{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:31:51Z","timestamp":1791246711079,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Therapy"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1007\/s12325-008-0020-3","type":"journal-article","created":{"date-parts":[[2008,3,5]],"date-time":"2008-03-05T22:18:01Z","timestamp":1204755481000},"page":"133-142","source":"Crossref","is-referenced-by-count":4,"title":["Chondroprotective effect of salicylate and chloroquine in pyogenic septic arthritis"],"prefix":"10.1007","volume":"25","author":[{"given":"Abdullah","family":"Eren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ender","family":"Ugutmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korhan","family":"\u00d6zkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalcin","family":"Turhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin","family":"Eceviz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feridun","family":"Cilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,3,6]]},"reference":[{"key":"20_CR1","first-page":"479","volume":"24","author":"D. Daniel","year":"1973","unstructured":"Daniel D, Boyer J, Green S. Cartilage destruction in experimentally produced staphylococcus aureus pyarthrosis in vitro study. Surg Forum. 1973;24:479\u2013481.","journal-title":"Surg Forum"},{"key":"20_CR2","first-page":"835","volume":"80","author":"S. Arvidson","year":"1972","unstructured":"Arvidson S, Holme T, Lindholm B. The formation of exstracellular proteolytic enzymes by Staphylacoccus aureus. Acta Path Microbial Scand [B] Microbiol Immunol. 1972;80:835\u2013844.","journal-title":"Acta Path Microbial Scand [B] Microbiol Immunol"},{"key":"20_CR3","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2106\/00004623-196547080-00013","volume":"47","author":"P.H. Curtiss Jr","year":"1965","unstructured":"Curtiss PH Jr, Klein L. Destruction of articular cartilage in septic arthritis in vivo studies. J Bone Joint Surg. 1965;47:1595\u20131604.","journal-title":"J Bone Joint Surg"},{"key":"20_CR4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2106\/00004623-197658030-00018","volume":"58","author":"D. Daniel","year":"1976","unstructured":"Daniel D, Akeson W, Amiel D, Ryder M, Boyer J. Lavage of septic joints in rabbits: effects of chondolysis. J Bone Joint Surg. 1976;58:393\u2013395.","journal-title":"J Bone Joint Surg"},{"key":"20_CR5","first-page":"109","volume":"55","author":"J.T. Dingle","year":"1962","unstructured":"Dingle JT. Lysosomal enzymes end the degradation of cartilage matrix. Proc Soc Med. 1962;55:109\u2013111.","journal-title":"Proc Soc Med"},{"key":"20_CR6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3181\/00379727-135-35040","volume":"135","author":"A. Janoff","year":"1970","unstructured":"Janoff A. Depletion of cartilage matrix by a neutral protease fraction of human leukocyte lysosomes. Proc Soc Exp Boil Med. 1970;135:302\u2013306.","journal-title":"Proc Soc Exp Boil Med"},{"key":"20_CR7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000230346","volume":"39","author":"S. Arora","year":"1970","unstructured":"Arora S, Lahiri PK, Sanyal RR. The role of prostaglandin E1 in inflammatory process in the rat. Int Arch Allergy. 1970;39:186\u2013191.","journal-title":"Int Arch Allergy"},{"key":"20_CR8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1749-6632.1971.tb53203.x","volume":"180","author":"G. Kaley","year":"1971","unstructured":"Kaley G, Weiner R. Prostaglandin E1: a potential mediator of inflammatory response. Ann N Y Acad Sci. 1971;180:338\u2013350.","journal-title":"Ann N Y Acad Sci"},{"key":"20_CR9","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/art.1780221011","volume":"22","author":"J.P. Fulkerson","year":"1979","unstructured":"Fulkerson JP, Chrisman OD. In vitro hexosamin deplation of intact articular cartilage by E-prostaglandins preventation by chloroquine. Arthritis Rheum.1979;22:1117\u20131121.","journal-title":"Arthritis Rheum"},{"key":"20_CR10","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/2181135a0","volume":"218","author":"N. Gilmore","year":"1968","unstructured":"Gilmore N, Vane JR, Wyllie JH. Prostaglandins released by the spleen. Nature.1968;218:1135\u20131140.","journal-title":"Nature"},{"key":"20_CR11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0090-6980(79)80058-1","volume":"18","author":"E. Gulbis","year":"1979","unstructured":"Gulbis E, Marion AM, Dumont JE. Prostaglandin formation in bacteria. Prostaglandins. 1979;18:397\u2013400.","journal-title":"Prostaglandins"},{"issue":"suppl39","key":"20_CR12","first-page":"3","volume":"20","author":"E. Balazs","year":"1993","unstructured":"Balazs E, Denlinger JL. Viscosupplementation: a new concept in the treatment of osteoarthritis. J Rheumatol. 1993;20(suppl 39):3\u20138.","journal-title":"J Rheumatol"},{"key":"20_CR13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.joca.2004.01.001","volume":"12","author":"K. Pavelka","year":"2004","unstructured":"Pavelka K, Forejtova S, Olejarova M, et al. Plasma hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis. Osteoarthritis Cartilage. 2004;12:277\u2013283.","journal-title":"Osteoarthritis Cartilage"},{"key":"20_CR14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/ard.56.5.299","volume":"56","author":"C. Belcher","year":"1997","unstructured":"Belcher C, Yaqub R, Fawthrop E, et al. Synovial fluid chondroitin and keratin sulphate epitops, glycosaminoglycans and hyaluronan in arthritic and normal knees. Ann Rheum Dis. 1997;56:299\u2013307.","journal-title":"Ann Rheum Dis"},{"key":"20_CR15","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/art.1780080506","volume":"8","author":"D.P. Simmons","year":"1965","unstructured":"Simmons DP, Chrisman OD. Salicylate inhibition of cartilage degeneration. Arthritis Rheum. 1965;8:960\u2013969.","journal-title":"Arthritis Rheum"},{"key":"20_CR16","doi-asserted-by":"crossref","unstructured":"Boyer J, Daniel D, Akeson WH, et al. Effect of salicylate therapy on cartilage destruction in experimental pyarthrosis. Clin Orthop Relat Res. 1977;(126):302\u2013304.","DOI":"10.1097\/00003086-197707000-00057"},{"key":"20_CR17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00003086-197303000-00033","volume":"91","author":"P. Volastro","year":"1973","unstructured":"Volastro P, Malawista S, Chrisman OD. Chloroquine: protective and destructive effects on injured rabbit cartilage in vivo. Clin Orthop Relat Res. 1973;91:243\u2013248.","journal-title":"Clin Orthop Relat Res"},{"key":"20_CR18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/bj0980011C","volume":"98","author":"M. Whitehouse","year":"1966","unstructured":"Whitehouse M, Cowey F. Inhibition of connective tissue proteases by antimalarial, anti-rheumatic drugs. Biochem J. 1966;98:11.","journal-title":"Biochem J"},{"key":"20_CR19","first-page":"760","volume":"7","author":"N. Zvaifler","year":"1964","unstructured":"Zvaifler N. The subcellular localization of chloroquine and its effects on lysosomal disruption. Arth Rheum. 1964;7:760.","journal-title":"Arth Rheum"},{"key":"20_CR20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1042\/bj1050549","volume":"105","author":"S.Y. Ali","year":"1967","unstructured":"Ali SY, Evans L, Stainthorpe E, Lack CH. Characterization of cathepsins in cartilage. Biochem J. 1967;105:549\u2013557.","journal-title":"Biochem J"},{"key":"20_CR21","volume-title":"The Healing of Osseous Tissue","author":"O.D. Chrisman","year":"1967","unstructured":"Chrisman OD, Semonsky C, Bensch K. Cathepsins in articular cartilage. In: The Healing of Osseous Tissue. Robinson RA, ed. Washington: National Academy of Sciences-National Research Council; 1967."},{"key":"20_CR22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM196507012730105","volume":"273","author":"D. Hurvitz","year":"1965","unstructured":"Hurvitz D, Hirschhorn K. Suppression of in vitro lymphocyte responses by chloroquine. N Engl J Med. 1965;273:23\u201326.","journal-title":"N Engl J Med"},{"key":"20_CR23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0042-6822(66)90046-8","volume":"28","author":"L. Malluci","year":"1966","unstructured":"Malluci L. Effect of chloroquine on lysosomes and on growth of mouse hepatitis virus (MHV-3). Virology. 1966;28:355.","journal-title":"Virology"},{"key":"20_CR24","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1476-5381.1957.tb00146.x","volume":"12","author":"J.R. Vane","year":"1957","unstructured":"Vane JR. A sensitive method for assay of 5-hydroxytryptamine. Br J Pharmacol Chemother. 1957;12:344\u2013349.","journal-title":"Br J Pharmacol Chemother"},{"key":"20_CR25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/path.1711010306","volume":"101","author":"J.P. Giroud","year":"1970","unstructured":"Giroud JP, Willoughby DA. The interrelation of compliment and a prostaglandin like substance in acute inflammation. J Pathol. 1970;101:241\u2013249.","journal-title":"J Pathol"},{"key":"20_CR26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/path.1711110302","volume":"111","author":"G.P. Velo","year":"1973","unstructured":"Velo GP, Dunn CJ, Grioud JP, Timsit J, Willoughby DA. Distribution of prostaglandins in inflammatory exudate. J Pathol. 1973;111:149\u2013158.","journal-title":"J Pathol"},{"key":"20_CR27","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0090-6980(76)90057-5","volume":"12","author":"E.W. Gold","year":"1976","unstructured":"Gold EW, Anderson LB. The effect of salicylate on prostaglandin levels in rabbit knees following inducement of osteoartritic changes. Prostaglandins. 1976;12:837\u2013842.","journal-title":"Prostaglandins"},{"key":"20_CR28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00003086-197505000-00039","volume":"108","author":"C.C. Teitz","year":"1975","unstructured":"Teitz CC, Chrisman OD. The effect of salicylate and chloroquine on prostaglandin induced articular damage in the rabbit knee. Clin Orthop. 1975;108:264\u2013274.","journal-title":"Clin Orthop"},{"key":"20_CR29","first-page":"260","volume":"207","author":"E.J. Eyring","year":"1969","unstructured":"Eyring EJ. Salicylates slow cartilage destruction. JAMA. 1969;207:260.","journal-title":"JAMA"},{"key":"20_CR30","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3181\/00379727-122-31212","volume":"122","author":"W. Miller","year":"1966","unstructured":"Miller W, Smith JG Jr. Effect of acetylsalicylic acid on lysosomes. Proc Soc Exp Boil Med. 1966;122:634\u2013636.","journal-title":"Proc Soc Exp Boil Med"},{"key":"20_CR31","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/art.1780110605","volume":"11","author":"R. Ennis","year":"1968","unstructured":"Ennis R, Granada J, Posner A. Effect of gold salts and other drugs on the release and activity of lysosomal hydrolysis. Arth Rheum. 1968;11:756\u2013764.","journal-title":"Arth Rheum"},{"key":"20_CR32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/01241398-199603000-00019","volume":"16","author":"S.J. Stricker","year":"1996","unstructured":"Stricker SJ, Lozman PR, Makowski AL, Gunja-Smith Z. Chondroprotective effect of betamethasone in lapine pyogenic arthritis. J Pediatr Orthop. 1996;16:231\u2013236.","journal-title":"J Pediatr Orthop"},{"key":"20_CR33","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/jor.1100150619","volume":"15","author":"R.L. Smith","year":"1997","unstructured":"Smith RL, Kajiyama G, Schurman DJ. Staphylococcal septic arthritis: antibiotic and nonsteroidal anti-inflammatory drug treatment in a rabbit model. J Orthop Res. 1997;15:919\u2013926.","journal-title":"J Orthop Res"},{"key":"20_CR34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.micpath.2004.12.005","volume":"38","author":"I. Gjertsson","year":"2005","unstructured":"Gjertsson I, Innocenti M, Matrisian LM, Tarkowski A. Metalloproteinase-7 contributes to joint destruction in Staphylococcus aureus induced arthritis. Microb Pathog. 2005;38:97\u2013105.","journal-title":"Microb Pathog"},{"key":"20_CR35","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/jor.20317","volume":"25","author":"M. Verdrengh","year":"2007","unstructured":"Verdrengh M, Carlsten H, Ohlsson C, Tarkowski A. Addition of bisphosphonate to antibiotic and anti-inflammatory treatment reduces bone resorption in experimental Staphylococcus aureus-induced arthritis. J Orthop Res. 2007;25:304\u2013310.","journal-title":"J Orthop Res"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-008-0020-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-008-0020-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-008-0020-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T03:55:50Z","timestamp":1559447750000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-008-0020-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["20"],"URL":"https:\/\/doi.org\/10.1007\/s12325-008-0020-3","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}