{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:00:44Z","timestamp":1783166444803,"version":"3.54.6"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Therapy"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1007\/s12325-008-0127-6","type":"journal-article","created":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T04:52:09Z","timestamp":1229403129000},"page":"89-98","source":"Crossref","is-referenced-by-count":14,"title":["Effects of loratadine\/montelukast on vigilance and alertness task Performance in a simulated cabin environment"],"prefix":"10.1007","volume":"26","author":[{"given":"P. J. L.","family":"Valk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Simons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"127_CR1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1365-2273.2003.00706.x","volume":"28","author":"R.J. Salib","year":"2003","unstructured":"Salib RJ, Drake-Lee A, Howarth PH. Allergic rhinitis: past, present and the future. Clin Otolaryngol Allied Sci. 2003;28:291\u2013303.","journal-title":"Clin Otolaryngol Allied Sci."},{"key":"127_CR2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jaci.2005.09.047","volume":"117","author":"J. Bousquet","year":"2006","unstructured":"Bousquet J, Neukirch F, Bousquet PJ, et al. Severity and impairment of allergic rhinitis in patients consulting in primary care.J Allergy Clin Immunol. 2006;117:158\u2013162.","journal-title":"J Allergy Clin Immunol."},{"key":"127_CR3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3132\/pcrj.2007.00062","volume":"16","author":"R.J. Green","year":"2007","unstructured":"Green RJ, Davis G, Price D. Concerns of patients with allergic rhinitis: the Allergic Rhinitis Care Programme in South Africa. Prim Care Respir J. 2007; 16:299\u2013303.","journal-title":"Prim Care Respir J"},{"key":"127_CR4","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1185\/030079907X178793","volume":"23","author":"D.E. Stull","year":"2007","unstructured":"Stull DE, Roberts L, Frank L, Heithoff K. Relationship of nasal congestion with sleep, mood, and productivity. Curr Med Res Opin. 2007;23:811\u2013819.","journal-title":"Curr Med Res Opin."},{"key":"127_CR5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2165\/00151829-200504060-00007","volume":"4","author":"A. Shedden","year":"2005","unstructured":"Shedden A. Impact of nasal congestion on quality of life and work productivity in allergic rhinitis: findings from a large online survey. Treat Respir Med. 2005;4:439\u2013446.","journal-title":"Treat Respir Med."},{"key":"127_CR6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jadohealth.2007.01.003","volume":"40","author":"R. Sundberg","year":"2007","unstructured":"Sundberg R, Toren K, Hoglund D, Aberg N, Brisman J. Nasal symptoms are associated with school performance in adolescents. J Adolesc Health. 2007; 40:581\u2013583.","journal-title":"J Adolesc Health"},{"key":"127_CR7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3132\/pcrj.2007.00015","volume":"16","author":"S.L. Szeinbach","year":"2007","unstructured":"Szeinbach SL, Seoane-Vazquez EC, Beyer A, Williams PB. The impact of allergic rhinitis on work productivity. Prim Care Respir J. 2007;16:98\u2013105.","journal-title":"Prim Care Respir J"},{"key":"127_CR8","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1177\/014556130007900908","volume":"79","author":"J.P. Corey","year":"2000","unstructured":"Corey JP, Houser SM, Ng BA. Nasal congestion: a review of its etiology, evaluation, and treatment. Ear Nose Throat J. 2000;79:690\u2013702.","journal-title":"Ear Nose Throat J"},{"key":"127_CR9","first-page":"12","volume":"27","author":"J. Stokes","year":"2006","unstructured":"Stokes J, Fenstad E, Casale TB. Managing impairment in patients with allergic rhinitis. Allergy Asthma Proc. 2006;27:12\u201316.","journal-title":"Allergy Asthma Proc."},{"key":"127_CR10","doi-asserted-by":"crossref","first-page":"S835","DOI":"10.1067\/mai.2003.1550","volume":"111","author":"T.B. Casale","year":"2003","unstructured":"Casale TB, Blaiss MS, Gelfand E, et al. First do no harm: managing antihistamine impairment in patients with allergic rhinitis. J Allergy Clin Immunol. 2003;111:S835\u2013S842.","journal-title":"J Allergy Clin Immunol."},{"key":"127_CR11","first-page":"514","volume":"78","author":"A. Sen","year":"2007","unstructured":"Sen A, Akin A, Craft KJ, Canfield DV, Chaturvedi AK. First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005. Aviat Space Environ Med. 2007;78:514\u2013522.","journal-title":"Aviat Space Environ Med."},{"key":"127_CR12","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1080\/07420520600865574","volume":"23","author":"C.A. Eriksen","year":"2006","unstructured":"Eriksen CA, Akerstedt T. Aircrew fatigue in trans-Atlantic morning and evening flights. Chronobiol Int. 2006;23:843\u2013858.","journal-title":"Chronobiol Int."},{"key":"127_CR13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/00140130150203893","volume":"44","author":"N. Wright","year":"2001","unstructured":"Wright N, McGown A. Vigilance on the civil flight deck: incidence of sleepiness and sleep during long-haul flights and associated changes in physiological parameters. Ergonomics. 2001;44:82\u2013106.","journal-title":"Ergonomics"},{"key":"127_CR14","first-page":"1145","volume":"76","author":"A.K. Chaturvedi","year":"2005","unstructured":"Chaturvedi AK, Craft KJ, Canfield DV, Whinnery JE. Toxicological findings from 1587 civil aviation accident pilot fatalities, 1999-2003. Aviat Space Environ Med. 2005;76:1145\u20131150.","journal-title":"Aviat Space Environ Med."},{"key":"127_CR15","first-page":"1206","volume":"71","author":"J.W. Soper","year":"2000","unstructured":"Soper JW, Chaturvedi AK, Canfield DV. Prevalence of chlorpheniramine in aviation accident pilot fatalities, 1991-1996. Aviat Space Environ Med. 2000;71:1206\u20131209.","journal-title":"Aviat Space Environ Med."},{"key":"127_CR16","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/00004032-200011000-00021","volume":"79","author":"G.C. Butler","year":"2000","unstructured":"Butler GC, Nicholas J, Lackland DT, Friedberg W. Perspectives of those impacted: airline pilot\u2019s perspective. Health Phys. 2000;79:602\u2013607.","journal-title":"Health Phys."},{"key":"127_CR17","first-page":"794","volume":"76","author":"A. Smith","year":"2005","unstructured":"Smith A. Hypoxia symptoms reported during helicopter operations below 10,000 ft: a retrospective survey. Aviat Space Environ Med. 2005;76:794\u2013798.","journal-title":"Aviat Space Environ Med."},{"key":"127_CR18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2500\/105065897781446838","volume":"11","author":"P. Valk","year":"1997","unstructured":"Valk P, Simons M, Struyvenberg P, Kruit H, Van berge Hengouwen M. Effects of a single dose of loratadine on flying ability under conditions of simulated cabin pressure. Am J Rhinology. 1997; 11:27\u201333.","journal-title":"Am J Rhinology"},{"key":"127_CR19","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1001\/archinte.1997.00440410082009","volume":"157","author":"G.G. Kay","year":"1997","unstructured":"Kay GG, Berman B, Mockoviak SH, et al. Initial and steady-state effects of diphenhydramine and loratadine on sedation, cognition, mood, and psychomotor performance. Arch Intern Med. 1997;157: 2350\u20132356.","journal-title":"Arch Intern Med."},{"key":"127_CR20","volume-title":"Soesterberg","author":"M. Simons","year":"1994","unstructured":"Simons M, Valk P, de Ree J, Veldhuijzen van Zanten O, D\u2019Huyvetter K. Quantity and quality of onboard and layover sleep; effects on crew performance and alertness. Soesterberg, The Netherlands: Netherlands Aerospace Medical Centre; 1994."},{"issue":"suppl.3","key":"127_CR21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-2222.1999.0290s3147.x","volume":"29","author":"G.G. Kay","year":"1999","unstructured":"Kay GG, Harris AG. Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clin Exp Allergy. 1999;29(suppl. 3):147\u2013150.","journal-title":"Clin Exp Allergy"},{"key":"127_CR22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.7326\/0003-4819-132-5-200003070-00004","volume":"132","author":"J.M. Weiler","year":"2000","unstructured":"Weiler JM, Bloomfield JR, Woodworth GG, et al. Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. Ann Intern Med. 2000;132:354\u2013363.","journal-title":"Ann Intern Med."}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-008-0127-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-008-0127-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-008-0127-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T20:19:39Z","timestamp":1589401179000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-008-0127-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,16]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["127"],"URL":"https:\/\/doi.org\/10.1007\/s12325-008-0127-6","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,16]]}}}