{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:19:03Z","timestamp":1790705943619,"version":"4.1.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s12325-018-0849-z","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T17:24:42Z","timestamp":1544549082000},"page":"72-85","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Use of Micronized Purified Flavonoid Fraction Together with Rivaroxaban Improves Clinical and Ultrasound Outcomes in Femoropopliteal Venous Thrombosis: Results of a Pilot Clinical Trial"],"prefix":"10.1007","volume":"36","author":[{"given":"Kirill","family":"Lobastov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Schastlivtsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Barinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,11]]},"reference":[{"key":"849_CR1","unstructured":"O\u0431\u0449a\u044f \u0437a\u0431o\u043be\u0432ae\u043coc\u0442\u044c \u0432ce\u0433o \u043dace\u043be\u043d\u0438\u044f Pocc\u0438\u0438 \u0432 2012 \u0433o\u0434y. C\u0442a\u0442\u0438c\u0442\u0438\u0447ec\u043a\u0438e \u043ca\u0442ep\u0438a\u043b\u044b, \u0427ac\u0442\u044c II 2013. [The general prevalences of diseases in the total population of Russia in 2012. Statistical Materials, Part II 2013 (In Russian)]. http:\/\/www.rosminzdrav.ru\/documents\/8029-statisticheskaya-informatsiya-2012. Accessed 19 Oct 2018."},{"key":"849_CR2","unstructured":"\u0417a\u0431o\u043be\u0432ae\u043coc\u0442\u044c \u0432ce\u0433o \u043dace\u043be\u043d\u0438\u044f Pocc\u0438\u0438 \u0432 2014 \u0433o\u0434y. C\u0442a\u0442\u0438c\u0442\u0438\u0447ec\u043a\u0438e \u043ca\u0442ep\u0438a\u043b\u044b, \u0427ac\u0442\u044c II 2015 [The prevalences of diseases in the total population of Russia in 2014. Statistical Materials, Part II 2015 (In Russian)]. https:\/\/www.rosminzdrav.ru\/documents\/9479-statisticheskaya-informatsiya-za-2014.  Accessed 19 Oct 2018."},{"key":"849_CR3","unstructured":"\u0417a\u0431o\u043be\u0432ae\u043coc\u0442\u044c \u0432ce\u0433o \u043dace\u043be\u043d\u0438\u044f Pocc\u0438\u0438 \u0432 2016 \u0433o\u0434y. C\u0442a\u0442\u0438c\u0442\u0438\u0447ec\u043a\u0438e \u043ca\u0442ep\u0438a\u043b\u044b \u0427ac\u0442\u044c II 2017. [The prevalences of diseases in the total population of Russia in 2016. Statistical Materials, Part II 2017 (In Russian)]. https:\/\/www.rosminzdrav.ru\/ministry\/61\/22\/stranitsa-979\/statisticheskie-i-informatsionnye-materialy\/statisticheskiy-sbornik-2016-god. Accessed 19 Oct 2018."},{"key":"849_CR4","doi-asserted-by":"publisher","first-page":"d4656","DOI":"10.1136\/bmj.d4656","volume":"343","author":"J Hippisley-Cox","year":"2011","unstructured":"Hippisley-Cox J, Coupland C. Development and validation of risk prediction algorithm (QThrombosis) to estimate future risk of venous thromboembolism: prospective cohort study. BMJ. 2011;343:d4656.","journal-title":"BMJ"},{"key":"849_CR5","doi-asserted-by":"crossref","unstructured":"Oger E. Incidence of venous thromboembolism: a community-based study in Western France. EPI-GETBP Study Group. Groupe d\u2019Etude de la Thrombose de Bretagne Occidentale. J Thromb Haemost. 2000;83(5):657\u201360.","DOI":"10.1055\/s-0037-1613887"},{"issue":"4","key":"849_CR6","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1538-7836.2007.02450.x","volume":"5","author":"IA Naess","year":"2007","unstructured":"Naess IA, Christiansen SC, Romundstad P, Cannegieter SC, Rosendaal FR, Hammerstrom J. Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost. 2007;5(4):692\u20139.","journal-title":"J Thromb Haemost"},{"key":"849_CR7","first-page":"471","volume-title":"Epidemiology of venous thromboembolism. A textbook of vascular medicine","author":"E Van Beek","year":"1996","unstructured":"Van Beek E, Buller H, Ten Cate J. Epidemiology of venous thromboembolism. A textbook of vascular medicine. London: Arnold; 1996. p. 471\u201388."},{"issue":"6","key":"849_CR8","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1001\/archinte.158.6.585","volume":"158","author":"MD Silverstein","year":"1998","unstructured":"Silverstein MD, Heit JA, Mohr DN, Petterson TM, O\u2019Fallon WM, Melton LJ 3rd. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998;158(6):585\u201393.","journal-title":"Arch Intern Med"},{"issue":"1","key":"849_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7326\/0003-4819-125-1-199607010-00001","volume":"125","author":"P Prandoni","year":"1996","unstructured":"Prandoni P, Lensing AW, Cogo A, et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med. 1996;125(1):1\u20137.","journal-title":"Ann Intern Med"},{"key":"849_CR10","doi-asserted-by":"crossref","unstructured":"Mohr DN, Silverstein MD, Heit JA, Petterson TM, O\u2019fallon WM, Melton LJ. The venous stasis syndrome after deep venous thrombosis or pulmonary embolism: a population-based study. Mayo Clin Proc. 2000;75(12):1249\u201356.","DOI":"10.4065\/75.12.1249"},{"issue":"1","key":"849_CR11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1161\/01.CIR.93.1.74","volume":"93","author":"UK Franzeck","year":"1996","unstructured":"Franzeck UK, Schalch I, J\u00e4ger KA, Schneider E, Grimm J, Bollinger A. Prospective 12-year follow-up study of clinical and hemodynamic sequelae after deep vein thrombosis in low-risk patients (Z\u00fcrich study). Circulation. 1996;93(1):74\u20139.","journal-title":"Circulation"},{"issue":"10","key":"849_CR12","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1001\/archinte.1995.00430100053006","volume":"155","author":"RJ Beyth","year":"1995","unstructured":"Beyth RJ, Cohen AM, Landefeld CS. Long-term outcomes of deep-vein thrombosis. Arch Intern Med. 1995;155(10):1031\u20137.","journal-title":"Arch Intern Med"},{"key":"849_CR13","doi-asserted-by":"crossref","unstructured":"Kahn S, Comerota A, Cushman M. Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing. The postthrombotic syndrome: evidence-based prevention, diagnosis, and treatment strategies: a scientific statement from the American Heart Association. Circulation. 2014;130(18):1636\u201361.","DOI":"10.1161\/CIR.0000000000000130"},{"issue":"2","key":"849_CR14","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1538-7836.2004.01106.x","volume":"3","author":"P Prandoni","year":"2005","unstructured":"Prandoni P, Frulla M, Sartor D, Concolato A, Girolami A. Vein abnormalities and the post-thrombotic syndrome. J Thromb Haemost. 2005;3(2):401\u20132.","journal-title":"J Thromb Haemost"},{"issue":"4","key":"849_CR15","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1160\/TH13-06-0442","volume":"110","author":"V Vedovetto","year":"2013","unstructured":"Vedovetto V, Dalla Valle F, Milan M, Pesavento R, Prandoni P. Residual vein thrombosis and trans-popliteal reflux in patients with and without the post-thrombotic syndrome. Thromb Haemost. 2013;110(4):854\u20135.","journal-title":"Thromb Haemost"},{"issue":"3","key":"849_CR16","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/jth.12106","volume":"11","author":"J Galanaud","year":"2013","unstructured":"Galanaud J, Holcroft C, Rodger M, et al. Predictors of post-thrombotic syndrome in a population with a first deep vein thrombosis and no primary venous insufficiency. J Thromb Haemost. 2013;11(3):474\u201380.","journal-title":"J Thromb Haemost"},{"issue":"12","key":"849_CR17","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1111\/j.1538-7836.2008.03180.x","volume":"6","author":"L Tick","year":"2008","unstructured":"Tick L, Kramer M, Rosendaal F, Faber W, Doggen C. Risk factors for post-thrombotic syndrome in patients with a first deep venous thrombosis. J Thromb Haemost. 2008;6(12):2075\u201381.","journal-title":"J Thromb Haemost"},{"issue":"3","key":"849_CR18","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.jvs.2011.10.032","volume":"55","author":"AJ Comerota","year":"2012","unstructured":"Comerota AJ, Grewal N, Martinez JT, et al. Postthrombotic morbidity correlates with residual thrombus following catheter-directed thrombolysis for iliofemoral deep vein thrombosis. J Vasc Surg. 2012;55(3):768\u201373.","journal-title":"J Vasc Surg"},{"key":"849_CR19","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.it.2018.04.010","volume":"39","author":"I Budnik","year":"2018","unstructured":"Budnik I, Brill A. Immune factors in deep vein thrombosis initiation. Trends Immunol. 2018;39:610\u201323.","journal-title":"Trends Immunol"},{"key":"849_CR20","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1016\/S0049-3848(09)70148-3","volume":"123","author":"PK Henke","year":"2009","unstructured":"Henke PK, Wakefield T. Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes. Thromb Res. 2009;123:S72\u20138.","journal-title":"Thromb Res"},{"issue":"21","key":"849_CR21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1182\/blood.V122.21.36.36","volume":"122","author":"A Rabinovich","year":"2013","unstructured":"Rabinovich A, Cohen JM, Cushman M, et al. Inflammation markers and the risk of post thrombotic syndrome: results from the Bio-Sox Study. Blood. 2013;122(21):36.","journal-title":"Blood"},{"issue":"4","key":"849_CR22","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.jvsv.2015.04.005","volume":"3","author":"A Rabinovich","year":"2015","unstructured":"Rabinovich A, Cohen JM, Cushman M, et al. Association between inflammation biomarkers, anatomic extent of deep venous thrombosis, and venous symptoms after deep venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2015;3(4):347\u201353.","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"issue":"4","key":"849_CR23","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/j.1538-7836.2009.03286.x","volume":"7","author":"E Roumen-Klappe","year":"2009","unstructured":"Roumen-Klappe E, Janssen M, Van Rossum J, et al. Inflammation in deep vein thrombosis and the development of post-thrombotic syndrome: a prospective study. J Thromb Haemost. 2009;7(4):582\u20137.","journal-title":"J Thromb Haemost"},{"issue":"03","key":"849_CR24","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1160\/TH08-08-0511","volume":"101","author":"H Shbaklo","year":"2009","unstructured":"Shbaklo H, Holcroft CA, Kahn SR. Levels of inflammatory markers and the development of the post-thrombotic syndrome. J Thromb Haemost. 2009;101(03):505\u201312.","journal-title":"J Thromb Haemost"},{"issue":"8","key":"849_CR25","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1111\/j.1538-7836.2012.04798.x","volume":"10","author":"A Bouman","year":"2012","unstructured":"Bouman A, Smits J, Ten Cate H, Ten Cate-Hoek A. Markers of coagulation, fibrinolysis and inflammation in relation to post-thrombotic syndrome. J Thromb Haemost. 2012;10(8):1532\u20138.","journal-title":"J Thromb Haemost"},{"issue":"Suppl 1","key":"849_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000054070","volume":"36","author":"RJ Korthuis","year":"1999","unstructured":"Korthuis RJ, Gute DC. Adhesion molecule expression in postischemic microvascular dysfunction: activity of a micronized purified flavonoid fraction. J Vasc Res. 1999;36(Suppl 1):15\u201323.","journal-title":"J Vasc Res"},{"issue":"1","key":"849_CR27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1549-8719.2000.tb00741.x","volume":"7","author":"S Takase","year":"2000","unstructured":"Takase S, Lerond L, Bergan JJ, Schmid-Schonbein GW. The inflammatory reaction during venous hypertension in the rat. Microcirculation. 2000;7(1):41\u201352.","journal-title":"Microcirculation"},{"issue":"5","key":"849_CR28","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.ejvs.2004.05.012","volume":"28","author":"S Takase","year":"2004","unstructured":"Takase S, Pascarella L, Lerond L, Bergan JJ, Schmid-Schonbein GW. Venous hypertension, inflammation and valve remodeling. Eur J Vasc Endovasc Surg. 2004;28(5):484\u201393.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"849_CR29","doi-asserted-by":"crossref","unstructured":"Maria das Gra\u00e7as C, Cyrino FZ, de Carvalho JJ, Blanc-Guillemaud V, Bouskela E. Protective effects of micronized purified flavonoid fraction (MPFF) on a novel experimental model of chronic venous hypertension. Eur J Vasc Endovasc Surg. 2018;55(5):694\u2013702.","DOI":"10.1016\/j.ejvs.2018.02.009"},{"issue":"3","key":"849_CR30","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1067\/mva.2000.102724","volume":"31","author":"SS Shoab","year":"2000","unstructured":"Shoab SS, Porter JB, Scurr JH, Coleridge-Smith PD. Effect of oral micronized purified flavonoid fraction treatment on leukocyte adhesion molecule expression in patients with chronic venous disease: a pilot study. J Vasc Surg. 2000;31(3):456\u201361.","journal-title":"J Vasc Surg"},{"issue":"1","key":"849_CR31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.23736\/S0392-9590.17.03868-8","volume":"37","author":"VY Bogachev","year":"2018","unstructured":"Bogachev VY, Boldin BV, Lobanov VN. Benefits of micronized purified flavonoid fraction as adjuvant therapy on inflammatory response after sclerotherapy. Int Angiol. 2018;37(1):71\u20138.","journal-title":"Int Angiol"},{"issue":"13","key":"849_CR32","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1056\/NEJMoa023153","volume":"349","author":"PS Wells","year":"2003","unstructured":"Wells PS, Anderson DR, Rodger M, et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Eng J Med. 2003;349(13):1227\u201335.","journal-title":"N Eng J Med"},{"key":"849_CR33","doi-asserted-by":"crossref","unstructured":"Vasquez MA, Munschauer CE. Venous Clinical Severity Score and quality-of-life assessment tools: application to vein practice. Phlebology. 2008:259\u201375.","DOI":"10.1258\/phleb.2008.008018"},{"key":"849_CR34","unstructured":"CIVIQ users\u2019 guide. http:\/\/www.civiq-20.com. Accessed 19 Oct 2018."},{"key":"849_CR35","unstructured":"Villalta S, Bagatella P, Piccioli A, Lensing A, Prins M, Prandoni P. Assessment of validity and reproducibility of a clinical scale for the post-thrombotic syndrome [abstract]. Haemostasis. 1994(24 suppl 1):158a."},{"issue":"5","key":"849_CR36","first-page":"1018","volume":"89","author":"VJ Marder","year":"1977","unstructured":"Marder VJ, Soulen RL, Atichartakarn V, et al. Quantitative venographic assessment of deep vein thrombosis in the evaluation of streptokinase and heparin therapy. J Lab Clin Med. 1977;89(5):1018\u201329.","journal-title":"J Lab Clin Med"},{"issue":"4","key":"849_CR37","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","volume":"3","author":"S Schulman","year":"2005","unstructured":"Schulman S, Kearon C. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost. 2005;3(4):692\u20134.","journal-title":"J Thromb Haemost"},{"key":"849_CR38","first-page":"121","volume-title":"Acute and chronic venous thrombosis: pathogenesis and new insights. Handbook of venous and lymphatic disorders","author":"PK Henke","year":"2017","unstructured":"Henke PK, Wakefield TW, Diaz JA. Acute and chronic venous thrombosis: pathogenesis and new insights. Handbook of venous and lymphatic disorders. Boca Raton: CRC; 2017. p. 121\u201336."},{"issue":"5","key":"849_CR39","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/S0741-5214(95)70038-2","volume":"22","author":"MH Meissner","year":"1995","unstructured":"Meissner MH, Caps MT, Bergelin RO, Manzo RA, Strandness DE Jr. Propagation, rethrombosis and new thrombus formation after acute deep venous thrombosis. J Vasc Surg. 1995;22(5):558\u201367.","journal-title":"J Vasc Surg"},{"issue":"1","key":"849_CR40","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1053\/pcad.2001.24684","volume":"44","author":"P Egermayer","year":"2001","unstructured":"Egermayer P. The effects of heparin and oral anticoagulants on thrombus propagation and prevention of the postphlebitic syndrome: a critical review of the literature. Prog Cardiovasc Dis. 2001;44(1):69\u201380.","journal-title":"Prog Cardiovasc Dis"},{"issue":"8","key":"849_CR41","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.amjmed.2011.02.033","volume":"124","author":"RD Hull","year":"2011","unstructured":"Hull RD, Liang J, Townshend G. Long-term low-molecular-weight heparin and the post-thrombotic syndrome: a systematic review. Am J Med. 2011;124(8):756\u201365.","journal-title":"Am J Med"},{"issue":"4","key":"849_CR42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.23736\/S0392-9590.18.04001-4","volume":"37","author":"P Poredos","year":"2018","unstructured":"Poredos P, Jezovnik M. Heparin promotes recanalization of venous thrombotic occlusions. Int Angiol. 2018;37(4):261\u20138.","journal-title":"Int Angiol"},{"issue":"1","key":"849_CR43","first-page":"16","volume":"34","author":"A Roussin","year":"2015","unstructured":"Roussin A. Effective management of acute deep vein thrombosis: direct oral anticoagulants. Int Angiol. 2015;34(1):16\u201329.","journal-title":"Int Angiol"},{"key":"849_CR44","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.thromres.2018.01.013","volume":"163","author":"K Utne","year":"2018","unstructured":"Utne K, Dahm A, Wik H, Jelsness-J\u00f8rgensen L, Sandset P, Ghanima W. Rivaroxaban versus warfarin for the prevention of post-thrombotic syndrome. Thromb Res. 2018;163:6\u201311.","journal-title":"Thromb Res"},{"key":"849_CR45","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.thromres.2017.05.029","volume":"157","author":"L Jeraj","year":"2017","unstructured":"Jeraj L, Jezovnik M, Poredos P. Rivaroxaban versus warfarin in the prevention of post-thrombotic syndrome. Thromb Res. 2017;157:46\u20138.","journal-title":"Thromb Res"},{"key":"849_CR46","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.thromres.2017.03.022","volume":"153","author":"P Prandoni","year":"2017","unstructured":"Prandoni P, Ageno W, Mumoli N, et al. Recanalization rate in patients with proximal vein thrombosis treated with the direct oral anticoagulants. Thromb Res. 2017;153:97\u2013100.","journal-title":"Thromb Res"},{"key":"849_CR47","doi-asserted-by":"crossref","unstructured":"Rothmeier AS, Ruf W. Protease-activated receptor 2 signaling in inflammation. Semin Immunopathol. 2012;34(1):133\u20134.","DOI":"10.1007\/s00281-011-0289-1"},{"issue":"1","key":"849_CR48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.23736\/S0392-9590.17.03894-9","volume":"37","author":"E Ramacciotti","year":"2018","unstructured":"Ramacciotti E, Volpiani GG, Davila R, Resende VA, Silveira FM, Fareed J. Early recanalization of veins in patients with DVT treated with rivaroxaban: do we need to move from bedside to bench again? Int Angiol. 2018;37(1):1\u20133.","journal-title":"Int Angiol"},{"issue":"5","key":"849_CR49","first-page":"515","volume":"87","author":"F Piovella","year":"2002","unstructured":"Piovella F, Crippa L, Barone M, et al. Normalization rates of compression ultrasonography in patients with a first episode of deep vein thrombosis of the lower limbs: association with recurrence and new thrombosis. Haematologica. 2002;87(5):515\u201322.","journal-title":"Haematologica"},{"issue":"3","key":"849_CR50","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1182\/blood-2008-01-131656","volume":"112","author":"S Siragusa","year":"2008","unstructured":"Siragusa S, Malato A, Anastasio R, et al. Residual vein thrombosis to establish duration of anticoagulation after a first episode of deep vein thrombosis: the Duration of Anticoagulation based on Compression UltraSonography (DACUS) study. Blood. 2008;112(3):511\u20135.","journal-title":"Blood"},{"issue":"12","key":"849_CR51","doi-asserted-by":"publisher","first-page":"955","DOI":"10.7326\/0003-4819-137-12-200212170-00008","volume":"137","author":"P Prandoni","year":"2002","unstructured":"Prandoni P, Lensing AW, Prins MH, et al. Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism. Ann Intern Med. 2002;137(12):955\u201360.","journal-title":"Ann Intern Med"},{"issue":"9","key":"849_CR52","doi-asserted-by":"publisher","first-page":"577","DOI":"10.7326\/0003-4819-150-9-200905050-00003","volume":"150","author":"P Prandoni","year":"2009","unstructured":"Prandoni P, Prins MH, Lensing AW, et al. Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial. Ann Intern Med. 2009;150(9):577\u201385.","journal-title":"Ann Intern Med"},{"issue":"2","key":"849_CR53","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jvsv.2017.12.033","volume":"6","author":"F Trinh","year":"2018","unstructured":"Trinh F, Paolini D, Fish J, Kasper G, Lurie F. Use of Villalta score for defining post-thrombotic disease may lead to false-positive diagnosis in 42% of patients with primary chronic venous disease. J Vasc Surg Venous Lymphat Disord. 2018;6(2):291.","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"issue":"2","key":"849_CR54","doi-asserted-by":"crossref","first-page":"143","DOI":"10.23736\/S0392-9590.18.03975-5","volume":"37","author":"SK Kakkos","year":"2018","unstructured":"Kakkos SK, Nicolaides AN. Efficacy of micronized purified flavonoid fraction (Daflon\u00ae) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials. Int Angiol. 2018;37(2):143\u201354.","journal-title":"Int Angiol"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-018-0849-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-018-0849-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-018-0849-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:37:40Z","timestamp":1724413060000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-018-0849-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,11]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["849"],"URL":"https:\/\/doi.org\/10.1007\/s12325-018-0849-z","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,11]]},"assertion":[{"value":"25 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2018","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}