{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:27:17Z","timestamp":1780964837514,"version":"3.54.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P50 AR070588-01"],"award-info":[{"award-number":["P50 AR070588-01"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["U01 AR067173-02"],"award-info":[{"award-number":["U01 AR067173-02"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s12325-017-0540-9","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T08:41:38Z","timestamp":1498207298000},"page":"1586-1593","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Changing Landscape of Alopecia Areata: The Translational Landscape"],"prefix":"10.1007","volume":"34","author":[{"given":"Etienne C. E.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Christiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"issue":"7","key":"540_CR1","doi-asserted-by":"publisher","first-page":"628","DOI":"10.4065\/70.7.628","volume":"70","author":"KH Safavi","year":"1995","unstructured":"Safavi KH, et al. Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc. 1995;70(7):628\u201333.","journal-title":"Mayo Clin Proc"},{"key":"540_CR2","first-page":"397","volume":"8","author":"AC Villasante Fricke","year":"2015","unstructured":"Villasante Fricke AC, Miteva M. Epidemiology and burden of alopecia areata: a systematic review. Clin Cosmet Investig Dermatol. 2015;8:397\u2013403.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"1","key":"540_CR3","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1038\/jidsymp.2013.5","volume":"16","author":"L Petukhova","year":"2013","unstructured":"Petukhova L, Christiano AM. The genetic architecture of alopecia areata. J Investig Dermatol Symp Proc. 2013;16(1):S16\u201322.","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"7302","key":"540_CR4","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature09114","volume":"466","author":"L Petukhova","year":"2010","unstructured":"Petukhova L, et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature. 2010;466(7302):113\u20137.","journal-title":"Nature"},{"issue":"5 Pt 1","key":"540_CR5","first-page":"757","volume":"33","author":"BW Colombe","year":"1995","unstructured":"Colombe BW, et al. HLA class II antigen associations help to define two types of alopecia areata. J Am Acad Dermatol. 1995;33(5 Pt 1):757\u201364.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"540_CR6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/sj.jid.5700009","volume":"126","author":"N Barahmani","year":"2006","unstructured":"Barahmani N, et al. Major histocompatibility complex class I chain-related gene A polymorphisms and extended haplotypes are associated with familial alopecia areata. J Invest Dermatol. 2006;126(1):74\u20138.","journal-title":"J Invest Dermatol"},{"issue":"6","key":"540_CR7","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00403-016-1652-9","volume":"308","author":"NH Moftah","year":"2016","unstructured":"Moftah NH, et al. ULBP3: a marker for alopecia areata incognita. Arch Dermatol Res. 2016;308(6):415\u201321.","journal-title":"Arch Dermatol Res"},{"key":"540_CR8","doi-asserted-by":"publisher","first-page":"5966","DOI":"10.1038\/ncomms6966","volume":"6","author":"RC Betz","year":"2015","unstructured":"Betz RC, et al. Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci. Nat Commun. 2015;6:5966.","journal-title":"Nat Commun"},{"issue":"1","key":"540_CR9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/JID.2015.402","volume":"136","author":"L Petukhova","year":"2016","unstructured":"Petukhova L, Christiano AM. Functional interpretation of genome-wide association study evidence in alopecia areata. J Invest Dermatol. 2016;136(1):314\u20137.","journal-title":"J Invest Dermatol"},{"issue":"5","key":"540_CR10","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1159\/000254125","volume":"136","author":"AJ Penders","year":"1968","unstructured":"Penders AJ. Alopecia areata and atopy. Dermatologica. 1968;136(5):395\u20139.","journal-title":"Dermatologica"},{"issue":"3","key":"540_CR11","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/j.1365-2133.2007.07943.x","volume":"157","author":"Y Kuwano","year":"2007","unstructured":"Kuwano Y, et al. Serum chemokine profiles in patients with alopecia areata. Br J Dermatol. 2007;157(3):466\u201373.","journal-title":"Br J Dermatol"},{"issue":"3","key":"540_CR12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1556\/030.62.2015.3.5","volume":"62","author":"S Sadeghi","year":"2015","unstructured":"Sadeghi S, et al. Study of Th1\/Th2 balance in peripheral blood mononuclear cells of patients with alopecia areata. Acta Microbiol Immunol Hung. 2015;62(3):275\u201385.","journal-title":"Acta Microbiol Immunol Hung"},{"issue":"5","key":"540_CR13","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.jaci.2015.06.032","volume":"136","author":"M Suarez-Farinas","year":"2015","unstructured":"Suarez-Farinas M, et al. Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17\/TH22 skewing. J Allergy Clin Immunol. 2015;136(5):1277\u201387.","journal-title":"J Allergy Clin Immunol"},{"key":"540_CR14","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.ebiom.2016.03.036","volume":"7","author":"A Jabbari","year":"2016","unstructured":"Jabbari A, et al. Molecular signatures define alopecia areata subtypes and transcriptional biomarkers. EBioMedicine. 2016;7:240\u20137.","journal-title":"EBioMedicine"},{"issue":"1","key":"540_CR15","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1038\/jidsymp.2013.7","volume":"16","author":"R Paus","year":"2013","unstructured":"Paus R, Bertolini M. The role of hair follicle immune privilege collapse in alopecia areata: status and perspectives. J Investig Dermatol Symp Proc. 2013;16(1):S25\u20137.","journal-title":"J Investig Dermatol Symp Proc"},{"key":"540_CR16","doi-asserted-by":"crossref","unstructured":"Wang EH, et al. Identification of autoantigen epitopes in alopecia areata. J Invest Dermatol. 2016;136(8):1617\u201326.","DOI":"10.1016\/j.jid.2016.04.004"},{"issue":"3","key":"540_CR17","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/1523-1747.ep12335848","volume":"109","author":"DJ Tobin","year":"1997","unstructured":"Tobin DJ, et al. Autoantibodies to hair follicles in C3H\/HeJ mice with alopecia areata-like hair loss. J Invest Dermatol. 1997;109(3):329\u201333.","journal-title":"J Invest Dermatol"},{"issue":"10","key":"540_CR18","doi-asserted-by":"publisher","first-page":"5153","DOI":"10.1021\/pr100422u","volume":"9","author":"MC Leung","year":"2010","unstructured":"Leung MC, et al. Trichohyalin is a potential major autoantigen in human alopecia areata. J Proteome Res. 2010;9(10):5153\u201363.","journal-title":"J Proteome Res"},{"issue":"5 Suppl","key":"540_CR19","doi-asserted-by":"publisher","first-page":"16S","DOI":"10.1038\/jid.1995.38","volume":"104","author":"JP Sundberg","year":"1995","unstructured":"Sundberg JP, et al. C3H\/HeJ mouse model for alopecia areata. J Invest Dermatol. 1995;104(5 Suppl):16S\u20137S.","journal-title":"J Invest Dermatol"},{"issue":"5","key":"540_CR20","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1046\/j.1523-1747.1998.00380.x","volume":"111","author":"KJ McElwee","year":"1998","unstructured":"McElwee KJ, et al. Experimental induction of alopecia areata-like hair loss in C3H\/HeJ mice using full-thickness skin grafts. J Invest Dermatol. 1998;111(5):797\u2013803.","journal-title":"J Invest Dermatol"},{"issue":"10","key":"540_CR21","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1038\/jid.2015.176","volume":"135","author":"EH Wang","year":"2015","unstructured":"Wang EH, et al. Transfer of alopecia areata to C3H\/HeJ mice using cultured lymph node-derived cells. J Invest Dermatol. 2015;135(10):2530\u20132.","journal-title":"J Invest Dermatol"},{"issue":"1","key":"540_CR22","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1038\/jidsymp.2013.11","volume":"16","author":"A Gilhar","year":"2013","unstructured":"Gilhar A, Keren A, Paus R. A new humanized mouse model for alopecia areata. J Investig Dermatol Symp Proc. 2013;16(1):S37\u20138.","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"4","key":"540_CR23","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.4049\/jimmunol.1501798","volume":"197","author":"Z Dai","year":"2016","unstructured":"Dai Z, et al. CXCR3 blockade inhibits T cell migration into the skin and prevents development of alopecia areata. J Immunol. 2016;197(4):1089\u201399.","journal-title":"J Immunol"},{"issue":"2","key":"540_CR24","first-page":"121","volume":"13","author":"J Estefan","year":"2015","unstructured":"Estefan J, et al. Alopecia areata\u2013Part II: diagnosis and pathology. Skinmed. 2015;13(2):121\u20136.","journal-title":"Skinmed"},{"issue":"1","key":"540_CR25","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jaad.2008.03.031","volume":"59","author":"A Tosti","year":"2008","unstructured":"Tosti A, et al. The role of scalp dermoscopy in the diagnosis of alopecia areata incognita. J Am Acad Dermatol. 2008;59(1):64\u20137.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"540_CR26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1001\/archdermatol.2010.288","volume":"147","author":"M Ardigo","year":"2011","unstructured":"Ardigo M, et al. Reflectance confocal microscopy of the yellow dot pattern in alopecia areata. Arch Dermatol. 2011;147(1):61\u20134.","journal-title":"Arch Dermatol"},{"issue":"3","key":"540_CR27","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s40257-014-0086-4","volume":"15","author":"M Hordinsky","year":"2014","unstructured":"Hordinsky M, Donati A. Alopecia areata: an evidence-based treatment update. Am J Clin Dermatol. 2014;15(3):231\u201346.","journal-title":"Am J Clin Dermatol"},{"issue":"2","key":"540_CR28","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/jidsymp.2015.41","volume":"17","author":"MK Hordinsky","year":"2015","unstructured":"Hordinsky MK. Current treatments for alopecia areata. J Investig Dermatol Symp Proc. 2015;17(2):44\u20136.","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"1","key":"540_CR29","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/ajh.23871","volume":"90","author":"L Pieri","year":"2015","unstructured":"Pieri L, Guglielmelli P, Vannucchi AM. Ruxolitinib-induced reversal of alopecia universalis in a patient with essential thrombocythemia. Am J Hematol. 2015;90(1):82\u20133.","journal-title":"Am J Hematol"},{"issue":"2","key":"540_CR30","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.jaci.2014.12.1867","volume":"135","author":"E Higgins","year":"2015","unstructured":"Higgins E, et al. Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation. J Allergy Clin Immunol. 2015;135(2):551\u20133.","journal-title":"J Allergy Clin Immunol"},{"issue":"15","key":"540_CR31","doi-asserted-by":"publisher","first-page":"e89776","DOI":"10.1172\/jci.insight.89776","volume":"1","author":"M Kennedy Crispin","year":"2016","unstructured":"Kennedy Crispin M, et al. Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight. 2016;1(15):e89776.","journal-title":"JCI Insight"},{"issue":"15","key":"540_CR32","doi-asserted-by":"publisher","first-page":"e89790","DOI":"10.1172\/jci.insight.89790","volume":"1","author":"J Mackay-Wiggan","year":"2016","unstructured":"Mackay-Wiggan J, et al. Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata. JCI Insight. 2016;1(15):e89790.","journal-title":"JCI Insight"},{"issue":"3","key":"540_CR33","doi-asserted-by":"publisher","first-page":"e0149441","DOI":"10.1371\/journal.pone.0149441","volume":"11","author":"H Patel","year":"2016","unstructured":"Patel H, et al. Association of cytotoxic T-lymphocyte antigen 4 (CTLA4) and thyroglobulin (TG) genetic variants with autoimmune hypothyroidism. PLoS One. 2016;11(3):e0149441.","journal-title":"PLoS One"},{"issue":"10","key":"540_CR34","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s10067-011-1752-z","volume":"30","author":"K Benhatchi","year":"2011","unstructured":"Benhatchi K, et al. CTLA4 exon1 A49G polymorphism in Slovak patients with rheumatoid arthritis and Hashimoto thyroiditis-results and the review of the literature. Clin Rheumatol. 2011;30(10):1319\u201324.","journal-title":"Clin Rheumatol"},{"issue":"10","key":"540_CR35","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1089\/dna.2010.1021","volume":"29","author":"K Repnik","year":"2010","unstructured":"Repnik K, Potocnik U. CTLA4 CT60 single-nucleotide polymorphism is associated with Slovenian inflammatory bowel disease patients and regulates expression of CTLA4 isoforms. DNA Cell Biol. 2010;29(10):603\u201310.","journal-title":"DNA Cell Biol"},{"issue":"7","key":"540_CR36","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00403-013-1348-3","volume":"305","author":"F Megiorni","year":"2013","unstructured":"Megiorni F, et al. Cytotoxic T-lymphocyte antigen 4 (CTLA4) +49AG and CT60 gene polymorphisms in alopecia areata: a case-control association study in the Italian population. Arch Dermatol Res. 2013;305(7):665\u201370.","journal-title":"Arch Dermatol Res"},{"issue":"3","key":"540_CR37","first-page":"489","volume":"34","author":"HG Nusslein","year":"2016","unstructured":"Nusslein HG, et al. Efficacy and prognostic factors of treatment retention with intravenous abatacept for rheumatoid arthritis: 24-month results from an international, prospective, real-world study. Clin Exp Rheumatol. 2016;34(3):489\u201399.","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"540_CR38","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1529-8019.2011.01411.x","volume":"24","author":"L Petukhova","year":"2011","unstructured":"Petukhova L, et al. The genetics of alopecia areata: what\u2019s new and how will it help our patients? Dermatol Ther. 2011;24(3):326\u201336.","journal-title":"Dermatol Ther"},{"issue":"1","key":"540_CR39","first-page":"62","volume":"9","author":"A Ali","year":"2010","unstructured":"Ali A, Martin JMT. Hair growth in patients alopecia areata totalis after treatment with simvastatin and ezetimibe. J Drugs Dermatol. 2010;9(1):62\u20134.","journal-title":"J Drugs Dermatol"},{"issue":"2","key":"540_CR40","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jaad.2014.11.006","volume":"72","author":"C Lattouf","year":"2015","unstructured":"Lattouf C, et al. Treatment of alopecia areata with simvastatin\/ezetimibe. J Am Acad Dermatol. 2015;72(2):359\u201361.","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"540_CR41","doi-asserted-by":"publisher","first-page":"e99","DOI":"10.1016\/j.jaad.2015.09.071","volume":"74","author":"C Loi","year":"2016","unstructured":"Loi C, Starace M, Piraccini BM. Alopecia areata (AA) and treatment with simvastatin\/ezetimibe: experience of 20 patients. J Am Acad Dermatol. 2016;74(5):e99\u2013100.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"540_CR42","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.lfs.2014.01.001","volume":"98","author":"FT Moreira","year":"2014","unstructured":"Moreira FT, et al. Effects of two lipid lowering therapies on immune responses in hyperlipidemic subjects. Life Sci. 2014;98(2):83\u20137.","journal-title":"Life Sci"},{"issue":"4","key":"540_CR43","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1177\/120347541201600407","volume":"16","author":"C Bolduc","year":"2012","unstructured":"Bolduc C, Bissonnette R. Safety and efficacy of adalimumab for the treatment of severe alopecia areata: case series of three patients. J Cutan Med Surg. 2012;16(4):257\u201360.","journal-title":"J Cutan Med Surg"},{"issue":"5","key":"540_CR44","first-page":"892","volume":"27","author":"MV Hernandez","year":"2009","unstructured":"Hernandez MV, et al. Development of alopecia areata after biological therapy with TNF-alpha blockers: description of a case and review of the literature. Clin Exp Rheumatol. 2009;27(5):892\u20133.","journal-title":"Clin Exp Rheumatol"},{"issue":"9","key":"540_CR45","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/nm.3645","volume":"20","author":"L Xing","year":"2014","unstructured":"Xing L, et al. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition. Nat Med. 2014;20(9):1043\u20139.","journal-title":"Nat Med"},{"issue":"3","key":"540_CR46","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1365-2133.2006.07377.x","volume":"155","author":"P Freyschmidt-Paul","year":"2006","unstructured":"Freyschmidt-Paul P, et al. Interferon-gamma-deficient mice are resistant to the development of alopecia areata. Br J Dermatol. 2006;155(3):515\u201321.","journal-title":"Br J Dermatol"},{"issue":"3","key":"540_CR47","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/j.0022-202X.2005.10130_5.x","volume":"10","author":"P Freyschmidt-Paul","year":"2005","unstructured":"Freyschmidt-Paul P, et al. The functional relevance of the type 1 cytokines IFN-gamma and IL-2 in alopecia areata of C3H\/HeJ mice. J Investig Dermatol Symp Proc. 2005;10(3):282\u20133.","journal-title":"J Investig Dermatol Symp Proc"},{"key":"540_CR48","first-page":"651","volume":"6","author":"MN Pham","year":"2015","unstructured":"Pham MN, von Herrath MG, Vela JL. Antigen-specific regulatory T cells and low dose of IL-2 in treatment of type 1 diabetes. Front Immunol. 2015;6:651.","journal-title":"Front Immunol"},{"issue":"7","key":"540_CR49","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1001\/jamadermatol.2014.504","volume":"150","author":"E Castela","year":"2014","unstructured":"Castela E, et al. Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata. JAMA Dermatol. 2014;150(7):748\u201351.","journal-title":"JAMA Dermatol"},{"issue":"1","key":"540_CR50","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jaci.2015.11.001","volume":"137","author":"E Guttman-Yassky","year":"2016","unstructured":"Guttman-Yassky E, et al. Extensive alopecia areata is reversed by IL-12\/IL-23p40 cytokine antagonism. J Allergy Clin Immunol. 2016;137(1):301\u20134.","journal-title":"J Allergy Clin Immunol"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-017-0540-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-017-0540-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-017-0540-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T05:52:52Z","timestamp":1589694772000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-017-0540-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,23]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["540"],"URL":"https:\/\/doi.org\/10.1007\/s12325-017-0540-9","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,23]]},"assertion":[{"value":"20 February 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2017","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}