{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:31:43Z","timestamp":1785148303172,"version":"3.55.0"},"reference-count":134,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2010,9,6]],"date-time":"2010-09-06T00:00:00Z","timestamp":1283731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Therapy"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1007\/s12325-010-0065-y","type":"journal-article","created":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T09:19:05Z","timestamp":1283937545000},"page":"796-813","source":"Crossref","is-referenced-by-count":93,"title":["Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs"],"prefix":"10.1007","volume":"27","author":[{"given":"Venkatramanujam","family":"Srinivasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarnail","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seithikurippu R.","family":"Pandi-Perumal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Warren","family":"Spence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Cardinali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,9,6]]},"reference":[{"key":"65_CR1","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1126\/science.284.5423.2177","volume":"284","author":"C.A. Czeisler","year":"1999","unstructured":"Czeisler CA, Duffy JF, Shanahan TL, et al. Stability, precision, and near-24-hour period of the human circadian pacemaker. Science. 1999;284:2177\u20132181.","journal-title":"Science"},{"key":"65_CR2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0079-6123(08)60406-9","volume":"111","author":"M.H. Hastings","year":"1996","unstructured":"Hastings MH, Best JD, Ebling FJ, et al. Entrainment of the circadian clock. Prog Brain Res. 1996;111:147\u2013174.","journal-title":"Prog Brain Res."},{"key":"65_CR3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1081\/CBI-120024215","volume":"20","author":"A.J. Lewy","year":"2003","unstructured":"Lewy AJ, Emens J, Sack RL, et al. Zeitgeber hierarchy in humans: resetting the circadian phase positions of blind people using melatonin. Chronobiol Int. 2003;20:837\u2013852.","journal-title":"Chronobiol Int."},{"key":"65_CR4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2165\/00023210-200115040-00005","volume":"15","author":"N. Zisapel","year":"2001","unstructured":"Zisapel N. Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. CNS Drugs. 2001;15:311\u2013328.","journal-title":"CNS Drugs"},{"key":"65_CR5","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ncpneuro0847","volume":"4","author":"S.R. Pandi-Perumal","year":"2008","unstructured":"Pandi-Perumal SR, Trakht I, Spence DW, et al. The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. Nat Clin Pract Neurol. 2008;4:436\u2013447.","journal-title":"Nat Clin Pract Neurol."},{"key":"65_CR6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.smrv.2006.06.001","volume":"11","author":"P.C. Zee","year":"2007","unstructured":"Zee PC, Manthena P. The brain\u2019s master circadian clock: implications and opportunities for therapy of sleep disorders. Sleep Med Rev. 2007;11:59\u201370.","journal-title":"Sleep Med Rev."},{"key":"65_CR7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pmr.2008.10.009","volume":"20","author":"C. Samuels","year":"2009","unstructured":"Samuels C. Sleep, recovery, and performance: the new frontier in high-performance athletics. Phys Med Rehabil Clin N Am. 2009;20:149\u2013159,ix.","journal-title":"Phys Med Rehabil Clin N Am."},{"key":"65_CR8","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1056\/NEJMcp0909838","volume":"362","author":"R.L. Sack","year":"2010","unstructured":"Sack RL. Clinical practice. Jet lag. N Engl J Med. 2010;362:440\u2013447.","journal-title":"Jet lag. N Engl J Med."},{"key":"65_CR9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.smrv.2008.10.001","volume":"13","author":"J. Waterhouse","year":"2009","unstructured":"Waterhouse J, Reilly T. Managing jet lag. Sleep Med Rev. 2009;13:247\u2013248.","journal-title":"Sleep Med Rev."},{"key":"65_CR10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/bmj.284.6310.144","volume":"284","author":"J. Arendt","year":"1982","unstructured":"Arendt J, Marks V. Physiological changes underlying jet lag. Br Med J (Clin Res Ed). 1982;284:144\u2013146.","journal-title":"Br Med J (Clin Res Ed)"},{"key":"65_CR11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.tics.2010.03.007","volume":"14","author":"C.P. Kyriacou","year":"2010","unstructured":"Kyriacou CP, Hastings MH. Circadian clocks: genes, sleep, and cognition. Trends Cogn Sci. 2010; 14:259\u2013267.","journal-title":"Trends Cogn Sci."},{"key":"65_CR12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.smrv.2008.07.011","volume":"13","author":"J. Arendt","year":"2009","unstructured":"Arendt J. Managing jet lag: some of the problems and possible new solutions. Sleep Med Rev. 2009;13:249\u2013256.","journal-title":"Sleep Med Rev."},{"key":"65_CR13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tmaid.2008.08.003","volume":"7","author":"R.R. Auger","year":"2009","unstructured":"Auger RR, Morgenthaler TI. Jet 13. lag and other sleep disorders relevant to the traveler. Travel Med Infect Dis. 2009;7:60\u201368.","journal-title":"Travel Med Infect Dis."},{"key":"65_CR14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/026404197367371","volume":"15","author":"T. Reilly","year":"1997","unstructured":"Reilly T, Atkinson G, Waterhouse J. Travel fatigue and jet-lag. J Sports Sci. 1997;15:365\u2013369.","journal-title":"J Sports Sci."},{"key":"65_CR15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.tmaid.2009.01.004","volume":"7","author":"A.N. Nicholson","year":"2009","unstructured":"Nicholson AN. Intercontinental air travel: the cabin atmosphere and circadian realignment. Travel Med Infect Dis. 2009;7:57\u201359.","journal-title":"Travel Med Infect Dis."},{"key":"65_CR16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev-physiol-021909-135821","volume":"72","author":"C. Dibner","year":"2010","unstructured":"Dibner C, Schibler U, Albrecht U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol. 2010;72:517\u2013549.","journal-title":"Annu Rev Physiol."},{"key":"65_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2005.08.003","volume":"51","author":"L.P. Morin","year":"2006","unstructured":"Morin LP, Allen CN. The circadian visual system, 2005. Brain Res Brain Res Rev. 2006;51:1\u201360.","journal-title":"Brain Res Brain Res Rev."},{"key":"65_CR18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/07420520500464528","volume":"23","author":"A. Kalsbeek","year":"2006","unstructured":"Kalsbeek A, Perreau-Lenz S, Buijs RM. A network of (autonomic) clock outputs. Chronobiol Int. 2006;23:201\u2013215.","journal-title":"Chronobiol Int."},{"key":"65_CR19","first-page":"311","volume-title":"Handbook of Behavioral Neurobiology. Volume 4. Biological Rhythms","author":"J. Aschoff","year":"1981","unstructured":"Aschoff J, Wever R. The circadian system of man. In: Aschoff J, ed. Handbook of Behavioral Neurobiology. Volume 4. Biological Rhythms. New York: Plenum Press; 1981:311\u2013331."},{"key":"65_CR20","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/0748730405277378","volume":"20","author":"T.H. Monk","year":"2005","unstructured":"Monk TH. Aging human circadian rhythms: conventional wisdom may not always be right. J Biol Rhythms. 2005;20:366\u2013374.","journal-title":"J Biol Rhythms."},{"key":"65_CR21","doi-asserted-by":"crossref","first-page":"R914","DOI":"10.1016\/j.cub.2006.09.058","volume":"16","author":"A.J. Davidson","year":"2006","unstructured":"Davidson AJ, Sellix MT, Daniel J, et al. Chronic jet-lag increases mortality in aged mice. Curr Biol. 2006;16:R914\u2013R916.","journal-title":"Curr Biol."},{"key":"65_CR22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1034\/j.1600-079X.2001.310103.x","volume":"31","author":"J. Tresguerres","year":"2001","unstructured":"Tresguerres J, Ariznavarreta C, Granados B, et al. Circadian urinary 6-sulphatoxymelatonin, cortisol excretion and locomotor activity in airline pilots during transmeridian flights. J Pineal Res. 2001;31:16\u201322.","journal-title":"J Pineal Res."},{"key":"65_CR23","first-page":"445","volume":"73","author":"C. Ariznavarreta","year":"2002","unstructured":"Ariznavarreta C, Cardinali DP, Villanua M, et al. Circadian rhythms in airline pilots submitted to long-haul transmeridian flights. Aviat Space Environ Med. 2002;73:445\u2013455.","journal-title":"Aviat Space Environ Med."},{"key":"65_CR24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1053\/sper.2000.9123","volume":"24","author":"T.L. Shanahan","year":"2000","unstructured":"Shanahan TL, Czeisler CA. Physiological effects of light on the human circadian pacemaker. Semin Perinatol. 2000;24:299\u2013320.","journal-title":"Semin Perinatol."},{"key":"65_CR25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1440-1819.2002.00988.x","volume":"56","author":"T. Takahashi","year":"2002","unstructured":"Takahashi T, Sasaki M, Itoh H, et al. Melatonin alleviates jet lag symptoms caused by an 11.hour eastward flight. Psychiatry Clin Neurosci. 2002;56:301\u2013302.","journal-title":"Psychiatry Clin Neurosci."},{"key":"65_CR26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.tmaid.2006.01.009","volume":"4","author":"A.N. Nicholson","year":"2006","unstructured":"Nicholson AN. Sleep and intercontinental flights. Travel Med Infect Dis. 2006;4:336\u2013339.","journal-title":"Travel Med Infect Dis."},{"key":"65_CR27","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/sleep\/23.6.1f","volume":"23","author":"T. Roehrs","year":"2000","unstructured":"Roehrs T, Turner L, Roth T. Effects of sleep loss on waking actigraphy. Sleep. 2000;23:793\u2013797.","journal-title":"Sleep"},{"key":"65_CR28","first-page":"B53","volume":"57","author":"H.M. Wegmann","year":"1986","unstructured":"Wegmann HM, Gundel A, Naumann M, et al. Sleep, sleepiness, and circadian rhythmicity in aircrews operating on transatlantic routes. Aviat Space Environ Med. 1986;57:B53\u2013B64.","journal-title":"Aviat Space Environ Med."},{"key":"65_CR29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1365-2869.1995.tb00223.x","volume":"4","author":"A. Samel","year":"1995","unstructured":"Samel A, Wegmann HM, Vejvoda M. Jet lag and sleepiness in aircrew. J Sleep Res. 1995;4:30\u201336.","journal-title":"J Sleep Res."},{"key":"65_CR30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1152\/japplphysiol.00940.2002","volume":"96","author":"M. Beaumont","year":"2004","unstructured":"Beaumont M, Batejat D, Pierard C, et al. Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel. J Appl Physiol. 2004;96:50\u201358.","journal-title":"J Appl Physiol."},{"key":"65_CR31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.tmaid.2009.01.006","volume":"7","author":"R.L. Sack","year":"2009","unstructured":"Sack RL. The pathophysiology of jet lag. Travel Med Infect Dis. 2009;7:102\u2013110.","journal-title":"Travel Med Infect Dis."},{"key":"65_CR32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5271\/sjweh.2899","volume":"36","author":"G. Costa","year":"2010","unstructured":"Costa G, Haus E, Stevens R. Shift work and cancer \u2014 considerations on rationale, mechanisms, and epidemiology. Scand J Work Environ Health. 2010;36:163\u2013179.","journal-title":"Scand J Work Environ Health"},{"key":"65_CR33","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1289\/ehp.10200","volume":"115","author":"R.G. Stevens","year":"2007","unstructured":"Stevens RG, Blask DE, Brainard GC, et al. Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases. Environ Health Perspect. 2007;115:1357\u20131362.","journal-title":"Environ Health Perspect."},{"key":"65_CR34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/occmed\/kqp162","volume":"60","author":"J. Arendt","year":"2010","unstructured":"Arendt J. Shift work: coping with the biological clock. Occup Med (Lond). 2010;60:10\u201320.","journal-title":"Occup Med (Lond)."},{"key":"65_CR35","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3109\/07420520903399987","volume":"26","author":"A. Grundy","year":"2009","unstructured":"Grundy A, Sanchez M, Richardson H, et al. Light intensity exposure, sleep duration, physical activity, and biomarkers of melatonin among rotating shift nurses. Chronobiol Int. 2009;26:1443\u20131461.","journal-title":"Chronobiol Int."},{"key":"65_CR36","first-page":"S24","volume":"59","author":"M.J. Thorpy","year":"2010","unstructured":"Thorpy MJ. Managing the patient with shift-work disorder. J Fam Pract. 2010;59:S24\u2013S31.","journal-title":"J Fam Pract."},{"key":"65_CR37","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1081\/CBI-120005391","volume":"19","author":"B. Lemmer","year":"2002","unstructured":"Lemmer B, Kern RI, Nold G, et al. Jet lag in athletes after eastward and westward time-zone transition. Chronobiol Int. 2002;19:743\u2013764.","journal-title":"Chronobiol Int."},{"key":"65_CR38","first-page":"366","volume":"20","author":"K. Steenland","year":"1997","unstructured":"Steenland K, Deddens JA. Effect of travel and rest on performance of professional basketball players. Sleep. 1997;20:366\u2013369.","journal-title":"Sleep"},{"issue":"Suppl16","key":"65_CR39","first-page":"46","volume":"65","author":"J.R. Schwartz","year":"2004","unstructured":"Schwartz JR. Pharmacologic management of daytime sleepiness. J Clin Psychiatry. 2004;65Suppl 16:46\u201349.","journal-title":"J Clin Psychiatry"},{"key":"65_CR40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tmaid.2004.07.008","volume":"3","author":"J.A. Caldwell","year":"2005","unstructured":"Caldwell JA. Fatigue in aviation. Travel Med Infect Dis. 2005;3:85\u201396.","journal-title":"Travel Med Infect Dis."},{"key":"65_CR41","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1111\/j.1742-4658.2006.05322.x","volume":"273","author":"S.R. Pandi-Perumal","year":"2006","unstructured":"Pandi-Perumal SR, Srinivasan V, Maestroni GJM, et al. Melatonin: nature\u2019s most versatile biological signal? FEBS Lett. 2006;273:2813\u20132838.","journal-title":"FEBS Lett."},{"key":"65_CR42","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.brainresbull.2009.12.001","volume":"81","author":"V. Srinivasan","year":"2010","unstructured":"Srinivasan V, Pandi-Perumal SR, Spence DW, et al. Potential use of melatonergic drugs in analgesia: mechanisms of action. Brain Res Bull. 2010;81:362\u2013371.","journal-title":"Brain Res Bull."},{"key":"65_CR43","doi-asserted-by":"crossref","unstructured":"Srinivasan V, Pandi-Perumal SR, Spence DW, et al. Melatonin in septic shock: some recent concepts. J Crit Care. In press.","DOI":"10.1016\/j.jcrc.2010.03.006"},{"key":"65_CR44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/07420520500545862","volume":"23","author":"A.J. Lewy","year":"2006","unstructured":"Lewy AJ, Emens J, Jackman A, et al. Circadian uses of melatonin in humans. Chronobiol Int. 2006;23:403\u2013412.","journal-title":"Chronobiol Int."},{"key":"65_CR45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0163-7258(95)02020-9","volume":"69","author":"D. Dawson","year":"1996","unstructured":"Dawson D, Armstrong SM. Chronobiotics \u2014 drugs that shift rhythms. Pharmacol Ther. 1996;69:15\u201336X.","journal-title":"Pharmacol Ther."},{"key":"65_CR46","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/BF01953051","volume":"45","author":"T.J. Bartness","year":"1989","unstructured":"Bartness TJ, Goldman BD. Mammalian pineal melatonin: a clock for all seasons. Experientia. 1989;45:939\u2013945.","journal-title":"Experientia"},{"key":"65_CR47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tmaid.2008.09.004","volume":"7","author":"G.M. Brown","year":"2009","unstructured":"Brown GM, Pandi-Perumal SR, Trakht I, et al. Melatonin and its relevance to jet lag. Travel Med Infect Dis. 2009;7:69\u201381.","journal-title":"Travel Med Infect Dis."},{"key":"65_CR48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.smrv.2004.08.001","volume":"9","author":"B. Claustrat","year":"2005","unstructured":"Claustrat B, Brun J, Chazot G. The basic physiology and pathophysiology of melatonin. Sleep Med Rev. 2005;9:11\u201324.","journal-title":"Sleep Med Rev."},{"key":"65_CR49","first-page":"149","volume-title":"Seasonal Affective Disorder Practice and Research","author":"G.M. Brown","year":"2010","unstructured":"Brown GM, Pandi-Perumal SR, Trakht I, et al. The role of melatonin in seasonal affective disorder.In: Partonen T and Pandi-Perumal SR, eds. Seasonal Affective Disorder Practice and Research. 2nd ed. Oxford: Oxford University Press; 2010:149\u2013162.","edition":"2nd ed."},{"key":"65_CR50","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0009-9236(95)90040-3","volume":"57","author":"I.V. Zhdanova","year":"1995","unstructured":"Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther. 1995;57:552\u2013558.","journal-title":"Clin Pharmacol Ther."},{"key":"65_CR51","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1073\/pnas.91.5.1824","volume":"91","author":"A.B. Dollins","year":"1994","unstructured":"Dollins AB, Zhdanova IV, Wurtman RJ, et al. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci U S A. 1994;91:1824\u20131828.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"65_CR52","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.smrv.2004.05.002","volume":"9","author":"J. Arendt","year":"2005","unstructured":"Arendt J, Skene DJ. Melatonin as a chronobiotic. Sleep Med Rev. 2005;9:25\u201339.","journal-title":"Sleep Med Rev."},{"key":"65_CR53","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1087-0792(01)90215-1","volume":"6","author":"H.J. Burgess","year":"2002","unstructured":"Burgess HJ, Sharkey KM, Eastman CI. Bright light, dark and melatonin can promote circadian adaptation in night shift workers. Sleep Med Rev. 2002;6:407\u2013420.","journal-title":"Sleep Med Rev."},{"key":"65_CR54","unstructured":"Dubocovich ML, Delagrange P, Krause DN, et al. International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. Nomenclature, classification and pharmacology of G proteincoupled melatonin receptors. Phamacol Rev. In press."},{"key":"65_CR55","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/ENDO:27:2:101","volume":"27","author":"M.L. Dubocovich","year":"2005","unstructured":"Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine. 2005;27:101\u2013110.","journal-title":"Endocrine"},{"key":"65_CR56","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0896-6273(00)80350-5","volume":"19","author":"C. Liu","year":"1997","unstructured":"Liu C, Weaver DR, Jin X, et al. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron. 1997;19:91\u2013102.","journal-title":"Neuron"},{"key":"65_CR57","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00441-002-0581-4","volume":"309","author":"C. Gall von","year":"2002","unstructured":"von Gall C, Stehle JH, Weaver DR. Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res. 2002;309:151\u2013162.","journal-title":"Cell Tissue Res."},{"key":"65_CR58","doi-asserted-by":"crossref","first-page":"C110","DOI":"10.1152\/ajpcell.2001.280.1.C110","volume":"280","author":"A.E. Hunt","year":"2001","unstructured":"Hunt AE, Al Ghoul WM, Gillette MU, et al. Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock. Am J Physiol Cell Physiol. 2001;280:C110\u2013C118.","journal-title":"Am J Physiol Cell Physiol."},{"key":"65_CR59","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/8062","volume":"2","author":"Q. Wan","year":"1999","unstructured":"Wan Q, Man HY, Liu F, et al. Differential modulation of GABAA receptor function by Mel1a and Mel1b receptors. Nat Neurosci. 1999;2:401\u2013403.","journal-title":"Nat Neurosci."},{"key":"65_CR60","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0896-6273(00)80876-4","volume":"25","author":"C. Liu","year":"2000","unstructured":"Liu C, Reppert SM. GABA synchronizes clock cells within the suprachiasmatic circadian clock. Neuron. 2000;25:123\u2013128.","journal-title":"Neuron"},{"key":"65_CR61","first-page":"833","volume":"28","author":"T. Gherardin","year":"1999","unstructured":"Gherardin T. Jet lag. A problem for \u2018long haul\u2019 travellers. Aust Fam Physician. 1999;28:833.","journal-title":"Aust Fam Physician."},{"key":"65_CR62","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(05)78236-2","volume":"351","author":"J. Arendt","year":"1998","unstructured":"Arendt J. Jet-lag. Lancet. 1998;351:293\u2013294.","journal-title":"Lancet"},{"key":"65_CR63","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2174\/1568026023394380","volume":"2","author":"D.J. Kennaway","year":"2002","unstructured":"Kennaway DJ, Wright H. Melatonin and circadian rhythms. Curr Top Med Chem. 2002;2:199\u2013209.","journal-title":"Curr Top Med Chem."},{"key":"65_CR64","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00213-009-1737-7","volume":"208","author":"M.A. Paul","year":"2010","unstructured":"Paul MA, Miller JC, Gray GW, et al. Melatonin treatment for eastward and westward travel preparation. Psychopharmacology (Berl). 2010;208:377\u2013386.","journal-title":"Psychopharmacology (Berl)"},{"key":"65_CR65","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1034\/j.1600-079x.2002.10820.x","volume":"32","author":"D.P. Cardinali","year":"2002","unstructured":"Cardinali DP, Bortman GP, Liotta G, et al. A multifactorial approach employing melatonin to accelerate resynchronization of sleep-wake cycle after a 12 time-zone westerly transmeridian flight in elite soccer athletes. J Pineal Res. 2002;32:41\u201346.","journal-title":"J Pineal Res."},{"key":"65_CR66","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1136\/bmj.292.6529.1170","volume":"292","author":"J. Arendt","year":"1986","unstructured":"Arendt J, Aldhous M, Marks V. Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial. Br Med J (Clin Res Ed). 1986;292:1170.","journal-title":"Br Med J (Clin Res Ed)"},{"key":"65_CR67","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0006-3223(93)90007-Z","volume":"33","author":"K. Petrie","year":"1993","unstructured":"Petrie K, Dawson AG, Thompson L, et al. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Biol Psychiatry. 1993;33:526\u2013530.","journal-title":"Biol Psychiatry"},{"key":"65_CR68","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0006-3223(92)90300-O","volume":"32","author":"B. Claustrat","year":"1992","unstructured":"Claustrat B, Brun J, David M, et al. Melatonin and jet lag: confirmatory result using a simplified protocol. Biol Psychiatry. 1992;32:705\u2013711.","journal-title":"Biol Psychiatry"},{"key":"65_CR69","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0006-3223(93)90208-U","volume":"34","author":"A. Lino","year":"1993","unstructured":"Lino A, Silvy S, Condorelli L, et al. Melatonin and jet lag: treatment schedule. Biol Psychiatry. 1993;34:587.","journal-title":"Biol Psychiatry"},{"key":"65_CR70","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1176\/ajp.156.9.1392","volume":"156","author":"R.L. Spitzer","year":"1999","unstructured":"Spitzer RL, Terman M, Williams JB, et al. Jet lag: clinical features, validation of a new syndromespecific scale, and lack of response to melatonin in a randomized, double-blind trial. Am J Psychiatry. 1999;156:1392\u20131396.","journal-title":"Am J Psychiatry"},{"key":"65_CR71","first-page":"385","volume":"4","author":"A. Samel","year":"1999","unstructured":"Samel A. Melatonin and jet-lag. Eur J Med Res. 1999;4:385\u2013388.","journal-title":"Eur J Med Res."},{"key":"65_CR72","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1080\/001401300750003934","volume":"43","author":"B.J. Edwards","year":"2000","unstructured":"Edwards BJ, Atkinson G, Waterhouse J, et al. Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones. Ergonomics. 2000;43:1501\u20131513.","journal-title":"Ergonomics"},{"key":"65_CR73","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1210\/jc.2005-1009","volume":"91","author":"V.L. Revell","year":"2006","unstructured":"Revell VL, Burgess HJ, Gazda CJ, et al. Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. J Clin Endocrinol Metab. 2006;91:54\u201359.","journal-title":"J Clin Endocrinol Metab."},{"key":"65_CR74","first-page":"53","volume":"5","author":"J. Arendt","year":"1986","unstructured":"Arendt J, Aldhous M. Further evaluation of the treatment of jet-lag by melatonin: a double-blind crossover study. Annu Rev Chronopharmacol. 1986;5:53\u201355.","journal-title":"Annu Rev Chronopharmacol."},{"key":"65_CR75","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/bmj.298.6675.705","volume":"298","author":"K. Petrie","year":"1989","unstructured":"Petrie K, Conaglen JV, Thompson L, et al. Effect of melatonin on jet lag after long haul flights. BMJ. 1989;298:705\u2013707.","journal-title":"BMJ"},{"key":"65_CR76","first-page":"303","volume":"5","author":"I. Nickelsen","year":"1991","unstructured":"Nickelsen I, Lang A, Bergau I. The effect of 6, 9, and 11-hour time shifts on circadian rhythms: adaptation of sleep parameters and hormonal patterns following the intake of melatonin or placebo. Adv Pineal Res. 1991;5:303\u2013306.","journal-title":"Adv Pineal Res."},{"key":"65_CR77","first-page":"520","volume":"67","author":"C.A. Comperatore","year":"1996","unstructured":"Comperatore CA, Lieberman HR, Kirby AW, et al. Melatonin efficacy in aviation missions requiring rapid deployment and night operations. Aviat Space Environ Med. 1996;67:520\u2013524.","journal-title":"Aviat Space Environ Med."},{"key":"65_CR78","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3109\/07420529808993201","volume":"15","author":"A. Suhner","year":"1998","unstructured":"Suhner A, Schlagenhauf P, Johnson R, et al. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int. 1998;15:655\u2013666.","journal-title":"Chronobiol Int."},{"key":"65_CR79","first-page":"638","volume":"72","author":"A. Suhner","year":"2001","unstructured":"Suhner A, Schlagenhauf P, Hofer I, et al. Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag. Aviat Space Environ Med. 2001;72:638\u2013646.","journal-title":"Aviat Space Environ Med."},{"key":"65_CR80","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s004210100418","volume":"85","author":"C. Pierard","year":"2001","unstructured":"Pierard C, Beaumont M, Enslen M, et al. Resynchronization of hormonal rhythms after an eastbound flight in humans: effects of slow-release caffeine and melatonin. Eur J Appl Physiol. 2001;85:144\u2013150.","journal-title":"Eur J Appl Physiol."},{"key":"65_CR81","first-page":"439","volume":"75","author":"M.A. Paul","year":"2004","unstructured":"Paul MA, Gray G, Sardana TM, et al. Melatonin and zopiclone as facilitators of early circadian sleep in operational air transport crews. Aviat Space Environ Med. 2004;75:439\u2013443.","journal-title":"Aviat Space Environ Med."},{"key":"65_CR82","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s10552-005-9009-2","volume":"17","author":"D.P. Cardinali","year":"2006","unstructured":"Cardinali DP, Furio AM, Reyes MP, et al. The use of chronobiotics in the resynchronization of the sleep\/wake cycle. Cancer Causes Control. 2006;17:601\u2013609.","journal-title":"Cancer Causes Control"},{"key":"65_CR83","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/074873049701200616","volume":"12","author":"J. Arendt","year":"1997","unstructured":"Arendt J, Skene DJ, Middleton B, et al. Efficacy of melatonin treatment in jet lag, shift work, and blindness. J Biol Rhythms. 1997;12:604\u2013617.","journal-title":"J Biol Rhythms."},{"key":"65_CR84","doi-asserted-by":"crossref","unstructured":"Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev. 2002;(2):CD001520.","DOI":"10.1002\/14651858.CD001520"},{"key":"65_CR85","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1126\/science.2734611","volume":"244","author":"C.A. Czeisler","year":"1989","unstructured":"Czeisler CA, Kronauer RE, Allan JS, et al. Bright light induction of strong (type 0) resetting of the human circadian pacemaker. Science. 1989;244:1328\u20131333.","journal-title":"Science"},{"key":"65_CR86","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/07420520903044331","volume":"26","author":"M.A. Paul","year":"2009","unstructured":"Paul MA, Miller JC, Love RJ, et al. Timing light treatment for eastward and westward travel preparation. Chronobiol Int. 2009;26:867\u2013890.","journal-title":"Chronobiol Int."},{"key":"65_CR87","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00424-007-0242-2","volume":"454","author":"D.M. Berson","year":"2007","unstructured":"Berson DM. Phototransduction in ganglion-cell photoreceptors. Pflugers Arch. 2007;454:849\u2013855.","journal-title":"Pflugers Arch."},{"key":"65_CR88","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/sleep\/30.11.1460","volume":"30","author":"R.L. Sack","year":"2007","unstructured":"Sack RL, Auckley D, Auger RR, et al. Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review. Sleep. 2007;30:1460\u20131483.","journal-title":"Sleep"},{"key":"65_CR89","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00131746-200607000-00005","volume":"12","author":"A. Bellon","year":"2006","unstructured":"Bellon A. Searching for new options for treating insomnia: are melatonin and ramelteon beneficial? J Psychiatr Pract. 2006;12:229\u2013243.","journal-title":"J Psychiatr Pract."},{"key":"65_CR90","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1258\/mi.2009.009002","volume":"15","author":"R.D. Dobkin","year":"2009","unstructured":"Dobkin RD, Menza M, Bienfait KL, et al. Ramelteon for the treatment of insomnia in menopausal women. Menopause Int. 2009;15:13\u201318.","journal-title":"Menopause Int."},{"key":"65_CR91","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5664\/jcsm.27389","volume":"5","author":"P.K. Gross","year":"2009","unstructured":"Gross PK, Nourse R, Wasser TE. Ramelteon for insomnia symptoms in a community sample of adults with generalized anxiety disorder: an open label study. J Clin Sleep Med. 2009;5:28\u201333.","journal-title":"J Clin Sleep Med."},{"key":"65_CR92","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/0748730404269890","volume":"20","author":"K. Hirai","year":"2005","unstructured":"Hirai K, Kita M, Ohta H, et al. Ramelteon (TAK- 375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats. J Biol Rhythms. 2005;20:27\u201337.","journal-title":"J Biol Rhythms"},{"key":"65_CR93","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuropharm.2004.09.007","volume":"48","author":"K. Kato","year":"2005","unstructured":"Kato K, Hirai K, Nishiyama K, et al. Neurochemical properties of ramelteon (TAK-375), a selective MT1\/MT2 receptor agonist. Neuropharmacology. 2005;48:301\u2013310.","journal-title":"Neuropharmacology"},{"key":"65_CR94","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.sleep.2005.09.004","volume":"7","author":"M. Erman","year":"2006","unstructured":"Erman M, Seiden D, Zammit G, et al. An efficacy, safety, and dose-response study of ramelteon in patients with chronic primary insomnia. Sleep Med. 2006;7:17\u201324.","journal-title":"Sleep Med."},{"key":"65_CR95","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1185\/030079907X178874","volume":"23","author":"T. Roth","year":"2007","unstructured":"Roth T, Seiden D, Wang-Weigand S, et al. A 2-night, 3-period, crossover study of ramelteon\u2019s efficacy and safety in older adults with chronic insomnia. Curr Med Res Opin. 2007;23:1005\u20131014.","journal-title":"Curr Med Res Opin."},{"key":"65_CR96","doi-asserted-by":"crossref","first-page":"495","DOI":"10.5664\/jcsm.26914","volume":"3","author":"G. Zammit","year":"2007","unstructured":"Zammit G, Erman M, Wang-Weigand S, et al. Evaluation of the efficacy and safety of ramelteon in subjects with chronic insomnia. J Clin Sleep Med. 2007;3:495\u2013504.","journal-title":"J Clin Sleep Med."},{"key":"65_CR97","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/S0149-2918(08)80056-2","volume":"30","author":"L. Mini","year":"2008","unstructured":"Mini L, Wang-Weigand S, Zhang J. Ramelteon 8 mg\/d versus placebo in patients with chronic insomnia: post hoc analysis of a 5-week trial using 50% or greater reduction in latency to persistent sleep as a measure of treatment effect. Clin Ther. 2008;30:1316\u20131323.","journal-title":"Clin Ther."},{"key":"65_CR98","doi-asserted-by":"crossref","first-page":"456","DOI":"10.5664\/jcsm.27282","volume":"4","author":"G.S. Richardson","year":"2008","unstructured":"Richardson GS, Zee PC, Wang-Weigand S, et al. Circadian phase-shifting effects of repeated ramelteon administration in healthy adults. J Clin Sleep Med. 2008;4:456\u2013461.","journal-title":"J Clin Sleep Med."},{"key":"65_CR99","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.sleep.2010.03.010","volume":"11","author":"P.C. Zee","year":"2010","unstructured":"Zee PC, Wang-Weigand S, Wright KP Jr., et al. Effects of ramelteon on insomnia symptoms induced by rapid, eastward travel. Sleep Med. 2010;11:525\u2013533.","journal-title":"Sleep Med."},{"key":"65_CR100","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0304-3940(91)90051-T","volume":"133","author":"D.S. Minors","year":"1991","unstructured":"Minors DS, Waterhouse JM, Wirz-Justice A. A human phase-response curve to light. Neurosci Lett. 1991;133:36\u201340.","journal-title":"Neurosci Lett."},{"key":"65_CR101","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0140-6736(08)61812-7","volume":"373","author":"S.M. Rajaratnam","year":"2009","unstructured":"Rajaratnam SM, Polymeropoulos MH, Fisher DM, et al. Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials. Lancet. 2009;373:482\u2013491.","journal-title":"Lancet"},{"key":"65_CR102","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1192\/bjp.140.3.231","volume":"140","author":"P. Jauhar","year":"1982","unstructured":"Jauhar P, Weller MP. Psychiatric morbidity and time zone changes: a study of patients from Heathrow airport. Br J Psychiatry. 1982;140:231\u2013235.","journal-title":"Br J Psychiatry"},{"key":"65_CR103","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0010-440X(95)90086-B","volume":"36","author":"D.M. Young","year":"1995","unstructured":"Young DM. Psychiatric morbidity in travelers to Honolulu, Hawaii. Compr Psychiatry. 1995;36:224\u2013228.","journal-title":"Compr Psychiatry"},{"key":"65_CR104","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1053\/comp.2002.29849","volume":"43","author":"G. Katz","year":"2002","unstructured":"Katz G, Knobler HY, Laibel Z, et al. Time zone change and major psychiatric morbidity: the results of a 6-year study in Jerusalem. Compr Psychiatry. 2002;43:37\u201340.","journal-title":"Compr Psychiatry"},{"key":"65_CR105","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tmaid.2007.12.002","volume":"6","author":"V. Srinivasan","year":"2008","unstructured":"Srinivasan V, Spence DW, Pandi-Perumal SR, et al. Jet lag: therapeutic use of melatonin and possible application of melatonin analogues. Travel Med Infect Dis. 2008;6:17\u201328.","journal-title":"Travel Med Infect Dis."},{"key":"65_CR106","first-page":"299","volume":"51","author":"F. Halberg","year":"1968","unstructured":"Halberg F, Vestergaard P, Sakai M. Rhythmometry on urinary 17-ketosteroid excretion by healthy men and women and patients with chronic schizophrenia; possible chronopathology in depressive illness. Arch Anat Histol Embryol. 1968;51:299\u2013311.","journal-title":"Arch Anat Histol Embryol."},{"key":"65_CR107","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-2007-1019506","volume":"15","author":"T.A. Wehr","year":"1982","unstructured":"Wehr TA, Wirz-Justice A. Circadian rhythm mechanisms in affective illness and in antidepressant drug action. Pharmacopsychiatria. 1982;15:31\u201339.","journal-title":"Pharmacopsychiatria"},{"key":"65_CR108","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0163-7258(94)00077-G","volume":"65","author":"D. Healy","year":"1995","unstructured":"Healy D, Waterhouse JM. The circadian system and the therapeutics of the affective disorders. Pharmacol Ther. 1995;65:241\u2013263.","journal-title":"Pharmacol Ther."},{"key":"65_CR109","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1053\/smrv.1999.0075","volume":"4","author":"L. Lustberg","year":"2000","unstructured":"Lustberg L, Reynolds CF. Depression and insomnia: questions of cause and effect. Sleep Med Rev. 2000;4:253\u2013262.","journal-title":"Sleep Med Rev."},{"key":"65_CR110","doi-asserted-by":"crossref","first-page":"M39","DOI":"10.1093\/geronj\/46.2.M39","volume":"46","author":"C.F. Reynolds III","year":"1991","unstructured":"Reynolds CF, III, Monk TH, Hoch CC, et al. Electroencephalographic sleep in the healthy \u201cold old\u201d: a comparison with the \u201cyoung old\u201d in visually scored and automated measures. J Gerontol. 1991;46:M39\u2013M46.","journal-title":"J Gerontol."},{"key":"65_CR111","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/bmb\/ldn019","volume":"86","author":"J.N. Bunney","year":"2008","unstructured":"Bunney JN, Potkin SG. Circadian abnormalities, molecular clock genes and chronobiological treatments in depression. Br Med Bull. 2008;86:23\u201332.","journal-title":"Br Med Bull."},{"key":"65_CR112","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/hup.1112","volume":"25","author":"M.A. Quera-Salva","year":"2010","unstructured":"Quera-Salva MA, Lemoine P, Guilleminault C. Impact of the novel antidepressant agomelatine on disturbed sleep-wake cycles in depressed patients. Hum Psychopharmacol. 2010;25:222\u2013229.","journal-title":"Hum Psychopharmacol."},{"key":"65_CR113","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0301-0511(01)00090-4","volume":"57","author":"D. Riemann","year":"2001","unstructured":"Riemann D, Berger M, Voderholzer U. Sleep and depression \u2014 results from psychobiological studies: an overview. Biol Psychol. 2001;57:67\u2013103.","journal-title":"Biol Psychol."},{"issue":"suppl.1","key":"65_CR114","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1097\/01.yic.0000195658.91524.61","volume":"21","author":"R.W. Lam","year":"2006","unstructured":"Lam RW. Sleep disturbances and depression: a challenge for antidepressants. Int Clin Psychopharmacol. 2006;21(suppl. 1):S25\u2013S29.","journal-title":"Int Clin Psychopharmacol."},{"key":"65_CR115","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.2174\/156802606778249810","volume":"6","author":"E.K. Moltzen","year":"2006","unstructured":"Moltzen EK, Bang-Andersen B. Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century \u2014 a medicinal chemistry survey. Curr Top Med Chem. 2006;6:1801\u20131823.","journal-title":"Curr Top Med Chem."},{"key":"65_CR116","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1021\/jm00086a018","volume":"35","author":"S. Yous","year":"1992","unstructured":"Yous S, Andrieux J, Howell HE, et al. Novel naphthalenic ligands with high affinity for the melatonin receptor. J Med Chem. 1992;35:1484\u20131486.","journal-title":"J Med Chem."},{"key":"65_CR117","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1124\/jpet.103.051797","volume":"306","author":"M.J. Millan","year":"2003","unstructured":"Millan MJ, Gobert A, Lejeune F, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003;306:954\u2013964.","journal-title":"J Pharmacol Exp Ther."},{"key":"65_CR118","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00004850-200209000-00004","volume":"17","author":"H. Loo","year":"2002","unstructured":"Loo H, Hale A, D\u2019haenen H. Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT(2C) antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study. Int Clin Psychopharmacol. 2002;17:239\u2013247.","journal-title":"Int Clin Psychopharmacol."},{"key":"65_CR119","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.euroneuro.2005.09.002","volume":"16","author":"S.H. Kennedy","year":"2006","unstructured":"Kennedy SH, Emsley R. Placebo-controlled trial of agomelatine in the treatment of major depressive disorder. Eur Neuropsychopharmacol. 2006;16:93\u2013100.","journal-title":"Eur Neuropsychopharmacol."},{"issue":"suppl.5","key":"65_CR120","doi-asserted-by":"crossref","first-page":"S633","DOI":"10.1016\/S0924-977X(06)70009-8","volume":"16","author":"S.A. Montgomery","year":"2006","unstructured":"Montgomery SA. Major depressive disorders: clinical efficacy and tolerability of agomelatine, a new melatonergic agonist. Eur Neuropsychopharmacol. 2006;16(suppl. 5):S633\u2013S638.","journal-title":"Eur Neuropsychopharmacol."},{"issue":"suppl.5","key":"65_CR121","doi-asserted-by":"crossref","first-page":"S639","DOI":"10.1016\/S0924-977X(06)70010-4","volume":"16","author":"D.J. Kupfer","year":"2006","unstructured":"Kupfer DJ. Depression and associated sleep disturbances: patient benefits with agomelatine. Eur Neuropsychopharmacol. 2006;16(suppl. 5):S639\u2013S643.","journal-title":"Eur Neuropsychopharmacol."},{"key":"65_CR122","first-page":"138","volume":"7","author":"V. Srinivasan","year":"2006","unstructured":"Srinivasan V, Smits M, Spence W, et al. Melatonin in mood disorders. 2006;7:138\u2013151.","journal-title":"Melatonin in mood disorders"},{"key":"65_CR123","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000117903","volume":"8","author":"L. Branchey","year":"1982","unstructured":"Branchey L, Weinberg U, Branchey M, et al. Simultaneous study of 24-hour patterns of melatonin and cortisol secretion in depressed patients. Neuropsychobiology. 1982;8:225\u2013232.","journal-title":"Neuropsychobiology"},{"key":"65_CR124","first-page":"1215","volume":"19","author":"B. Claustrat","year":"1984","unstructured":"Claustrat B, Chazot G, Brun J, et al. A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression. Biol Psychiatry. 1984;19:1215\u20131228.","journal-title":"Biol Psychiatry"},{"key":"65_CR125","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0278-5846(84)90044-7","volume":"8","author":"N.P. Nair","year":"1984","unstructured":"Nair NP, Hariharasubramanian N, Pilapil C. Circadian rhythm of plasma melatonin in endogenous depression. Prog Neuropsychopharmacol Biol Psychiatry. 1984;8:715\u2013718.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"65_CR126","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0447.1985.tb02531.x","volume":"71","author":"J. Beck-Friis","year":"1985","unstructured":"Beck-Friis J, Kjellman BF, Aperia B, et al. Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome. Acta Psychiatr Scand. 1985;71:319\u2013330.","journal-title":"Acta Psychiatr Scand."},{"key":"65_CR127","first-page":"593","volume":"85","author":"T.A. Wehr","year":"1985","unstructured":"Wehr TA, Sack DA, Rosenthal NE. Antidepressant effects of sleep deprivation and phototherapy. Acta Psychiatr Belg. 1985;85:593\u2013602.","journal-title":"Acta Psychiatr Belg."},{"key":"65_CR128","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/archpsyc.1992.01820070052008","volume":"49","author":"R.T. Rubin","year":"1992","unstructured":"Rubin RT, Heist EK, McGeoy SS, et al. Neuroendocrine aspects of primary endogenous depression. XI. Serum melatonin measures in patients and matched control subjects. Arch Gen Psychiatry. 1992;49:558\u2013567.","journal-title":"Arch Gen Psychiatry"},{"key":"65_CR129","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0165-1781(96)02937-X","volume":"69","author":"L.K. Sekula","year":"1997","unstructured":"Sekula LK, Lucke JF, Heist EK, et al. Neuroendocrine aspects of primary endogenous depression. XV: mathematical modeling of nocturnal melatonin secretion in major depressives and normal controls. Psychiatry Res. 1997;69:143\u2013153.","journal-title":"Psychiatry Res."},{"key":"65_CR130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4530(02)00123-3","volume":"29","author":"M. Crasson","year":"2004","unstructured":"Crasson M, Kjiri S, Colin A, et al. Serum melatonin and urinary 6-sulfatoxymelatonin in major depression. Psychoneuroendocrinology. 2004;29:1\u201312.","journal-title":"Psychoneuroendocrinology"},{"key":"65_CR131","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0165-0327(01)00303-2","volume":"69","author":"A. Tuunainen","year":"2002","unstructured":"Tuunainen A, Kripke DF, Elliott JA, et al. Depression and endogenous melatonin in postmenopausal women. J Affect Disord. 2002;69:149\u2013158.","journal-title":"J Affect Disord."},{"key":"65_CR132","first-page":"1","volume":"58","author":"R. Hardeland","year":"2008","unstructured":"Hardeland R, Poeggeler B, Srinivasan V, et al. Melatonergic drugs in clinical practice. Arzneimittelforschung. 2008;58:1\u201310.","journal-title":"Arzneimittelforschung"},{"key":"65_CR133","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1365-2265.2005.02341.x","volume":"63","author":"R. Leproult","year":"2005","unstructured":"Leproult R, Van Onderbergen A, L\u2019hermite-Baleriaux M, et al. Phase-shifts of 24-h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men. Clin Endocrinol (Oxf). 2005;63:298\u2013304.","journal-title":"Clin Endocrinol (Oxf)."},{"key":"65_CR134","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00213-006-0645-3","volume":"190","author":"E. Pjrek","year":"2007","unstructured":"Pjrek E, Winkler D, Konstantinidis A, et al. Agomelatine in the treatment of seasonal affective disorder. Psychopharmacology (Berl). 2007;190:575\u2013579.","journal-title":"Psychopharmacology (Berl)."}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-010-0065-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-010-0065-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-010-0065-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T06:31:51Z","timestamp":1685773911000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-010-0065-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,6]]},"references-count":134,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["65"],"URL":"https:\/\/doi.org\/10.1007\/s12325-010-0065-y","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,6]]}}}