Capital Medical University (Support Program for Top-notch Talents\uff09","award":["HZ2025ZCBJ004"],"award-info":[{"award-number":["HZ2025ZCBJ004"]}],"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Gaochuang Program of Xuanwu Hospital, Capital Medical University","id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"DOI":"10.1007\/s12311-026-02087-y","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:53:20Z","timestamp":1790754800000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non-paraneoplastic Autoimmune Cerebellar Ataxia with Sensory Ataxia Associated with the Anti-Ca\/ARHGAP26 Antibody: A Case Report"],"prefix":"10.1007","volume":"25","author":[{"given":"Hongchao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wancheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"2087_CR1","doi-asserted-by":"publisher","first-page":"830","DOI":"10.3760\/cma.j.cn113694-20231127-00344","volume":"57","author":"Chinese Society of Infectious Diseases and Cerebrospinal Fluid Cytology, Autoimmune Encephalitis Professional Committee of China Rare Disease Alliance","year":"2024","unstructured":"Chinese Society of Infectious Diseases and Cerebrospinal Fluid Cytology, Autoimmune Encephalitis Professional Committee of China Rare Disease Alliance. Expert consensus on the diagnosis of autoimmune cerebellar ataxia. Zhonghua Shen Jing Ke Za Zhi. 2024;57:830\u20139. https:\/\/doi.org\/10.3760\/cma.j.cn113694-20231127-00344. (in Chinese).","journal-title":"Zhonghua Shen Jing Ke Za Zhi"},{"key":"2087_CR2","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s12311-022-01412-5","volume":"22","author":"M Liu","year":"2023","unstructured":"Liu M, Ren H, Zhu Y, Fan S, Bai L, Wang J, et al. Autoimmune cerebellar ataxia: etiology and clinical characteristics of a case series from China. Cerebellum. 2023;22:379\u201385. https:\/\/doi.org\/10.1007\/s12311-022-01412-5.","journal-title":"Cerebellum"},{"key":"2087_CR3","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s12311-020-01132-8","volume":"19","author":"M Hadjivassiliou","year":"2020","unstructured":"Hadjivassiliou M, Graus F, Honnorat J, Jarius S, Titulaer M, Manto M, et al. Diagnostic criteria for primary autoimmune cerebellar ataxia\u2014guidelines from an international task force on immune-mediated cerebellar ataxias. Cerebellum. 2020;19:605\u201310. https:\/\/doi.org\/10.1007\/s12311-020-01132-8.","journal-title":"Cerebellum"},{"key":"2087_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12311-021-01359-z","volume":"22","author":"H Mitoma","year":"2023","unstructured":"Mitoma H, Manto M. Advances in the pathogenesis of auto-antibody-induced cerebellar synaptopathies. Cerebellum. 2023;22:129\u201347. https:\/\/doi.org\/10.1007\/s12311-021-01359-z.","journal-title":"Cerebellum"},{"key":"2087_CR5","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1136\/jnnp.2007.138016","volume":"80","author":"J Honnorat","year":"2009","unstructured":"Honnorat J, Cartalat-Carel S, Ricard D, Camdessanch\u00e9 JP, Carpentier AF, Rogemond V, et al. Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2\/CRMP5 antibodies. J Neurol Neurosurg Psychiatry. 2009;80:412\u20136. https:\/\/doi.org\/10.1136\/jnnp.2007.138016.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2087_CR6","doi-asserted-by":"publisher","first-page":"e1014","DOI":"10.1212\/NXI.0000000000001014","volume":"8","author":"F Graus","year":"2021","unstructured":"Graus F, Vogrig A, Mu\u00f1iz-Castrillo S, Antoine JC, Desestret V, Dubey D, et al. Updated diagnostic criteria for paraneoplastic neurologic syndromes. Neurol Neuroimmunol Neuroinflamm. 2021;8:e1014. https:\/\/doi.org\/10.1212\/NXI.0000000000001014.","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"2087_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1468-1331.2010.03220.x","volume":"18","author":"MJ Titulaer","year":"2011","unstructured":"Titulaer MJ, Soffietti R, Dalmau J, Gilhus NE, Giometto B, Graus F, et al. Screening for tumours in paraneoplastic syndromes: report of an EFNS task force. Eur J Neurol. 2011;18:19\u2013e3. https:\/\/doi.org\/10.1111\/j.1468-1331.2010.03220.x.","journal-title":"Eur J Neurol"},{"key":"2087_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40673-016-0060-4","volume":"4","author":"P Zis","year":"2017","unstructured":"Zis P, Rao DG, Wagner BE, Nicholson-Goult L, Hoggard N, Hadjivassiliou M. Cerebellar ataxia and sensory neuronopathy associated with light-chain myeloma. Cerebellum Ataxias. 2017;4:1. https:\/\/doi.org\/10.1186\/s40673-016-0060-4.","journal-title":"Cerebellum Ataxias"},{"key":"2087_CR9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1742-2094-10-7","volume":"10","author":"S Jarius","year":"2013","unstructured":"Jarius S, Mart\u00ednez-Garc\u00eda P, Hernandez AL, Brase JC, Borowski K, Regula JU, et al. Two new cases of anti-Ca (anti-ARHGAP26\/GRAF) autoantibody-associated cerebellar ataxia. J Neuroinflammation. 2013;10:7. https:\/\/doi.org\/10.1186\/1742-2094-10-7.","journal-title":"J Neuroinflammation"},{"key":"2087_CR10","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1002\/mdc3.13036","volume":"7","author":"SJ Pittock","year":"2020","unstructured":"Pittock SJ, Alfugham N, O\u2019Connor K, Hinson S, Kunchok A, Lennon VA, et al. GTPase regulator associated with focal adhesion kinase 1 (GRAF1) immunoglobulin-associated ataxia and neuropathy. Mov Disord Clin Pract. 2020;7:904\u20139. https:\/\/doi.org\/10.1002\/mdc3.13036.","journal-title":"Mov Disord Clin Pract"},{"key":"2087_CR11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1742-2094-7-21","volume":"7","author":"S Jarius","year":"2010","unstructured":"Jarius S, Wandinger KP, Horn S, Heuer H, Wildemann B. A new Purkinje cell antibody (anti-Ca) associated with subacute cerebellar ataxia: immunological characterization. J Neuroinflammation. 2010;7:21. https:\/\/doi.org\/10.1186\/1742-2094-7-21.","journal-title":"J Neuroinflammation"},{"key":"2087_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jneuroim.2017.05.011","volume":"309","author":"U Wallwitz","year":"2017","unstructured":"Wallwitz U, Brock S, Schunck A, Wildemann B, Jarius S, Hoffmann F. From dizziness to severe ataxia and dysarthria: new cases of anti-Ca\/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum. J Neuroimmunol. 2017;309:77\u201381. https:\/\/doi.org\/10.1016\/j.jneuroim.2017.05.011.","journal-title":"J Neuroimmunol"},{"key":"2087_CR13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jneuroim.2013.10.010","volume":"267","author":"S Doss","year":"2014","unstructured":"Doss S, N\u00fcmann A, Ziegler A, Siebert E, Borowski K, St\u00f6cker W, et al. Anti-Ca\/anti-ARHGAP26 antibodies associated with cerebellar atrophy and cognitive decline. J Neuroimmunol. 2014;267:102\u20134. https:\/\/doi.org\/10.1016\/j.jneuroim.2013.10.010.","journal-title":"J Neuroimmunol"},{"key":"2087_CR14","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3389\/fneur.2018.00656","volume":"9","author":"F Bartels","year":"2018","unstructured":"Bartels F, Pr\u00fcss H, Finke C. Anti-ARHGAP26 autoantibodies are associated with isolated cognitive impairment. Front Neurol. 2018;9:656. https:\/\/doi.org\/10.3389\/fneur.2018.00656.","journal-title":"Front Neurol"},{"key":"2087_CR15","doi-asserted-by":"publisher","first-page":"136","DOI":"10.2337\/dc16-2042","volume":"40","author":"R Pop-Busui","year":"2017","unstructured":"Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, et al. Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes Care. 2017;40:136\u201354. https:\/\/doi.org\/10.2337\/dc16-2042.","journal-title":"Diabetes Care"},{"key":"2087_CR16","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.3390\/jcm10102154","volume":"10","author":"F Aberer","year":"2021","unstructured":"Aberer F, Hochfellner DA, Sourij H, Mader JK. A practical guide for the management of steroid-induced hyperglycaemia in the hospital. J Clin Med. 2021;10:2154. https:\/\/doi.org\/10.3390\/jcm10102154.","journal-title":"J Clin Med"},{"key":"2087_CR17","doi-asserted-by":"publisher","first-page":"5420","DOI":"10.1007\/s00415-022-11178-9","volume":"269","author":"S Jarius","year":"2022","unstructured":"Jarius S, Komorowski L, Regula JU, Haas J, Brakopp S, Wildemann B. Rho GTPase-activating protein 10 (ARHGAP10\/GRAF2) is a novel autoantibody target in patients with autoimmune encephalitis. J Neurol. 2022;269:5420\u201330. https:\/\/doi.org\/10.1007\/s00415-022-11178-9.","journal-title":"J Neurol"},{"key":"2087_CR18","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1093\/brain\/awp136","volume":"132","author":"JP Camdessanch\u00e9","year":"2009","unstructured":"Camdessanch\u00e9 JP, Jousserand G, Ferraud K, Vial C, Petiot P, Honnorat J, et al. The pattern and diagnostic criteria of sensory neuronopathy: a case-control study. Brain. 2009;132:1723\u201333. https:\/\/doi.org\/10.1093\/brain\/awp136.","journal-title":"Brain"},{"key":"2087_CR19","doi-asserted-by":"publisher","first-page":"578547","DOI":"10.1016\/j.jneuroim.2025.578547","volume":"400","author":"H Ren","year":"2025","unstructured":"Ren H, Liu M, Qian M, Yang Y, Guan H. Cerebellar ataxia and depression associated with anti-RhoGTPase-activating protein 26 antibody: a case report. J Neuroimmunol. 2025;400:578547. https:\/\/doi.org\/10.1016\/j.jneuroim.2025.578547.","journal-title":"J Neuroimmunol"},{"key":"2087_CR20","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.cub.2008.10.044","volume":"18","author":"R Lundmark","year":"2008","unstructured":"Lundmark R, Doherty GJ, Howes MT, Cortese K, Vallis Y, Parton RG, et al. The GTPase-activating protein GRAF1 regulates the CLIC\/GEEC endocytic pathway. Curr Biol. 2008;18:1802\u20138. https:\/\/doi.org\/10.1016\/j.cub.2008.10.044.","journal-title":"Curr Biol"},{"key":"2087_CR21","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S1474-4422(13)70282-5","volume":"13","author":"N Gresa-Arribas","year":"2014","unstructured":"Gresa-Arribas N, Titulaer MJ, Torrents A, Aguilar E, McCracken L, Leypoldt F, et al. Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. Lancet Neurol. 2014;13:167\u201377. doi.org.","journal-title":"Lancet Neurol"},{"key":"2087_CR22","doi-asserted-by":"publisher","first-page":"e659","DOI":"10.1212\/NXI.0000000000000659","volume":"7","author":"M Guasp","year":"2020","unstructured":"Guasp M, M\u00f3dena Y, Armangue T, Dalmau J, Graus F. Clinical features of seronegative, but CSF antibody-positive, anti-NMDA receptor encephalitis. Neurol Neuroimmunol Neuroinflamm. 2020;7:e659. https:\/\/doi.org\/10.1212\/NXI.0000000000000659.","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"2087_CR23","doi-asserted-by":"publisher","first-page":"e1127","DOI":"10.1212\/NXI.0000000000001127","volume":"9","author":"AEM Bastiaansen","year":"2022","unstructured":"Bastiaansen AEM, de Bruijn MAAM, Schuller SL, Martinez-Hernandez E, Brenner J, Paunovic M, et al. Anti-NMDAR encephalitis in the Netherlands, focusing on late-onset patients and antibody test accuracy. Neurol Neuroimmunol Neuroinflamm. 2022;9:e1127. https:\/\/doi.org\/10.1212\/NXI.0000000000001127.","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"2087_CR24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.seizure.2015.04.005","volume":"29","author":"R Wang","year":"2015","unstructured":"Wang R, Guan HZ, Ren HT, Wang W, Hong Z, Zhou D. CSF findings in patients with anti-N-methyl-D-aspartate receptor encephalitis. Seizure. 2015;29:137\u201342. https:\/\/doi.org\/10.1016\/j.seizure.2015.04.005.","journal-title":"Seizure"},{"key":"2087_CR25","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1007\/s12311-017-0851-z","volume":"16","author":"T Petrijan","year":"2017","unstructured":"Petrijan T, Menih M. Low-titre GAD antibody-associated late-onset cerebellar ataxia with a significant clinical response to intravenous immunoglobulin treatment. Cerebellum. 2017;16:868\u201371. https:\/\/doi.org\/10.1007\/s12311-017-0851-z.","journal-title":"Cerebellum"},{"key":"2087_CR26","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1007\/s12311-023-01550-4","volume":"23","author":"M Manto","year":"2024","unstructured":"Manto M, Hadjivassiliou M, Baizabal-Carvallo JF, Hampe CS, Honnorat J, Joubert B, et al. Consensus paper: latent autoimmune cerebellar ataxia (LACA). Cerebellum. 2024;23:838\u201355. https:\/\/doi.org\/10.1007\/s12311-023-01550-4.","journal-title":"Cerebellum"},{"key":"2087_CR27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.31083\/j.jin2304079","volume":"23","author":"M Manto","year":"2024","unstructured":"Manto M, Mitoma H. Immune ataxias: the continuum of latent ataxia, primary ataxia and clinical ataxia. J Integr Neurosci. 2024;23:79. https:\/\/doi.org\/10.31083\/j.jin2304079.","journal-title":"J Integr Neurosci"},{"key":"2087_CR28","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1007\/s00415-023-12128-9","volume":"271","author":"M Liu","year":"2024","unstructured":"Liu M, Ren H, Wang L, Fan S, Bai L, Guan H. Prognostic and relapsing factors of primary autoimmune cerebellar ataxia: a prospective cohort study. J Neurol. 2024;271:1072\u20139. https:\/\/doi.org\/10.1007\/s00415-023-12128-9.","journal-title":"J Neurol"}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-026-02087-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12311-026-02087-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12311-026-02087-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:02:21Z","timestamp":1792792941000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12311-026-02087-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["2087"],"URL":"https:\/\/doi.org\/10.1007\/s12311-026-02087-y","relation":{},"ISSN":["1473-4230"],"issn-type":[{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"12 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This single-patient case report was conducted in accordance with the ethical principles of the Declaration of Helsinki. In accordance with the policy of Xuanwu Hospital, Capital Medical University, formal ethics committee review and approval are not required for retrospective reports involving a single patient; written informed consent was obtained from the patient (see below).","order":1,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent to participate was obtained from the patient.","order":2,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent for publication of the clinical details and accompanying images was obtained from the patient.","order":3,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"149"}}